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Associate Scientist II in Vaccine Research

Vaxcyte, Inc.San Carlos, California, United States
On-site Full-time $105K/yr - $123K/yr

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Experience Level

Experience

Qualifications

Applicants must hold a Bachelor's degree in a relevant field and have hands-on experience in chromatographic techniques. A strong analytical mindset and a passion for vaccine research are essential.

About the job

About Vaxcyte

Vaxcyte, Inc. is advancing vaccine research in San Carlos, California, with a focus on high-fidelity vaccines targeting serious bacterial diseases. The team works to address infections such as invasive pneumococcal disease, Group A Streptococcus, and Shigella. Vaxcyte’s mission centers on reducing or managing these health threats through innovative science and a clear, strategic vision.

Our Values

  • Rethink Convention: Encourage creativity and welcome diverse perspectives to improve vaccine delivery.
  • Aim High: Pursue ambitious goals in developing complex biologics for public health.
  • Lead with Heart: Foster a collaborative culture rooted in kindness, inclusivity, and healthy debate.
  • Model Excellence: Commit to integrity, accountability, and clear communication in all work.

Role Overview: Associate Scientist II, Vaccine Research

The Research team relies on a broad set of chromatographic techniques to purify vaccine antigens. This role calls for hands-on experience with multiple chromatography methods, including monoclonal antibody/Protein A workflows. Candidates should have worked on selecting, screening, developing, scaling up, and characterizing various chromatography techniques.

Main Responsibilities

  • Carry out AKTA FPLC chromatography, including:
    • Immobilized metal affinity chromatography (IMAC)
    • Ion-exchange chromatography (IEX)
    • Hydrophobic interaction chromatography (HIC)
    • Size-exclusion chromatography (SEC)
    • Hydroxyapatite (CHT / HA)
  • Design chromatography trains to reduce host cell proteins, endotoxins, and aggregates by combining complementary techniques.
  • Apply Design of Experiments (DoE) for multimodal optimization (experience in this area is a plus).
  • Use membrane chromatography for high-throughput contaminant analysis.

About Vaxcyte, Inc.

Vaxcyte, Inc. is dedicated to pioneering vaccine solutions that address significant bacterial health threats. Our innovative approach and commitment to excellence position us as leaders in vaccine development aimed at improving global health outcomes.

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