About the job
About Vaxcyte
Vaxcyte, Inc. is advancing vaccine research in San Carlos, California, with a focus on high-fidelity vaccines targeting serious bacterial diseases. The team works to address infections such as invasive pneumococcal disease, Group A Streptococcus, and Shigella. Vaxcyte’s mission centers on reducing or managing these health threats through innovative science and a clear, strategic vision.
Our Values
- Rethink Convention: Encourage creativity and welcome diverse perspectives to improve vaccine delivery.
- Aim High: Pursue ambitious goals in developing complex biologics for public health.
- Lead with Heart: Foster a collaborative culture rooted in kindness, inclusivity, and healthy debate.
- Model Excellence: Commit to integrity, accountability, and clear communication in all work.
Role Overview: Associate Scientist II, Vaccine Research
The Research team relies on a broad set of chromatographic techniques to purify vaccine antigens. This role calls for hands-on experience with multiple chromatography methods, including monoclonal antibody/Protein A workflows. Candidates should have worked on selecting, screening, developing, scaling up, and characterizing various chromatography techniques.
Main Responsibilities
- Carry out AKTA FPLC chromatography, including:
- Immobilized metal affinity chromatography (IMAC)
- Ion-exchange chromatography (IEX)
- Hydrophobic interaction chromatography (HIC)
- Size-exclusion chromatography (SEC)
- Hydroxyapatite (CHT / HA)
- Design chromatography trains to reduce host cell proteins, endotoxins, and aggregates by combining complementary techniques.
- Apply Design of Experiments (DoE) for multimodal optimization (experience in this area is a plus).
- Use membrane chromatography for high-throughput contaminant analysis.

