Technical Program Manager for Chemistry Initiatives

Your Impact at Lila Sciences The Director of Discovery Chemistry will spearhead the design, synthesis, and optimization of small molecules across Lila’s discovery platform, emphasizing organic synthesis, molecular design, and scalable chemistry execution. This pivotal role will cultivate and expand a premier molecular chemistry program that translates AI-generated molecular hypotheses into high-quality, synthetically viable, and functionally validated chemical entities. Collaboration is key, as you will work closely with Lila’s AI, automation, computational biology, and platform teams to establish the chemistry infrastructure necessary to swiftly advance novel molecules from conception to validated candidates across diverse discovery initiatives. You will drive synthetic strategy, route design, analog generation, molecular property optimization, and chemistry-enabled innovation while ensuring seamless integration with robotic synthesis and platform-based experimentation. This leadership position is crucial in shaping Lila’s molecular discovery engine by leveraging deep expertise in synthetic organic chemistry, molecular design, and data-driven experimentation to expedite the discovery of high-value molecules for therapeutic and broader platform applications. What You Will Be Building Lead the discovery chemistry strategy across programs, focusing on small molecule design, synthetic innovation, analog generation, and optimization of chemical matter. Oversee the design and implementation of synthetic routes for novel small molecules, prioritizing speed, robustness, scalability, and compatibility with automated synthesis platforms. Develop and enhance efficient workflows for molecular design, compound prioritization, analog generation, and iterative design–make–test cycles in partnership with AI and computational teams. Collaborate closely with automation and platform teams to establish robotic and high-throughput chemistry capabilities that expand accessible chemical space and accelerate molecule generation. Guide the selection of reagents, reaction modalities, and synthetic methodologies to facilitate rapid exploration of structurally diverse and functionally relevant chemical entities.

Company Overview Fulcrum Therapeutics, Inc. (NASDAQ: FULC) is a pioneering clinical-stage biopharmaceutical company dedicated to developing innovative small molecules aimed at enhancing the quality of life for patients with genetically defined rare diseases. We are steadfast in our mission to provide hope and new treatment alternatives for individuals afflicted by rare hematologic disorders and are actively expanding our pipeline of clinical and preclinical assets. Our flagship clinical asset, pociredir, represents a groundbreaking small molecule engineered to boost fetal hemoglobin expression, offering potential treatment for sickle cell disease and other hemoglobinopathies. We are seeking a dynamic and strategic leader to direct our Analytical Chemistry function as we grow our portfolio of clinical-stage assets. Position Overview In this pivotal role, reporting to the Head of Technical Operations, the Director of Analytical Chemistry will spearhead the formulation and implementation of control strategies for the manufacture of drug substances and products within Fulcrum’s developmental programs. The successful candidate will provide expert oversight of all Quality Control (QC) operations at contract manufacturers for drug substances (DS) and drug products (DP). Responsibilities include collaborating with pharmaceutics on pre-formulation tasks, engaging with Quality Assurance (QA) on Out of Specification (OOS) and Out of Trend (OOT) investigations, managing CMC risks, and assisting Regulatory CMC in drafting essential sections of regulatory submissions. Key Responsibilities Deliver technical leadership to Contract Manufacturing Organizations (CMOs) and Contract Research Organizations (CROs) for drug substance and product development, incorporating cGMP method development, validation, method transfer, method remediation, data analysis, and reporting to uphold compliance with GCP, GLP, and cGMP standards. Collaborate with cross-functional teams including Drug Substance, Drug Product, QA, and Regulatory CMC to ensure plans are cohesive, phase-appropriate, and timely. Design and oversee stability studies, including managing shelf-life and retest dates, to guarantee uninterrupted clinical supply. Lead and manage strategies for reference standards, in-process controls, and specifications throughout the asset pipeline. Review and approve a diverse array of documents, such as Test Methods, Qualification/Validation Protocols, Specifications, and Reports at CMOs. Generate, review, and authorize documentation related to the control of DS and DP for Regulatory submissions (IND/IMPD and NDA/MAA). Travel to contract manufacturing sites both domestically and internationally to support crucial production milestones and foster strong business relationships.

Join Flagship Pioneering Inc. as the Director of Antibody Discovery, where you will lead innovative initiatives in antibody research and development. This pivotal role involves overseeing a talented team, driving strategic projects, and collaborating with cross-functional teams to advance our cutting-edge therapeutic programs. Your expertise will be crucial in shaping the future of antibody therapeutics, fostering a culture of scientific excellence, and ensuring the successful execution of discovery projects.

Flagship Pioneering, Inc. is seeking a visionary and experienced Director of Antibody Discovery to lead our innovative research team in Cambridge, UK. In this pivotal role, you will be responsible for spearheading the development of novel antibody therapeutics that will define the future of medicine. You will leverage cutting-edge technologies and methodologies to drive our antibody discovery efforts, collaborating closely with cross-functional teams to bring groundbreaking solutions to patients.

Your Impact at LilaThe Senior Scientist in Analytical Chemistry will spearhead the development and application of cutting-edge analytical and characterization techniques to bolster Discovery Chemistry initiatives across Lila’s innovative platform. This role is pivotal in facilitating the swift design, synthesis, screening, and optimization of small molecules and related molecular entities. You will be instrumental in producing high-quality, informative experimental data that guides chemistry decisions and enhances platform learning.By collaborating closely with teams in Discovery Chemistry, automation, AI/computational fields, and screening, you will establish and scale multimodal characterization workflows that surpass conventional analytical chemistry methodologies. Your expertise will help create an integrated analytical framework that includes compound characterization, reaction monitoring, molecular profiling, and rapid data generation to support fast-paced design–make–test–analyze cycles.Your contributions will be vital in molding Lila’s next-generation discovery engine, merging profound analytical chemistry knowledge with high-throughput experimentation and AI-driven workflows.

Amylyx Pharmaceuticals Inc. is on a bold mission to innovate the treatment landscape for diseases with significant unmet needs. Instead of viewing challenges as roadblocks, we embrace them as opportunities to advance solutions with urgency, scientific rigor, and a steadfast commitment to the communities we serve. As a clinical-stage company, we are currently addressing conditions such as post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).Our mission thrives on the passion of our people. We embody core values of audacity, curiosity, authenticity, engagement, and accountability, fostering a culture of care. With a seasoned team ready to make impactful changes, we invite you to join us in this endeavor if you share our enthusiasm for tackling some of the most challenging issues in medicine.The OpportunityAmylyx Pharmaceuticals Inc. is seeking a seasoned Senior Director of Chemistry, Manufacturing, and Controls (CMC) to lead our CMC organization in the development of our pipeline, including Phase III synthetic peptide Avexitide and Phase I antisense oligonucleotide AMX0114. The CMC team partners with external CDMOs to implement robust, scalable, and compliant processes for clinical and commercial supply. This role may involve direct leadership or managing leads of internal matrix CMC Asset teams, serving as the CMC representative on Asset program teams. This leader will collaborate across functions to drive technical excellence and ensure CMC alignment with program objectives.The ideal candidate will exhibit strong strategic leadership while actively engaging in hands-on execution as needed. This position reports to the Senior Vice President of Global CMC and External Manufacturing.

About Lila Sciences Lila Sciences stands at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory, dedicated to life sciences, chemistry, and materials science. Our mission is to revolutionize the scientific method by harnessing AI capabilities to tackle humanity's most pressing challenges in health, climate, and sustainability. Discover more about our vision at www.lila.ai. At Lila, we foster a culture of collaboration and inclusivity, encouraging diverse perspectives and creative problem-solving within our teams. We believe that all contributions matter and strive to create an environment where every voice is valued. If you resonate with our values and are excited about the possibility of contributing, we encourage you to apply even if you meet only some of the qualifications below. Your Impact at Lila As a Scientist on our Physical Sciences team, you will play a pivotal role in developing innovative flow chemistry workflows. You will design, construct, and optimize cutting-edge flow chemistry platforms, seamlessly integrating real-time analytics and AI-driven decision-making. Collaborating closely with systems engineers and AI scientists, you will enhance our autonomous chemistry capabilities and expedite discovery processes at an unprecedented scale. What You Will Create Design & Commission: Architect and develop versatile flow chemistry platforms for autonomous synthesis, ensuring seamless integration with the Lila platform.

Role Overview Isomorphic Labs is seeking a Director of Computational Drug Design to join its Cambridge, MA site. This leader will shape computational chemistry strategy for both internal research and collaborative projects. The position sits within the Drug Design and Medical Research division, working closely with AI and machine learning specialists to advance the company’s drug design engine and accelerate new medicine development. About Isomorphic Labs Founded in 2021, Isomorphic Labs (IsoLabs) builds on the AlphaFold system, applying advanced AI to solve complex problems in human health. The team combines drug discovery expertise with machine learning to create predictive and generative models that speed up scientific discovery. The company’s mission is to design novel molecules, predict drug performance, and develop new treatments for challenging diseases by modeling biological systems with AI. Isomorphic Labs has developed an AI-driven drug design engine capable across various therapeutic areas and drug types. The organization continues to refine model architectures and expand capabilities, aiming to realize the promise of digital biology and ultimately eradicate disease through artificial intelligence. About the Computational Drug Design Team The Cambridge-based Computational Drug Design team brings together computational chemists focused on driving strategy, supporting both internal and partner projects. Close collaboration with AI/ML colleagues is central to the group’s work, ensuring the continued evolution of the Isomorphic Labs Drug Design Engine. The team values a supportive environment, ongoing learning, and professional development for every member.

Your Impact at LilaAs an intern in Analytical Chemistry, you will play a vital role in our analytical lab operations. You will be responsible for developing analytical methods, acquiring precise data, and working collaboratively with scientists and engineers to advance the field of autonomous chemistry. Your contributions will directly support closed-loop optimization campaigns, significantly expediting the transition from concept to discovery. This position emphasizes hands-on involvement.What You Will Be DevelopingDesign and implement high-throughput optimization cycles for chemical analysis.Employ Process Analytical Technology (PAT) to monitor reaction progress and final products (solids, liquids, gases), while refining methods for analytical screening.Collaborate with scientists to review and benchmark product profiles, propose subsequent closed-loop cycles, and carry out quality controls, with reporting on findings.Maintain a digital log of experimental conditions, metadata, and outcomes to ensure data integrity for AI-driven analysis.Adhere to Environmental Health and Safety (EHS) protocols when handling reagents, maintaining flow equipment, and calibrating analytical instruments.

Join Eurofins Scientific as a Business Development Manager specializing in Drug Discovery. In this dynamic role, you will drive strategic initiatives to enhance our laboratory testing services, fostering collaboration with clients and stakeholders. You will leverage your expertise to identify market opportunities, develop client relationships, and contribute to the growth of our innovative drug discovery solutions.

Join our innovative team at Flagship Pioneering Inc., where we are at the forefront of therapeutic discovery. As a Senior Research Associate, you will play a critical role in advancing our understanding of novel therapeutic pathways and contribute to groundbreaking research in the life sciences.

Join Isomorphic Labs as the Head of Chemistry in Drug Design, where you will be at the forefront of innovative drug discovery. You will lead a talented team of chemists, collaborating with interdisciplinary groups to design and optimize drug candidates. Your expertise will guide the development of cutting-edge pharmaceutical solutions that have the potential to transform patient outcomes.

Role overview Bicycle Therapeutics seeks a Senior Scientist specializing in Computational Chemistry to join the team in Cambridge. The position focuses on using computational methods to design and optimize new therapeutic candidates, directly supporting the company’s goal of developing new medicines. What you will do Lead molecular modeling studies for ongoing drug discovery projects. Use advanced simulation techniques to analyze and predict molecular behavior. Collaborate with scientists from various disciplines to integrate computational insights into laboratory research. Share research findings through publications and presentations at scientific meetings and conferences. Requirements Extensive experience with computational chemistry methods and tools. Strong foundation in molecular modeling and simulation. Proven ability to work effectively within cross-functional teams. Drive to advance drug discovery using computational science.

Join AbbVie as a Senior Scientist II in our Assay Development team, focusing on innovative research in Discovery Psychiatry. This role involves designing, developing, and optimizing assays to advance our understanding of psychiatric disorders. You will collaborate with cross-functional teams to drive research initiatives and contribute to the discovery of effective treatments.The ideal candidate will possess strong scientific expertise, a passion for psychiatric research, and the ability to thrive in a dynamic environment.

Your Impact at Lila The Scientist I/II, Process Chemistry will utilize cutting-edge process chemistry methodologies to enhance Discovery Chemistry initiatives across Lila’s diverse platform. This role emphasizes reaction and reactor engineering, process design, high-throughput experimentation, and digital chemistry workflows aimed at small molecules and associated molecular constructs. We seek a hands-on scientist who possesses a robust background in synthetic and process chemistry, complemented by an engineering mindset and experience in developing scalable, data-driven experimental workflows. Collaboration is key in this role; you will work closely with teams in Discovery Chemistry, analytical chemistry, automation, platform engineering, and AI/computational science to design, implement, and refine reaction and process workflows. These improvements will enhance the speed, reliability, and scalability of chemical transformations. The Scientist I/II will play a crucial role in bridging early-stage discovery chemistry with contemporary process development by establishing efficient, digitally enabled, and automation-friendly methods for reaction screening, process optimization, and chemistry execution. This position is perfect for a scientist passionate about the convergence of chemistry, engineering, high-throughput technologies, process intensification, and digital experimentation and eager to contribute to the evolution of next-generation process chemistry capabilities beyond traditional methods. What You Will Be Building Design, execute, and optimize process-relevant chemical transformations that advance Discovery Chemistry programs and the creation of small molecules. Develop reaction and process workflows with a focus on engineering rigor, scalability, reproducibility, throughput, and data integrity. Implement high-throughput experimentation (HTE) for reaction screening, process optimization, condition scouting, and assessment of process-relevant variables. Create and execute workflows that integrate reaction setup, process screening, workup, analytical readout, and data capture into streamlined experimental cycles. Contribute to the design of digitally enabled process chemistry workflows, including structured experimental data generation, electronic documentation, and the integration of chemistry data into computational and AI-ready systems. Collaborate with automation and platform teams to refine reaction and process workflows for robotics-enabled experimentation.

Your Impact at Lila Sciences Lila Sciences is seeking a dynamic and visionary Director of Product, Life Sciences to lead our innovative product strategies. In this pivotal role, reporting directly to the Vice President of Life Science Product, you will be at the forefront of enhancing our therapeutic research and development capabilities, shaping the future of drug discovery, chemical synthesis, and scientific intelligence. What You'll Be Building Steer the strategic direction for developing breakthrough AI solutions in drug discovery, chemical synthesis, and molecular characterization. Convert strategic goals into comprehensive target product profiles (TPPs) and development campaigns that will empower our science and engineering teams to achieve groundbreaking innovations in life sciences. Lead customer and internal-user discovery initiatives, acting as the primary technical liaison between external customers and partners. Pinpoint and cultivate product opportunities driven by real-world discovery challenges, collaborating closely with stakeholders to ensure relevance and maximize downstream value. Transform insights into precise product requirements, acceptance criteria, and experimental plans that will guide our engineering and science teams. Oversee product execution from inception to launch, leading cross-functional teams across various disciplines including science, machine learning, automation, and software engineering. Manage resource allocations effectively (budget, compute, lab access, personnel) against a complex array of priorities. Establish clear success metrics and milestones, communicating progress to the organization, including executive leadership. What You'll Need to Succeed Advanced degree (MS, PhD, or equivalent experience) in medicinal chemistry, chemical biology, chemical engineering, biochemistry, or a related field, with a solid foundation in experimental science. 7+ years of experience in Product Management, particularly in developing new or experimental products in drug discovery, molecular profiling, machine learning, or scientific software development. In-depth understanding of drug development processes, molecular and cellular research tools, as well as wet and dry lab workflows. Experience with small molecule discovery workflows (e.g., lead optimization, ADMET profiling, synthesis planning) is highly preferred.

Your Role at Lila Sciences As a key contributor to our Physical Sciences division, you will focus on advancing the field of in silico materials discovery techniques. Your responsibilities will involve designing autonomous workflows and data-driven pipelines that effectively integrate simulation with artificial intelligence. You will lead the development of strategies that empower agents to analyze simulation data, derive hidden insights, and facilitate hypothesis generation and materials design. Your innovative approach will enhance our utilization of simulation outputs for discovery, fostering a seamless integration of physics-based modeling with AI reasoning systems. Collaboration with specialists in simulation, AI agents, and experimental automation will be pivotal as we strive to redefine the landscape of digital discovery. Key Contributions Create cutting-edge workflows for in silico materials discovery that link physics-based simulations and generative AI models. Develop intelligent systems where AI agents autonomously design, execute, interpret, and optimize simulations. Establish frameworks that maximize the utility of simulation data for prediction, inference, and discovery, with features like automatic data extraction and model training. Prototype and assess novel paradigms for simulation-aware agents that learn from and interact with scientific simulations. Design data structures, metadata specifications, and APIs to ensure smooth information transfer among simulations, machine learning models, and experimental data repositories. Build scalable, modular workflows that connect electronic structure, atomistic, and mesoscale simulations with AI-driven reasoning and hypothesis generation. Work alongside computational scientists, machine learning professionals, and platform engineers to integrate in silico discovery pipelines into Lila’s overarching scientific superintelligence framework. Qualifications for Success PhD or equivalent experience in Computer Science, Materials Science, Chemistry, Physics, Applied Mathematics, or related fields. Strong background in in silico materials discovery, computational materials modeling, and/or simulation workflow design. Familiarity with large language models and their applications in scientific research. Experience in developing AI-driven or agentic workflows for scientific automation and discovery. Proficient programming skills in Python and scientific computing libraries.

Your Impact at Lila As a Scientist I/II in Organic Chemistry, you will play a pivotal role in the development, execution, and optimization of cutting-edge chemical transformations that enhance Discovery Chemistry initiatives across Lila Sciences. Your focus will be on the rapid synthesis of small molecules and a diverse range of chemical compounds. This position is tailored for an experimental organic chemist who possesses a robust foundation in synthetic chemistry, complemented by practical experience in high-throughput experimentation (HTE), reaction workup, and analytical characterization. Collaborating closely with teams specializing in Discovery Chemistry, analytical chemistry, automation, screening, and AI/computational methods, you will aid in constructing and implementing efficient chemistry workflows designed to expedite molecular design–make–test–analyze cycles. The Scientist II will be integral to reaction development, analog generation, and route execution utilizing contemporary organic chemistry techniques that are compatible with scalable, data-driven, and increasingly automated discovery environments. This role is ideal for a chemist passionate about addressing synthetic challenges at the intersection of reaction innovation, high-throughput experimentation, process efficiency, and analytical insight, and who is driven to contribute to the evolution of next-generation discovery workflows that extend beyond conventional bench chemistry. What You'll Be Building Design and optimize chemical transformations pertinent to Discovery Chemistry programs, with a strong emphasis on the swift synthesis of small molecules and analog series. Utilize modern synthetic organic chemistry methodologies to facilitate efficient exploration of a wide spectrum of structurally diverse and medicinally relevant chemical spaces. Plan and execute multi-step synthesis, reaction optimization, workup, purification, and compound characterization to support molecular discovery campaigns. Develop and implement HTE workflows aimed at reaction screening, condition optimization, reagent evaluation, and rapid assessment of transformation scopes. Establish robust methodologies for reaction setup, workup, sample preparation, and analytical readout to support rapid and information-rich experimentation. Employ analytical tools such as chromatography, NMR, and other related methods to evaluate reaction performance, characterize products, and inform synthetic strategies. Contribute to the evolution of practical and scalable chemistry workflows that integrate reaction discovery, optimization, and downstream compound generation.

Role overview Lila Sciences seeks a Scientist I/II in Drug Delivery Chemistry for its Cambridge, MA location. This role centers on advancing drug delivery systems that align with the company’s broader research objectives. Key responsibilities Collaborate with fellow researchers to design and refine drug delivery technologies. Apply chemistry expertise to enhance scientific strategies and laboratory processes. Contribute to projects focused on improving patient outcomes through innovative drug delivery solutions. Location This position is based in Cambridge, Massachusetts.