Technical Program Manager for Chemistry Initiatives

Lila Sciences, located in Cambridge, MA, develops technology for chemical discovery through its autonomous science platform. The company’s projects include advanced synthesis, new catalyst development, and sustainable molecular design for applications in energy and industry. The Chemistry experiment team is searching for a Technical Program Manager to coordinate complex scientific programs in close partnership with the Chemistry domain lead and teams across the organization. Role overview This position centers on managing the daily operations and long-term planning for the Chemistry experiment team. The Technical Program Manager will keep project plans up to date, monitor milestones, and help ensure scientific programs meet both deadlines and quality standards. Acting as the main point of contact between Chemistry and platform partners, such as Automation, Machine Learning, and Engineering, the role involves communicating needs, aligning priorities, and making sure dependencies are clear and managed. What you will do Maintain project plans, track progress, and ensure delivery of scientific programs on schedule and to quality expectations. Coordinate with cross-functional partners to communicate requirements, align on priorities, and track dependencies. Break down scientific goals into actionable workstreams to support scalable autonomous experimentation. Lead program routines, including sprint planning, stand-ups, and retrospectives, with a focus on purposeful meetings and clear documentation. Work with Chemistry leads to surface and address blockers, risks, and interdependencies early in the process. Support execution of commercial contracts by collaborating with the Product & Revenue team, ensuring commitments are defined, tracked, and communicated. Assist with capacity planning and resource coordination alongside scientific leadership. Requirements At least 10 years of program or project management experience in chemistry, pharmaceuticals, or deep tech sectors. Bachelor’s degree in Chemistry, Chemical Engineering, or a related discipline. Proven ability to manage several programs in complex, evolving environments. Experience building programs from the ground up and working in early-stage startups is a strong plus. Skilled in coordinating with both scientific and operational teams, and managing cross-functional groups.

Role overview Lila Sciences uses its autonomous science platform to tackle challenges in materials discovery, from advanced structural materials and coatings for harsh environments to clean energy catalysts and carbon capture technologies. The Materials Science experimentation team moves quickly and relies on solid operational management to keep projects on track. The Materials Technical Program Manager plays a key role in maintaining this operational discipline. This position focuses on managing execution: overseeing project plans, coordinating dependencies across teams, and removing obstacles before they slow progress. The Technical Program Manager works closely with Materials Science domain leaders, who set the scientific direction, and takes responsibility for building the structure and processes that enable rapid, scalable experimentation. This role does not direct scientific research but ensures the environment supports high-velocity scientific work. It suits someone who enjoys program management in complex technical fields. What you will do Direct daily program execution for the Materials Science experimentation team by managing project plans, tracking milestones, and keeping autonomous science programs on schedule. Act as the main operational point of contact between the Materials Science team and partners in Automation, ML, and Engineering. Communicate needs, align priorities, and resolve cross-functional dependencies. Translate scientific objectives into structured workstreams that support efficient and scalable autonomous experimentation. Lead program rituals such as sprint planning, stand-ups, and retrospectives. Ensure meetings are purposeful, documentation is thorough, and follow-up actions are completed. Collaborate with domain leaders to identify blockers, risks, and interdependencies early, and drive resolution. Support delivery of commercial contracts by working with the Product & Revenue team to define, monitor, and communicate program commitments to stakeholders. Contribute to capacity planning and resource allocation in partnership with scientific leadership. Requirements Minimum 10 years of program or project management experience in materials science, advanced manufacturing, or deep tech settings. Bachelor’s degree in Materials Science, Chemistry, Chemical Engineering, or a related discipline. Proven ability to manage multiple concurrent programs in evolving, ambiguous environments. Strong motivation to build programs from the ground up; experience in early-stage startups is a significant advantage. Location Cambridge, MA, USA

Join lilasciences as a Technical Program Manager in the vibrant city of Cambridge, MA. In this role, you will lead cross-functional teams to drive projects that enhance our innovative life sciences solutions. Your expertise will guide the successful execution of programs from inception through completion, ensuring alignment with our strategic goals.

Lila Sciences is forming a dedicated AI safety team to address the unique risks and challenges posed by scientific superintelligence. The company seeks a Senior or Principal Technical Program Manager to guide the operational side of AI safety research, helping to shape how the team approaches complex and evolving problems. Role overview This Technical Program Manager position connects research, engineering, model development, policy, and executive leadership. The work involves translating fast-moving research into structured, accountable plans. While this is not a research role, curiosity about the technical aspects of AI safety is important. The team values clear communication and the ability to bring clarity and structure as the organization expands. What you will do Act as the primary communication link between the AI safety team and technical, research, and scientific groups. Share complex results and coordinate resource needs. Establish information flows to keep teams connected. Promote accountability within cross-functional, distributed teams, building consensus and trust through open communication and sound judgment. Support rapid experimentation and iteration by refining and applying effective program management practices. Create clear documentation and reports to communicate vision, track progress, and ensure alignment with company objectives. Accurately represent program status and risks, even in uncertain or shifting situations. Requirements Bachelor’s or Master’s degree in Computer Science, Engineering, Life Sciences, or a related discipline. Minimum of 6 years of program or project management experience in technology or life sciences. Demonstrated success in program management, leading cross-functional teams, and delivering projects. Strong analytical and problem-solving abilities, with skill in turning technical requirements into actionable plans. Excellent written and verbal communication skills, including experience preparing executive-level documents, roadmaps, and updates. Location This position is based in Cambridge, MA or San Francisco, CA, USA.

Your Impact at Lila Sciences The Director of Discovery Chemistry will spearhead the design, synthesis, and optimization of small molecules across Lila’s discovery platform, emphasizing organic synthesis, molecular design, and scalable chemistry execution. This pivotal role will cultivate and expand a premier molecular chemistry program that translates AI-generated molecular hypotheses into high-quality, synthetically viable, and functionally validated chemical entities. Collaboration is key, as you will work closely with Lila’s AI, automation, computational biology, and platform teams to establish the chemistry infrastructure necessary to swiftly advance novel molecules from conception to validated candidates across diverse discovery initiatives. You will drive synthetic strategy, route design, analog generation, molecular property optimization, and chemistry-enabled innovation while ensuring seamless integration with robotic synthesis and platform-based experimentation. This leadership position is crucial in shaping Lila’s molecular discovery engine by leveraging deep expertise in synthetic organic chemistry, molecular design, and data-driven experimentation to expedite the discovery of high-value molecules for therapeutic and broader platform applications. What You Will Be Building Lead the discovery chemistry strategy across programs, focusing on small molecule design, synthetic innovation, analog generation, and optimization of chemical matter. Oversee the design and implementation of synthetic routes for novel small molecules, prioritizing speed, robustness, scalability, and compatibility with automated synthesis platforms. Develop and enhance efficient workflows for molecular design, compound prioritization, analog generation, and iterative design–make–test cycles in partnership with AI and computational teams. Collaborate closely with automation and platform teams to establish robotic and high-throughput chemistry capabilities that expand accessible chemical space and accelerate molecule generation. Guide the selection of reagents, reaction modalities, and synthetic methodologies to facilitate rapid exploration of structurally diverse and functionally relevant chemical entities.

Cambridge Mobile Telematics (CMT) stands as the world's largest telematics service provider, dedicated to enhancing road safety for drivers everywhere. Our innovative AI-driven platform, DriveWell Fusion®, aggregates sensor data from millions of IoT devices—including smartphones, proprietary Tags, connected vehicles, dashcams, and third-party devices—merging them with contextual data to deliver a comprehensive view of vehicle and driver behavior. Our insights empower auto insurers, automakers, commercial mobility companies, and public sector entities to enhance risk assessment, safety measures, claims processing, and driver improvement initiatives. With our headquarters in Cambridge, MA, and offices around the globe—including Budapest, Chennai, Seattle, Tokyo, and Zagreb—CMT safeguards millions of drivers daily.We are in search of an exceptional Principal Technical Program Manager who will take the helm in leading extensive cross-organizational initiatives from inception through to release. This pivotal role encompasses the coordination of release activities and the assembly of all CMT product lines. Our products are instrumental in our mission to promote safer drivers and roads by seamlessly integrating with a variety of applications and services. Your leadership will be crucial in ensuring the timely and effective delivery of our technological solutions to partners and customers, making a significant impact on global safety.You will play a key role in influencing organizational roadmap priorities, determining system ownership, team composition, and guiding technical direction. Your ability to clearly communicate complex trade-off decisions to senior leadership will be essential in helping them navigate options. Identifying when a solution necessitates further technical guidance or can unlock substantial capabilities will be part of your expertise. You will also manage cross-functional communications to keep all stakeholders informed and aligned with project needs. Your guidance will ensure that the technical direction adheres to CMT's high standards for customer satisfaction, efficiency, stability, extensibility, simplicity, and operational excellence.If you are a collaborative, customer-focused, and innovative professional, we invite you to join us in our mission to make the world’s roads safer!

About Lila Sciences Lila Sciences stands at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory, dedicated to life sciences, chemistry, and materials science. Our mission is to revolutionize the scientific method by harnessing AI capabilities to tackle humanity's most pressing challenges in health, climate, and sustainability. Discover more about our vision at www.lila.ai. At Lila, we foster a culture of collaboration and inclusivity, encouraging diverse perspectives and creative problem-solving within our teams. We believe that all contributions matter and strive to create an environment where every voice is valued. If you resonate with our values and are excited about the possibility of contributing, we encourage you to apply even if you meet only some of the qualifications below. Your Impact at Lila As a Scientist on our Physical Sciences team, you will play a pivotal role in developing innovative flow chemistry workflows. You will design, construct, and optimize cutting-edge flow chemistry platforms, seamlessly integrating real-time analytics and AI-driven decision-making. Collaborating closely with systems engineers and AI scientists, you will enhance our autonomous chemistry capabilities and expedite discovery processes at an unprecedented scale. What You Will Create Design & Commission: Architect and develop versatile flow chemistry platforms for autonomous synthesis, ensuring seamless integration with the Lila platform.

Company Overview Fulcrum Therapeutics, Inc. (NASDAQ: FULC) is a pioneering clinical-stage biopharmaceutical company dedicated to developing innovative small molecules aimed at enhancing the quality of life for patients with genetically defined rare diseases. We are steadfast in our mission to provide hope and new treatment alternatives for individuals afflicted by rare hematologic disorders and are actively expanding our pipeline of clinical and preclinical assets. Our flagship clinical asset, pociredir, represents a groundbreaking small molecule engineered to boost fetal hemoglobin expression, offering potential treatment for sickle cell disease and other hemoglobinopathies. We are seeking a dynamic and strategic leader to direct our Analytical Chemistry function as we grow our portfolio of clinical-stage assets. Position Overview In this pivotal role, reporting to the Head of Technical Operations, the Director of Analytical Chemistry will spearhead the formulation and implementation of control strategies for the manufacture of drug substances and products within Fulcrum’s developmental programs. The successful candidate will provide expert oversight of all Quality Control (QC) operations at contract manufacturers for drug substances (DS) and drug products (DP). Responsibilities include collaborating with pharmaceutics on pre-formulation tasks, engaging with Quality Assurance (QA) on Out of Specification (OOS) and Out of Trend (OOT) investigations, managing CMC risks, and assisting Regulatory CMC in drafting essential sections of regulatory submissions. Key Responsibilities Deliver technical leadership to Contract Manufacturing Organizations (CMOs) and Contract Research Organizations (CROs) for drug substance and product development, incorporating cGMP method development, validation, method transfer, method remediation, data analysis, and reporting to uphold compliance with GCP, GLP, and cGMP standards. Collaborate with cross-functional teams including Drug Substance, Drug Product, QA, and Regulatory CMC to ensure plans are cohesive, phase-appropriate, and timely. Design and oversee stability studies, including managing shelf-life and retest dates, to guarantee uninterrupted clinical supply. Lead and manage strategies for reference standards, in-process controls, and specifications throughout the asset pipeline. Review and approve a diverse array of documents, such as Test Methods, Qualification/Validation Protocols, Specifications, and Reports at CMOs. Generate, review, and authorize documentation related to the control of DS and DP for Regulatory submissions (IND/IMPD and NDA/MAA). Travel to contract manufacturing sites both domestically and internationally to support crucial production milestones and foster strong business relationships.

Your Impact at LilaAs an intern in Analytical Chemistry, you will play a vital role in our analytical lab operations. You will be responsible for developing analytical methods, acquiring precise data, and working collaboratively with scientists and engineers to advance the field of autonomous chemistry. Your contributions will directly support closed-loop optimization campaigns, significantly expediting the transition from concept to discovery. This position emphasizes hands-on involvement.What You Will Be DevelopingDesign and implement high-throughput optimization cycles for chemical analysis.Employ Process Analytical Technology (PAT) to monitor reaction progress and final products (solids, liquids, gases), while refining methods for analytical screening.Collaborate with scientists to review and benchmark product profiles, propose subsequent closed-loop cycles, and carry out quality controls, with reporting on findings.Maintain a digital log of experimental conditions, metadata, and outcomes to ensure data integrity for AI-driven analysis.Adhere to Environmental Health and Safety (EHS) protocols when handling reagents, maintaining flow equipment, and calibrating analytical instruments.

Harvard University is hiring a Program Manager, Student Programs, to join the team in Cambridge. This position focuses on shaping and delivering initiatives that foster both academic achievement and personal growth among students. The Program Manager works closely with faculty, staff, and students to help create a welcoming and engaging campus community. Key Responsibilities Design and launch student programs aimed at supporting learning and personal development Collaborate with faculty, staff, and students to maintain a supportive and inclusive environment Use project management skills to oversee new and ongoing student initiatives Apply knowledge of student development to guide program success Collaboration and Impact This role requires regular partnership with various campus groups. By working across departments, the Program Manager helps ensure that student programs are effective and responsive to community needs.

About the Cambridge Boston Alignment InitiativeThe Cambridge Boston Alignment Initiative (CBAI) is a nonprofit organization dedicated to pioneering research and education that facilitates a safe and beneficial transition to advanced artificial intelligence systems. Our mission is to produce original research and expedite AI safety initiatives through fellowship programs.Following the successful launch of our AI Safety Research Fellowship in 2025, where our inaugural cohort made significant contributions including a spotlight paper at the Mechanistic Interpretability Workshop at NeurIPS and placements at prestigious conferences such as ICLR, we are poised for rapid growth in 2026. We are excited to introduce the inaugural AIxBio Research Fellowship, which will apply our mentor-driven research model to the critical intersection of AI and biosecurity.We invite you to refer candidates and earn a $5,000 reward for any successful hires.

Scholar Rock is a pioneering biopharmaceutical firm dedicated to discovering, developing, and delivering transformative therapies for individuals facing serious diseases with significant unmet needs. As a global frontrunner in the biology of the transforming growth factor beta (TGFβ) superfamily of cell proteins, the company is named for the visual resemblance of a scholar rock to protein structures. Focused on advancing innovative treatments where protein growth factors are crucial, Scholar Rock has built a promising pipeline aimed at enhancing care standards for neuromuscular diseases, cardiometabolic disorders, cancer, and beyond, where growth factor-targeted medications can lead to transformative outcomes. Scholar Rock is the sole entity to demonstrate clinical proof of concept for a muscle-targeted therapy in spinal muscular atrophy (SMA). This dedication to pioneering distinct therapeutic strategies is driven by the broad application of a proprietary platform that has successfully developed novel monoclonal antibodies to precisely modulate protein growth factors. By leveraging cutting-edge scientific advancements in historically under-addressed disease areas, Scholar Rock strives daily to create new opportunities for patients. Discover more about the company's innovative approach at ScholarRock.com and follow us on @ScholarRock and LinkedIn.Summary of the Role:Scholar Rock is on the lookout for a Director of Program Management to act as the primary operational partner for the Myostatin Core Team. As the company progresses apitegromab through late-stage development and into commercialization, this role is critical in ensuring the Core Team operates with precision, speed, and alignment.This position is tailored for a highly accountable operator who collaborates seamlessly with the Program Leader. While the Program Leader concentrates on executive alignment and organizational strategy ("managing up and out"), the Program Manager focuses on internal team efficiency and execution ("managing in and down"). We seek a leader with the professional maturity to navigate the complexities of Lifecycle Management, coupled with the humility to own the details—from high-level scenario planning to the tactical nuances of meeting governance and documentation.Key Responsibilities:

Join Isomorphic Labs as the Head of Chemistry in Drug Design, where you will be at the forefront of innovative drug discovery. You will lead a talented team of chemists, collaborating with interdisciplinary groups to design and optimize drug candidates. Your expertise will guide the development of cutting-edge pharmaceutical solutions that have the potential to transform patient outcomes.

Your Impact at LilaThe Senior Scientist in Analytical Chemistry will spearhead the development and application of cutting-edge analytical and characterization techniques to bolster Discovery Chemistry initiatives across Lila’s innovative platform. This role is pivotal in facilitating the swift design, synthesis, screening, and optimization of small molecules and related molecular entities. You will be instrumental in producing high-quality, informative experimental data that guides chemistry decisions and enhances platform learning.By collaborating closely with teams in Discovery Chemistry, automation, AI/computational fields, and screening, you will establish and scale multimodal characterization workflows that surpass conventional analytical chemistry methodologies. Your expertise will help create an integrated analytical framework that includes compound characterization, reaction monitoring, molecular profiling, and rapid data generation to support fast-paced design–make–test–analyze cycles.Your contributions will be vital in molding Lila’s next-generation discovery engine, merging profound analytical chemistry knowledge with high-throughput experimentation and AI-driven workflows.

Role overview Bicycle Therapeutics seeks a Senior Scientist specializing in Computational Chemistry to join the team in Cambridge. The position focuses on using computational methods to design and optimize new therapeutic candidates, directly supporting the company’s goal of developing new medicines. What you will do Lead molecular modeling studies for ongoing drug discovery projects. Use advanced simulation techniques to analyze and predict molecular behavior. Collaborate with scientists from various disciplines to integrate computational insights into laboratory research. Share research findings through publications and presentations at scientific meetings and conferences. Requirements Extensive experience with computational chemistry methods and tools. Strong foundation in molecular modeling and simulation. Proven ability to work effectively within cross-functional teams. Drive to advance drug discovery using computational science.

Your Impact at Lila The Scientist I/II, Process Chemistry will utilize cutting-edge process chemistry methodologies to enhance Discovery Chemistry initiatives across Lila’s diverse platform. This role emphasizes reaction and reactor engineering, process design, high-throughput experimentation, and digital chemistry workflows aimed at small molecules and associated molecular constructs. We seek a hands-on scientist who possesses a robust background in synthetic and process chemistry, complemented by an engineering mindset and experience in developing scalable, data-driven experimental workflows. Collaboration is key in this role; you will work closely with teams in Discovery Chemistry, analytical chemistry, automation, platform engineering, and AI/computational science to design, implement, and refine reaction and process workflows. These improvements will enhance the speed, reliability, and scalability of chemical transformations. The Scientist I/II will play a crucial role in bridging early-stage discovery chemistry with contemporary process development by establishing efficient, digitally enabled, and automation-friendly methods for reaction screening, process optimization, and chemistry execution. This position is perfect for a scientist passionate about the convergence of chemistry, engineering, high-throughput technologies, process intensification, and digital experimentation and eager to contribute to the evolution of next-generation process chemistry capabilities beyond traditional methods. What You Will Be Building Design, execute, and optimize process-relevant chemical transformations that advance Discovery Chemistry programs and the creation of small molecules. Develop reaction and process workflows with a focus on engineering rigor, scalability, reproducibility, throughput, and data integrity. Implement high-throughput experimentation (HTE) for reaction screening, process optimization, condition scouting, and assessment of process-relevant variables. Create and execute workflows that integrate reaction setup, process screening, workup, analytical readout, and data capture into streamlined experimental cycles. Contribute to the design of digitally enabled process chemistry workflows, including structured experimental data generation, electronic documentation, and the integration of chemistry data into computational and AI-ready systems. Collaborate with automation and platform teams to refine reaction and process workflows for robotics-enabled experimentation.

Join the Management Training Program at eoctebp, a leading organization committed to developing future leaders across various industries. This program is designed to equip aspiring managers with the skills and knowledge necessary to excel in a dynamic business environment.

Amylyx Pharmaceuticals Inc. is on a bold mission to innovate the treatment landscape for diseases with significant unmet needs. Instead of viewing challenges as roadblocks, we embrace them as opportunities to advance solutions with urgency, scientific rigor, and a steadfast commitment to the communities we serve. As a clinical-stage company, we are currently addressing conditions such as post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).Our mission thrives on the passion of our people. We embody core values of audacity, curiosity, authenticity, engagement, and accountability, fostering a culture of care. With a seasoned team ready to make impactful changes, we invite you to join us in this endeavor if you share our enthusiasm for tackling some of the most challenging issues in medicine.The OpportunityAmylyx Pharmaceuticals Inc. is seeking a seasoned Senior Director of Chemistry, Manufacturing, and Controls (CMC) to lead our CMC organization in the development of our pipeline, including Phase III synthetic peptide Avexitide and Phase I antisense oligonucleotide AMX0114. The CMC team partners with external CDMOs to implement robust, scalable, and compliant processes for clinical and commercial supply. This role may involve direct leadership or managing leads of internal matrix CMC Asset teams, serving as the CMC representative on Asset program teams. This leader will collaborate across functions to drive technical excellence and ensure CMC alignment with program objectives.The ideal candidate will exhibit strong strategic leadership while actively engaging in hands-on execution as needed. This position reports to the Senior Vice President of Global CMC and External Manufacturing.

Your Impact at Lila As a Scientist I/II in Organic Chemistry, you will play a pivotal role in the development, execution, and optimization of cutting-edge chemical transformations that enhance Discovery Chemistry initiatives across Lila Sciences. Your focus will be on the rapid synthesis of small molecules and a diverse range of chemical compounds. This position is tailored for an experimental organic chemist who possesses a robust foundation in synthetic chemistry, complemented by practical experience in high-throughput experimentation (HTE), reaction workup, and analytical characterization. Collaborating closely with teams specializing in Discovery Chemistry, analytical chemistry, automation, screening, and AI/computational methods, you will aid in constructing and implementing efficient chemistry workflows designed to expedite molecular design–make–test–analyze cycles. The Scientist II will be integral to reaction development, analog generation, and route execution utilizing contemporary organic chemistry techniques that are compatible with scalable, data-driven, and increasingly automated discovery environments. This role is ideal for a chemist passionate about addressing synthetic challenges at the intersection of reaction innovation, high-throughput experimentation, process efficiency, and analytical insight, and who is driven to contribute to the evolution of next-generation discovery workflows that extend beyond conventional bench chemistry. What You'll Be Building Design and optimize chemical transformations pertinent to Discovery Chemistry programs, with a strong emphasis on the swift synthesis of small molecules and analog series. Utilize modern synthetic organic chemistry methodologies to facilitate efficient exploration of a wide spectrum of structurally diverse and medicinally relevant chemical spaces. Plan and execute multi-step synthesis, reaction optimization, workup, purification, and compound characterization to support molecular discovery campaigns. Develop and implement HTE workflows aimed at reaction screening, condition optimization, reagent evaluation, and rapid assessment of transformation scopes. Establish robust methodologies for reaction setup, workup, sample preparation, and analytical readout to support rapid and information-rich experimentation. Employ analytical tools such as chromatography, NMR, and other related methods to evaluate reaction performance, characterize products, and inform synthetic strategies. Contribute to the evolution of practical and scalable chemistry workflows that integrate reaction discovery, optimization, and downstream compound generation.

Role overview Lila Sciences seeks a Scientist I/II in Drug Delivery Chemistry for its Cambridge, MA location. This role centers on advancing drug delivery systems that align with the company’s broader research objectives. Key responsibilities Collaborate with fellow researchers to design and refine drug delivery technologies. Apply chemistry expertise to enhance scientific strategies and laboratory processes. Contribute to projects focused on improving patient outcomes through innovative drug delivery solutions. Location This position is based in Cambridge, Massachusetts.