Senior Scientist II - Assay Development in Discovery Psychiatry

Join our innovative team at Flagship Pioneering Inc., where we are at the forefront of therapeutic discovery. As a Senior Research Associate, you will play a critical role in advancing our understanding of novel therapeutic pathways and contribute to groundbreaking research in the life sciences.

COMPANY DESCRIPTION We are a pioneering start-up dedicated to transforming the landscape of chemical discovery. Our innovative platform integrates artificial intelligence with a state-of-the-art laboratory discovery pipeline to redefine molecular formulation development. Our interdisciplinary team is exploring uncharted chemical territories, facilitating significant advancements in drug delivery, agricultural formulations, and sustainable, high-performance industrial chemicals. Backed by Flagship Pioneering, a leader in biotechnology origination, we have fostered over 115 scientific ventures in 25 years, generating more than $20 billion in aggregate value, 500+ patents, and over 50 clinical trials for groundbreaking therapeutic agents. THE ROLE We are on the lookout for a passionate and skilled Senior Research Associate or Associate Scientist to enhance our formulation discovery platform by characterizing biomolecules. This position involves utilizing a range of biophysical and biochemical methodologies to analyze the effects of formulations on biomolecular integrity, aggregation, and functional stability. You will collaborate closely with chemists and machine-learning experts to produce high-quality experimental data that drives formulation design and predictive modeling initiatives. The ideal candidate will possess a solid background in biochemistry, structural biology, or biopolymer engineering, complemented by practical experience with analytical instrumentation for biomolecular characterization. KEY RESPONSIBILITIES Conduct experiments assessing biomolecular stability and solubility across various formulation conditions. Evaluate cargo structural integrity and folding utilizing circular dichroism (CD) spectroscopy and complementary biophysical techniques. Measure biomolecular interactions and stability through spectroscopy, dynamic light scattering, and electrophoretic methods. Prepare samples for diverse external workflows to evaluate molecular integrity and degradation. Experimental Pipeline Support Collaborate with formulation chemists to investigate cargo-formulation interactions across different experimental contexts. Generate high-quality experimental datasets to assist internal modeling and data analysis processes. Support laboratory instrumentation maintenance and troubleshooting. Maintain organized laboratory records, analyze results, and communicate findings effectively to cross-functional teams.

We are seeking a highly motivated Senior Research Associate to join our dynamic team at Integrated Resources, Inc. In this pivotal role, you will conduct advanced research, analyze data, and contribute to innovative projects that drive our mission forward. If you are passionate about scientific research and eager to make an impact, we want to hear from you!

We are seeking a talented and dedicated Senior Research Associate to join our dynamic team in Cambridge. In this role, you will contribute to innovative research projects and collaborate with interdisciplinary teams to drive impactful findings.

Your Impact at Lila The Senior Director of Small Molecule Therapeutics will spearhead the biological evaluation and screening of small molecule therapeutics within Lila’s innovative discovery platform. This pivotal leader will cultivate and expand a top-tier screening organization, effectively translating AI-designed and robotically synthesized molecules into validated biological insights and promising therapeutic opportunities. Collaborating closely with Lila’s chemistry, automation, and AI/computational teams, the Senior Director will establish the biological screening infrastructure necessary for the rapid evaluation of novel chemical entities. This role involves designing and implementing high-throughput and high-content screening strategies, constructing automated assay platforms, and developing creative methodologies to explore extensive chemical libraries. As a key architect of Lila’s small molecule discovery engine, this leader will integrate biology, automation, and data science into scalable discovery workflows, significantly accelerating the identification of high-quality therapeutic candidates. What You’ll Be Building Lead and develop Lila’s small molecule biology and screening organization, focusing on hiring, mentoring, and fostering a high-performing scientific team. Design and implement automated, high-throughput screening platforms to assess small molecules generated through Lila’s AI-driven chemistry and robotic synthesis systems. Develop and refine biochemical, biophysical, and cell-based assays for the identification and validation of novel small molecule hits. Establish scalable automation-enabled workflows for assay execution, screening campaigns, and data generation. Guide the development and execution of DNA-encoded library (DEL) screening strategies and subsequent validation pipelines. Work in partnership with chemistry, computational, and automation teams to harmonize screening results with molecular design and synthesis initiatives. Define and execute screening strategies targeting new therapeutic areas, including target validation, assay design, and hit identification. Oversee large-scale screening initiatives, including hit triage, orthogonal validation, and preliminary mechanism-of-action studies. Implement data-driven methodologies to analyze screening outputs and inform iterative molecule design processes. Set best practices for screening data quality, reproducibility, and assay robustness. Collaborate across various disciplines to translate screening hits into validated chemical starting points for therapeutic development. What You’ll Need to Succeed PhD in Molecular Biology, Biochemistry, or a related field.

Flagship Pioneering, Inc. is seeking a visionary and experienced Director of Antibody Discovery to lead our innovative research team in Cambridge, UK. In this pivotal role, you will be responsible for spearheading the development of novel antibody therapeutics that will define the future of medicine. You will leverage cutting-edge technologies and methodologies to drive our antibody discovery efforts, collaborating closely with cross-functional teams to bring groundbreaking solutions to patients.

Join our dynamic team at Integrated Resources Inc. as a Senior Neurology Research Associate, where you will play a pivotal role in advancing groundbreaking research in neurology. You will collaborate with top-tier professionals, contributing to innovative projects that drive the future of neurological health.

Your Role at Lila Sciences As a key contributor to our Physical Sciences division, you will focus on advancing the field of in silico materials discovery techniques. Your responsibilities will involve designing autonomous workflows and data-driven pipelines that effectively integrate simulation with artificial intelligence. You will lead the development of strategies that empower agents to analyze simulation data, derive hidden insights, and facilitate hypothesis generation and materials design. Your innovative approach will enhance our utilization of simulation outputs for discovery, fostering a seamless integration of physics-based modeling with AI reasoning systems. Collaboration with specialists in simulation, AI agents, and experimental automation will be pivotal as we strive to redefine the landscape of digital discovery. Key Contributions Create cutting-edge workflows for in silico materials discovery that link physics-based simulations and generative AI models. Develop intelligent systems where AI agents autonomously design, execute, interpret, and optimize simulations. Establish frameworks that maximize the utility of simulation data for prediction, inference, and discovery, with features like automatic data extraction and model training. Prototype and assess novel paradigms for simulation-aware agents that learn from and interact with scientific simulations. Design data structures, metadata specifications, and APIs to ensure smooth information transfer among simulations, machine learning models, and experimental data repositories. Build scalable, modular workflows that connect electronic structure, atomistic, and mesoscale simulations with AI-driven reasoning and hypothesis generation. Work alongside computational scientists, machine learning professionals, and platform engineers to integrate in silico discovery pipelines into Lila’s overarching scientific superintelligence framework. Qualifications for Success PhD or equivalent experience in Computer Science, Materials Science, Chemistry, Physics, Applied Mathematics, or related fields. Strong background in in silico materials discovery, computational materials modeling, and/or simulation workflow design. Familiarity with large language models and their applications in scientific research. Experience in developing AI-driven or agentic workflows for scientific automation and discovery. Proficient programming skills in Python and scientific computing libraries.

Join Flagship Pioneering Inc. as the Director of Antibody Discovery, where you will lead innovative initiatives in antibody research and development. This pivotal role involves overseeing a talented team, driving strategic projects, and collaborating with cross-functional teams to advance our cutting-edge therapeutic programs. Your expertise will be crucial in shaping the future of antibody therapeutics, fostering a culture of scientific excellence, and ensuring the successful execution of discovery projects.

Senior Research Associate in Chemical BiologyLocation: Cambridge, MA, USACompany: Flagship Pioneering, Inc. (FL116) About FL116 FL116, backed by Flagship Pioneering, focuses on advancing biomolecule synthesis. The team is developing a platform aimed at changing how research, diagnostic, and therapeutic molecules are manufactured. Role Overview The Senior Research Associate in Chemical Biology will join a collaborative group dedicated to applying chemical approaches to biological questions. This position centers on enzyme-mediated biomolecular synthesis, with attention to both mechanistic and molecular details. Main Responsibilities Design and conduct high-throughput experiments to study enzyme-substrate interactions Characterize biomolecular products using established and emerging techniques Support development of scalable assays to expand platform capabilities What We Look For Strong experimental skills and attention to detail Intellectual curiosity about the chemical nature of biological systems Interest in manipulating and measuring biological activities at the molecular level Comfort working in a hands-on, execution-focused, and pipeline-driven setting Motivation to grow with a rapidly evolving technology platform Work Environment This role offers the chance to build expertise at the intersection of chemistry and biology within a collaborative startup supported by Flagship Pioneering. The team values problem solvers who enjoy working on challenging scientific questions and developing new tools for biotechnology and therapeutics.

We are seeking a detail-oriented and motivated Research Associate to join our dynamic team at Integrated Resources, Inc. As a Research Associate, you will play a pivotal role in conducting research, analyzing data, and supporting various projects that contribute to the advancement of our organization’s goals.Your responsibilities will include collaborating with cross-functional teams, preparing reports, and presenting findings to stakeholders. This position offers an excellent opportunity for professional growth and development in a fast-paced environment.

Join our team at Integrated Resources Inc. as an Associate Research Scientist, where you will contribute to cutting-edge research projects that impact real-world applications. We are looking for passionate individuals eager to innovate and collaborate in a dynamic environment. In this role, you will support senior scientists in the design and execution of experiments, analyze data, and contribute to publications. This is a fantastic opportunity to grow your career in scientific research.

Fathem develops tools that help scientists visualize and interpret biology at the molecular level. The company integrates cryo-electron microscopy (cryo-EM), artificial intelligence, advanced hardware, and automation to make molecular structures more accessible and speed up drug discovery. As part of Flagship Pioneering, Fathem draws on substantial resources to reshape how biology is explored and applied. Role overview The Senior Research Associate - Cryo-EM will play a key part in refining and executing cryo-EM workflows. This hands-on position focuses on preparing high-quality cryo-EM grids and datasets from a variety of biomolecular samples, including soluble proteins, membrane proteins, and nanoparticles. The role requires close collaboration with protein biochemistry, structural biology, and computational teams to ensure reliable grid preparation and imaging processes that feed into advanced computational modeling. Success in this position means solving complex biochemical challenges and seeing direct impact on scientific outcomes. What you will do Prepare cryo-EM grids and collect data from diverse biomolecular systems, maintaining efficiency and high standards for dataset quality. Carry out the full cryo-EM process, including grid vitrification, screening, and high-throughput data acquisition using Thermo Fisher microscopes. Operate and improve workflows to ensure reproducible, scalable data generation and increase throughput and reliability. Adjust and optimize protocols for challenging samples, refining grid preparation and imaging methods to boost success rates. Run experiments for external partners and clients, ensuring datasets align with project requirements. Work closely with protein science and computational teams to integrate cryo-EM data into broader research projects. Location This position is based in Cambridge, MA, USA.

Your Contribution at Lila Sciences Lila Sciences is actively seeking a dedicated (Senior) Research Associate to become an integral part of our dynamic Life Sciences team. This pivotal role will be centered around the formulation of lipid nanoparticles (LNPs), their functionalization with targeting ligands, and the characterization of the resulting targeted LNPs (tLNPs). The ideal candidate will possess substantial hands-on experience in LNP formulation and characterization, bioconjugation, protein characterization, and automation technologies. Your expertise will significantly enhance our understanding of the delivery space, enabling a high-throughput closed-loop screening cascade for tLNPs. You will work collaboratively with professionals across protein, cell biology, automation, chemistry, machine learning, and data science teams to establish advanced tools for targeted nucleic acid delivery. Your Key Responsibilities Design, execute, and characterize LNP formulations utilizing various scales and mixing modalities (e.g., DLS, ribogreen, TNS). Develop and optimize high-throughput ligand conjugation and purification methodologies, leveraging automation and robotics to maximize throughput. Collaborate with cell assay and antibody experts to screen candidates across diverse tissue targets in in vivo models. Engage with chemists, biologists, engineers, and data scientists to document processes, share insights, and refine best practices in autonomous flow chemistry. Create, implement, and uphold Standard Operating Procedures (SOPs) for both existing and emerging lab processes. Your Qualifications for Success MSc in Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences, or a closely related field with 3+ years of hands-on experience in targeted LNP production or a BSc with 5+ years of relevant experience. Industry experience is highly desirable. Strong proficiency in bioanalytical techniques (e.g., DLS, fluorescence spectroscopy, electrophoresis, in vitro assays). Experience in protein and antibody design and characterization. Familiarity with automation and high-throughput workflows is preferred. Exceptional troubleshooting, communication, and collaboration skills, with a proven ability to work effectively across interdisciplinary teams. About Lila Sciences Lila Sciences is at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory focused on life sciences, chemistry, and materials science. We are pioneering a new era of limitless discovery by harnessing AI capabilities to enhance every facet of the scientific method. Our mission is to leverage scientific superintelligence to address humanity's most pressing challenges.

Join Lila Sciences as a Senior Research Associate or Associate Scientist in the Protein Science department, focusing on our cutting-edge Antibody Platform. You will play a crucial role in advancing our research initiatives, contributing to the development of innovative antibody-based therapeutics. This position offers the opportunity to collaborate with a talented team dedicated to scientific excellence and the pursuit of transformative solutions in healthcare.

Your Impact at Lila Sciences Join our innovative high-throughput autonomous chemistry team as a Senior Research Associate / Associate Scientist. This hands-on position bridges the fields of organic and inorganic synthesis, advanced characterization, and laboratory automation. You will design and implement high-throughput experiments, synthesize small molecules, and conduct thorough downstream analysis alongside senior scientists. Your efforts will contribute to translating ambitious product objectives into scalable experimental workflows that significantly influence our company's growth. This role provides a unique opportunity to engage with automated chemistry platforms, giving you real ownership of experiments that shape our scientific strategy and direction. Ideal candidates are execution-oriented, excel in dynamic laboratory settings, and are passionate about developing deep technical skills while making impactful contributions to the future of chemical discovery at Lila Sciences. What You’ll Be Building Independently conduct experiments for the synthesis, purification, and characterization of organic and inorganic small molecules. Optimize reactions, develop methodologies, and analyze analytical data to inform project decisions. Convert initial concepts into reliable, functional experiments. Utilize retrosynthetic analysis to assist in the synthesis of target molecules. Operate Schlenk lines, gloveboxes, and various inert-atmosphere systems for sensitive materials. Employ PAT tools (UPLC, LCMS, NMR, IR, Fluorescence, DLS) to monitor reactions, ensure quality control, and produce high-quality data for machine learning workflows. Leverage automation and AI-driven technologies to streamline workflows and reduce experimental turnaround times. Collaborate with engineers, ML scientists, and stakeholders to validate model-recommended conditions, analyze trends, troubleshoot challenges, and clearly communicate results through reports, discussions, and presentations. Maintain meticulous documentation of results, ensuring accurate digital records while adhering to EHS and laboratory best practices. What You’ll Need to Succeed M.S. in Chemistry or a related field (such as organic, organometallics, or catalysis) with a minimum of 2 years of relevant laboratory experience, or a B.S. with 5 years of experience. Hands-on experience in organic and inorganic synthesis, purification processes, chromatographic techniques, and product analysis. Strong grasp of retrosynthesis, reaction mechanisms, and method optimization workflows. Proficiency in utilizing laboratory automation tools and systems. Excellent problem-solving skills and the ability to work collaboratively in a team-oriented environment.

Your Role at Lila Sciences Lila Sciences is searching for a skilled Senior Research Associate with expertise in Protein Purification, Analytics, and Developability. You will play a crucial role in the establishment and daily functioning of a cutting-edge high-throughput protein characterization platform. This position involves optimizing biophysical characterization workflows, collaborating with cross-functional teams, and ensuring the generation of high-quality, reproducible data as you contribute to the advancement of Lila's Scientific Superintelligence platform. Key Responsibilities Execute and refine high-throughput workflows for protein characterization across various modalities, including antibodies, bi-specifics, and enzymes. Operate and maintain automated chromatography systems, utilizing Size Exclusion Chromatography (SEC), Hydrophobic Interaction Chromatography (HIC), and affinity chromatography via HPLC platforms. Conduct biophysical characterization using advanced techniques such as Dynamic Light Scattering (DLS), melting temperature analysis (DSF), binding assays (BLI/SPR), and capillary electrophoresis (CE-SDS, cIEF) to evaluate protein critical quality attributes. Support workflows for characterizing protein post-translational modifications (PTMs), ensuring thorough sample preparation and precise data capture. Collaborate with scientists, engineers, and automation specialists to identify and implement enhancements in the efficiency, robustness, and scalability of developability workflows. Innovate and adjust protocols to accommodate new protein formats, targets, and analytical strategies. Ensure rigorous data quality, documentation, and reproducibility in all experiments; actively participate in knowledge sharing and continuous improvement initiatives. Work closely with computational scientists to support data analysis pipelines, data processing, and the creation of predictive models for protein characteristics.

Harvard University is seeking an innovative and strategic Associate Director of Research to lead groundbreaking research initiatives. The ideal candidate will possess a deep understanding of research methodologies, strong leadership skills, and a passion for academic excellence. This role involves collaborating with faculty and students to enhance research output and drive impactful scholarship.

Join eGenesis as a Senior Clinical Research AssociateAt eGenesis, we are at the forefront of innovation in biotechnology, developing human-compatible engineered organs to combat the critical global organ shortage. Our cutting-edge genome engineering platform allows for extensive gene modifications, effectively removing biological barriers and introducing protective human transgenes. Our leading program, EGEN-2784, involves a genetically engineered porcine kidney currently under a multi-patient Expanded Access study at Massachusetts General Hospital (MGH). We are proudly headquartered in Cambridge, MA, and are dedicated to making a significant impact on healthcare.We are currently in search of a highly skilled Senior Clinical Research Associate with over 4 years of experience in monitoring intricate clinical trials within pharmaceutical, biotechnology, and CRO settings. The ideal candidate will demonstrate proven expertise in managing investigative sites, conducting site qualifications, initiation, routine monitoring (both on-site and remote), and closeout visits while ensuring adherence to ICH-GCP, regulatory requirements, and study protocols. You will be tasked with overseeing site performance, preserving data integrity through source data verification and CRF review, and maintaining timely documentation in eTMF, CTMS, and EDC systems. Additionally, you will support site start-up activities, provide training for investigators and site staff, and offer operational guidance to academic medical centers, particularly those with limited IND experience. The right candidate will possess strong capabilities in identifying operational risks, implementing effective mitigation strategies, and managing high volumes of clinical data to uphold patient safety, data quality, and study compliance. Reporting to the Lead CRA or Clinical Operations leadership, you will execute monitoring strategies and facilitate consistent oversight of assigned sites. We value collaboration and are looking for a team player who can work closely with investigative sites and cross-functional teams to enhance enrollment, address operational challenges, and ensure inspection readiness.