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Senior Research Associate in Protein Science Developability

Lila SciencesCambridge, MA USA
On-site Full-time $80K/yr - $102K/yr

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Experience Level

Mid to Senior

Qualifications

Qualifications for Success Bachelor's or Master's degree in Biochemistry, Biophysics, Molecular Biology, Bioengineering, or a related field with 2-5+ years of hands-on industry or academic experience in protein production and characterization. Demonstrated hands-on experience with HPLC techniques such as SEC, HIC, and affinity purification methods. Familiarity with biophysical characterization techniques including DLS, DSF, BLI/SPR, CE-SDS, cIEF, or similar analytical methodologies. Strong problem-solving skills and the ability to work collaboratively within a dynamic team environment. Excellent communication skills, both verbal and written, to effectively share findings and insights.

About the job

Your Role at Lila Sciences

Lila Sciences is searching for a skilled Senior Research Associate with expertise in Protein Purification, Analytics, and Developability. You will play a crucial role in the establishment and daily functioning of a cutting-edge high-throughput protein characterization platform. This position involves optimizing biophysical characterization workflows, collaborating with cross-functional teams, and ensuring the generation of high-quality, reproducible data as you contribute to the advancement of Lila's Scientific Superintelligence platform.

Key Responsibilities

  • Execute and refine high-throughput workflows for protein characterization across various modalities, including antibodies, bi-specifics, and enzymes.
  • Operate and maintain automated chromatography systems, utilizing Size Exclusion Chromatography (SEC), Hydrophobic Interaction Chromatography (HIC), and affinity chromatography via HPLC platforms.
  • Conduct biophysical characterization using advanced techniques such as Dynamic Light Scattering (DLS), melting temperature analysis (DSF), binding assays (BLI/SPR), and capillary electrophoresis (CE-SDS, cIEF) to evaluate protein critical quality attributes.
  • Support workflows for characterizing protein post-translational modifications (PTMs), ensuring thorough sample preparation and precise data capture.
  • Collaborate with scientists, engineers, and automation specialists to identify and implement enhancements in the efficiency, robustness, and scalability of developability workflows.
  • Innovate and adjust protocols to accommodate new protein formats, targets, and analytical strategies.
  • Ensure rigorous data quality, documentation, and reproducibility in all experiments; actively participate in knowledge sharing and continuous improvement initiatives.
  • Work closely with computational scientists to support data analysis pipelines, data processing, and the creation of predictive models for protein characteristics.

About Lila Sciences

Lila Sciences is pioneering advancements in protein science through innovative technology and research. Our mission is to enhance the scientific understanding and development of proteins, contributing to the next generation of biotherapeutics and scientific discovery.

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