Principal Research Scientist II - Analytical Development

Join Our Team as a Senior / Principal ADME ScientistAt Genesis Molecular AI, we are at the forefront of revolutionizing drug discovery through innovative artificial intelligence-driven approaches. Our San Diego lab is actively seeking a dynamic and skilled Senior / Principal ADME Scientist to enhance our Non-Clinical Development team and propel our compounds through the phases of preclinical and clinical development.This full-time position offers an exciting opportunity to work in a fast-paced biotech environment alongside a collaborative team of experts, all focused on achieving clear scientific and developmental objectives. We provide comprehensive medical and dental benefits, flexible working hours, generous vacation time, and the chance to gain extensive exposure to the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in a range of ADME-related assays, including metabolic stability, protein binding, and drug-drug interactions. You will be instrumental in developing, executing, and troubleshooting assays, as well as managing outsourced work. As a subject matter expert in in-vitro ADME, your strategic input will be crucial to project teams. Experience with bioanalytical assays and method development is highly desirable.

Join Genesis Molecular AI as a Senior / Principal ADME Scientist in San Diego, CA!At Genesis Molecular AI, we are at the forefront of utilizing artificial intelligence to revolutionize rational drug design and tackle significant unmet medical needs. We are looking for an enthusiastic and adaptable ADME Scientist to become a vital part of our Non-Clinical Development team, facilitating the progression of our innovative compounds through both preclinical and clinical phases.This full-time role is set in a dynamic biotech environment where collaboration thrives among a talented team of professionals, all working towards clear scientific objectives. We offer an attractive benefits package, including comprehensive medical and dental insurance, flexible working hours, generous vacation time, and the chance to engage deeply with the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in various ADME-related assays such as metabolic stability, protein binding, drug-drug interactions, and more. They will be skilled in developing, executing, and troubleshooting assays both independently and in collaboration with external partners. As the subject matter expert in in-vitro ADME, you will provide critical strategic input to our project teams. Experience in bioanalytical assays and method development is a plus.

Are you an enthusiastic and detail-oriented individual eager to kickstart your career in human resources? Join our dynamic HR team at Genesis Molecular AI as a Human Resources Intern. This internship presents a valuable opportunity to acquire practical experience across various HR functions, including recruitment, onboarding, employee engagement, benefits administration, compliance, and systems management. We are looking for a candidate who is passionate about learning HR processes and contributing to a vibrant workplace culture. This position is based on-site at our laboratory in San Diego.Key Responsibilities:Assist with recruitment administration by providing on-site interview support for candidates and employees.Facilitate new hire onboarding by preparing necessary documentation, coordinating orientation sessions, and updating employee records.Organize and maintain electronic HR documents, employee files, and databases.Contribute to the planning and execution of employee engagement activities and company events.Help ensure compliance with labor laws and internal policies.Assist in maintaining HRIS data accuracy.Support office administration and maintenance tasks.Perform additional administrative and HR-related tasks as required.Qualifications:Currently pursuing or recently graduated with a degree in Human Resources, Business Administration, Psychology, or a related field.Excellent organizational and communication skills.Ability to handle confidential information with integrity and professionalism.Familiarity with Google Suite; knowledge of HR software is a plus.Detail-oriented with strong analytical and problem-solving skills.A proactive and positive attitude, with a strong willingness to learn.

Chemistry InternJoin Genesis Molecular AI, where we are revolutionizing drug design through artificial intelligence to meet critical medical needs. Our cutting-edge laboratory in San Diego invites passionate and proactive individuals to become part of our chemistry team. As a Chemistry Intern, you will gain hands-on experience with laboratory techniques while tackling current chemistry challenges.Your ResponsibilitiesAcquire and apply essential laboratory skills in chemistry.Maintain thorough documentation of all laboratory findings.Participate in project meetings with mentors and effectively communicate your findings.Compile a comprehensive report of your findings at the conclusion of the internship.Perform additional tasks and responsibilities as assigned.Your QualificationsCurrently pursuing a Bachelor’s degree in Organic Chemistry, Biochemistry, Medicinal Chemistry, or a related field.Prior experience in an organic chemistry lab is preferred.Strong organizational, communication, and multitasking skills, with an ability to thrive in a collaborative environment.Demonstrated enthusiasm, integrity, self-motivation, and meticulous attention to detail.

We are seeking a highly skilled Senior Director of Medicinal Chemistry to join our innovative team at Genesis Molecular AI. In this pivotal role, you will leverage our cutting-edge platform to spearhead medicinal chemistry initiatives that drive drug discovery from Hit Identification to candidate nomination. You will be a key collaborator and leader in multidisciplinary drug discovery projects, shaping the medicinal chemistry strategy for each project. As a recognized leader in medicinal chemistry, you will possess exceptional communication skills, facilitating collaboration with both internal teams and external partners.Key ResponsibilitiesDevelop and implement medicinal chemistry strategies utilizing the Genesis platform to effectively manage drug discovery programs from Hit ID through to candidate nomination.Apply Structure-Based Drug Design (SBDD) principles, optimize physicochemical properties, and interpret in vitro and in vivo ADME/PK/Toxicology data to advance projects.Employ data visualization software and metrics-driven analysis to formulate medicinal chemistry hypotheses and prioritize project strategies.Engage and collaborate with industry partners on various drug discovery projects.Work closely with other drug discovery disciplines, including biology, DMPK, software engineering, and computational chemistry, to foster hypothesis-driven decisions and enhance platform capabilities.Maintain regular communication and engagement with project teams and management to ensure alignment and progress.Mentor and guide internal chemists and other scientific professionals on medicinal chemistry best practices.

Join our dynamic HR team as a Human Resources Intern at Genesis Therapeutics, where your enthusiasm and attention to detail will help shape our workplace culture. This internship offers a rich opportunity for hands-on experience in multiple HR areas, including recruitment, onboarding, employee engagement, benefits administration, compliance, and systems management. We value a proactive attitude and a willingness to learn as you contribute to creating a positive work environment. Please note that this position requires on-site work at our San Diego lab.Key Responsibilities:Provide administrative support for recruitment processes, including on-site interview coordination for candidates and staff.Facilitate new hire onboarding by preparing necessary documentation, coordinating orientation sessions, and maintaining up-to-date employee records.Organize and maintain electronic HR documents, employee files, and databases efficiently.Assist in the planning and execution of employee engagement initiatives and company events.Help ensure adherence to labor laws and internal policies.Support HRIS data maintenance activities.Contribute to office administration and maintenance tasks as required.Perform various administrative and HR-related tasks as assigned.Qualifications:Currently pursuing or recently graduated with a degree in Human Resources, Business Administration, Psychology, or a similar field.Excellent organizational and communication abilities.Capacity to manage confidential information with integrity and professionalism.Familiarity with Google Suite and HR software is advantageous.Detail-oriented with a knack for problem-solving.A proactive and enthusiastic approach, with a strong desire to learn.

Join Genesis Molecular AI as an Associate Director/Director of Medicinal Chemistry, where you will play a pivotal role in utilizing our cutting-edge AI platform to spearhead drug discovery initiatives, guiding projects from Hit Identification through to candidate nomination. Collaborate with multidisciplinary teams to shape the medicinal chemistry vision and drive innovative solutions in drug development.Key Responsibilities:Develop and implement medicinal chemistry strategies using the Genesis platform for drug discovery from Hit ID through to candidate nomination.Apply Structure-Based Drug Design (SBDD) methodologies, optimize physicochemical properties, and analyze in vitro and in vivo ADME/PK/Toxicology data to advance programs.Leverage data visualization tools and metrics to formulate medicinal chemistry hypotheses and prioritize approaches effectively.Foster communication and collaboration with industry partners on drug discovery initiatives.Engage with diverse drug discovery teams (biology, DMPK, software engineers, computational chemists) to drive data-driven decisions, enhance platform capabilities, and uphold scientific excellence.Maintain regular communication with project team members and management to ensure alignment and progress.

Join Our Mission to Advance Global Health!Becton, Dickinson and Company (BD) is a leading global medical technology company dedicated to advancing the world of health. We strive to enhance medical discovery, diagnostics, and the delivery of care. With over 65,000 employees across the globe, we are committed to tackling some of the most pressing health challenges worldwide. As the Health Economics and Outcomes Research Lead, you will report to the Director of Scientific Affairs & Clinical Evidence within our Medical Affairs team. In this critical role, you will be tasked with developing and executing agile HEOR strategies in collaboration with both global and regional teams. Your expertise will drive impactful research and ultimately improve patient outcomes.

At Genesis Molecular AI, we are creating an elite team of experts in computational chemistry to transform the landscape of drug discovery through advanced machine learning and biophysical simulations. We invite a Senior Computational Aided Drug Discovery (CADD) Scientist to join us in our mission, collaborating closely with scientists in our advanced wet lab and our distributed teams in computational chemistry across the United States.Key ResponsibilitiesEmploy a mix of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse array of targets, including innovative targets with limited chemical history.Utilize techniques such as virtual screening, molecular simulations, and ADMET prediction to facilitate critical decision-making during drug discovery.Work closely with medicinal chemists on molecular design and the creation of tailored computational methodologies for specific projects.Serve as a liaison across teams, effectively bridging communication between our computational and medicinal chemistry departments to ensure smooth information exchange and collaborative strategies.Thrive in a fast-paced environment that encourages innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. Candidates with a PhD in organic or medicinal chemistry and substantial laboratory experience transitioning into industry roles in CADD are also encouraged to apply.Extensive knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools, including MOE, PyMOL, and Schrodinger Suite.A minimum of 2 years of experience in the pharmaceutical or biotech industry as a CADD scientist, with practical involvement in active drug discovery projects.While onsite presence at our San Diego lab is preferred for collaboration, we are open to considering remote team members as well.What We OfferAttractive SalaryComprehensive Health Care Plans (Medical, Dental, and Vision fully covered for employees)An opportunity to work in a pioneering environment with the latest technologies in drug discovery.

At Genesis Molecular AI, we are assembling a premier computational chemistry team dedicated to transforming drug discovery through state-of-the-art machine learning and biophysical simulations. We invite applications for the role of Principal CADD Scientist, who will collaborate closely with our scientists in the advanced wet lab and our distributed computational chemistry and CADD teams located across the United States.Key ResponsibilitiesEmploy a mix of industry-leading and proprietary AI-driven CADD tools to steer small molecule drug discovery projects across a wide array of targets, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and ADMET prediction to facilitate critical decision-making during the drug discovery process.Work in tandem with medicinal chemists in molecular design and the formulation of project-specific computational strategies.Serve as an effective liaison among the computational and medicinal chemistry teams, ensuring smooth communication and collaborative decision-making.Thrive in a fast-paced environment that champions innovation and rapid iteration.QualificationsPh.D. in Computational Chemistry, Structural Biology, or a closely related discipline. Candidates with a Ph.D. in organic or medicinal chemistry and substantial laboratory experience transitioning to industry roles in CADD may also be considered.Comprehensive understanding of structure-based drug design and protein-ligand interactions.Expertise in industry-standard CADD software such as MOE, PyMOL, and Schrödinger Suite.A minimum of 5 years of experience as a CADD scientist in the pharmaceutical or biotechnology sector, with direct involvement in active drug discovery projects.While onsite collaboration in our San Diego lab is preferred, we are open to accommodating remote team members.What We OfferCompetitive salary and benefitsComprehensive health care plans, including medical, dental, and vision insurance fully covered for employeesEligibility for stock options

At Bee Genius, we are pioneering the future of work, today.This post was generated on behalf of our client:Job Description: We are seeking a highly accomplished and motivated Principal Scientist to become an integral part of our innovative team. In this role, you will spearhead groundbreaking scientific research and development initiatives, offer expert technical guidance, and catalyze innovation within our organization.Responsibilities:Lead and oversee scientific research projects from conception through to execution.Design and refine scientific methodologies and protocols for optimal outcomes.Conduct thorough analysis and interpretation of intricate data, effectively presenting insights to stakeholders.Mentor and provide technical support to junior scientists, fostering their professional growth.Collaborate with cross-functional teams to convert scientific discoveries into actionable applications.Remain abreast of the latest advancements and industry trends in your field.

At Genesis Molecular AI, we are on a mission to transform the landscape of drug discovery by forming a premier computational chemistry team that leverages advanced machine learning techniques and biophysical simulations. We are actively looking for a Principal CADD Scientist to collaborate with our scientists in our cutting-edge wet lab and coordinate with our remote computational chemistry and CADD science teams throughout the United States.Key ResponsibilitiesEmploy both established and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse range of targets, including innovative targets with minimal chemical precedents.Implement strategies such as virtual screening, molecular simulations, and predictive analytics for potency and ADMET to inform critical decision-making in drug development.Work collaboratively with medicinal chemists on molecular design and the formulation of project-specific computational methodologies.Serve as a liaison among teams, ensuring effective communication between computational chemistry and medicinal chemistry groups to facilitate seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that fosters innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. This role is also suitable for PhD-level professionals in organic or medicinal chemistry with substantial lab experience who have transitioned into CADD roles.In-depth knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.A minimum of 5 years of relevant industry experience as a CADD scientist in pharmaceuticals or biotechnology, with direct involvement in active drug discovery projects.While onsite presence in our San Diego lab is preferred for collaboration, we welcome applicants interested in remote opportunities.What We OfferCompetitive salary and benefits packageComprehensive health care plans (including medical, dental, and vision, fully covered for employees)Eligibility for stock options

We seek an innovative and passionate Senior Principal Software Engineer to lead the development of transformative healthcare software aimed at significantly enhancing the experiences of patients, clinicians, and caregivers. In this pivotal role, you will guide a talented team through the crucial early stages of product development while also contributing your own coding expertise and expanding your skill set.The ideal candidate boasts extensive full stack experience in crafting SaaS and/or Cloud Native solutions tailored for the regulated healthcare industry. You will possess significant knowledge in advanced technologies, including distributed microservice architecture, Go, Ent, gRPC, Twirp, and AWS services such as EventBridge and Aurora. Your ability to share insights and mentor developing team members will be essential for our growth.As a Senior Principal Software Engineer, you will thrive in an Agile, collaborative setting alongside product managers, designers, external partners, and fellow engineers, all working together to create high-quality, consumer-focused products from the ground up.About TendoJoin a mission-driven team making a real difference!At Tendo, we are rapidly expanding, fostering a culture that empowers teams and individuals to excel. Our commitment to a team-oriented environment has earned us recognition as one of Forbes’ Top Startup Employers for both 2024 and 2025. Guided by an experienced leadership team, we uphold our values and continuously seek motivated individuals from diverse backgrounds to enhance the care journey for all stakeholders by developing intuitive, user-friendly software.If you are excited to work with cutting-edge technologies and want to be part of a growing team that is reshaping the healthcare landscape, we invite you to apply today!

The Challenge Ahead: Exceptional products are the result of creativity, experimentation, and a willingness to explore uncharted territories.As an Innovation Scientist at Juneshine, you will collaborate closely with the Innovation Manager, contributing to the ideation, testing, and enhancement of new offerings within the Juneshine Brands portfolio. This dynamic, laboratory-focused position is perfect for a mid-level innovator who thrives on experimentation, problem-solving, and transforming concepts into tangible products.If you thrive in a fast-paced, startup-like atmosphere where innovation, flexibility, and ownership are integral to the daily workflow, this is the role for you!

At Art of Problem Solving (AoPS), we believe that data is a cornerstone of our innovative approach to designing, developing, and enhancing our educational products. We cater to a diverse community of students across the globe through our digital platforms that facilitate discovery, enrollment, learning, and sustained engagement. Our products generate comprehensive behavioral and operational data, which we leverage to make informed decisions that elevate student experiences. We are seeking a Senior Data Scientist to join us as an integral strategic partner within the Product team. This full-stack individual contributor role is ideal for someone who excels at defining key metrics, designing experiments, and addressing complex, high-stakes product inquiries. Your mission will be to enhance our product decision-making processes and bridge the gap between analytics and strategic direction. Collaborating closely with product leadership, engineers, and designers, you will help shape the direction of our products, assess trade-offs, and ensure we are crafting experiences that deliver genuine value to students and their families.

Role Overview iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams focused on automated experimentation, AI-driven molecular design, property prediction, and bioassay data generation. What You Will Do Design and refine strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties, using multivariate SAR analysis and hypothesis-driven design. Apply a broad range of modern organic chemistry transformations and synthetic methodologies, including parallel experimentation, to advance project goals. Work closely with colleagues in molecular and cellular biology, pharmacology, computational chemistry, ADME, and related groups to drive discovery efforts. Shape the use of computational approaches, automated synthesis, and high-throughput experimentation in medicinal chemistry projects. Collaborate with AI and machine learning teams to build and apply predictive models for novel molecule design. Clearly communicate project updates and findings to the broader team and stakeholders. Contribute to the Chemistry research group, supporting a culture of scientific rigor, innovation, and teamwork. Qualifications BS, MS, or PhD in chemistry, with a focus on synthetic organic chemistry. Direct experience in small molecule drug discovery within biotech or pharma: minimum 15+ years with a BS, 12+ years with an MS, or 8+ years with a PhD. Documented success advancing drug discovery programs from lead identification through advanced candidate stages. Deep experience optimizing lead compounds for potency, selectivity, ADME, and pharmacokinetics. Expert knowledge of modern synthetic organic chemistry methods, supported by publications and patents. Hands-on familiarity with target protein degradation and modalities such as molecular glues and PROTACs. This position is based onsite at our San Diego HQ.

Are you ready to enhance your career in a dynamic, inclusive, and supportive environment? Do you want to be part of a company that is dedicated to creating impactful change for its employees, clients, and the community? If you are passionate about fostering sustainable practices that benefit both society and the environment, we have the ideal opportunity for you!Join our Environment and Health division as a Principal Consultant and collaborate with our talented team to help bridge the gap towards a sustainable future.Your Role:We are on the lookout for a Principal Consultant in the San Diego area to bolster our local office's growth. Ideal candidates will possess a consulting background in site investigation and remediation, due diligence, compliance, or air quality management. As our new Principal, you will become an integral part of our team, addressing a wide spectrum of environmental challenges faced by our clients. Bring your expertise in Environmental Consulting and Business Development to the forefront as you work towards innovative and sustainable solutions. You will serve as a reliable advisor to clients, delivering technical and business insights while collaborating with our skilled professionals in areas like due diligence, site remediation for contaminated materials, real estate redevelopment, hazardous waste management, and compliance with environmental regulations. A strong emphasis will be placed on business development, ensuring a steady flow of projects that support the office's expansion. Typically, Principals are expected to generate enough business to sustain 2-3 full-time staff members and guide clients throughout the project lifecycle. Additionally, you will be responsible for managing projects effectively, ensuring timely, profitable, and high-quality delivery. We value your commitment to mentoring the next generation of leaders, empowering them to excel and build fulfilling careers.Your Responsibilities:Identify and pursue new business opportunities while fostering client relationships;Oversee project management, client interaction, team leadership, and regulatory agency engagement;Conduct critical reviews of project requirements, applicable environmental regulations, and communicate findings effectively;Deliver projects that may involve site visits, preparation, and review of deliverables;Act as a role model, ensuring the health, safety, and security of our team.Your Team:As a member of our Environment and Health team, you will collaborate with passionate individuals dedicated to solving client challenges and making a positive impact.

Our MissionAt Altos Labs, we are dedicated to revitalizing cell health and resilience. Our innovative approach to cellular rejuvenation aims to reverse diseases, injuries, and the limitations that may arise throughout life.For more details, visit our website at altoslabs.com.Our ValuesWe embody a singular value at Altos: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosDiversity is essential for scientific innovation and inquiry. At Altos, we bring together exceptional scientists and industry leaders from diverse backgrounds to pursue a common goal. Our commitment to Belonging ensures that all employees feel valued for their unique perspectives, fostering a diverse and inclusive workplace.Your Contributions to AltosJoin us at Altos Labs, where we seek passionate, innovative, and collaborative individuals eager to leverage their expertise in advancing the understanding of cellular rejuvenation programming. This role encompasses contributions to foundational research, pre-clinical studies, and clinical-stage programs.Key ResponsibilitiesEngage in pioneering scientific research.Facilitate and supervise collaborations across multidisciplinary projects to accelerate pivotal research efforts.Investigate the mechanistic foundations of cellular programming for health and revitalization.Mentor graduate students.Develop project-specific experimental strategies, techniques, and protocols.Assist the Principal Investigator (PI) in training lab members, including scientists and technicians.Contribute to the writing and dissemination of research findings.Collaborate on research projects alongside the PI.

WORK SCHEDULEThis position operates on a 4x10 schedule, requiring three days of work between Tuesday and Friday, plus every Saturday, leading to a total of four days per week with ten hours each day. The work starts at 1:00 PM PST.Why Choose Millennium Health?Millennium Health LLC is a highly regarded accredited specialty laboratory with over ten years of experience in medication monitoring and drug testing services. We empower clinicians to monitor both the use and misuse of prescription medications and illicit substances, offering vital insights into patients’ recent substance use. Our commitment to quality and integrity is fundamental to our mission to support healthcare professionals and their patients effectively.GENERAL SUMMARYThe Clinical Laboratory Scientist will execute a variety of standardized urinalysis tests in our advanced toxicology lab, utilizing cutting-edge LC-MS-MS technology for the detection of prescription and illicit drugs. This role involves approving reports and patient results for ordering physicians.ESSENTIAL FUNCTIONSThe Clinical Laboratory Scientist will be accountable for the following functions while adhering to our quality standards:Conducting and reporting laboratory test results for all methods sanctioned by CAP, NY, and CLIA.Ensuring accuracy and timely delivery of test results.Entering testing data and performing standardized tests on urine samples using advanced LC-MS-MS technology.Evaluating result validity, maintaining detailed records, and generating comprehensive reports.Overseeing quality control and chromatographic data prior to releasing results to physicians.Adhering to established quality control protocols and assisting in preparing chromatographic data reports.Identifying, troubleshooting, documenting, and resolving issues with test results.Utilizing the Laboratory Occurrence Management (LOM) form for documentation purposes.Serving as a resource and trainer for laboratory technicians and assistants.Preparing and maintaining laboratory reagents and supplies, ensuring equipment is well-maintained and the lab is orderly.Following safe laboratory practices while participating in operational support activities to enhance testing capabilities.Overseeing the activities of clinical laboratory technicians and assistants as needed.