Principal Research Scientist II - Analytical Development

At Genesis Molecular AI, we are on a mission to transform the landscape of drug discovery by forming a premier computational chemistry team that leverages advanced machine learning techniques and biophysical simulations. We are actively looking for a Principal CADD Scientist to collaborate with our scientists in our cutting-edge wet lab and coordinate with our remote computational chemistry and CADD science teams throughout the United States.Key ResponsibilitiesEmploy both established and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse range of targets, including innovative targets with minimal chemical precedents.Implement strategies such as virtual screening, molecular simulations, and predictive analytics for potency and ADMET to inform critical decision-making in drug development.Work collaboratively with medicinal chemists on molecular design and the formulation of project-specific computational methodologies.Serve as a liaison among teams, ensuring effective communication between computational chemistry and medicinal chemistry groups to facilitate seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that fosters innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. This role is also suitable for PhD-level professionals in organic or medicinal chemistry with substantial lab experience who have transitioned into CADD roles.In-depth knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.A minimum of 5 years of relevant industry experience as a CADD scientist in pharmaceuticals or biotechnology, with direct involvement in active drug discovery projects.While onsite presence in our San Diego lab is preferred for collaboration, we welcome applicants interested in remote opportunities.What We OfferCompetitive salary and benefits packageComprehensive health care plans (including medical, dental, and vision, fully covered for employees)Eligibility for stock options

At Genesis Molecular AI, we are assembling a premier computational chemistry team dedicated to transforming drug discovery through state-of-the-art machine learning and biophysical simulations. We invite applications for the role of Principal CADD Scientist, who will collaborate closely with our scientists in the advanced wet lab and our distributed computational chemistry and CADD teams located across the United States.Key ResponsibilitiesEmploy a mix of industry-leading and proprietary AI-driven CADD tools to steer small molecule drug discovery projects across a wide array of targets, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and ADMET prediction to facilitate critical decision-making during the drug discovery process.Work in tandem with medicinal chemists in molecular design and the formulation of project-specific computational strategies.Serve as an effective liaison among the computational and medicinal chemistry teams, ensuring smooth communication and collaborative decision-making.Thrive in a fast-paced environment that champions innovation and rapid iteration.QualificationsPh.D. in Computational Chemistry, Structural Biology, or a closely related discipline. Candidates with a Ph.D. in organic or medicinal chemistry and substantial laboratory experience transitioning to industry roles in CADD may also be considered.Comprehensive understanding of structure-based drug design and protein-ligand interactions.Expertise in industry-standard CADD software such as MOE, PyMOL, and Schrödinger Suite.A minimum of 5 years of experience as a CADD scientist in the pharmaceutical or biotechnology sector, with direct involvement in active drug discovery projects.While onsite collaboration in our San Diego lab is preferred, we are open to accommodating remote team members.What We OfferCompetitive salary and benefitsComprehensive health care plans, including medical, dental, and vision insurance fully covered for employeesEligibility for stock options

Genesis Molecular AI is on a mission to transform drug discovery through innovative computational chemistry solutions. We are building a premier team of experts in computational chemistry, and we invite you to join us as a Senior CADD Scientist. In this pivotal role, you will collaborate closely with our cutting-edge wet lab scientists and work alongside our distributed computational chemistry and CADD science teams throughout the United States.Key Responsibilities:Employ a blend of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a varied target landscape, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and potency and ADMET prediction to facilitate critical decision-making processes in drug discovery.Work collaboratively with medicinal chemists to design molecules and develop tailored computational strategies for specific projects.Serve as a bridge among teams, effectively communicating between our computational chemistry and medicinal chemistry groups to promote seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that encourages innovation and rapid iteration.

At Bee Genius, we are pioneering the future of work, today.This post was generated on behalf of our client:Job Description: We are seeking a highly accomplished and motivated Principal Scientist to become an integral part of our innovative team. In this role, you will spearhead groundbreaking scientific research and development initiatives, offer expert technical guidance, and catalyze innovation within our organization.Responsibilities:Lead and oversee scientific research projects from conception through to execution.Design and refine scientific methodologies and protocols for optimal outcomes.Conduct thorough analysis and interpretation of intricate data, effectively presenting insights to stakeholders.Mentor and provide technical support to junior scientists, fostering their professional growth.Collaborate with cross-functional teams to convert scientific discoveries into actionable applications.Remain abreast of the latest advancements and industry trends in your field.

AbbVie is seeking a highly skilled Principal Research Scientist II specializing in Lipid Chemistry to join our innovative team in San Diego. This role is pivotal in advancing our research efforts and driving the development of novel lipid-based therapies. The ideal candidate will possess a robust background in lipid biochemistry, with a proven track record of impactful research and development.

Role Overview iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams focused on automated experimentation, AI-driven molecular design, property prediction, and bioassay data generation. What You Will Do Design and refine strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties, using multivariate SAR analysis and hypothesis-driven design. Apply a broad range of modern organic chemistry transformations and synthetic methodologies, including parallel experimentation, to advance project goals. Work closely with colleagues in molecular and cellular biology, pharmacology, computational chemistry, ADME, and related groups to drive discovery efforts. Shape the use of computational approaches, automated synthesis, and high-throughput experimentation in medicinal chemistry projects. Collaborate with AI and machine learning teams to build and apply predictive models for novel molecule design. Clearly communicate project updates and findings to the broader team and stakeholders. Contribute to the Chemistry research group, supporting a culture of scientific rigor, innovation, and teamwork. Qualifications BS, MS, or PhD in chemistry, with a focus on synthetic organic chemistry. Direct experience in small molecule drug discovery within biotech or pharma: minimum 15+ years with a BS, 12+ years with an MS, or 8+ years with a PhD. Documented success advancing drug discovery programs from lead identification through advanced candidate stages. Deep experience optimizing lead compounds for potency, selectivity, ADME, and pharmacokinetics. Expert knowledge of modern synthetic organic chemistry methods, supported by publications and patents. Hands-on familiarity with target protein degradation and modalities such as molecular glues and PROTACs. This position is based onsite at our San Diego HQ.

At Genesis Molecular AI, we are creating an elite team of experts in computational chemistry to transform the landscape of drug discovery through advanced machine learning and biophysical simulations. We invite a Senior Computational Aided Drug Discovery (CADD) Scientist to join us in our mission, collaborating closely with scientists in our advanced wet lab and our distributed teams in computational chemistry across the United States.Key ResponsibilitiesEmploy a mix of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse array of targets, including innovative targets with limited chemical history.Utilize techniques such as virtual screening, molecular simulations, and ADMET prediction to facilitate critical decision-making during drug discovery.Work closely with medicinal chemists on molecular design and the creation of tailored computational methodologies for specific projects.Serve as a liaison across teams, effectively bridging communication between our computational and medicinal chemistry departments to ensure smooth information exchange and collaborative strategies.Thrive in a fast-paced environment that encourages innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. Candidates with a PhD in organic or medicinal chemistry and substantial laboratory experience transitioning into industry roles in CADD are also encouraged to apply.Extensive knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools, including MOE, PyMOL, and Schrodinger Suite.A minimum of 2 years of experience in the pharmaceutical or biotech industry as a CADD scientist, with practical involvement in active drug discovery projects.While onsite presence at our San Diego lab is preferred for collaboration, we are open to considering remote team members as well.What We OfferAttractive SalaryComprehensive Health Care Plans (Medical, Dental, and Vision fully covered for employees)An opportunity to work in a pioneering environment with the latest technologies in drug discovery.

JOB SUMMARYIambic Therapeutics is on the lookout for a talented and highly motivated Senior/Principal Scientist specializing in Computational Chemistry to join our innovative Computational Sciences team at our San Diego headquarters. As a vital contributor, you will leverage advanced ligand and structure-based methodologies to propel our drug discovery initiatives. You will actively engage with research teams focused on developing groundbreaking therapeutics across various indications. Collaborating closely with experts in machine learning, medicinal chemistry, and biology, you will implement state-of-the-art Structure-Based Drug Design (SBDD) techniques throughout hit identification, lead optimization, and candidate selection phases. This hands-on position demands robust expertise in computational chemistry, a keen interest in co-folding applications, and a proactive drug-hunter mindset.KEY RESPONSIBILITIESUtilize diverse ligand and structure-based strategies during the hit identification, lead optimization, and candidate selection phases (including cheminformatics, pharmacophore modeling, docking, shape-based virtual screening, de novo molecular design, and molecular dynamics simulations).Lead design cycles by identifying structure-activity relationships and integrating computational predictions with bioactivity data.Collaborate with medicinal chemists to design, assess, and prioritize virtual libraries, proposing concrete molecular designs.Work alongside machine learning scientists to meld SBDD methodologies with our proprietary transformer-based property prediction technology (Enchant).Enhance and utilize our proprietary protein-ligand co-folding technology (NeuralPLexer) to generate novel and actionable structural hypotheses.Translate scientific inquiries into computational workflows, delivering actionable insights.Present findings to project teams, elucidating methods, implications, and recommendations.Develop, validate, and maintain computational workflows and tools.QUALIFICATIONSRequired:PhD or equivalent in Computational Chemistry (or a related field) with a minimum of 5 years of experience in an industrial drug discovery setting.Proven experience in supporting active small molecule drug discovery programs.Experience with ligand and structure-based drug design methodologies.

Join Genesis Molecular AI as a Senior / Principal ADME Scientist in San Diego, CA!At Genesis Molecular AI, we are at the forefront of utilizing artificial intelligence to revolutionize rational drug design and tackle significant unmet medical needs. We are looking for an enthusiastic and adaptable ADME Scientist to become a vital part of our Non-Clinical Development team, facilitating the progression of our innovative compounds through both preclinical and clinical phases.This full-time role is set in a dynamic biotech environment where collaboration thrives among a talented team of professionals, all working towards clear scientific objectives. We offer an attractive benefits package, including comprehensive medical and dental insurance, flexible working hours, generous vacation time, and the chance to engage deeply with the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in various ADME-related assays such as metabolic stability, protein binding, drug-drug interactions, and more. They will be skilled in developing, executing, and troubleshooting assays both independently and in collaboration with external partners. As the subject matter expert in in-vitro ADME, you will provide critical strategic input to our project teams. Experience in bioanalytical assays and method development is a plus.

Job Overview: We are seeking a dedicated Bench Scientist II to join our dynamic team in San Diego. This role entails collaborating with fellow scientists to advance translational pharmacology research focusing on various clinical candidate compounds and late-stage assets. Key responsibilities include performing tissue culture, conducting cell-based assays, and executing western blot analysis. The ideal candidate will possess a solid background in cancer biology and relevant laboratory experience while demonstrating strong communication and teamwork skills.Key Responsibilities: Conduct tissue culture, cell-based assays, and western blot analysisWork with unscreened blood, human tissue, or human cell lines

Join Our Team as a Senior / Principal ADME ScientistAt Genesis Molecular AI, we are at the forefront of revolutionizing drug discovery through innovative artificial intelligence-driven approaches. Our San Diego lab is actively seeking a dynamic and skilled Senior / Principal ADME Scientist to enhance our Non-Clinical Development team and propel our compounds through the phases of preclinical and clinical development.This full-time position offers an exciting opportunity to work in a fast-paced biotech environment alongside a collaborative team of experts, all focused on achieving clear scientific and developmental objectives. We provide comprehensive medical and dental benefits, flexible working hours, generous vacation time, and the chance to gain extensive exposure to the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in a range of ADME-related assays, including metabolic stability, protein binding, and drug-drug interactions. You will be instrumental in developing, executing, and troubleshooting assays, as well as managing outsourced work. As a subject matter expert in in-vitro ADME, your strategic input will be crucial to project teams. Experience with bioanalytical assays and method development is highly desirable.

Join Veracyte, a trailblazer in transforming cancer care on a global scale. Our team is dedicated to making a profound impact on patient lives while fostering an environment of continuous learning and growth. We embody the Veracyte way, a collaborative spirit driven by our core values to equip clinicians with the critical insights necessary for impactful patient decisions.Our Core Values:We Seek A Better Way: Innovating with courage, learning from challenges, and resiliently pursuing advancements in cancer care.We Make It Happen: Acting with urgency and dedication to quality while finding joy in our endeavors.We Are Stronger Together: Fostering open collaboration, understanding, and celebrating our collective successes.We Care Deeply: Valuing our differences, committing to integrity, and supporting one another. The Role:We are in search of a skilled Bioinformatics Scientist to enhance our Sustaining and Continuous Improvement team within Global Operations. This pivotal role involves constructing, refining, and supervising comprehensive quality control (QC) processes for RNA-based microarray and NGS high-volume Laboratory Developed Test (LDT) diagnostic products in CLIA labs. The Bioinformatics Scientist will ensure operational excellence, drive process enhancements, and collaborate with cross-functional teams for effective troubleshooting. The selected candidate will maintain product consistency through routine CLIA updates, contribute to verification and validation documentation, and engage in design reviews. This role promises valuable exposure to diagnostic product development and sustainability, with a direct impact on improving patient outcomes.

Join Veracyte as a Senior Computational Development Scientist, where you will play a pivotal role in our mission to transform patient care through innovative genomics. In this remote position, you will leverage cutting-edge computational techniques to analyze complex genomic data, contributing to groundbreaking discoveries in cancer diagnostics.

Join our dynamic team as a Scientist II, where you will leverage your expertise to drive innovation and contribute to cutting-edge research projects. You will work collaboratively with a team of professionals in a stimulating environment that fosters growth and creativity.

Join our innovative team at Artech Information Systems LLC as a Research Scientist. We are seeking a dedicated individual to contribute to groundbreaking research initiatives. You will engage in scientific inquiry, data analysis, and collaborative projects that push the boundaries of knowledge in your field.

At Art of Problem Solving (AoPS), data is at the heart of our mission to engage and retain families across the globe. With a reach extending to tens of thousands of students, our marketing strategies encompass various channels, including acquisition, campaign performance, lifecycle engagement, brand awareness, and community growth. The insights we gain from these initiatives are only as valuable as the decisions they inform.We are seeking a skilled Data Scientist to join our Marketing and Growth teams as a vital analytical partner. This role is designed for a full-stack individual contributor adept at conducting in-depth analyses, creating customer segments, measuring attribution, designing experiments, and addressing complex, high-impact marketing questions. Your contributions will enhance our marketing and growth strategies, bridging the gap between analytics and strategic decision-making.In collaboration with our marketing and growth teams, you will help shape our marketing strategies, assess channel performance, and ensure we effectively reach and convert audiences with compelling messages that drive enrollment.

Join LanceSoft, Inc. as a Research Scientist I in the vibrant city of San Diego, California. In this entry-level role, you will play a crucial part in supporting scientific research initiatives, collaborating with senior scientists, and contributing to innovative projects within our dynamic team.

We are seeking a passionate and detail-oriented Protein Purification Scientist to join our dynamic team in San Diego. This role is critical to our mission of advancing biopharmaceutical development through innovative protein purification techniques.The ideal candidate will have experience in utilizing various purification methodologies and will be responsible for developing and optimizing protocols to ensure the highest quality of protein products. You will collaborate with cross-functional teams to support ongoing research projects.

Join our dynamic team at Integrated Resources, Inc. as a Research Scientist I. In this role, you will contribute to cutting-edge research initiatives, collaborating with multidisciplinary teams to innovate and develop groundbreaking solutions.