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Nucleic Acids Platform Scientist

On-site Full-time

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Key Responsibilities:Lead the design and optimization of nucleic acid constructs (mRNA, ASOs, siRNAs) to enhance potency, stability, and targeted delivery to specific cell types or tissues. Implement sequence design strategies, chemical modifications, and structural elements (e.g., modified nucleotides, backbone chemistries, conjugates) to increase efficacy while minimizing immunogenicity or off-target effects. Refine multiplexed screening platforms to assess the performance of diverse nucleic acid-LNP formulations for payload delivery. Conduct research at the intersection of molecular biology, RNA/oligonucleotide chemistry, and formulation science. Prepare DNA templates for in vitro transcription and produce mRNA via enzymatic IVT. Synthesize or procure ASOs and siRNAs; purify and characterize all nucleic acid constructs, incorporating reporter or sequencing-based readouts as necessary.

About the job

About Us:

GT Biosciences is an innovative techbio startup focused on revolutionizing drug delivery through our groundbreaking platform, Deliveromics. This AI-powered, high-throughput, multiplexed in vivo data engine is designed to uncover the fundamental rules of drug delivery. Founded by a team of MIT PhDs and an esteemed MIT professor, and supported by leading investors, we are dedicated to developing next-generation, non-viral, cell-type-specific delivery systems. Our passionate, science-driven team is on a mission to make routine in vivo cell reprogramming a reality.

We embrace a culture of transparency and collaboration, seeking enthusiastic team members who thrive in an open, cooperative environment and aspire to grow alongside the company and their colleagues.

Job Overview:

We are looking for a dedicated and multidisciplinary Nucleic Acids Platform Scientist to join our Deliveromics Platform Development team. In this pivotal role, you will design and optimize innovative nucleic acid constructs and chemistries, including mRNA, ASO, and siRNA, for targeted delivery applications. Your responsibilities will include supporting Deliveromics in vivo screening and conducting thorough evaluations of performance through both in vitro assays and animal models. You will independently plan and execute experiments, analyze complex datasets, and communicate findings effectively. As an early scientific hire at our emerging biotech firm, you will play a crucial role in shaping our platform, fostering interdisciplinary collaboration, and contributing to transformative delivery solutions for genetic medicines. This is a full-time, on-site position located in Cambridge, MA.

About GT Biosciences

GT Biosciences is a forward-thinking techbio startup at the forefront of drug delivery innovation. Our team, comprised of leading experts and driven by a shared passion for science, aims to transform the landscape of genetic medicine through our Deliveromics platform. With a commitment to excellence and a collaborative spirit, we are dedicated to redefining the possibilities of drug delivery.

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