About the job
Flagship Pioneering’s Pioneering Medicines (PM) initiative focuses on creating new therapies for serious diseases by integrating multiple scientific platforms. The team aims to address significant unmet medical needs through advanced biopharmaceutical R&D.
Role overview
The Executive Director, CMC (Chemistry, Manufacturing & Controls) will provide both strategic and operational leadership across the full PM portfolio, spanning research through late-stage clinical development. This position reports to the SVP, CMC & Technical Operations and plays a central role in shaping CMC as a core strength for Pioneering Medicines.
This leader will develop long-term CMC strategies, resolve technical challenges at both the portfolio and program levels, and define approaches for emerging modalities. Building and managing a top-tier network of external Contract Development and Manufacturing Organizations (CDMOs) is a key part of the role. The Executive Director will also guide resource allocation and promote adoption of innovative, including AI-enabled, CMC tools.
Key responsibilities
- Serve as a senior member of the Technical Operations leadership team, overseeing CMC areas such as Drug Substance Development, Drug Delivery/Pre-formulation, Analytical Development, Product Development, and Regulatory CMC. Responsible for CMC strategy and portfolio deliverables.
- Grow and guide the CMC organization by recruiting, developing, and retaining talent. Foster a culture focused on excellence, accountability, and ongoing improvement.
- Lead end-to-end CMC processes for a diverse and expanding portfolio of multimodality compounds. Ensure timely advancement of programs and proactively identify and manage portfolio-level CMC risks.
What sets this role apart
This position sits at the intersection of science, strategy, and operations. The Executive Director will influence how Pioneering Medicines approaches new therapeutic modalities and will be recognized as a thought leader in the field, especially in adopting innovative methodologies and digital tools.

