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Director/Senior Director of Regulatory CMC (Biologics)

Oruka TherapeuticsWaltham, Massachusetts, United States
Hybrid Full-time $213K/yr - $286K/yr

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Experience Level

Senior Level Manager

Qualifications

Key Responsibilities:Lead and implement global regulatory CMC strategies for drug substances and products across all phases from IND to BLA. Develop high-quality regulatory submissions in alignment with applicable guidelines. Guide and mentor cross-functional teams on regulatory expectations. Collaborate effectively with various internal departments and external partners to enhance program outcomes.

About the job

Join Our Mission:

Oruka Therapeutics (Nasdaq: ORKA) is at the forefront of developing cutting-edge biologics aimed at revolutionizing the treatment of chronic skin diseases. Our commitment is to provide patients afflicted by conditions such as plaque psoriasis with unprecedented freedom by achieving significant disease clearance with infrequent dosing, sometimes as little as once or twice a year. We are advancing a proprietary pipeline of potentially best-in-class antibodies that target the fundamental mechanisms of plaque psoriasis and other dermatological and inflammatory ailments. Discover more about us at www.orukatx.com.

As we expand our core team, we are looking for exceptional individuals who are not just seeking employment but are passionate about contributing to a broader cause. We value candidates who are eager to foster an inclusive and dynamic company culture.

Position Overview:

We are in search of a seasoned and motivated leader in regulatory CMC to shape our strategy and execution across various stages of biologics programs. In this role, you will be responsible for the development of high-quality regulatory CMC submissions and will provide guidance to cross-functional teams on global regulatory expectations appropriate for different phases. Ideal candidates will bring extensive expertise in biologics development and manufacturing, particularly in drug substance and product CMC submissions. You will play a crucial role in influencing program strategies, facilitating collaboration across CMC, QA, RA, Supply Chain, and external partners, and driving pivotal decisions that support our expanding biologics pipeline. This highly visible role involves ensuring compliance with FDA, EMA, ICH, and WHO guidelines while meeting corporate and program-level objectives.

About Oruka Therapeutics

Oruka Therapeutics is committed to pioneering innovative biologics that set new standards in treating chronic skin conditions. Our mission is to empower patients with effective and infrequent treatment options, aiming for high rates of disease clearance and improved quality of life.

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