Director of Systems

About Us At Flagship Pioneering, we are at the forefront of biotechnology innovation. Our mission is to create and nurture transformative companies that are dedicated to solving the world’s most pressing challenges. By assembling leading scientific experts and entrepreneurial visionaries, we empower groundbreaking advancements in human health and sustainability, spanning areas from precision cancer therapies to sustainable agricultural solutions. What distinguishes Flagship is our unique methodology that integrates life science innovation, enterprise creation, and strategic investment within a single framework. Our dedicated scientific founders, entrepreneurial leaders, and investment professionals collaborate effectively, driving an institutionalized process that fosters innovation and delivers significant benefits to society and the environment. Many of our portfolio companies have made substantial contributions to global health and sustainability, including mass COVID-19 vaccination efforts, curing chronic diseases, enhancing overall health, and developing resilient agricultural practices. Flagship has received prestigious accolades, including placements on FORTUNE’s “Change the World” list and recognition as one of Fast Company’s Most Innovative Companies. Our Lab IT and Research Systems teams are committed to facilitating scientific breakthroughs throughout the Flagship ecosystem by providing robust, scalable, and secure technological solutions that support both laboratory and computational research. We work in close partnership with our research teams to optimize their tools, systems, and environments to enhance productivity, reproducibility, and innovation. Position Overview The Lab Systems Analyst I plays a key role in overseeing the management, reliability, and improvement of laboratory and research systems across Flagship’s internal and portfolio companies. This position emphasizes the maintenance of effective lab system environments, ensuring secure and compliant data handling, and supporting integrations that streamline the capture, storage, and analysis of scientific data. We seek a candidate who combines foundational IT support experience with a keen interest in scientific systems, cloud infrastructure, and data workflows. The Lab Systems Analyst will collaborate closely with Lab IT, Research Systems, and scientific teams to ensure laboratory environments are robust and aligned with research objectives. Key Responsibilities Lab Systems Management Assist in the administration and lifecycle management of lab systems, ensuring optimal performance and compliance.

Join Zifo Technologies as a GxP Lab Computing Analyst, where you'll leverage your expertise to enhance laboratory systems within a regulated environment. You will collaborate with cross-functional teams to ensure compliance with Good Laboratory Practices (GLP) and Good Manufacturing Practices (GMP). Your role will involve troubleshooting, validating, and optimizing lab computing solutions while supporting data integrity and regulatory requirements.

The Lab Operations Analyst plays a critical role in optimizing laboratory processes and ensuring efficiency within our operations. This position involves analyzing workflows, identifying areas for improvement, and implementing solutions to enhance productivity and quality. You will collaborate with cross-functional teams to develop strategies that drive operational excellence in lab environments.

Your Contribution at Lila Sciences Lila Sciences is on the lookout for a dynamic Staff Software Engineer to join our innovative AI Lab Execution System team. In this pivotal role, you will have the opportunity to design, develop, and enhance intelligent, data-driven applications, with a strong emphasis on front-end development. Your focus will include the creation of user interfaces, services, high-performance APIs, and databases, ensuring seamless integration of advanced AI frameworks into our scientific analytics and laboratory workflows. Collaborating closely with ML researchers, platform engineers, and scientists, you will develop systems capable of managing diverse workloads and scaling efficiently. This includes working with structured SQL databases, data lake houses, and vector databases. If you are passionate about creating high-performance, elegant systems that make a real scientific impact, we invite you to apply! Your Responsibilities Include: UI and API Design & Development: Create high-performance, secure, and well-documented user interfaces and APIs that integrate seamlessly with AI-driven applications. Database Design & Management: Develop schemas and manage various data systems (SQL, NoSQL, Vector DBs) to ensure optimal performance and scalability. Application Development: Lead the development of both front-end and backend services, prioritizing performance, maintainability, and reliability. Performance Optimization: Identify and resolve system bottlenecks, ensuring high availability and low-latency performance across extensive workloads. Cloud Infrastructure: Utilize AWS services, Kubernetes, and modern DevOps practices to build and deploy scalable production systems. Collaborative Development: Work alongside ML researchers and scientists to integrate data pipelines, APIs, and cloud infrastructure into scientific workflows.

Join our team as a Research Lab Technician where you will play a crucial role in supporting innovative research projects within a dynamic laboratory environment. You will be responsible for conducting experiments, collecting data, and assisting in the development of cutting-edge technologies.

Flagship Pioneering seeks a Business Systems Analyst focused on SharePoint and collaboration platforms. Based in Cambridge, MA, this position plays a central role in managing and improving the company’s knowledge management systems. Role overview This analyst will administer and optimize SharePoint, ensuring it supports the company’s enterprise knowledge needs. The role also involves supporting other collaboration tools, including Slack, Notion, and Smartsheet. Attention to governance, usability, and user adoption is key. What you will do Administer and continually improve SharePoint to align with business requirements. Support governance and enhance usability for Slack, Notion, and Smartsheet. Promote adoption of SharePoint and related platforms throughout the organization. Refine knowledge structures and help streamline workflows. Serve as a subject matter expert for SharePoint and other collaboration solutions. Location This position is based in Cambridge, MA, USA.

We are seeking a passionate and detail-oriented Scientist I to join our innovative team at Integrated Resources Inc. This entry-level position offers a fantastic opportunity to contribute to groundbreaking research and development projects. You will work closely with experienced scientists to support various laboratory activities, including experimental design, data collection, and analysis.

Join our innovative team at Zifo Technology as a Lab Computing Technician. In this role, you will be responsible for ensuring the efficiency and functionality of our laboratory computing systems. You will collaborate with scientists and engineers to support research initiatives, troubleshoot technical issues, and maintain laboratory equipment.

The Company Flagship Labs 119 Inc. (FL119) is an innovative technology firm at the cutting edge of neuroscience and computation. We are on a mission to revolutionize the landscape of intelligent system development, driven by the belief that the future of artificial intelligence necessitates a radical re-evaluation of existing paradigms. Our objective is ambitious and urgent: to cultivate a future in which naturalistic, resilient intelligence can thrive and function sustainably at scale. Supported by Flagship Pioneering, we possess the courage, strategic vision, and resources essential for achieving extraordinary outcomes. At FL119, we foster a culture that is interdisciplinary and collaborative. Our teams flourish in dynamic and imaginative settings where every voice is valued, recognizing that diverse experiences, transferable skills, and genuine passion are key to our success. The Role: We are in search of a visionary and technically proficient Neuromorphic Systems Architect to join our team. We offer flexible leveling based on your experience. This position will concentrate on converting nonlinear neural dynamics into state-of-the-art computational architectures. You will engage at the intersection of neuroscience, dynamical systems theory, and hardware engineering to design and prototype electronic systems that integrate biologically inspired computation principles. This is not your typical AI accelerator role; we are looking for someone who can reconceptualize computing from foundational principles, designing architectures that embrace recurrence, nonlinearity, sparsity, event-driven signaling, and adaptive dynamics as core components rather than limitations. Your Responsibilities: Translate brain-inspired computation through dynamical systems theory into hardware-relevant abstractions. Design innovative neuromorphic or neuro-inspired hardware systems (analog, mixed-signal, in-memory, or alternative substrates). Establish system-level architecture that encompasses memory models, communication protocols, and energy-efficient computing primitives. Collaborate closely with teams in neuroscience, signal processing, and machine learning to ensure a seamless integration of biological insights with architectural design. Lead feasibility studies, simulations, and early-stage prototyping initiatives. Assess trade-offs across CMOS, emerging devices, photonic, memristive, or other unconventional computing substrates. Contribute to our intellectual property strategy, including invention disclosures and patents. Help define the long-term computing vision of the company.

We are seeking a motivated and detail-oriented Scientist I to join our dynamic team in Cambridge. The ideal candidate will have a strong background in scientific research, with a passion for innovation and problem-solving. This entry-level role offers an exciting opportunity to contribute to groundbreaking projects and advance your career in a collaborative environment.

Harvard University’s Psychology Lab in Cambridge seeks a Research Assistant I to support research projects in the social sciences. This position offers the chance to work directly with ongoing studies and gain experience in a university research environment. Main responsibilities Assist with data collection for laboratory studies Conduct literature reviews to support research directions Help with experimental design and setup Who will thrive in this role This position is a strong fit for those interested in practical research experience in psychology or related disciplines. It provides hands-on involvement in lab work and exposure to the daily operations of a university research team.

Join our dynamic team as a Molecular Biology and Tissue Culture Lab Associate in Cambridge, MA. This is an exciting opportunity for individuals passionate about advancing scientific research and laboratory techniques. You will be involved in various laboratory processes, focusing on molecular biology and tissue culture methodologies.

Your Impact at Lila In this pivotal role, you will spearhead the innovation and validation of advanced pooled assays utilizing mammalian cells. Your work will encompass everything from proof of concept to automated screening processes, enabling the generation of intricate, high-dimensional datasets. This position involves collaboration across cell biology, protein design, and nucleic acid teams to facilitate biologic development programs, focusing on the rapid assessment of binding, stability, function, and immunogenicity of diverse biologics. What You'll Be Building Create next-generation mammalian display-based assays for binding, stability, function, and immunogenicity. Implement cutting-edge multiomic, single-cell, and in situ sequencing workflows to design innovative, highly multiplexed assays. Collaborate with protein design, nucleic acid, and automation teams to leverage these workflows in biologics development. Closed-Loop Experimentation and Execution: Work closely with engineering and automation teams to architect automated, high-throughput experimentation platforms that yield data-rich workflows. Join forces with the AI team to conduct iterative experiments in real time, facilitating rapid optimization and discovery cycles. Collaborate, Lead & Communicate: Engage with cell biologists, synthetic biologists, automation engineers, protein design scientists, and data scientists to document systems, share insights, and refine best practices in autonomous science. Mentor junior scientists, align project milestones with internal and external collaborators, contribute to intellectual property and publications, and present findings across the organization. What You’ll Need to Succeed Ph.D. in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, Immunology, or a related discipline (or M.S./B.S. with 5–8+ years of relevant industry experience). Proficiency in the development and/or application of mammalian display or similar pooled mammalian systems (perturb-seq, MPRA, etc.). Experience in designing, executing, and analyzing single-cell, in situ, or multiomic sequencing experiments. Expertise in creating complex libraries of defined sequences in mammalian cells. Experience in designing, executing, and analyzing flow cytometry and sorting experiments. Familiarity with next-generation sequencing (NGS) based experimental design and analysis.

The Computational Policy Lab at the Shorenstein Center at Harvard Kennedy School is on the lookout for a Senior Software Engineer with deep expertise in software development, generative AI, and data science. This role is embedded within the Shorenstein Center, which focuses on critical areas of inquiry at the intersection of media, politics, and public policy. As part of our team, you will play a vital role in advancing teaching and research initiatives that strive to make a meaningful impact.Application RequirementsTo be considered, applications must include:A detailed resumeA cover letter that includes:A link to a code sample on GitHub that showcases your technical abilities, ideally a project you would enjoy discussing in an interviewA brief description of the linked projectVerification of your legal authorization to work in the United States without sponsorship for a minimum of two yearsJob-Specific Responsibilities:Your main duties will include:Independently managing complex applications/web development for large-scale projectsDesigning and implementing sophisticated software systems geared towards large-scale research projects, focusing on educational technology and generative AI tools.Utilizing recent advancements in machine learning and natural language processing to create, test, and deploy cutting-edge algorithmic tools that support empirical research.Leading and collaborating on projects that involve AI, machine learning, natural language processing, and extensive experimentation.Contributing to the design and implementation of randomized controlled trials and other empirical methodologies to assess the effectiveness of AI-driven interventions.Working closely with researchers to convert theoretical models into high-performance, production-ready systems.Co-authoring or contributing to academic papers and reports for peer-reviewed journals, conferences, and broader audiences.Keeping up with emerging technologies and research in AI, computational social science, and causal inference.Adhering to Harvard University’s IT technical standards and Code of Conduct.Projects you may be involved in include, but are not limited to:AI in Education: We are developing AI-powered technologies that exceed standard tools by providing customized support for student learning. Our flagship tool, PingPong, is currently being evaluated through a large-scale randomized experiment.

Join Our Visionary Team At Flagship Labs 109, Inc. (FL109), we are at the forefront of revolutionizing biology through cutting-edge artificial intelligence, advanced physics, and innovative hardware solutions. Our mission-driven environment fosters creativity and collaboration, empowering you to contribute to groundbreaking advancements in science. Your Role in Our Journey As a vital member of our interdisciplinary team, you will engage in the development and deployment of state-of-the-art AI solutions that enhance our understanding of molecular biology. Your expertise will facilitate the construction of scalable platforms and the effective management of vast datasets, all while collaborating with diverse teams to achieve extraordinary results. We're Excited to Find Talent in the Following Areas: Artificial Intelligence Software Engineering Automation Physics Hardware Engineering

Your Contribution at Lila Sciences Lila Sciences is seeking a passionate Software Engineer to spearhead the development of cutting-edge Lab Instrument Integration Software, a crucial element of our AI-powered laboratory ecosystem. We want innovative thinkers who thrive at the intersection of software, science, and hardware, delivering impactful solutions that propel scientific advancements. Key Responsibilities Lab Instrument Software Development: Design and implement reliable software that facilitates seamless communication between robotic systems and automation hardware (e.g., robotic arms, liquid handlers, sensors) and control software, guaranteeing effective hardware integration. System Integration: Integrate lab instruments into our next-gen AI-driven lab automation framework, managing intricate connections between cloud and edge infrastructures, along with device execution. Testing and Debugging: Conduct comprehensive testing, debugging, and troubleshooting of drivers to pinpoint, isolate, and resolve performance issues, bugs, and compatibility hurdles. Technical Documentation: Develop, revise, and maintain thorough documentation for driver interfaces, APIs, and integration procedures, ensuring clarity for internal teams and end-users. Collaboration and Support: Partner with cross-functional teams, including hardware engineers, software developers, product managers, and end-users, to provide technical assistance and resolve integration challenges efficiently. AI-Driven Development: Leverage advanced coding models and development tools to enhance the speed and quality of software delivery. Qualifications for Success Proficiency in Python, C#/.NET, or other programming languages/frameworks is essential. Proven experience in debugging and problem-solving, particularly in hardware-software integration contexts. Strong analytical skills and a methodical approach to troubleshooting complex technical challenges. Excellent verbal and written communication skills to facilitate effective collaboration within multidisciplinary teams. Bonus Qualifications A keen interest or background in science. Experience in developing software for laboratory instruments.

Our MissionAt Altos Labs, our mission is to enhance cell health and resilience through innovative cell rejuvenation techniques, aimed at reversing diseases, injuries, and disabilities that may arise throughout life.Learn more by visiting our website at altoslabs.com.Our ValueOur core value is simple yet profound: Everyone is responsible for achieving our inspiring mission.Diversity at AltosWe believe that diverse perspectives are crucial for scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from all over the globe collaborate to advance our shared mission. We prioritize belonging, ensuring that all employees feel valued for their unique contributions. We are collectively accountable for maintaining a diverse and inclusive environment.Don't See a Position That Interests You? Submit Your Resume!Thank you for your interest in Altos Labs! If you haven't found a job that suits you, please submit your resume here. Your profile will be added to our system, and we will consider you for future opportunities that align with your qualifications.In the meantime, be sure to regularly check our job board as we post new openings every week.Before submitting your application:- Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice)- This Privacy Notice is not a contract, express or implied, and does not set employment terms or conditions.Equal Opportunity EmploymentWe cherish collaboration and scientific excellence.Diverse perspectives and a culture of belonging are fundamental to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world join forces to advance our mission. Our commitment to belonging ensures that every employee is appreciated for their unique insights. We are all responsible for fostering an inclusive environment.

Role Overview The Building Engineer I at LPC supports the daily operation and maintenance of building systems in Cambridge, MA. Working under the guidance of senior engineers, this role focuses on HVAC, plumbing, and electrical systems. The position involves routine maintenance, responding to tenant requests, and helping ensure safe, efficient building operations. Main Responsibilities Perform regular maintenance, repairs, and inspections of building systems. Respond to service requests, including temperature adjustments, plumbing issues, and lighting repairs. Diagnose minor equipment problems and escalate complex issues to senior staff as needed. Replace light fixtures, filters, and other key components. Keep accurate records of inspections and system performance. Communicate clearly with tenants, contractors, and property managers to resolve concerns and coordinate activities. Work closely with senior engineers and technicians to support smooth building operations. Assist with preventive maintenance tasks and oversee contractor work when required. Conduct property inspections to identify and document deficiencies. Record equipment readings to confirm compliance with operational standards. Follow safety protocols, wear required PPE, and comply with OSHA, NEC, NFC, and NFPA regulations. Report hazards and participate in safety inspections. Offer guidance to junior technicians when needed. Communicate professionally in both verbal and written formats with teammates, leadership, vendors, tenants, and client employees. Collaborate with senior engineers to build technical skills and participate in professional development programs. Complete additional duties as assigned.

We are seeking a detail-oriented and analytical Procurement and Contract Analyst to join our team in Cambridge, MA. In this role, you will manage procurement processes, analyze contracts, and ensure compliance with corporate policies and regulations. You will work closely with various departments to assess needs, negotiate terms, and optimize purchasing strategies.