Director of Systems

Join Riverlane as the Director of Systems in Cambridge, UK. This is a full-time, permanent position with a hybrid working model.Compensation: £125,000 to £150,000, dependent on experience, along with bonus and equity options.We welcome applications from candidates with varying levels of experience. Salary offers will be tailored to individual backgrounds, including industry experience, transferable skills, and notable achievements.We are open to part-time applications for this role; please specify your preferred schedule in your cover letter.

Amylyx Pharmaceuticals is dedicated to revolutionizing the treatment of diseases with significant unmet needs. We embrace challenges as opportunities, driven by a sense of urgency, rigorous scientific methodology, and a steadfast commitment to the communities we serve. Our focus is on clinical-stage development for conditions such as post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).Our mission thrives on our talented team, which embodies core values of audacity, curiosity, authenticity, engagement, and accountability — all of which foster a culture of care. Amylyx has curated a skilled workforce ready to act swiftly because the communities we support cannot afford to wait. If you are passionate about addressing some of the most challenging issues in medicine, we invite you to explore the opportunity below and apply.The OpportunityThe Associate Director of Computer System Validation (CSV) & Quality Compliance will provide enterprise-level leadership, strategic direction, and governance for the validation, lifecycle management, and continuous compliance of GxP-relevant computerized systems, particularly focusing on the Veeva Quality Suite. This position is pivotal in ensuring that our digital quality solutions and supporting systems comply with global regulatory standards (FDA, EMA, ICH, GAMP 5), safeguard data integrity, and maintain a sustainable, inspection-ready status across the organization.This role entails close collaboration with Quality, IT, Regulatory, Clinical, and business process owners to define system requirements, oversee new system implementations and significant enhancements, and promote harmonized, risk-based validation practices. Additionally, this position supervises quality compliance processes such as Change Control, Deviations, CAPA, and continuous improvement, ensuring timely resolutions, trend analysis, and effective governance through leadership of key forums, including Quality Management Review and cross-functional compliance meetings.

Scholar Rock is a pioneering biopharmaceutical company dedicated to discovering, developing, and delivering transformative therapies for patients with serious diseases that exhibit significant unmet needs. Renowned globally for our expertise in the biology of the transforming growth factor beta (TGFβ) superfamily, we are committed to advancing innovative treatments where protein growth factors are critical. Over the last decade, we have built a robust pipeline that has the potential to redefine the standard of care for neuromuscular diseases, cardiometabolic disorders, cancer, and various other conditions where growth factor-targeted therapies can make a significant impact.Scholar Rock uniquely demonstrated clinical proof of concept for a muscle-targeted treatment in spinal muscular atrophy (SMA). Our dedication to exploring fundamentally different therapeutic avenues is driven by the innovative application of our proprietary platform, which has produced novel monoclonal antibodies that modulate protein growth factors with remarkable precision. By leveraging cutting-edge scientific research in disease areas historically underserved by conventional treatments, we work tirelessly to create new opportunities for patients. Discover more about our approach at ScholarRock.com and follow us on @ScholarRock and on LinkedIn.Position Overview:The Director or Senior Director of Regulatory Strategy, reporting directly to the Senior Vice President, Global Head of Regulatory Affairs, will be responsible for formulating and executing the global regulatory strategy for designated clinical and pipeline programs. As a subject matter expert, this individual will engage with program teams to identify regulatory risks and opportunities, thereby informing strategic direction and planning. The ideal candidate will spearhead interactions with regulatory authorities, overseeing the preparation and submission of all regulatory documentation and correspondence.

Join Flagship Pioneering Inc. as the Director/Senior Director of Compensation, where you will lead the strategic development and execution of our compensation programs. Your role will involve designing competitive compensation structures, ensuring alignment with industry standards, and driving initiatives that enhance employee engagement and performance. You will collaborate with senior leadership to shape compensation policies that reflect our commitment to attracting and retaining top talent.

Your Role at Lila Sciences Lila Sciences is seeking a proactive and strategic Director of Facilities to oversee the daily operations and long-term management of our diverse facilities. You will be responsible for developing a scalable facilities strategy, ensuring safety and compliance across all sites, and managing budgets, capital planning, vendor relationships, and KPI reporting. This role is a pivotal cross-functional leadership position, with the opportunity to build and nurture a world-class facilities team that aligns with our growth and supports our scientific mission. Your Key Contributions Strategic Leadership Develop and implement a comprehensive facilities strategy that aligns with company growth, scientific initiatives, and operational risk management. Recruit, mentor, and lead a high-performing facilities organization, fostering a culture of safety, reliability, and continuous improvement. Team Development Directly manage and mentor facility managers, supervisors, and support staff, promoting a collaborative culture focused on employee engagement and professional development. Encourage cross-functional collaboration with business development, technology, finance, legal, and HR teams to drive informed decisions and improvements. Safety and Compliance Establish and maintain enterprise-wide safety standards and compliance across all facilities; lead audits and implement corrective actions. Direct capital planning, lifecycle management, and end-of-life decisions for critical equipment using ROI-driven analyses. Financial Management Oversee multi-site budgets, long-term capital planning, and KPI performance; optimize total cost of ownership. Manage the vendor lifecycle, including RFPs, contract negotiations, service level agreements, and vendor performance evaluations. Operations Excellence Standardize and enhance maintenance processes utilizing documentation, digital tools, and scalable playbooks; champion improvements focused on employee and occupant satisfaction. Implement governance, risk management, and compliance controls to ensure audit readiness and transparent reporting. Stakeholder Engagement Act as the primary liaison with clients, senior leadership, the Facilities Organization, and key business teams, translating facilities strategy into measurable business value. Collaborate with HR on workforce planning, safety training, and related initiatives.

Join Iterative Health as our Director of Compliance, where you will play a pivotal role in shaping our compliance strategy and ensuring adherence to regulatory requirements. This leadership position will involve developing and implementing compliance programs, monitoring compliance performance, and liaising with regulatory bodies. You will lead a team of compliance professionals and collaborate with various departments to cultivate a culture of compliance within the organization.

Your Role at Lila Sciences Lila Sciences stands at the forefront of scientific innovation, operating as the world’s first scientific superintelligence platform and autonomous laboratory dedicated to life sciences, chemistry, and materials science. Our mission is to revolutionize the process of scientific discovery by seamlessly integrating AI into every facet of the scientific method, empowering researchers to address humanity’s most pressing challenges in health, climate change, and sustainability at unprecedented speed and scale. Position Overview As the Director/Senior Director of Applied AI, you will spearhead the establishment of our foundational Applied AI team, responsible for refining and adapting our AI models for practical product deployment. You will ensure their safe integration with diverse customer datasets and oversee the development of high-performance interfaces, including chat experiences and inference endpoints like gRPC, HTTP, and PCP servers. Reporting directly to the CTO, you will manage the complete roadmap from data acquisition to model deployment, collaborating closely with Research, Product, Software, Application, Safety, and Security teams to deliver models that are functional, quantifiable, and dependable. Key Responsibilities Lead and mentor a high-performing Applied AI team to produce exceptional scientific reasoning models for consumer applications. Manage an end-to-end model customization pipeline to generate impactful models from Lila’s base models for high-value applications, including inference, chat, and API integration. Develop a comprehensive evaluation framework to facilitate ongoing model enhancement and performance optimization. Collaborate with cross-functional teams to define project requirements, deliver customer proofs of concept (POCs), and transition successful pilots into scalable products. Establish technical standards, documentation, and incident response protocols for AI systems in production. Recruit, mentor, and foster a diverse and inclusive team environment. Qualifications for Success 8+ years of experience in applied machine learning or ML systems, with a minimum of 3 years in a leadership role; proven track record of deploying large language models (LLMs) into production. Extensive experience in fine-tuning and evaluating large-scale models for customer interactions. Production inference expertise, including familiarity with serving frameworks (Triton, vLLM, TGI, Ray, Kubernetes), GPU orchestration, caching, and observability. Strong understanding of data privacy and security best practices in multi-tenant systems. Preferred Qualifications Experience with instruction fine-tuning and optimization techniques. Proficiency in developing chat user experiences, implementing guardrails, tool/function calling, and managing long-context interactions.

About Flagship Pioneering, Inc. Flagship Pioneering is at the forefront of innovation, dedicated to inventing and nurturing platform companies that have the potential to revolutionize human health, sustainability, and more. Since our inception in 2000, we have successfully launched over 100 companies that tackle some of the world's most pressing challenges, such as vaccinating billions against COVID-19, curing difficult diseases, enhancing human health, preventing illness, and improving agricultural resilience and sustainability. Our commitment to impactful innovation has earned us recognition on FORTUNE's 'Change the World' list, highlighting companies that make a significant social and environmental impact, and we have appeared on Fast Company's annual list of the World’s Most Innovative Companies. Position Summary: We are looking for a passionate and experienced individual to join our Communications and Public Affairs team as the Senior Director of Communications. In this role, you will spearhead the development and implementation of communications and branding strategies for a selection of companies within Flagship Pioneering's diverse portfolio. The ideal candidate will possess a robust background in biotech corporate communications and excel in a fast-paced, startup atmosphere. This is a remarkable opportunity to influence the trajectory of groundbreaking life sciences and technology firms across human health, agriculture, and AI sectors. This full-time role requires in-office presence four days a week in Cambridge, MA. Key Responsibilities: Provide strategic counsel to the founders and leadership of emergent Flagship companies (Flagship NewCos) in developing their brand, voice, foundational messaging, and overall communication strategies. Oversee brand development, visual identity, and website design for NewCos, collaborating with external agencies. Create and implement tailored, integrated communication strategies for company launches, encompassing all written content, media engagement, and social media components. Manage PR agency support as necessary. Develop and execute communication strategies for both NewCos and more established companies (Flagship GrowthCos), including milestone announcements, internal communications, social and digital media strategies, speaking opportunities, and issue management, in close collaboration with company leadership.

Join our innovative team as a Systems Software Architect at ttp1 in Cambridge. In this role, you will be pivotal in designing, developing, and implementing advanced software solutions that drive our deep tech initiatives. We’re looking for a visionary who can blend technical expertise with strategic insight to create systems that are not only functional but also scalable and robust.Your responsibilities will include collaborating with cross-functional teams, conducting system architecture assessments, and ensuring software meets both technical and user requirements. If you are passionate about technology and eager to work in a dynamic environment, we want to hear from you!

At Flagship Pioneering, we are dedicated to the inventive process that transforms human health, sustainability, and beyond. Since our inception in 2000, we have pioneered over 100 companies that tackle some of the most pressing challenges faced by humanity. Our innovations include efforts such as vaccinating billions against COVID-19, curing complex diseases, improving health outcomes, preventing illness, and enhancing agricultural sustainability.Flagship has earned prestigious recognition, appearing twice on FORTUNE’s “Change the World” list and being named among Fast Company’s World’s Most Innovative Companies. Explore more about our groundbreaking work at www.flagshippioneering.com.We embrace ambitious missions that require bold thinking, guided by our core values that lead us through uncertainty and towards meaningful impact.

Redgate Software develops tools that help data professionals manage and protect critical databases. As organizations face growing data needs, evolving regulations, and new technologies, Redgate’s products play a key role in supporting these changes. The Shared Applications & Services team oversees the business systems and data flows that underpin daily operations. This group addresses complex technical problems and values collaborative decision-making, drawing on input from across the team to shape its direction. Role overview The Business Systems Architect leads the design and structure of Redgate’s internal systems. This includes a varied landscape of SaaS platforms, services, data integrations, and business processes. The role involves developing and sharing an architectural vision and roadmap for Shared Applications & Services, balancing long-term strategy with immediate needs. Working closely with teams in Sales, Marketing, Finance, and Operations, the Business Systems Architect makes practical decisions that align business goals with technical delivery. The position requires designing and guiding cross-system solutions, relying on experience, sound judgment, and facilitation skills rather than authority. Establishing architectural standards and shaping group decision-making processes are also key parts of this role. Location This position is based in Cambridge.

The Opportunity: Join Relay Therapeutics as a Senior Medical Director, where you will be pivotal in propelling our clinical pipeline from IND to proof of concept and ultimately to registration. In this role, you will partner with senior medical staff to shape clinical strategies, design clinical trials, and ensure successful execution. Collaborating across various functions including clinical project management, regulatory affairs, clinical operations, biostatistics, data management, and medical writing, you will significantly contribute as Relay Therapeutics continues to advance product candidates into clinical settings. You will provide clinical leadership to R&D teams and closely collaborate with Development leadership. We are open to remote employees

Scholar Rock is a pioneering biopharmaceutical entity dedicated to the discovery, development, and delivery of transformative therapies aimed at addressing significant unmet medical needs. As a recognized leader in the biology of the transforming growth factor beta (TGFβ) superfamily, and inspired by the structural resemblance of a scholar rock to protein formations, our clinical-stage company is devoted to advancing groundbreaking treatments that leverage protein growth factors. Over the last decade, we have established a robust pipeline designed to redefine the standard of care for conditions such as neuromuscular diseases, cardiometabolic disorders, and cancer, where growth factor-targeted therapies can make a substantial impact. Scholar Rock stands out as the sole organization demonstrating clinical proof of concept for a muscle-targeted therapy in spinal muscular atrophy (SMA). Our commitment to unlocking innovative therapeutic pathways is underscored by the extensive application of our proprietary platform, which has yielded novel monoclonal antibodies to selectively modulate protein growth factors. By harnessing cutting-edge scientific advancements in traditionally underserved disease areas, we strive each day to create new possibilities for patients. Discover more about our mission at ScholarRock.com and connect with us on @ScholarRock and LinkedIn.Position Overview:As Scholar Rock embarks on a pivotal phase with the impending launch of our inaugural commercial product, we are in search of a strategic and operationally-savvy Senior Director of Global Facilities. This role transcends purely administrative functions; we require a visionary builder who comprehends the intricacies of scaling infrastructure within a rapidly evolving biotech setting while adeptly navigating day-to-day operational challenges.With facilities strategically located worldwide and poised for future growth, you will be responsible for ensuring our environments are safe, compliant, efficient, and conducive to supporting both research and commercial initiatives. If you are a proactive self-starter who thrives in dynamic, transformative organizations and is eager to contribute significantly, this opportunity allows you to apply your expertise, learn extensively, and make a meaningful impact.

About Fulcrum Therapeutics Fulcrum Therapeutics, Inc. (NASDAQ: FULC) is a clinical-stage biopharmaceutical company based in Cambridge, MA. The team focuses on developing small molecule therapies for genetically defined rare diseases, with an emphasis on areas where patients have limited treatment options. The lead program, Pociredir, aims to increase fetal hemoglobin expression as a novel approach for treating sickle cell disease (SCD). Role Summary: Director of Biostatistics The Director of Biostatistics plays a key role within the Biometrics Department and reports to the VP of Biometrics. This position acts as the statistical subject matter expert for Fulcrum’s clinical development programs and individual studies. The director oversees statistical activities for outsourced clinical trials and ensures all work meets regulatory requirements. Main Responsibilities Serve as the lead statistician for clinical development programs and studies Oversee statistical activities in outsourced clinical trials Ensure compliance with regulatory standards in all statistical work Apply advanced study designs and statistical methods, including estimand strategies, endpoint selection, and approaches for missing data and multiplicity Work closely with teams across biometrics, clinical development, clinical operations, pharmacovigilance, medical writing, and regulatory affairs

Role Overview Lila Sciences is hiring a Director or Senior Director of Talent Acquisition in Cambridge, MA. This leader will guide the full recruitment function, shaping hiring strategy and team structure as the company grows. What You Will Do Lead and mentor the talent acquisition team, setting clear goals and supporting professional development Design and refine recruitment processes to attract and retain skilled professionals in biotechnology Develop strategies to build a diverse and creative workforce Collaborate with leadership to align hiring plans with company objectives About Lila Sciences Lila Sciences advances work in the biotechnology sector from its Cambridge, MA headquarters. The company values innovation, inclusion, and building strong teams to support its mission.

Riverlane seeks a Director of IT Infrastructure to lead technology operations at its Cambridge, UK headquarters. This permanent, full-time position offers a hybrid work arrangement and a salary range of £100,000 to £130,000 depending on experience. Role overview This senior leadership role oversees all aspects of IT at Riverlane, from managing corporate systems to optimizing high-performance computing (HPC) infrastructure. The Director will shape IT strategy, execute plans, and collaborate with engineering, operations, security, and finance teams to ensure infrastructure remains secure, scalable, and aligned with company growth. What you will do Lead and refine Riverlane's IT strategy, policies, and roadmap to support company objectives and security needs. Manage and improve corporate IT systems, including endpoint management, identity and access management (IAM), collaboration tools, SaaS platforms, and networking. Direct IT procurement, oversee vendor relationships, and optimize software licensing across all platforms. Establish and maintain IT support processes to ensure high availability and responsiveness for a team of scientists and engineers. Develop and manage Riverlane’s information security framework, covering policies, risk management, access controls, and compliance with standards such as ISO 27001. Compensation Salary: £100,000 to £130,000 DOE

Join Gearset as a Systems Administrator specializing in MacOS and Jamf! In this pivotal role, you will be responsible for managing and optimizing our Mac environments, ensuring seamless integration and functionality across our platforms. You will work closely with our IT team to support our infrastructure, troubleshoot issues, and implement innovative solutions to enhance user experience.

Iterative Health is seeking a Clinical Research Systems Specialist to help advance clinical research operations by supporting and maintaining system solutions. This position plays a key role in ensuring that clinical research management systems run smoothly and meet the needs of various teams across the organization. What you will do Work with cross-functional teams to address clinical research system requirements Implement new clinical research management systems and handle ongoing maintenance Support data integrity and compliance throughout all research activities Location This role is based in either Cambridge, Massachusetts or New York, New York.

Scholar Rock is a pioneering biopharmaceutical company dedicated to the discovery, development, and delivery of transformative therapies for patients suffering from serious diseases with significant unmet medical needs. As a global frontrunner in the understanding of the transforming growth factor beta (TGFβ) superfamily of cell proteins, Scholar Rock is aptly named for the visual resemblance of a scholar rock to protein structures. The company is currently in the clinical stage, focusing on advancing groundbreaking treatments that leverage protein growth factors to create better health outcomes. Over the past decade, Scholar Rock has cultivated a robust pipeline aimed at improving the standard of care for conditions such as neuromuscular diseases, cardiometabolic disorders, cancer, and other areas where growth factor-targeted therapies could effectuate significant change. Scholar Rock stands out as the sole company to demonstrate clinical proof of concept for a muscle-targeted treatment for spinal muscular atrophy (SMA). We are committed to pioneering fundamentally different therapeutic approaches, supported by our proprietary platform that has developed novel monoclonal antibodies capable of exquisitely modulating protein growth factors. By utilizing cutting-edge scientific advancements in disease areas that have been historically underserved by conventional therapies, Scholar Rock is dedicated to unlocking new possibilities for patients. To learn more about our innovative approach, visit ScholarRock.com and follow us on @ScholarRock and LinkedIn.Position Overview:The Medical Director/Senior Director will report directly to the Senior Vice President of Clinical Research and will play a crucial role within the late-stage development team. This individual will be responsible for overseeing the clinical development activities for product candidates, guiding them from Proof-of-Concept through to marketing approval and ongoing lifecycle management. The ideal candidate will provide medical leadership for the clinical development of apitegromab and other late-stage product candidates in accordance with the overall corporate strategy. This role requires an enthusiastic physician-scientist with substantial hands-on experience in advancing late-stage product candidates to deliver revolutionary therapies.

Harvard University seeks a dynamic and innovative Director of Pedagogy to lead the development and implementation of pedagogical strategies that enhance the learning experience across our diverse academic programs. This leadership role will focus on fostering a culture of excellence in teaching and learning, utilizing evidence-based practices to drive student engagement and success.The ideal candidate will possess a deep understanding of contemporary pedagogical theories and practices, as well as a passion for education that inspires faculty and students alike. They will be responsible for collaborating with academic departments to design curriculum, lead professional development initiatives, and assess educational outcomes.