Systems Software Architect

The Company Flagship Labs 119 Inc. (FL119) is an innovative technology firm at the cutting edge of neuroscience and computation. We are on a mission to revolutionize the landscape of intelligent system development, driven by the belief that the future of artificial intelligence necessitates a radical re-evaluation of existing paradigms. Our objective is ambitious and urgent: to cultivate a future in which naturalistic, resilient intelligence can thrive and function sustainably at scale. Supported by Flagship Pioneering, we possess the courage, strategic vision, and resources essential for achieving extraordinary outcomes. At FL119, we foster a culture that is interdisciplinary and collaborative. Our teams flourish in dynamic and imaginative settings where every voice is valued, recognizing that diverse experiences, transferable skills, and genuine passion are key to our success. The Role: We are in search of a visionary and technically proficient Neuromorphic Systems Architect to join our team. We offer flexible leveling based on your experience. This position will concentrate on converting nonlinear neural dynamics into state-of-the-art computational architectures. You will engage at the intersection of neuroscience, dynamical systems theory, and hardware engineering to design and prototype electronic systems that integrate biologically inspired computation principles. This is not your typical AI accelerator role; we are looking for someone who can reconceptualize computing from foundational principles, designing architectures that embrace recurrence, nonlinearity, sparsity, event-driven signaling, and adaptive dynamics as core components rather than limitations. Your Responsibilities: Translate brain-inspired computation through dynamical systems theory into hardware-relevant abstractions. Design innovative neuromorphic or neuro-inspired hardware systems (analog, mixed-signal, in-memory, or alternative substrates). Establish system-level architecture that encompasses memory models, communication protocols, and energy-efficient computing primitives. Collaborate closely with teams in neuroscience, signal processing, and machine learning to ensure a seamless integration of biological insights with architectural design. Lead feasibility studies, simulations, and early-stage prototyping initiatives. Assess trade-offs across CMOS, emerging devices, photonic, memristive, or other unconventional computing substrates. Contribute to our intellectual property strategy, including invention disclosures and patents. Help define the long-term computing vision of the company.

Redgate Software develops tools that help data professionals manage and protect critical databases. As organizations face growing data needs, evolving regulations, and new technologies, Redgate’s products play a key role in supporting these changes. The Shared Applications & Services team oversees the business systems and data flows that underpin daily operations. This group addresses complex technical problems and values collaborative decision-making, drawing on input from across the team to shape its direction. Role overview The Business Systems Architect leads the design and structure of Redgate’s internal systems. This includes a varied landscape of SaaS platforms, services, data integrations, and business processes. The role involves developing and sharing an architectural vision and roadmap for Shared Applications & Services, balancing long-term strategy with immediate needs. Working closely with teams in Sales, Marketing, Finance, and Operations, the Business Systems Architect makes practical decisions that align business goals with technical delivery. The position requires designing and guiding cross-system solutions, relying on experience, sound judgment, and facilitation skills rather than authority. Establishing architectural standards and shaping group decision-making processes are also key parts of this role. Location This position is based in Cambridge.

Join our dynamic team at Ramboll as a Senior / Principal Electrical Engineer. In this role, you will lead innovative projects, collaborate with a talented team, and contribute to the development of sustainable electrical solutions. Your expertise will be pivotal in driving forward our commitment to excellence in engineering.

Imagine... being part of an innovative organization that cultivates and develops life sciences companies dedicated to pioneering groundbreaking technologies aimed at revolutionizing health care and sustainability. Company Overview Expedition Medicines is a dynamic, privately held, early-stage biotechnology company at the forefront of the Protein Editing field. We specialize in creating small molecules that modify protein structure and function to target currently undruggable options across various therapeutic strategies. Our advanced platform combines cutting-edge small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to facilitate generative design. Backed by Flagship Pioneering, we leverage their vision, courage, and resources to propel Expedition Medicines from platform validation to impactful patient solutions. We seek passionate, collaborative, and determined problem solvers to join our mission! Role Overview: The Senior/Principal Scientist in Structural Biology will concentrate on determining protein-ligand complex structures using X-ray crystallography and cryo-electron microscopy (cryo-EM). This role involves delivering structural insights and collaborating with project teams to advance structure-based drug design and uncover the mechanisms of action of small molecules. Key Responsibilities: Design and implement structural biology strategies for multiple projects. Oversee the design, expression, and purification of protein constructs for structural determination. Develop and execute protocols to achieve high-quality crystals for X-ray crystallography. Create and implement protocols for grid optimization, data collection, and analysis in cryo-EM. Refine and communicate structures of protein-ligand complexes, collaborating with project teams to drive hit-to-lead and lead optimization processes. Manage contract research organizations (CROs) to ensure efficient delivery of protein expression and structural biology services. Enhance our capabilities and serve as a trusted authority in the field of structural biology.

Your Impact at Lila As a Senior or Principal Research Engineer specializing in Synthetic Data, you will play a pivotal role in shaping the vision, roadmap, and execution of our synthetic data initiatives. Your responsibilities will span from asset generation and simulation to integrating machine learning training and achieving measurable enhancements in model performance. Collaborating closely with our Research Engineering team, you will design, generate, and implement artificial datasets aimed at training, testing, and refining Lila’s platform to achieve our strategic objectives. What You Will Build Define and refine the synthetic data strategy along with a comprehensive multi-quarter roadmap. Create evaluation frameworks that effectively connect synthetic interventions with genuine model performance. Establish high standards for asset quality, diversity, thorough documentation, and reproducibility while fostering a robust review culture. What You Will Need to Succeed Over 6 years of experience in applied ML/ML systems, with at least 3 years leading industry initiatives, showcasing a strong track record in advanced algorithms and frameworks designed for large-scale synthetic data generation. More than 8 years of experience working with contemporary ML workflows, including Python, PyTorch, dataset tools, training loops, and evaluation frameworks; adept at profiling and optimizing GPU-intensive pipelines. Bonus Points For A proven history of constructing synthetic datasets from source data to significantly enhance model performance in specific domains. Experience with instruction fine-tuning and hill-climbing techniques. Ability to translate product requirements and feedback into a scalable synthetic data generation pipeline. Knowledge of quantization, distillation, routing, mixture-of-experts, and cost optimization at scale. Experience in compliance-heavy settings (HIPAA, PCI, FedRAMP) and with on-premises/VPC deployments. About Lila Lila Sciences stands at the forefront of innovation as the world’s first scientific superintelligence platform and autonomous lab, dedicated to life sciences, chemistry, and materials science. We are ushering in an era of limitless discovery by harnessing AI to enhance every facet of the scientific method. Our mission is to empower scientists to tackle humanity's most pressing challenges in health, climate, and sustainability at an unprecedented pace and scale. Discover more about our mission at www.lila.ai. If this sounds like an environment in which you would thrive, we encourage you to apply even if your experience doesn't perfectly align with every requirement listed.

The Senior Solutions Architect at HubSpot partners with key customers to design and deliver scalable, AI-powered solutions that help organizations grow. This position combines technical consulting with hands-on development, shaping long-term platform strategies and building AI-enhanced tools for internal teams and partners. The work supports platform adoption, speeds up customer engagement with HubSpot’s AI features, and creates reusable assets for the Solutions ecosystem. Design and Build Architect and implement agentic workflows and large language model (LLM) solutions to improve customer outcomes and increase engagement with HubSpot's platform. Create working prototypes and proof-of-concept automations that demonstrate measurable business value, helping customers move from evaluation to production. Document effective technical approaches by developing libraries, playbooks, and frameworks to improve delivery efficiency for Solutions teams and partners. Advise and Lead Translate complex, multi-portal business requirements into scalable solution strategies across the HubSpot platform to deepen engagement and usage. Lead solution design for large-scale HubSpot AI implementation projects, identifying ways to unify the platform and drive efficiency throughout the customer lifecycle. Develop and advocate for multi-quarter technical roadmaps that align solution choices with business objectives, building value propositions for director-level and senior stakeholders. Guide solution design for complex, multi-hub projects that use agentic AI, advanced CRM features, APIs, and the broader HubSpot ecosystem to address customer go-to-market challenges. Identify and mitigate technical risks on high-impact projects, serving as the primary technical authority for innovative use cases. Share consolidated field insights with Product and Engineering teams to help shape HubSpot's platform roadmap. Location: Cambridge, MA, USA

Charles River Analytics, a proud member of the GRVTY family, is at the forefront of developing innovative solutions and advanced technologies designed to address some of the most challenging issues faced globally. Our dynamic team of tech entrepreneurs collaborates to enhance AI, robotics, intelligent sensing, and human-centered computing. The research and technology we develop not only propel government initiatives but also unveil new opportunities in the commercial sector. At Charles River, we take immense pride in cultivating a workplace that attracts and retains top-tier talent and creative problem-solvers in the industry. Join us as we strive to accelerate our mission-driven innovations!We are currently seeking a dedicated Senior/Principal Scientist with expertise in Human-Systems Integration, Human Factors, or Human-Computer Interaction. In this role, you will spearhead the development of cutting-edge tools and interfaces that empower users to effectively collaborate with technology in demanding environments.Your responsibilities will include leading and expanding teams of researchers, designers, and engineers to assess work domains and user needs, create novel human-AI interaction concepts, and evaluate interactive prototypes. You will also be responsible for defining and directing technical projects, while fostering robust relationships with clients, sponsors, and collaborators. As a subject matter expert in Human Systems, you will work alongside multidisciplinary teams to explore and pursue research opportunities across various technical domains.

Join our innovative team at ttp1 as a Senior Systems Engineer (Software). In this pivotal role, you will leverage your expertise in software engineering to design and implement cutting-edge systems that drive our cellular technology initiatives. You will work collaboratively with cross-functional teams to develop solutions that enhance our product offerings, ensuring high performance and reliability.

Flagship Pioneering builds bioplatform companies focused on solving challenges in human health and sustainability. The organization brings together scientists, entrepreneurs, and investors to advance projects in cancer detection, disease treatment, and sustainable agriculture. By combining innovation in life sciences, company creation, and investment under one roof, Flagship enables scientific founders, business leaders, and capital managers to work together through a structured process. This collaborative approach aims to create measurable improvements for people and the planet. Flagship’s portfolio features ventures that have immunized billions against COVID-19, developed treatments for diseases once considered untreatable, improved health outcomes, and promoted sustainable agriculture. The company has been recognized on FORTUNE’s “Change the World” list twice and named among Fast Company’s most innovative companies. Role overview The Senior Manager of HR Operations and Systems leads the management and ongoing development of Flagship’s HR technology environment. This position is responsible for UKG and oversees platforms such as Greenhouse, along with other HR systems. The scope includes daily operations, system governance, integrations, and long-term HR technology strategy. Reporting to the Associate Director of HR Operations & Analytics, this leader partners with HR, Legal, Payroll, Finance, and IT teams. The focus is on designing and maintaining scalable, compliant HR operations that provide reliable service, strong data integrity, and a smooth employee experience throughout the employee lifecycle. Key responsibilities Manage and improve the HR systems ecosystem, with a focus on UKG and Greenhouse Oversee daily HR systems operations, including governance and integrations Maintain compliance, data quality, and effective service delivery across HR platforms Work with cross-functional teams to support scalable HR processes Guide the strategic direction of HR systems to align with company growth Location Cambridge, MA, USA

Are you ready to make a significant impact on the environment by joining a team of skilled ecologists? We invite you to become a vital member of our innovative Nature team as a Principal Ecologist in our expanding offices located in Cambridge, Basingstoke, Croydon, Leeds, Nottingham, Newcastle, Manchester, Birmingham, Glasgow, Edinburgh, Bristol, and Liverpool (other locations may also be considered). Enjoy the benefits of our flexible hybrid working model at AECOM, where we lead the way in delivering an exceptional portfolio of Ecology programs and projects through long-standing partnerships with key clients.We are currently engaged in a diverse array of projects across the power, renewables, infrastructure, environment, and transport sectors. Our collaborative efforts extend to other technical disciplines, including landscape, GIS, engineering, sustainability, and drainage. Recent projects include some of the largest solar farms in the UK, a cable tunnel beneath the River Thames, electricity network upgrades in Kent and Suffolk, and master planning for new residential developments.Your Responsibilities:Lead and support the delivery of high-quality ecological consultancy and advisory services to both internal and external clients.Oversee, plan, schedule, and organize all phases of ecological project work, ensuring that necessary resources, budgets, and controls are in place to meet program and budget requirements.Develop technically robust and pragmatic solutions to complex ecological challenges.Lead the production of ecology chapters for environmental statements and protected species license applications and ensure the high quality of project deliverables.Contribute to the ongoing development of our technical capabilities.Join Us in Our Growth Journey. Become part of our dynamic Nature business, which comprises around 230 professionals specializing in arboriculture, forestry, groundwater, surface water, and ecology. Our team includes national and global leaders in species licensing, impact assessment, habitat creation, ecosystem restoration, enhancement, and management. At AECOM, you will flourish in an inclusive and forward-thinking environment where your contributions are valued.Don't forget the amazing perks at AECOM! You will enjoy a variety of core and personalized benefits tailored to support your future and well-being, including career development opportunities, a flexible hybrid working model to enhance your work-life balance, technical practice networks, and access to AECOM University.

POS-31591About Our TeamThe Prospecting Solutions team is revolutionizing the way B2B SMB and mid-market sales teams cultivate their pipeline. The current outbound sales approach is often inefficient and outdated, with representatives dedicating excessive time to research, tool integration, and uncertain contact strategies. Our focus transcends mere outreach execution; we prioritize intelligent sourcing, prioritization, and trust.This team is developing a comprehensive, signal-driven prospecting ecosystem that aligns with contemporary B2B purchasing behavior: account-centered, aware of buying groups, and trust-oriented. Our mission is to merge human discernment with automation, enabling sales teams to generate consistent, high-quality pipeline without compromising their brand integrity or their representatives' well-being.About the RoleWe are seeking a Principal Software Engineer to serve as a pivotal technical leader for Prospecting Solutions. This role is highly hands-on, perfect for an innovator who excels in dynamic, product-defining environments.As a Principal Engineer within our team, you will play a crucial role in shaping how data, AI, and workflows converge to facilitate intelligent prospecting at scale. You won't just follow a roadmap; you will help craft it, transforming ambiguous challenges such as “who should I contact next and with what message?” into robust, transparent, production-grade systems utilized by millions of sales professionals.Key ResponsibilitiesDesign signal-driven prospecting systems: Define the integration of intent signals, firmographics, behavioral insights, and CRM context to create actionable prioritization and recommendations.Hands-on, impactful developer: Write production-quality code, steer complex projects from conception to completion, and scale prototypes into full-fledged systems.AI and systems integration: Guide the integration of machine learning and generative AI models into deterministic workflows, balancing efficiency with transparency and user trust.Influential technical leadership: Shape not only the construction of the product but also its vision, collaborating closely with Product to define interfaces, workflows, and necessary trade-offs.Extensibility focus: Design systems capable of functioning across diverse accounts, buying groups, and regions while ensuring adaptability and ongoing evolution.Cross-department collaboration: Work collaboratively across CRM, data, AI, and GTM teams to synchronize patterns and avoid localized optimizations.Elevate technical standards: Foster a culture of excellence in engineering practices and innovation.

As a Principal Terrestrial Ecologist at dev2, you will play a pivotal role in leading and managing ecological projects that contribute to sustainable environmental practices. You will be responsible for conducting extensive field studies, analyzing ecological data, and providing expert guidance on terrestrial ecosystems. Your insights will help shape strategies that promote biodiversity and conservation.

Collaboration Fuels Our Innovation. Join Roku, Revolutionizing Television ViewingRoku stands as the leading TV streaming platform across the U.S., Canada, and Mexico, with aspirations of transforming every television globally. As pioneers in TV streaming, our mission is to serve as the platform that unites the entire TV ecosystem, linking consumers to beloved content, enabling publishers to cultivate and monetize extensive audiences, and equipping advertisers with unique tools for consumer engagement.From day one at Roku, your contributions will be recognized and valued. We are a fast-evolving public company where every team member plays a significant role. Embrace the opportunity to delight millions of TV streamers globally while gaining invaluable experience across diverse disciplines. Role Overview At Roku, you will work on a platform utilized by real users. Showcase your achievements to friends and family, and see your work in leading electronics retailers.As a senior member of the Roku Core OS team, you will take part in designing and developing the core/system components of Roku OS. We seek a senior software engineer with profound expertise in embedded Linux development and integration.Roku boasts a proven history of creating successful products based on value SoCs, relying on our talented software engineers to optimize limited resources.We genuinely mean it when we say that Roku is a place where everyone contributes. If you aspire to work with top talent, developing products used by millions, and thrive in a tech culture that excels, we invite you to contact us. Join us in creating the next generation of cost-effective streaming players and TVs for our customers. Your Responsibilities Design and develop OS features within a multi-process environment that prioritize speed, efficiency, and platform flexibility.Exhibit excellence in C++ development to deliver high-performance and ultra-reliable software, focusing on optimization, performance, and memory management.Implement features with the necessary abstractions to ensure compatibility across various hardware.

Join our dynamic team at Integrated Resources, Inc. as a Principal Application Administrator. In this pivotal role, you will oversee and manage our application systems, ensuring optimal performance and user satisfaction. You will collaborate with various departments to implement innovative solutions and enhance our technology infrastructure.

Teamwork makes the stream work. Join Roku and be part of a transformative journey in television.As the leading TV streaming platform across the U.S., Canada, and Mexico, Roku is on a mission to revolutionize how the world experiences television. Our pioneering technology connects viewers to their favorite content while empowering content publishers to cultivate and monetize vast audiences. Additionally, we provide advertisers with unparalleled tools for consumer engagement.From your very first day at Roku, you will play a crucial role in shaping the future of streaming. We are a dynamic public company where your contributions will be recognized and celebrated. This is your opportunity to impact the lives of millions of TV streamers globally while gaining invaluable experience across various disciplines. About the TeamAt Roku, we are at the forefront of television innovation. Our success in shaping the future of streaming media is driven by talented embedded software engineers like you, who will join the Roku OS, OS Extensions, and Apps Team. About the RoleIn this position, you will be an integral part of a team dedicated to developing core features that facilitate streaming applications such as Netflix, YouTube, and BBC on the Roku platform. This role will leverage your expertise in NDK development, DRM, browser technologies, audio-video streaming standards, and optimization of graphics and application performance within embedded systems. The features and performance enhancements you deliver will impact millions of users daily. This is an excellent opportunity for a seasoned professional with innovative solutions for complex challenges, capable of translating concepts into highly reliable software.

About UsTetraScience is at the forefront of the Scientific Data and AI landscape, spearheading the Scientific AI revolution. Our mission is to design and industrialize AI-native scientific datasets, which we integrate into a robust suite of next-generation lab data management solutions, scientific applications, and AI-driven outcomes. As the category leader in this transformative market, TetraScience has outpaced all competitors in revenue generation. In the past year, we have attracted partnerships with the world's leading players in computing, cloud, data, and AI infrastructure, solidifying our position as the de facto standard in scientific data innovation.As part of your application process, we invite you to review the Tetra Way letter, penned by our co-founder and CEO, Patrick Grady. This document is crucial for understanding our values and culture, and we encourage you to reflect on its contents to assess your alignment with our unique approach to team building. If you join us, you will be expected to embrace and embody these principles daily.

Role Overview Lila Sciences is seeking a Principal Engineer with expertise in AI Security for its Cambridge, MA office. This senior individual contributor will help define and drive the technical strategy to secure AI applications across the organization. The role involves close collaboration with IT and business teams to ensure AI tools and platforms are implemented safely and in compliance with internal and external requirements. Securing both third-party and in-house AI tools is central to this position. The work will focus on protecting sensitive data, intellectual property, and scientific processes as AI becomes increasingly embedded in Lila's operations. What You Will Do Enterprise AI Security Strategy: Develop and roll out security controls and guidelines for using AI tools throughout the company, covering LLM APIs and SaaS AI platforms. AI Gateway & Agentic Gateway Security: Design and enforce controls for AI gateways, monitoring and managing access to AI systems. Ensure agentic workflows are secured with strong identity and authorization measures. AI Red Teaming & Adversarial Testing: Lead red teaming and adversarial testing efforts to uncover vulnerabilities in AI usage, such as prompt injection and data exfiltration risks. Data Protection for AI Usage: Establish and maintain safeguards to prevent sensitive data exposure through AI systems, with a focus on input/output filtering and secure data management. Multi-Layer AI Security: Integrate AI security practices with the organization's broader security framework, maintaining visibility and control over AI service access and data flows. AI Threat Modeling: Build and maintain threat models tailored to enterprise AI applications, addressing risks like data leaks and unauthorized agent actions. Vendor & Platform Security: Assess and advise on secure integration of third-party AI vendors, with close attention to their data handling practices and model behavior.

Are you an experienced AWS Architect looking to make an impact? Join Arete Technologies, Inc. and leverage your expertise in Amazon Web Services (AWS) provisioning and deployment. You will be responsible for automating processes and utilizing AWS technologies such as Elastic Compute Cloud (EC2), Simple Storage Service (S3), and CloudFormation. Your role will also involve creating infrastructure qualification documents, executing test plans, and collaborating with IT Quality Teams for document approval. Strong written and verbal communication skills are essential for success in this role.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence is a forward-thinking initiative that builds upon Flagship Pioneering's rich history of establishing groundbreaking scientific and computational enterprises. By leveraging cutting-edge advancements in artificial intelligence, machine learning, and data science, we aim to accelerate fundamental research and cultivate a dynamic portfolio of AI-first companies. As an integral part of Flagship's unique model that intertwines science, entrepreneurship, and investment, we transform revolutionary concepts into impactful companies, enhancing AI innovations that contribute to human health, sustainability, and more. THE ROLE We are on the lookout for a Principal Scientist specializing in Embedded Machine Learning and Computational Methods to spearhead various AI/ML and computational initiatives across early-stage ventures within our company origination framework. Your responsibilities will include defining and executing practical AI strategies, overseeing the development of methodologies and platforms (including systems design, drug design, molecular modeling, systems biology, protein design, and LLM-based workflows), and ensuring a high standard of rigor in model development, benchmarking, scaling, and reporting. You will also manage cross-functional teams as necessary, influence the strategic direction of our initiatives, and represent Pioneering Intelligence to venture teams and external collaborators. The ideal candidate is a self-motivated individual with a diverse skill set, capable of transitioning seamlessly from protein design to mass spectrometry or docking pipelines, and then creating LLM-based agents to streamline scientific workflows.