Spatial Biology Platform Scientist

Your Impact at Lila In this pivotal role, you will spearhead the innovation and validation of advanced pooled assays utilizing mammalian cells. Your work will encompass everything from proof of concept to automated screening processes, enabling the generation of intricate, high-dimensional datasets. This position involves collaboration across cell biology, protein design, and nucleic acid teams to facilitate biologic development programs, focusing on the rapid assessment of binding, stability, function, and immunogenicity of diverse biologics. What You'll Be Building Create next-generation mammalian display-based assays for binding, stability, function, and immunogenicity. Implement cutting-edge multiomic, single-cell, and in situ sequencing workflows to design innovative, highly multiplexed assays. Collaborate with protein design, nucleic acid, and automation teams to leverage these workflows in biologics development. Closed-Loop Experimentation and Execution: Work closely with engineering and automation teams to architect automated, high-throughput experimentation platforms that yield data-rich workflows. Join forces with the AI team to conduct iterative experiments in real time, facilitating rapid optimization and discovery cycles. Collaborate, Lead & Communicate: Engage with cell biologists, synthetic biologists, automation engineers, protein design scientists, and data scientists to document systems, share insights, and refine best practices in autonomous science. Mentor junior scientists, align project milestones with internal and external collaborators, contribute to intellectual property and publications, and present findings across the organization. What You’ll Need to Succeed Ph.D. in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, Immunology, or a related discipline (or M.S./B.S. with 5–8+ years of relevant industry experience). Proficiency in the development and/or application of mammalian display or similar pooled mammalian systems (perturb-seq, MPRA, etc.). Experience in designing, executing, and analyzing single-cell, in situ, or multiomic sequencing experiments. Expertise in creating complex libraries of defined sequences in mammalian cells. Experience in designing, executing, and analyzing flow cytometry and sorting experiments. Familiarity with next-generation sequencing (NGS) based experimental design and analysis.

Join us at Integrated Resources, Inc. as an Associate Scientist II specializing in Cell Culture. In this pivotal role, you will contribute to groundbreaking research and development in a collaborative environment. You will be responsible for executing cell culture experiments, analyzing data, and ensuring adherence to quality standards.

We are seeking a passionate and detail-oriented Scientist I to join our innovative team at Integrated Resources Inc. This entry-level position offers a fantastic opportunity to contribute to groundbreaking research and development projects. You will work closely with experienced scientists to support various laboratory activities, including experimental design, data collection, and analysis.

We are seeking a motivated and detail-oriented Scientist I to join our dynamic team in Cambridge. The ideal candidate will have a strong background in scientific research, with a passion for innovation and problem-solving. This entry-level role offers an exciting opportunity to contribute to groundbreaking projects and advance your career in a collaborative environment.

Korrobio seeks an Associate Scientist to join its Compound Management, Cell Screening, and NGS teams at 60 First St, Cambridge, MA 02141. This position supports key research activities and collaborates with scientists across several disciplines. Main responsibilities Support daily compound management tasks and keep detailed records of inventory and usage. Assist with cell screening workflows, ensuring accuracy and consistency in experiments. Contribute to Next Generation Sequencing (NGS) projects, helping maintain efficient and reliable processes. Collaboration This role involves close teamwork with scientists from multiple research areas. Careful handling of compounds, execution of cell-based assays, and participation in sequencing efforts all help advance ongoing projects.

We are seeking a dedicated and detail-oriented Research Associate I / Cell Culture Technician to join our dynamic team. This role is pivotal in supporting our research initiatives through precise cell culture techniques and laboratory procedures. The ideal candidate will be responsible for maintaining cell lines, performing assays, and assisting in various research projects.

Join Integrated Resources Inc. as an Associate Scientist I, where you will contribute to innovative scientific research and development projects. As a pivotal part of our team, your role will involve conducting experiments, analyzing data, and collaborating with multidisciplinary teams to advance our scientific objectives.

We are seeking a highly motivated and detail-oriented Associate Scientist I to join our dynamic team in Cambridge. The ideal candidate will assist in the design and execution of experiments, analysis of data, and contribute to various projects within our research initiatives.

AbbVie is seeking a talented and motivated Associate Scientist II or Scientist I to join our dynamic In Vivo Pharmacology team in Cambridge. As part of our innovative research environment, you will play a crucial role in advancing our understanding of pharmacological mechanisms through in vivo studies. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to transform patient care.

Role Overview AbbVie is hiring a Scientist I to join the Immunology Discovery group in Cambridge. This is an entry-level role focused on research that supports new therapies in immunology. The team values creative problem-solvers who want to help drive scientific progress. What You Will Do Collaborate with scientists on research projects in immunology Apply modern laboratory techniques to investigate immune system pathways Contribute data and insights to support the development of new therapies Work as part of a team committed to advancing scientific understanding Location This position is based in Cambridge.

Join Lila Sciences as a Senior Research Associate or Associate Scientist in the Protein Science department, focusing on our cutting-edge Antibody Platform. You will play a crucial role in advancing our research initiatives, contributing to the development of innovative antibody-based therapeutics. This position offers the opportunity to collaborate with a talented team dedicated to scientific excellence and the pursuit of transformative solutions in healthcare.

Join GT Biosciences, a pioneering techbio startup based in Cambridge, MA, dedicated to revolutionizing drug delivery through our innovative Deliveromics platform. We are seeking a passionate and multidisciplinary LNP Scientist to join our team, focusing on the advancement of cutting-edge non-viral delivery technologies.In this pivotal role, you will spearhead the design and development of novel ionizable lipids and engineer ligand-conjugated lipid nanoparticle formulations. Your expertise will support in vivo screening for Deliveromics and evaluate performance through both in vitro assays and in vivo animal models. You will be responsible for experimental planning, execution, data analysis, interpretation, and effectively communicating results.As one of the earliest scientific hires at this innovative startup, you will play a crucial role in shaping platform development and collaborating across various disciplines to create transformative solutions for genetic medicine delivery. This is a full-time, in-person position based in Cambridge, MA.

Join our team at Integrated Resources Inc. as an Associate Scientist I, where you will have the opportunity to contribute to innovative research and development projects. This entry-level position is perfect for recent graduates or individuals looking to launch their careers in the scientific field. You will collaborate with experienced scientists, engage in hands-on laboratory work, and assist in conducting experiments that drive our mission forward.

About Us:GT Biosciences is an innovative techbio startup focused on revolutionizing drug delivery through our groundbreaking platform, Deliveromics. This AI-powered, high-throughput, multiplexed in vivo data engine is designed to uncover the fundamental rules of drug delivery. Founded by a team of MIT PhDs and an esteemed MIT professor, and supported by leading investors, we are dedicated to developing next-generation, non-viral, cell-type-specific delivery systems. Our passionate, science-driven team is on a mission to make routine in vivo cell reprogramming a reality.We embrace a culture of transparency and collaboration, seeking enthusiastic team members who thrive in an open, cooperative environment and aspire to grow alongside the company and their colleagues.Job Overview:We are looking for a dedicated and multidisciplinary Nucleic Acids Platform Scientist to join our Deliveromics Platform Development team. In this pivotal role, you will design and optimize innovative nucleic acid constructs and chemistries, including mRNA, ASO, and siRNA, for targeted delivery applications. Your responsibilities will include supporting Deliveromics in vivo screening and conducting thorough evaluations of performance through both in vitro assays and animal models. You will independently plan and execute experiments, analyze complex datasets, and communicate findings effectively. As an early scientific hire at our emerging biotech firm, you will play a crucial role in shaping our platform, fostering interdisciplinary collaboration, and contributing to transformative delivery solutions for genetic medicines. This is a full-time, on-site position located in Cambridge, MA.

Your Impact at Lila The Scientist I/II, Process Chemistry will utilize cutting-edge process chemistry methodologies to enhance Discovery Chemistry initiatives across Lila’s diverse platform. This role emphasizes reaction and reactor engineering, process design, high-throughput experimentation, and digital chemistry workflows aimed at small molecules and associated molecular constructs. We seek a hands-on scientist who possesses a robust background in synthetic and process chemistry, complemented by an engineering mindset and experience in developing scalable, data-driven experimental workflows. Collaboration is key in this role; you will work closely with teams in Discovery Chemistry, analytical chemistry, automation, platform engineering, and AI/computational science to design, implement, and refine reaction and process workflows. These improvements will enhance the speed, reliability, and scalability of chemical transformations. The Scientist I/II will play a crucial role in bridging early-stage discovery chemistry with contemporary process development by establishing efficient, digitally enabled, and automation-friendly methods for reaction screening, process optimization, and chemistry execution. This position is perfect for a scientist passionate about the convergence of chemistry, engineering, high-throughput technologies, process intensification, and digital experimentation and eager to contribute to the evolution of next-generation process chemistry capabilities beyond traditional methods. What You Will Be Building Design, execute, and optimize process-relevant chemical transformations that advance Discovery Chemistry programs and the creation of small molecules. Develop reaction and process workflows with a focus on engineering rigor, scalability, reproducibility, throughput, and data integrity. Implement high-throughput experimentation (HTE) for reaction screening, process optimization, condition scouting, and assessment of process-relevant variables. Create and execute workflows that integrate reaction setup, process screening, workup, analytical readout, and data capture into streamlined experimental cycles. Contribute to the design of digitally enabled process chemistry workflows, including structured experimental data generation, electronic documentation, and the integration of chemistry data into computational and AI-ready systems. Collaborate with automation and platform teams to refine reaction and process workflows for robotics-enabled experimentation.

Join AbbVie, a global biopharmaceutical company, as a Senior Scientist I in our Neuroscience division specializing in Biologics Screening. In this role, you will lead innovative research efforts to develop therapies that address unmet medical needs in the field of neuroscience.

Join AbbVie as a Senior Scientist I in the field of siRNA in vitro biology. In this role, you will leverage your extensive knowledge and skills in molecular biology to contribute to innovative research and development projects. Collaborate with a team of dedicated scientists to explore new therapeutic avenues and advance our understanding of RNA interference.

Your Impact at Lila As a Scientist I/II in Organic Chemistry, you will play a pivotal role in the development, execution, and optimization of cutting-edge chemical transformations that enhance Discovery Chemistry initiatives across Lila Sciences. Your focus will be on the rapid synthesis of small molecules and a diverse range of chemical compounds. This position is tailored for an experimental organic chemist who possesses a robust foundation in synthetic chemistry, complemented by practical experience in high-throughput experimentation (HTE), reaction workup, and analytical characterization. Collaborating closely with teams specializing in Discovery Chemistry, analytical chemistry, automation, screening, and AI/computational methods, you will aid in constructing and implementing efficient chemistry workflows designed to expedite molecular design–make–test–analyze cycles. The Scientist II will be integral to reaction development, analog generation, and route execution utilizing contemporary organic chemistry techniques that are compatible with scalable, data-driven, and increasingly automated discovery environments. This role is ideal for a chemist passionate about addressing synthetic challenges at the intersection of reaction innovation, high-throughput experimentation, process efficiency, and analytical insight, and who is driven to contribute to the evolution of next-generation discovery workflows that extend beyond conventional bench chemistry. What You'll Be Building Design and optimize chemical transformations pertinent to Discovery Chemistry programs, with a strong emphasis on the swift synthesis of small molecules and analog series. Utilize modern synthetic organic chemistry methodologies to facilitate efficient exploration of a wide spectrum of structurally diverse and medicinally relevant chemical spaces. Plan and execute multi-step synthesis, reaction optimization, workup, purification, and compound characterization to support molecular discovery campaigns. Develop and implement HTE workflows aimed at reaction screening, condition optimization, reagent evaluation, and rapid assessment of transformation scopes. Establish robust methodologies for reaction setup, workup, sample preparation, and analytical readout to support rapid and information-rich experimentation. Employ analytical tools such as chromatography, NMR, and other related methods to evaluate reaction performance, characterize products, and inform synthetic strategies. Contribute to the evolution of practical and scalable chemistry workflows that integrate reaction discovery, optimization, and downstream compound generation.

Job Summary:The Research Assistant III will play a vital role in the Ramanathan lab at Harvard University, collaborating closely with graduate students and postdoctoral researchers. This position involves conducting scientific experiments in the specialized field of stem cell biology and human development with a high degree of independence. The successful candidate will coordinate various facets of ongoing research projects, execute laboratory experiments using advanced techniques and equipment, and manage collaborations with external laboratories as necessary. This role may also include the training of new lab members in established scientific methods.Key Responsibilities:Coordinate multiple aspects of research projects and perform laboratory experiments utilizing specific techniques and equipment.Generate cortical tissue from various cell lines, including induced pluripotent stem cells (iPS cells), embryonic stem cells, and a Good Manufacturing Practice (GMP) line.Conduct genetic modifications, manage passaging, and maintain both parental and modified fluorescent reporter lines.Utilize cell printing, optimize differentiation protocols for each cell line, and prepare tissues for shipment to collaborators working with primates.Prepare samples for single-cell transcriptomics and validate them using antibody staining techniques.Set up incubators and shakers, monitor differentiation processes, and establish a robust experimental pipeline.Collaborate with lab members on experimental design, protocol establishment, and the development of innovative laboratory techniques.Process, organize, summarize, and analyze data; report results using a variety of scientific, word processing, spreadsheet, or statistical software applications.May provide training and guidance to others in laboratory techniques and procedures.Assist with laboratory maintenance tasks, including the procurement of equipment and supplies, liaising with vendors, and engaging in special projects as required.Working Conditions:This position is primarily performed in a laboratory environment on the Cambridge campus.Involves working with hazardous materials and human cell cultures.Physical Requirements:May require lifting, moving, and transporting research equipment.