Senior Software Engineer at Vaxcyte | San Carlos, California

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine innovation firm focused on engineering high-fidelity vaccines aimed at protecting humanity from the severe and costly repercussions of bacterial diseases. Our commitment extends to eradicating or treating bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella. Our roadmap to success is well-defined, and Vaxcyte is poised for long-term impact. Our Approach: What we do is as crucial as how we do it! Our collaborative efforts are guided by four enduring core values: *RETHINK CONVENTION: We embrace creative and intellectual diversity across all aspects of our work to innovate and transform vaccine delivery. *AIM HIGH: We embody an audacious goal to tackle the most intricate biologics ever conceived to protect humanity. *LEAD WITH HEART: Everyone at Vaxcyte leads with kindness, fostering an inclusive atmosphere conducive to collaboration and vigorous debate that furthers our business aspirations. *MODEL EXCELLENCE: The scale of our challenge demands a collective commitment to integrity, accountability, and clarity in our communications and decision-making processes.Role Summary:We are in search of a dynamic, proactive, and self-motivated Lab Manager to join our expanding Facilities and Lab Operations Team. This role is highly hands-on, overseeing the daily operations of Vaxcyte laboratories, including vendor management, lab supply inventory, equipment maintenance, and new equipment orders. As a pivotal point of contact for lab personnel, the Lab Manager will handle service requests, prioritize and assign tasks, provide training, and nurture a culture of safety and compliance. This role also involves supporting the design of lab space equipment layouts, collaborating with various departments to develop essential SOPs for training, maintenance, calibration, and repair. The Lab Manager will work closely with procurement and lab teams on CAPEX/OPEX budgeting and management of lab assets and service contracts, support installation in lab spaces, and oversee any qualification and validation activities. Additionally, this role will involve providing feedback on lab efficiency, operations, and policies and making recommendations for improvements.

Vaxcyte, Inc. is a biotechnology company located in San Carlos, California. The team works on developing new vaccines and advancing vaccine science. Role overview The Project Manager leads projects that contribute to Vaxcyte’s vaccine development efforts. This position coordinates cross-functional teams and manages projects from the early planning stages through to completion. Responsibilities include keeping projects on track and ensuring that each one supports the company’s broader goals and strategies. Key responsibilities Oversee projects related to vaccine development, from concept through delivery Guide and coordinate cross-functional teams Ensure project objectives align with company strategy Location This role is based in San Carlos, California.

Join Our Mission to Protect Humankind!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines aimed at safeguarding humanity from the devastating impacts of bacterial diseases. Our mission focuses on eradicating or effectively treating bacterial infections such as invasive pneumococcal disease, Group A Streptococcus, and Shigella. We are committed to a clear and defined path to success, ensuring Vaxcyte is prepared for the long haul. Our Approach: The impact of our work is equally as significant as the methodology we employ! Our collaborative efforts are driven by four fundamental core values: *RETHINK CONVENTION: We cultivate creative and intellectual diversity in all our endeavors to continuously innovate vaccine delivery methods. *AIM HIGH: We collectively strive to achieve audacious goals, tackling the most complex biologics for humanity's protection. *LEAD WITH HEART: At Vaxcyte, everyone contributes with a kindness-first, inclusive ethos that promotes collaboration and constructive debate, advancing our organizational objectives. *MODEL EXCELLENCE: The scale of our challenges demands a shared commitment to integrity, accountability, equality, and clarity in communication and decision-making.Position Summary:Vaxcyte is in search of an Associate Scientist II (contract) to bolster our research and development efforts for a groundbreaking bacterial polysaccharide conjugate vaccine. This role will play a crucial part in the setup, synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates.The ideal candidate should possess a robust understanding of conjugation process development, analytical chemistry principles, and significant hands-on laboratory experience. The successful individual will be expected to independently optimize and troubleshoot upstream and downstream conjugation processing procedures with minimal supervision. Contributions will extend to various related areas, including analytical development, stability studies, and process optimization initiatives. Responsibilities will also encompass record management, data presentation at team meetings, and collaborative authorship of laboratory protocols and development reports.

Join Our Mission to Protect Humankind!At Vaxcyte, we are a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines aimed at safeguarding humanity from the serious health implications of bacterial diseases. Our efforts focus on eradicating or treating bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella, marking the beginning of our ambitious journey. Our roadmap to success is clear and robust, positioning Vaxcyte for long-term achievements. Our Approach: The significance of WHAT we do is matched only by the importance of HOW we do it! Our collaborative efforts are anchored in four enduring core values: *Rethink Convention: We inject creative and intellectual diversity into every aspect of our work, continuously innovating the delivery of vaccines. *Aim High: We are driven by an audacious collective goal to create the most complex biologics ever developed to protect humankind. *Lead with Heart: Every team member at Vaxcyte leads with a kindness-first, inclusive approach that fosters collaboration and robust debate, propelling us towards our business objectives. *Model Excellence: The magnitude of our challenges demands our shared commitment to integrity, accountability, equality, and clarity in our communications and decision-making processes.We are always on the lookout for bright, dedicated, and innovative individuals who are passionate about making a difference. If you don’t find a suitable role on our Careers Page, we invite you to submit your resume to join our Talent Community for future opportunities. We encourage you to frequently check our Careers Page as we expand our team and add more opportunities.Vaxcyte is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.

Vaxcyte, a clinical-stage vaccine company in San Carlos, California, develops vaccines targeting serious bacterial diseases such as invasive pneumococcal disease, Group A Strep, and Shigella. The team is committed to protecting people from bacterial infections and advancing vaccine technology. The company values creative thinking, ambitious goals, and a collaborative, inclusive culture. Integrity, accountability, and clear communication guide all decisions and actions at Vaxcyte. Role overview The Accounting Summer Intern position gives students the chance to apply academic knowledge to real-world accounting and finance projects. Interns will gain hands-on experience and develop practical skills that support future career growth. What you will do Assist with financial analysis and accounting tasks, such as variance analysis, manufacturing accounting, SOX compliance, and preparing financial statements. Research and benchmark finance and accounting tools, including AI-enabled solutions, to identify opportunities for process improvement, automation, and improved reporting. Help maintain and update financial documentation, including process flows, Standard Operating Procedures (SOPs), training materials, and internal controls documentation. Apply AI and advanced Excel tools to support data analysis, streamline reporting, and maintain accuracy in line with company policies and controls. This internship is based in San Carlos, CA.

Join Our Mission to Protect Humankind!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines designed to safeguard humanity from the severe health impacts of bacterial diseases. Our mission encompasses the eradication and treatment of bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella. With a clear and well-defined path to success, Vaxcyte is committed to making a meaningful difference. Our Approach is as vital as our Results! Our collective work is driven by four core values: *Rethink Convention: We embrace creative and intellectual diversity to innovate and continually improve vaccine delivery. *Aim High: We strive to achieve audacious goals to develop the most complex biologics aimed at protecting humankind. *Lead with Heart: Everyone at Vaxcyte leads with kindness, fostering an inclusive environment that promotes collaboration and healthy debate to meet our business objectives. *Model Excellence: Our challenge demands a shared commitment to integrity, accountability, equality, and clarity in communication and decision-making.Position Summary:Vaxcyte is thrilled to offer an exciting opportunity for a dynamic and skilled individual to join our Analytical Development team. The Associate Scientist II, Analytical Development will be responsible for executing analytical testing and supporting method development activities for our biologics and vaccine development programs. This role will entail performing both routine and non-routine analytical assays utilizing modern analytical techniques and contributing to method optimization, troubleshooting, and continuous improvement initiatives under supervision. Candidates should possess demonstrated hands-on laboratory experience, strong technical execution, and the ability to work independently on routine tasks while supporting more complex development activities.Essential Functions:Analytical Testing & Data GenerationConduct routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical or biophysical techniques).Prepare samples, reagents, standards, and controls for testing.

Join Our Team as a Manufacturing Engineer!Location: San Carlos, CA (on-site)At 1X, we design and manufacture cutting-edge humanoid robots that work alongside humans to address labor shortages and enhance productivity.Your RoleAs a Manufacturing Engineer at 1X, you will play a pivotal role in bringing our humanoid robots from prototype to full-scale production. You will be responsible for designing, optimizing, and overseeing manufacturing processes to ensure they are precise, efficient, and cost-effective. This is a hands-on opportunity that will directly influence the quality and scalability of our robotic systems.

About the Company At Swift Solar, we are dedicated to realizing the immense potential of solar energy. Our vision is that solar energy can power lives, enhance economies, and strengthen supply chains while safeguarding planetary health amidst global climate challenges. Although current solar technology is effective, we believe it can be significantly improved. We are revolutionizing solar energy with our innovative tandem technology, leveraging perovskite materials to produce solar solutions that surpass traditional technologies in efficiency and versatility. Our applications range from space solar systems to utility-scale power generation. As a mission-driven startup, Swift Solar is supported by the U.S. government and backed by leading global investors. We are committed to the long-term journey of bringing groundbreaking clean energy technology to market. Join our exceptional team as we develop cutting-edge solar technology that will redefine the future of the global solar industry. A Day in the Life Swift Solar is seeking a proactive IT and security leader who will manage our current IT operations while laying the groundwork for future manufacturing sites. In this role, you will oversee all aspects of Swift IT — managing onboarding and offboarding, device allocation, incident response, and system upgrades — ensuring our issue-management system is transparent to prevent any oversights. Security will be a vital aspect of this position: you will implement least-privilege access, establish boundaries for sensitive systems, enhance endpoint hygiene, and devise secure vendor-access strategies across our office, lab, and shared-system environments. You will also strengthen role-based access controls for technical cooperation between our teams in the U.S. and Germany and ensure that Swift's security measures evolve in line with the company’s growth. The major opportunity lies in shaping the future as Swift transitions to manufacturing. You will set standards for site networking, shared workstations, vendor access, and endpoint deployment at new facilities. This role offers a unique chance to join us at an early stage, create real impact, and expand your role as Swift progresses — evolving from a capable, hands-on leader today to architecting Swift's global IT infrastructure tomorrow.

Join Our Mission to Safeguard Human Health!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines that protect humanity from the severe and costly health consequences posed by bacterial diseases. Our commitment extends to eradicating or treating infections such as invasive pneumococcal disease, Group A Strep, and Shigella. Our roadmap to success is clear, and Vaxcyte is poised to make a lasting impact on global health. Our Approach: At Vaxcyte, we believe that what we do is just as crucial as how we do it. Our collaborative efforts are anchored in four core values: *Rethink Convention: We foster creativity and intellectual diversity in all aspects of our work, striving to innovate and continually improve vaccine delivery methods. *Aim High: We embody our ambitious goal of developing complex biologics that aim to protect humanity. *Lead with Heart: Our inclusive and kindness-first approach enhances collaboration and encourages vigorous debate to drive our business objectives forward. *Model Excellence: Our challenges necessitate a shared commitment to integrity, accountability, equality, and clear communication in all our decisions.Summary:Vaxcyte seeks a dynamic and skilled individual to join our analytical development team. The primary responsibilities will encompass method development, sample testing, data analysis, protocol and report authorization, and the oversight and coordination of analytical method transfers.Essential Functions:Independently conduct method development for a diverse array of analytical techniques utilized in raw material testing for quality control and characterization, supporting both pre-clinical and clinical projects.Facilitate method transfers to external contract testing laboratories; design and execute studies to troubleshoot QC testing, method qualification/validation, or any method-related issues as required.Conduct analytical testing, data analysis, and interpretation, presenting findings in various project and functional team meetings.Collaborate with cross-functional teams to meet project timelines and objectives.Maintain comprehensive and accurate records of laboratory activities.

About AetherfluxAetherflux is at the forefront of innovation, addressing the global energy crisis with cutting-edge infrastructure for abundant and reliable space-based solar energy. Our world-class team is dedicated to overcoming complex engineering challenges to deliver a groundbreaking power platform. Join us as we redefine how civilization harnesses energy, computation, and connectivity—from the depths of space to the surface of Earth.Position OverviewAs an Avionics Engineer at Aetherflux, you will play a crucial role in designing, developing, and integrating advanced electrical systems that support our state-of-the-art optical and laser satellite payloads. This hands-on position involves working with both electrical and optical components to ensure the flawless integration of high-power laser systems in our satellites. You will collaborate closely with a diverse team of optical, mechanical, software, and systems engineers to create solutions that meet stringent performance standards for space applications.This role is located on-site at our headquarters in San Carlos, CA, and you'll be part of an ambitious timeline, witnessing your contributions in space during our inaugural space demonstration planned for summer 2026.

Be a Part of Our Mission to Safeguard Humanity!Vaxcyte is at the forefront of vaccine innovation, focusing on the development of high-fidelity vaccines aimed at protecting society from severe bacterial diseases that can lead to significant health challenges. Our commitment to combating bacterial infections, including invasive pneumococcal disease, Group A Streptococcus, and Shigella, positions us as leaders in the field. With a clear and defined path toward success, Vaxcyte is committed to making a lasting impact on global health. Our Approach: Values that Drive Us We believe that our mission is as important as our methodology. Our work is guided by four foundational values: *RETHINK CONVENTION: We embrace creativity and diverse perspectives to continuously innovate the delivery of vaccines. *AIM HIGH: Our ambitious goal is to develop the most complex biologics designed to protect humanity. *LEAD WITH HEART: Collaboration at Vaxcyte is rooted in kindness and inclusivity, fostering an environment where vigorous debate leads to meaningful outcomes. *MODEL EXCELLENCE: Meeting our challenges requires a collective commitment to integrity, accountability, and clarity in communication and decision-making.Position Summary:The Executive Director of Clinical Regulatory is a leadership role responsible for crafting and executing global regulatory strategies for clinical investigations and the commercialization of vaccines across both adult and pediatric populations. Working closely with Clinical Development and Safety teams, this position will provide regulatory oversight that supports the preparation of clinical development protocols, interpretation and summarization of clinical data, and the creation and management of clinical and pre-clinical regulatory documents. This role also entails liaising with regulatory authorities to secure commercial approval for innovative vaccine products.Candidates should possess extensive experience in developing and executing regulatory strategies for vaccines and preparing investigational and commercial regulatory submissions, such as IND/IMPD, BLA/MAA, and post-approval clinical and safety notifications. Strong communication skills are essential, particularly the ability to simplify complex regulatory issues and effectively convey potential options and opportunities.

Location: San Carlos, CAEmployment Type: Full-Time OnsiteAbout 1XAt 1X, we are pioneering the development of humanoid robots that collaborate with humans to tackle labor shortages and foster a future of abundance.About the RoleAs a Configuration Management Engineer at 1X, you will be responsible for managing the systems and processes that ensure our product structure remains accurate, our changes are well-controlled, and our builds are reliable throughout all phases of development and production. You will navigate a complex multi-subsystem environment that includes mechanical assemblies, electromechanical actuators, electrical systems, and embedded computing.Your role will serve as the vital link that guarantees every engineer, manufacturer, and supplier is working from the correct revision at the appropriate time.This position is situated at the crossroad of engineering, manufacturing, and supply chain—essential for our capacity to scale production while continuously innovating.Key ResponsibilitiesOversee and manage our Product Lifecycle Management (PLM) system, which includes part number creation, multi-level BOM management, item master maintenance, lifecycle state governance, and user access control.Lead the end-to-end change management processes by conducting Change Control Board (CCB) meetings, processing Engineering Change Orders (ECOs) and deviations, and ensuring technically accurate change documentation with stringent revision control.Manage the top-level product assembly structure and BOM for NEO, overseeing interface requirements and master geometry models across all robot subsystems.Support New Product Introduction (NPI) builds (EVT/DVT/PVT) by ensuring BOM and drawing readiness, collaborating efficiently with Mechanical, Electrical, Software, Manufacturing, Quality, and Supply Chain teams.Review engineering drawings prior to release, ensuring clarity, accurate dimensioning, revision blocks, and compliance with GD&T as per ASME Y14.5 standards.Develop frameworks to track and release multiple product configurations that may be at different stages of development across our San Carlos and Hayward facilities.Implement component roadmaps including part obsolescence management, replacements, alternative vendors, and cost reduction strategies.

Join Our Mission to Protect Humanity!Vaxcyte is at the forefront of clinical-stage vaccine innovation, developing high-fidelity vaccines aimed at safeguarding humanity from the dire consequences of bacterial diseases. Our mission tackles serious health challenges, including invasive pneumococcal disease, Group A Strep, and Shigella. As we strive to eradicate or treat these infections, our path to success is clearly defined, and Vaxcyte is poised for long-term achievement. Our Work Ethos: At Vaxcyte, the importance of WHAT we do is matched only by HOW we do it. Our collaborative efforts are guided by four enduring core values: *Rethink Convention: We embrace creative and intellectual diversity to innovate and continuously improve the delivery of vaccines. *Aim High: Our audacious goal is to develop the most complex biologics ever attempted for the protection of humankind. *Lead with Heart: Kindness and inclusivity shape our collaborative and vigorous discussions, advancing our business objectives. *Model Excellence: Our commitment to integrity, accountability, equality, and clarity is vital to overcoming the challenges we face.

Join aetherflux as a Firmware Engineer and take part in shaping the future of technology. You will work on innovative projects, developing robust firmware solutions for cutting-edge devices. Collaborate with a talented team, enhance your skills, and contribute to exciting developments in the tech industry.

Test TechnicianLocation: San Carlos, CA (on-site)Shift: Day Shift, 6:00 AM to 2:30 PMAbout 1XAt 1X, we are pioneering the future of work with our innovative humanoid robots designed to assist humans in overcoming labor shortages and increasing productivity.The RoleWe are in search of a dedicated and meticulous Test Technician to become an integral part of our engineering team. In this role, you will be responsible for setting up, executing, and supporting a wide range of thermal, mechanical, and electrical tests. Your contributions will be vital in producing high-quality test data that drives design, reliability, and validation processes. This position requires a solid technical background, adaptability, and strong collaboration skills with test engineers, design engineers, and reliability teams.

Join Our Mission to Protect Humankind!Vaxcyte is an innovative clinical-stage vaccine company dedicated to engineering high-fidelity vaccines aimed at safeguarding humanity from the devastating impacts of bacterial diseases. Our mission involves not just the eradication but also the treatment of bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella. We have a clear and ambitious roadmap to success, and Vaxcyte is poised to achieve remarkable milestones. What we do is equally important as how we do it! Our collaborative efforts are anchored by four enduring core values: *RETHINK CONVENTION: We foster creative and intellectual diversity in every aspect of our work, continually innovating how vaccines are delivered. *AIM HIGH: We embody our ambitious goal to courageously create the most complex biologics ever developed for the protection of humankind. *LEAD WITH HEART: At Vaxcyte, every individual leads with a kindness-first and inclusive approach to collaboration, encouraging healthy debate that advances our objectives. *MODEL EXCELLENCE: The scale of our challenges necessitates a shared commitment to integrity, accountability, equality, and clarity in communication and decision-making.Position Summary:Vaxcyte offers an exciting opportunity for a Senior Manager, Quality Control Data Analyst to join our Quality Control (QC) organization. This role will serve as a vital link between our technical QC Operations team and Business teams. The successful candidate will be responsible for the systematic collection, evaluation, interpretation, and visualization of complex datasets, transforming them into actionable insights that inform both technical and business decisions. Key responsibilities include generating reports, managing databases, and utilizing analytical tools to identify trends, initiate quality events when necessary, enhance operational efficiency, and support the formulation of acceptance criteria as well as strategic planning.Essential Functions:Collaborate closely with analytical sub-teams and other departments within Analytics, Process Development, Quality Assurance, Operations, and Regulatory functions.Ensure data integrity, accuracy, and reliability, ensuring datasets are evaluated promptly and conform to quality and regulatory standards, thereby securing a continuous supply of Vaxcyte’s innovative therapies.

Role OverviewJoin our innovative team as a Camera Validation Engineer, where you will play a pivotal role in validating cutting-edge camera modules and image sensors. Your responsibilities will include defining and managing validation specifications, executing thorough image quality characterization and verification, and facilitating the camera module's journey from initial design and prototyping to qualification and mass production for the advanced vision systems of the 1X humanoid robot.The ideal candidate is a resourceful problem-solver who excels in a dynamic product development environment.

Join Robust AI as a Software Security Engineer, where you will play a pivotal role in enhancing the security posture of our innovative AI solutions. This position involves designing and implementing robust security measures to safeguard our software systems and data.As a key member of our engineering team, you will collaborate with cross-functional teams to identify vulnerabilities and develop strategies to mitigate risks. Your expertise will help us deliver secure, reliable, and high-performing AI products.

Join Our Mission to Safeguard Humanity!Vaxcyte, a pioneering clinical-stage vaccine innovation company, is dedicated to creating high-fidelity vaccines aimed at protecting humanity from the dire consequences of bacterial diseases. Our mission is to combat serious health threats posed by bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella. Our path forward is clear and strategically defined, positioning Vaxcyte to achieve long-lasting success. Our Approach: At Vaxcyte, the WHAT we do is as significant as the HOW we do it! Our collaborative efforts are governed by four core values: *Rethink Convention: We foster creative and intellectual diversity to revolutionize vaccine delivery. *Aim High: We passionately pursue audacious goals to devise the most complex biologics for humanity's protection. *Lead with Heart: Every member leads with kindness and inclusivity, fostering collaboration and constructive debate to drive our business objectives. *Model Excellence: Our shared commitment to integrity, accountability, equality, and transparent communication is essential in overcoming challenges.Position Summary:This role presents an exciting opportunity to serve as a strategic financial partner to Vaxcyte’s R&D organization, focusing on clinical studies. You will support Clinical Operations and the Immunoassay and Non-Clinical teams by overseeing clinical trial and serology finances while adapting to broader R&D needs. This position requires close collaboration with Clinical Operations and Serology on planning, forecasting, accruals, financial reporting, and decision support across multiple development programs.Key Responsibilities:Provide strategic oversight for clinical outsourcing by collaborating with Clinical Operations, Clinical Development, Finance, and Legal to evaluate the best fit for Vaxcyte’s pipeline and outsourced scope of work.Oversee financial and commercial aspects of RFP processes, vendor selection, and budget management for the Clinical organization.Manage financial updates for clinical trials and support the annual planning process, including detailed analyses.