Senior Scientist

FL122, a new venture from Flagship Pioneering based in Cambridge, MA, is building genomic technologies aimed at advancing human health and assisted reproduction. Flagship Pioneering has launched over 100 life sciences companies in the past two decades, including Moderna, Generate Biomedicines, and Tessera Therapeutics. The team addresses complex challenges in human health and sustainability. Role overview The Scientist in Reproductive and Molecular Biology will play a key part in establishing FL122’s scientific platform. This role focuses on developing and standardizing laboratory workflows that involve handling human gametes and performing molecular characterization. As part of the early scientific team, the Scientist will work closely with senior scientists and company leadership to define technical standards and carry out experimental strategies. What you will do Develop and improve laboratory workflows for handling human gametes and conducting molecular analysis Work directly with sensitive human samples in an IVF or embryology laboratory setting Use molecular biology techniques to support experimental goals Collaborate with colleagues and leadership to establish technical standards Help plan and execute experimental strategies Requirements Background in reproductive biology and molecular biology Hands-on experience in IVF or embryology laboratory environments Proficiency in molecular biology techniques Strong attention to detail and ability to work with sensitive human samples Adaptable and comfortable working across different scientific areas Collaborative approach suited to an early-stage startup team

About Serif Biomedicines, Inc. Serif Biomedicines, Inc. is a privately held biotechnology company in Cambridge, MA. The team is developing new approaches to gene therapy for diseases that current medical solutions cannot address. Serif Biomedicines was founded by Flagship Pioneering, known for launching over 100 innovative life sciences organizations focused on human health and sustainability. Role Overview The Senior Scientist, Molecular Biology will design and develop next-generation DNA constructs for programmable medicine. This position suits scientists experienced in synthetic biology, high-throughput cloning, and computational sequence engineering. The role centers on building scalable platforms for plasmid DNA design, construction, and optimization, using automation, algorithm-driven sequence design, and data-centric workflows. This scientist will report to the Director of Molecular Biology and may supervise a direct report. Collaboration with other scientists and group leaders across the R&D team is a key part of the job. What You Will Do Lead the design and construction of plasmid DNA constructs, including vector architecture, gene synthesis strategies, and high-efficiency cloning (such as Gibson, Golden Gate, and recombination-based methods). Advance automated and computational sequence design by applying advanced tools and pipelines for codon optimization, regulatory element tuning, and multi-parameter construct optimization. Establish and manage vendor relationships to support both internal and external capabilities, helping projects move forward efficiently and minimizing disruptions.

Join our team as a Biology Scientist, where you will engage in groundbreaking research and development in the field of biology. You will collaborate with a talented group of scientists and contribute to innovative projects that aim to advance our understanding of biological processes. This is an exciting opportunity to be part of a dynamic environment that fosters creativity and scientific inquiry.

Join us as a Senior Scientist in Computational Biology at Flagship Pioneering, Inc. In this pivotal role, you will leverage your expertise to drive innovative research and development in computational biology, contributing to groundbreaking discoveries and advancements in the field.

GT Biosciences is on the cutting edge of biotechnology, developing Deliveromics, the world’s first AI-driven, high-throughput, multiplexed in vivo data engine designed to decode the complexities of drug delivery. Established by a team of MIT scientists and supported by elite investors, we are pioneering next-generation, non-viral, cell-type-specific delivery vehicles, achieving notable advancements in crossing the blood-brain barrier and targeting specific brain cell types. Our dedicated and fast-paced team is committed to revolutionizing routine in vivo cell reprogramming.We are seeking a passionate and skilled Spatial Biology Platform Scientist to join our Platform Development Team. In this pivotal role, you will leverage your extensive knowledge in spatial biology, nucleic acid sequencing, and assay development to enhance our Deliveromics platform. As an early member of our scientific team, your collaborative efforts across biology, chemistry, and engineering will be crucial in generating high-quality data and insights driving our innovations. This full-time, in-person position is based in Cambridge, MA.

Join AbbVie as a Senior Scientist I in the field of siRNA in vitro biology. In this role, you will leverage your extensive knowledge and skills in molecular biology to contribute to innovative research and development projects. Collaborate with a team of dedicated scientists to explore new therapeutic avenues and advance our understanding of RNA interference.

Role overview Eurofins Scientific seeks an Associate Scientist in Cambridge with a focus on molecular biology and protein purification. This role supports ongoing research projects and daily laboratory operations, working closely with experienced scientists in a well-equipped environment. Key responsibilities Perform experiments in molecular biology and protein purification Manage laboratory workflows to ensure accuracy and reliability Work collaboratively with team members on research projects Support initiatives that advance scientific knowledge Work environment The position is based in a modern laboratory with advanced equipment and a team of specialists. Daily work involves hands-on research and collaboration within a supportive scientific community.

Imagine... being part of an innovative organization that cultivates and develops life sciences companies dedicated to pioneering groundbreaking technologies aimed at revolutionizing health care and sustainability. Company Overview Expedition Medicines is a dynamic, privately held, early-stage biotechnology company at the forefront of the Protein Editing field. We specialize in creating small molecules that modify protein structure and function to target currently undruggable options across various therapeutic strategies. Our advanced platform combines cutting-edge small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to facilitate generative design. Backed by Flagship Pioneering, we leverage their vision, courage, and resources to propel Expedition Medicines from platform validation to impactful patient solutions. We seek passionate, collaborative, and determined problem solvers to join our mission! Role Overview: The Senior/Principal Scientist in Structural Biology will concentrate on determining protein-ligand complex structures using X-ray crystallography and cryo-electron microscopy (cryo-EM). This role involves delivering structural insights and collaborating with project teams to advance structure-based drug design and uncover the mechanisms of action of small molecules. Key Responsibilities: Design and implement structural biology strategies for multiple projects. Oversee the design, expression, and purification of protein constructs for structural determination. Develop and execute protocols to achieve high-quality crystals for X-ray crystallography. Create and implement protocols for grid optimization, data collection, and analysis in cryo-EM. Refine and communicate structures of protein-ligand complexes, collaborating with project teams to drive hit-to-lead and lead optimization processes. Manage contract research organizations (CROs) to ensure efficient delivery of protein expression and structural biology services. Enhance our capabilities and serve as a trusted authority in the field of structural biology.

Join Scismic, a dynamic biotech startup located in Cambridge, MA, that is at the forefront of developing innovative mRNA-modulating therapies aimed at treating a wide array of genetic disorders. Our research is focused on leveraging novel platforms to address neurological conditions, heart disease, and muscular dystrophies.Position Summary:As a Research Associate specializing in cellular neurobiology, you will play a crucial role in establishing cellular assays to validate in vitro proof of concept for our tRNA therapeutic candidates. Your expertise will be instrumental in characterizing cellular activities and understanding disease-relevant biology, ultimately guiding the prioritization of candidates for in vivo studies.

Harvard University's Department of Molecular and Cellular Biology seeks a Staff Scientist to join its research team in Cambridge. This role centers on advancing scientific understanding in molecular biology through direct involvement in research projects. Role overview The Staff Scientist will work closely with faculty and fellow researchers, contributing to the design and execution of experiments. Responsibilities include developing research strategies, conducting laboratory work, and analyzing experimental data. Collaboration Collaboration is a key part of this position. The team values open communication and shared problem-solving as they pursue new discoveries in molecular and cellular biology. Impact This role supports scientific progress by helping to shape and carry out experiments that expand the field's knowledge base. The work performed will directly influence ongoing and future research directions within the department.

Eurofins Scientific is seeking a Molecular Biology Analyst in Cambridge. This position centers on analyzing molecular data and conducting experiments to support ongoing scientific projects. Role overview This role involves hands-on laboratory work, including the analysis of molecular samples and the execution of experiments. The Molecular Biology Analyst will contribute to projects that support health and safety initiatives. Key responsibilities Analyze molecular data using established laboratory methods Perform experiments as part of project teams Support scientific efforts that advance health and safety Location This position is based in Cambridge.

Join the esteemed team at Harvard University as a Research Assistant I in the Department of Molecular and Cellular Biology. This full-time position offers an exciting opportunity to contribute to groundbreaking research in the sciences. You will assist in various research projects, working closely with senior researchers to gather and analyze data, prepare reports, and participate in laboratory activities.

Our MissionAt Altos Labs, our mission is to rejuvenate cell health and resilience, aiming to reverse diseases, injuries, and the associated disabilities that arise throughout life.For further details, visit our website at altoslabs.com.Our ValuesWe embrace a singular value at Altos: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe hold a firm belief that diverse perspectives are crucial to scientific advancement and inquiry. At Altos, outstanding scientists and industry leaders collaborate from across the globe to further our shared mission. We prioritize creating a sense of belonging, ensuring that every employee feels valued for their unique contributions. We are collectively responsible for maintaining a diverse and inclusive workplace.Your Contributions to AltosIn the role of Senior or Principal Machine Learning Scientist, you will be instrumental in the development of generative AI/ML models for multi-modal, multiscale biology, spanning from virtual cells to agentic target assessment. We seek a hands-on, innovative, and collaborative individual to join our multidisciplinary team of scientists and engineers dedicated to transforming the treatment of aging and disease. The ideal candidate will flourish in a dynamic environment that values teamwork, transparency, scientific excellence, originality, rigor, and integrity.

About Serif Biomedicines, Inc. Serif Biomedicines, Inc. is a privately held biotechnology company based in Cambridge, MA. The team focuses on developing gene therapies for diseases that currently lack effective treatments. Founded by Flagship Pioneering, Serif is part of a network that has launched over 100 companies in the life sciences, including Moderna, Syros Pharmaceuticals, and Generate Biomedicines. Position Overview The Research Associate in Molecular Biology will contribute to the development of programmable medicines. This position suits a molecular virologist or biochemist with hands-on experience in nucleic acid production, characterization, and molecular cloning. Scientific rigor and a collaborative approach are essential. The role involves working closely with others to advance nucleic acid therapeutics in a setting that values curiosity and innovation. Main Responsibilities Plasmid Production: Design, carry out, and troubleshoot molecular cloning for inserts of various lengths and compositions. Ensure plasmid sequences meet specifications. Inventory Management: Organize storage of produced materials. Keep accurate electronic records of material details and storage locations. Enzymatic Reaction Optimization: Improve and troubleshoot enzymatic reactions to boost nucleic acid yield and purity. Nucleic Acid Production: Follow and refine protocols to produce high-quality DNA and RNA with different expression cassettes.

Flagship Pioneering, Inc. is seeking a Senior Research Associate in Chemical Biology for its FL116 team in Cambridge, MA. FL116 is dedicated to advancing biomolecule synthesis and is building a platform to transform the manufacturing of research, diagnostic, and therapeutic molecules. Role overview This position joins a collaborative group focused on applying chemical strategies to biological questions. The work centers on enzyme-mediated biomolecular synthesis, with careful attention to both mechanistic and molecular aspects. Main responsibilities Design and execute high-throughput experiments to investigate enzyme-substrate interactions Characterize biomolecular products using a range of established and new analytical methods Contribute to the development of scalable assays that support the growth of the platform Requirements Strong hands-on experimental skills and a close attention to detail Curiosity about the chemical nature of biological systems Interest in manipulating and measuring biological activity at the molecular scale Comfort working in an execution-focused, pipeline-driven environment Motivation to develop with a rapidly evolving technology platform Work environment The role provides the opportunity to deepen expertise at the intersection of chemistry and biology in a collaborative startup setting, supported by Flagship Pioneering. The team values problem solvers who enjoy tackling complex scientific challenges and building new tools for biotechnology and therapeutics.

Role Overview Flagship Pioneering, Inc. is on the lookout for a visionary Senior/Executive Director to serve as the Head of Biology. In this pivotal role, you will spearhead the biological strategy and target validation within our causality-driven discovery platform. Your expertise will be essential in converting human genetic data—such as GWAS, rare variants, Mendelian randomization, and functional genomics—into robust biological validations that are pertinent to disease, while also shaping preclinical programs across a range of therapeutic areas. The ideal candidate will possess extensive target validation experience across various therapeutic modalities, with a strong emphasis on neurodegenerative diseases (including Parkinson’s disease), genomic perturbation tools, and the capability to make significant contributions to cardiovascular and immune-mediated biology. You will be responsible for building and mentoring an exceptional biology team, establishing high standards for scientific rigor and decision-making quality, and collaborating closely with data science, chemistry, and platform operations to progress targets to development readiness.

Job Summary:The Research Assistant III will play a vital role in the Ramanathan lab at Harvard University, collaborating closely with graduate students and postdoctoral researchers. This position involves conducting scientific experiments in the specialized field of stem cell biology and human development with a high degree of independence. The successful candidate will coordinate various facets of ongoing research projects, execute laboratory experiments using advanced techniques and equipment, and manage collaborations with external laboratories as necessary. This role may also include the training of new lab members in established scientific methods.Key Responsibilities:Coordinate multiple aspects of research projects and perform laboratory experiments utilizing specific techniques and equipment.Generate cortical tissue from various cell lines, including induced pluripotent stem cells (iPS cells), embryonic stem cells, and a Good Manufacturing Practice (GMP) line.Conduct genetic modifications, manage passaging, and maintain both parental and modified fluorescent reporter lines.Utilize cell printing, optimize differentiation protocols for each cell line, and prepare tissues for shipment to collaborators working with primates.Prepare samples for single-cell transcriptomics and validate them using antibody staining techniques.Set up incubators and shakers, monitor differentiation processes, and establish a robust experimental pipeline.Collaborate with lab members on experimental design, protocol establishment, and the development of innovative laboratory techniques.Process, organize, summarize, and analyze data; report results using a variety of scientific, word processing, spreadsheet, or statistical software applications.May provide training and guidance to others in laboratory techniques and procedures.Assist with laboratory maintenance tasks, including the procurement of equipment and supplies, liaising with vendors, and engaging in special projects as required.Working Conditions:This position is primarily performed in a laboratory environment on the Cambridge campus.Involves working with hazardous materials and human cell cultures.Physical Requirements:May require lifting, moving, and transporting research equipment.

Join our dynamic team as a Molecular Biology and Tissue Culture Lab Associate in Cambridge, MA. This is an exciting opportunity for individuals passionate about advancing scientific research and laboratory techniques. You will be involved in various laboratory processes, focusing on molecular biology and tissue culture methodologies.

We are seeking a motivated and detail-oriented Bench Scientist to join our dynamic team in Cambridge. This entry-level position is an excellent opportunity for recent graduates or those new to the field of scientific research. As a Bench Scientist, you will play a crucial role in conducting experiments, analyzing data, and contributing to innovative projects. If you are passionate about science and eager to learn, we encourage you to apply!