About the job
About the Role:
Join 10x Genomics in our mission to revolutionize diagnostics by leveraging our pioneering single-cell and spatial genomics technologies for impactful clinical applications. We are currently looking for a talented and driven Senior Scientist to become a key member of our Diagnostic Assay Development team. This role is a hands-on bench scientist position that involves taking scientific ownership of assay development and optimization while providing mentorship and technical guidance to junior staff. As a Senior Scientist, you will execute, troubleshoot, and enhance 10x Genomics-based assays to facilitate the development of robust Laboratory Developed Tests (LDTs).
Key Responsibilities:
Assay Development & Execution
- Independently perform complex single-cell and spatial genomics workflows, including sample processing, library preparation, and sequencing.
- Act as a hands-on technical authority for 10x Genomics platforms (e.g., Chromium, Xenium), ensuring high standards in assay performance.
- Methodically troubleshoot and refine assay workflows to enhance robustness, sensitivity, and reproducibility.
- Adapt, refine, and expand existing protocols to fulfill clinical, regulatory, and scalability criteria.
- Design and conduct feasibility studies to assess new reagents, chemistries, instrumentation, and workflow enhancements.
- Process a variety of challenging clinical sample types to support clinical research and validation studies.
Analytical Validation & Documentation
- Design and implement experiments that support analytical validation, focusing on accuracy, precision, detection limits, and reproducibility.
- Create, review, and uphold high-quality laboratory documentation, including SOPs, validation protocols, and batch records, in compliance with Good Documentation Practices.
- Analyze assay performance metrics and quality control data to drive informed, data-based technical decisions.
- Present experimental data and scientific findings clearly in team meetings and written reports.
Scientific Leadership & Mentorship
- Provide daily technical guidance and mentorship to junior team members.
- Review experimental data and assist in the interpretation of results to foster a collaborative research environment.

