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Senior Scientist in Diagnostic Assay Development

10x GenomicsPleasanton, California, USA HQ
On-site Full-time $158.4K/yr - $214.4K/yr

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Experience Level

Senior

Qualifications

Qualifications: Ph. D. in Molecular Biology, Genetics, or a related field preferred. Extensive experience in assay development and validation, particularly in the context of clinical diagnostics. Proficient in single-cell and spatial genomics methodologies. Strong problem-solving skills and ability to troubleshoot complex technical issues. Excellent communication skills, with the ability to present complex scientific concepts clearly. Demonstrated leadership abilities and experience mentoring junior scientists.

About the job

About the Role:

Join 10x Genomics in our mission to revolutionize diagnostics by leveraging our pioneering single-cell and spatial genomics technologies for impactful clinical applications. We are currently looking for a talented and driven Senior Scientist to become a key member of our Diagnostic Assay Development team. This role is a hands-on bench scientist position that involves taking scientific ownership of assay development and optimization while providing mentorship and technical guidance to junior staff. As a Senior Scientist, you will execute, troubleshoot, and enhance 10x Genomics-based assays to facilitate the development of robust Laboratory Developed Tests (LDTs).

 

Key Responsibilities:

Assay Development & Execution

  • Independently perform complex single-cell and spatial genomics workflows, including sample processing, library preparation, and sequencing.
  • Act as a hands-on technical authority for 10x Genomics platforms (e.g., Chromium, Xenium), ensuring high standards in assay performance.
  • Methodically troubleshoot and refine assay workflows to enhance robustness, sensitivity, and reproducibility.
  • Adapt, refine, and expand existing protocols to fulfill clinical, regulatory, and scalability criteria.
  • Design and conduct feasibility studies to assess new reagents, chemistries, instrumentation, and workflow enhancements.
  • Process a variety of challenging clinical sample types to support clinical research and validation studies.

Analytical Validation & Documentation

  • Design and implement experiments that support analytical validation, focusing on accuracy, precision, detection limits, and reproducibility.
  • Create, review, and uphold high-quality laboratory documentation, including SOPs, validation protocols, and batch records, in compliance with Good Documentation Practices.
  • Analyze assay performance metrics and quality control data to drive informed, data-based technical decisions.
  • Present experimental data and scientific findings clearly in team meetings and written reports.

Scientific Leadership & Mentorship

  • Provide daily technical guidance and mentorship to junior team members.
  • Review experimental data and assist in the interpretation of results to foster a collaborative research environment.

About 10x Genomics

10x Genomics is a pioneering biotechnology company dedicated to advancing the frontiers of genomics. Our innovative platform technologies are transforming the landscape of single-cell and spatial genomics, enabling researchers and clinicians to unlock new insights into biology and disease.

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