Senior Scientist in Conjugation Biochemistry

COMPANY DESCRIPTION We are a pioneering start-up dedicated to transforming the landscape of chemical discovery. Our innovative platform integrates artificial intelligence with a state-of-the-art laboratory discovery pipeline to redefine molecular formulation development. Our interdisciplinary team is exploring uncharted chemical territories, facilitating significant advancements in drug delivery, agricultural formulations, and sustainable, high-performance industrial chemicals. Backed by Flagship Pioneering, a leader in biotechnology origination, we have fostered over 115 scientific ventures in 25 years, generating more than $20 billion in aggregate value, 500+ patents, and over 50 clinical trials for groundbreaking therapeutic agents. THE ROLE We are on the lookout for a passionate and skilled Senior Research Associate or Associate Scientist to enhance our formulation discovery platform by characterizing biomolecules. This position involves utilizing a range of biophysical and biochemical methodologies to analyze the effects of formulations on biomolecular integrity, aggregation, and functional stability. You will collaborate closely with chemists and machine-learning experts to produce high-quality experimental data that drives formulation design and predictive modeling initiatives. The ideal candidate will possess a solid background in biochemistry, structural biology, or biopolymer engineering, complemented by practical experience with analytical instrumentation for biomolecular characterization. KEY RESPONSIBILITIES Conduct experiments assessing biomolecular stability and solubility across various formulation conditions. Evaluate cargo structural integrity and folding utilizing circular dichroism (CD) spectroscopy and complementary biophysical techniques. Measure biomolecular interactions and stability through spectroscopy, dynamic light scattering, and electrophoretic methods. Prepare samples for diverse external workflows to evaluate molecular integrity and degradation. Experimental Pipeline Support Collaborate with formulation chemists to investigate cargo-formulation interactions across different experimental contexts. Generate high-quality experimental datasets to assist internal modeling and data analysis processes. Support laboratory instrumentation maintenance and troubleshooting. Maintain organized laboratory records, analyze results, and communicate findings effectively to cross-functional teams.

Join our team at Integrated Resources Inc. as an Associate Research Scientist, where you will contribute to cutting-edge research projects that impact real-world applications. We are looking for passionate individuals eager to innovate and collaborate in a dynamic environment. In this role, you will support senior scientists in the design and execution of experiments, analyze data, and contribute to publications. This is a fantastic opportunity to grow your career in scientific research.

Your Contribution at Lila Sciences Lila Sciences is actively seeking a dedicated (Senior) Research Associate to become an integral part of our dynamic Life Sciences team. This pivotal role will be centered around the formulation of lipid nanoparticles (LNPs), their functionalization with targeting ligands, and the characterization of the resulting targeted LNPs (tLNPs). The ideal candidate will possess substantial hands-on experience in LNP formulation and characterization, bioconjugation, protein characterization, and automation technologies. Your expertise will significantly enhance our understanding of the delivery space, enabling a high-throughput closed-loop screening cascade for tLNPs. You will work collaboratively with professionals across protein, cell biology, automation, chemistry, machine learning, and data science teams to establish advanced tools for targeted nucleic acid delivery. Your Key Responsibilities Design, execute, and characterize LNP formulations utilizing various scales and mixing modalities (e.g., DLS, ribogreen, TNS). Develop and optimize high-throughput ligand conjugation and purification methodologies, leveraging automation and robotics to maximize throughput. Collaborate with cell assay and antibody experts to screen candidates across diverse tissue targets in in vivo models. Engage with chemists, biologists, engineers, and data scientists to document processes, share insights, and refine best practices in autonomous flow chemistry. Create, implement, and uphold Standard Operating Procedures (SOPs) for both existing and emerging lab processes. Your Qualifications for Success MSc in Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences, or a closely related field with 3+ years of hands-on experience in targeted LNP production or a BSc with 5+ years of relevant experience. Industry experience is highly desirable. Strong proficiency in bioanalytical techniques (e.g., DLS, fluorescence spectroscopy, electrophoresis, in vitro assays). Experience in protein and antibody design and characterization. Familiarity with automation and high-throughput workflows is preferred. Exceptional troubleshooting, communication, and collaboration skills, with a proven ability to work effectively across interdisciplinary teams. About Lila Sciences Lila Sciences is at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory focused on life sciences, chemistry, and materials science. We are pioneering a new era of limitless discovery by harnessing AI capabilities to enhance every facet of the scientific method. Our mission is to leverage scientific superintelligence to address humanity's most pressing challenges.

Join Lila Sciences as a Senior Research Associate or Associate Scientist in the Protein Science department, focusing on our cutting-edge Antibody Platform. You will play a crucial role in advancing our research initiatives, contributing to the development of innovative antibody-based therapeutics. This position offers the opportunity to collaborate with a talented team dedicated to scientific excellence and the pursuit of transformative solutions in healthcare.

Your Impact at Lila Sciences Join our innovative high-throughput autonomous chemistry team as a Senior Research Associate / Associate Scientist. This hands-on position bridges the fields of organic and inorganic synthesis, advanced characterization, and laboratory automation. You will design and implement high-throughput experiments, synthesize small molecules, and conduct thorough downstream analysis alongside senior scientists. Your efforts will contribute to translating ambitious product objectives into scalable experimental workflows that significantly influence our company's growth. This role provides a unique opportunity to engage with automated chemistry platforms, giving you real ownership of experiments that shape our scientific strategy and direction. Ideal candidates are execution-oriented, excel in dynamic laboratory settings, and are passionate about developing deep technical skills while making impactful contributions to the future of chemical discovery at Lila Sciences. What You’ll Be Building Independently conduct experiments for the synthesis, purification, and characterization of organic and inorganic small molecules. Optimize reactions, develop methodologies, and analyze analytical data to inform project decisions. Convert initial concepts into reliable, functional experiments. Utilize retrosynthetic analysis to assist in the synthesis of target molecules. Operate Schlenk lines, gloveboxes, and various inert-atmosphere systems for sensitive materials. Employ PAT tools (UPLC, LCMS, NMR, IR, Fluorescence, DLS) to monitor reactions, ensure quality control, and produce high-quality data for machine learning workflows. Leverage automation and AI-driven technologies to streamline workflows and reduce experimental turnaround times. Collaborate with engineers, ML scientists, and stakeholders to validate model-recommended conditions, analyze trends, troubleshoot challenges, and clearly communicate results through reports, discussions, and presentations. Maintain meticulous documentation of results, ensuring accurate digital records while adhering to EHS and laboratory best practices. What You’ll Need to Succeed M.S. in Chemistry or a related field (such as organic, organometallics, or catalysis) with a minimum of 2 years of relevant laboratory experience, or a B.S. with 5 years of experience. Hands-on experience in organic and inorganic synthesis, purification processes, chromatographic techniques, and product analysis. Strong grasp of retrosynthesis, reaction mechanisms, and method optimization workflows. Proficiency in utilizing laboratory automation tools and systems. Excellent problem-solving skills and the ability to work collaboratively in a team-oriented environment.

Join Integrated Resources Inc. as an Associate Scientist III in Cambridge, where you'll contribute to groundbreaking scientific research and development. In this role, you will collaborate with a dynamic team to analyze and interpret data, develop experimental protocols, and ensure the highest standards of quality control. Your expertise will play a crucial role in advancing our innovative projects and achieving scientific excellence.

As an Associate Scientist III, you will play a crucial role in advancing our scientific research initiatives. You will collaborate with cross-functional teams to design, execute, and analyze experiments that contribute to our innovative projects. Your expertise will help drive our mission forward, ensuring that we continue to push the boundaries of scientific discovery.

Join Integrated Resources Inc. as an Associate Scientist I, where you will contribute to innovative scientific research and development projects. As a pivotal part of our team, your role will involve conducting experiments, analyzing data, and collaborating with multidisciplinary teams to advance our scientific objectives.

We are seeking a highly motivated Senior Research Associate to join our dynamic team at Integrated Resources, Inc. In this pivotal role, you will conduct advanced research, analyze data, and contribute to innovative projects that drive our mission forward. If you are passionate about scientific research and eager to make an impact, we want to hear from you!

We are seeking a talented and dedicated Senior Research Associate to join our dynamic team in Cambridge. In this role, you will contribute to innovative research projects and collaborate with interdisciplinary teams to drive impactful findings.

We are seeking a highly motivated and detail-oriented Associate Scientist III to join our dynamic team in Cambridge. In this role, you will contribute to innovative research projects, performing experiments and analyzing data to help drive our scientific advancements. This position requires a collaborative spirit and the ability to communicate findings effectively.

We are seeking a dedicated and detail-oriented Associate Scientist to join our dynamic team at Artech Information Systems LLC. In this role, you will contribute to innovative scientific research, engage in laboratory experiments, and support various projects aimed at advancing our scientific objectives. Your work will play a crucial role in developing solutions that impact our field positively.

We are seeking a dedicated and passionate Associate Scientist II to join our team in Cambridge. In this role, you will contribute to cutting-edge research and development initiatives, supporting our mission to innovate and enhance scientific solutions. You will work collaboratively with a multidisciplinary team to conduct experiments, analyze data, and interpret results, driving projects forward and contributing to significant advancements in our field.

Join our team at Integrated Resources, Inc. as an Associate Scientist II, where you will contribute to cutting-edge research and development in a dynamic and collaborative environment. In this role, you will utilize your scientific expertise to support various projects and drive innovation.

Join Integrated Resources Inc. as an Associate Scientist where you will engage in groundbreaking research and contribute to innovative projects. This role offers an exciting opportunity to work in a collaborative environment, driving advancements in our scientific endeavors.

Join our dynamic team as an Associate Scientist II, where you will contribute to innovative research and development initiatives. You will work collaboratively with cross-functional teams to advance scientific projects and support our mission to drive breakthroughs in biotechnology.

We are seeking a dedicated and innovative Associate Scientist specializing in Neurology to join our dynamic team. In this role, you will contribute to cutting-edge research projects that aim to advance our understanding of neurological disorders. You will collaborate with experienced scientists and researchers, utilizing state-of-the-art technologies and methodologies.Key responsibilities include conducting experiments, analyzing data, and contributing to scientific publications. If you are passionate about neuroscience and eager to make a significant impact in the field, we would love to hear from you!

Join Integrated Resources Inc. as an Associate Scientist III in Cambridge, where you'll contribute to groundbreaking research and scientific advancements. In this role, you will assist in the design and execution of experiments, analyze data, and collaborate with multidisciplinary teams to drive innovation.

As an Associate Scientist at Mindlance, you will play a crucial role in advancing innovative scientific research and development. You will collaborate with a dynamic team of professionals to conduct experiments, analyze data, and contribute to cutting-edge projects. Your expertise will help drive discoveries that make a real difference in various fields.