Senior Scientist I, siRNA in vitro Biology

Join our dynamic team as a Molecular Biology and Tissue Culture Lab Associate in Cambridge, MA. This is an exciting opportunity for individuals passionate about advancing scientific research and laboratory techniques. You will be involved in various laboratory processes, focusing on molecular biology and tissue culture methodologies.

About Serif Biomedicines, Inc. Serif Biomedicines, Inc. is a privately held biotechnology company based in Cambridge, MA. The team focuses on developing gene therapies for diseases that currently lack effective treatments. Founded by Flagship Pioneering, Serif is part of a network that has launched over 100 companies in the life sciences, including Moderna, Syros Pharmaceuticals, and Generate Biomedicines. Position Overview The Research Associate in Molecular Biology will contribute to the development of programmable medicines. This position suits a molecular virologist or biochemist with hands-on experience in nucleic acid production, characterization, and molecular cloning. Scientific rigor and a collaborative approach are essential. The role involves working closely with others to advance nucleic acid therapeutics in a setting that values curiosity and innovation. Main Responsibilities Plasmid Production: Design, carry out, and troubleshoot molecular cloning for inserts of various lengths and compositions. Ensure plasmid sequences meet specifications. Inventory Management: Organize storage of produced materials. Keep accurate electronic records of material details and storage locations. Enzymatic Reaction Optimization: Improve and troubleshoot enzymatic reactions to boost nucleic acid yield and purity. Nucleic Acid Production: Follow and refine protocols to produce high-quality DNA and RNA with different expression cassettes.

Role overview Eurofins Scientific seeks an Associate Scientist in Cambridge with a focus on molecular biology and protein purification. This role supports ongoing research projects and daily laboratory operations, working closely with experienced scientists in a well-equipped environment. Key responsibilities Perform experiments in molecular biology and protein purification Manage laboratory workflows to ensure accuracy and reliability Work collaboratively with team members on research projects Support initiatives that advance scientific knowledge Work environment The position is based in a modern laboratory with advanced equipment and a team of specialists. Daily work involves hands-on research and collaboration within a supportive scientific community.

FL122, a new venture from Flagship Pioneering based in Cambridge, MA, is building genomic technologies aimed at advancing human health and assisted reproduction. Flagship Pioneering has launched over 100 life sciences companies in the past two decades, including Moderna, Generate Biomedicines, and Tessera Therapeutics. The team addresses complex challenges in human health and sustainability. Role overview The Scientist in Reproductive and Molecular Biology will play a key part in establishing FL122’s scientific platform. This role focuses on developing and standardizing laboratory workflows that involve handling human gametes and performing molecular characterization. As part of the early scientific team, the Scientist will work closely with senior scientists and company leadership to define technical standards and carry out experimental strategies. What you will do Develop and improve laboratory workflows for handling human gametes and conducting molecular analysis Work directly with sensitive human samples in an IVF or embryology laboratory setting Use molecular biology techniques to support experimental goals Collaborate with colleagues and leadership to establish technical standards Help plan and execute experimental strategies Requirements Background in reproductive biology and molecular biology Hands-on experience in IVF or embryology laboratory environments Proficiency in molecular biology techniques Strong attention to detail and ability to work with sensitive human samples Adaptable and comfortable working across different scientific areas Collaborative approach suited to an early-stage startup team

Eurofins Scientific is seeking a Molecular Biology Analyst in Cambridge. This position centers on analyzing molecular data and conducting experiments to support ongoing scientific projects. Role overview This role involves hands-on laboratory work, including the analysis of molecular samples and the execution of experiments. The Molecular Biology Analyst will contribute to projects that support health and safety initiatives. Key responsibilities Analyze molecular data using established laboratory methods Perform experiments as part of project teams Support scientific efforts that advance health and safety Location This position is based in Cambridge.

About Serif Biomedicines, Inc. Serif Biomedicines, Inc. is a privately held biotechnology company in Cambridge, MA. The team is developing new approaches to gene therapy for diseases that current medical solutions cannot address. Serif Biomedicines was founded by Flagship Pioneering, known for launching over 100 innovative life sciences organizations focused on human health and sustainability. Role Overview The Senior Scientist, Molecular Biology will design and develop next-generation DNA constructs for programmable medicine. This position suits scientists experienced in synthetic biology, high-throughput cloning, and computational sequence engineering. The role centers on building scalable platforms for plasmid DNA design, construction, and optimization, using automation, algorithm-driven sequence design, and data-centric workflows. This scientist will report to the Director of Molecular Biology and may supervise a direct report. Collaboration with other scientists and group leaders across the R&D team is a key part of the job. What You Will Do Lead the design and construction of plasmid DNA constructs, including vector architecture, gene synthesis strategies, and high-efficiency cloning (such as Gibson, Golden Gate, and recombination-based methods). Advance automated and computational sequence design by applying advanced tools and pipelines for codon optimization, regulatory element tuning, and multi-parameter construct optimization. Establish and manage vendor relationships to support both internal and external capabilities, helping projects move forward efficiently and minimizing disruptions.

Join the esteemed team at Harvard University as a Research Assistant I in the Department of Molecular and Cellular Biology. This full-time position offers an exciting opportunity to contribute to groundbreaking research in the sciences. You will assist in various research projects, working closely with senior researchers to gather and analyze data, prepare reports, and participate in laboratory activities.

Join Scismic, a dynamic biotech startup located in Cambridge, MA, that is at the forefront of developing innovative mRNA-modulating therapies aimed at treating a wide array of genetic disorders. Our research is focused on leveraging novel platforms to address neurological conditions, heart disease, and muscular dystrophies.Position Summary:As a Research Associate specializing in cellular neurobiology, you will play a crucial role in establishing cellular assays to validate in vitro proof of concept for our tRNA therapeutic candidates. Your expertise will be instrumental in characterizing cellular activities and understanding disease-relevant biology, ultimately guiding the prioritization of candidates for in vivo studies.

Nuclera develops technology to make proteins more accessible for researchers. Based in Cambridge, UK, with a presence in Boston, the company’s eProtein Discovery™ platform brings together a benchtop instrument, cloud-based software, and proprietary cartridges. This system supports rapid protein expression, characterization, and purification for life science teams around the world. Role overview The Research Associate in Service Fulfillment supports custom scientific projects and DNA construct amplification using the eProtein Discovery Platform. The role requires careful adherence to Standard Operating Procedures (SOPs) and detailed work instructions to maintain quality and consistency. Success in this position calls for strong organizational skills, attention to detail, and the ability to work independently within set timelines. What you will do Prepare DNA constructs for cell-free protein expression using PCR techniques. Perform protein purification, quantification, SDS PAGE analysis, and either gel filtration chromatography or Surface Plasmon Resonance (SPR) analysis. Run experiments with the eProtein Discovery Platform. Follow established SOPs and work instructions to ensure quality standards are met. Organize and manage large collections of biological samples in a systematic way. Document experimental methods, observations, and results with precision.

Flagship Pioneering, Inc. is seeking a Senior Research Associate in Chemical Biology for its FL116 team in Cambridge, MA. FL116 is dedicated to advancing biomolecule synthesis and is building a platform to transform the manufacturing of research, diagnostic, and therapeutic molecules. Role overview This position joins a collaborative group focused on applying chemical strategies to biological questions. The work centers on enzyme-mediated biomolecular synthesis, with careful attention to both mechanistic and molecular aspects. Main responsibilities Design and execute high-throughput experiments to investigate enzyme-substrate interactions Characterize biomolecular products using a range of established and new analytical methods Contribute to the development of scalable assays that support the growth of the platform Requirements Strong hands-on experimental skills and a close attention to detail Curiosity about the chemical nature of biological systems Interest in manipulating and measuring biological activity at the molecular scale Comfort working in an execution-focused, pipeline-driven environment Motivation to develop with a rapidly evolving technology platform Work environment The role provides the opportunity to deepen expertise at the intersection of chemistry and biology in a collaborative startup setting, supported by Flagship Pioneering. The team values problem solvers who enjoy tackling complex scientific challenges and building new tools for biotechnology and therapeutics.

Join us at Integrated Resources, Inc. as an Associate Scientist II specializing in Cell Culture. In this pivotal role, you will contribute to groundbreaking research and development in a collaborative environment. You will be responsible for executing cell culture experiments, analyzing data, and ensuring adherence to quality standards.

Serif Biomedicines, Inc., based in Cambridge, MA, is a privately-held biotechnology company developing gene therapy approaches for diseases without current effective treatments. Founded by Flagship Pioneering, the company is part of a network that includes organizations such as Moderna, Syros Pharmaceuticals, and Evelo Biosciences. Role overview This Research Associate position centers on cell biology research, with a focus on understanding how nucleic acids function within cells. The role is laboratory-based and involves close collaboration with a multidisciplinary team. What you will do Culture and maintain a range of cell lines, including immune and non-immune cells. Design, perform, and refine assays to study nucleic acid function in primary cells and established cell lines in vitro. Communicate experimental plans and results through presentations and written reports, maintaining thorough electronic lab records. Work both independently and as part of a diverse research team.

We are seeking a dedicated and detail-oriented Research Associate I / Cell Culture Technician to join our dynamic team. This role is pivotal in supporting our research initiatives through precise cell culture techniques and laboratory procedures. The ideal candidate will be responsible for maintaining cell lines, performing assays, and assisting in various research projects.

Join our team as a Biology Scientist, where you will engage in groundbreaking research and development in the field of biology. You will collaborate with a talented group of scientists and contribute to innovative projects that aim to advance our understanding of biological processes. This is an exciting opportunity to be part of a dynamic environment that fosters creativity and scientific inquiry.

Join us as a Senior Scientist in Computational Biology at Flagship Pioneering, Inc. In this pivotal role, you will leverage your expertise to drive innovative research and development in computational biology, contributing to groundbreaking discoveries and advancements in the field.

Nuclera, based in Cambridge, UK, develops tools to improve protein accessibility for researchers. The company’s eProtein Discovery Platform combines a benchtop instrument, cloud software, and proprietary cartridges to accelerate protein workflows in life sciences. Role overview The Laboratory Technician - Service Fulfillment supports custom projects and DNA construct amplification using the eProtein Discovery Platform. This role involves following standard operating procedures and detailed work instructions to help achieve project goals within set timelines. What you will do Amplify DNA constructs for both customer and internal projects Carry out custom laboratory work using the eProtein Discovery Platform Follow SOPs and work instructions to ensure consistency and quality Organize and track samples as well as monitor project progress Work to meet deadlines in a laboratory where priorities may change quickly Requirements Background in protein science, molecular biology, or a related discipline Experience in an industry laboratory setting Keen attention to detail and strong organizational skills Ability to work accurately when facing tight deadlines Location This position is based in Cambridge, England, United Kingdom.

GT Biosciences is on the cutting edge of biotechnology, developing Deliveromics, the world’s first AI-driven, high-throughput, multiplexed in vivo data engine designed to decode the complexities of drug delivery. Established by a team of MIT scientists and supported by elite investors, we are pioneering next-generation, non-viral, cell-type-specific delivery vehicles, achieving notable advancements in crossing the blood-brain barrier and targeting specific brain cell types. Our dedicated and fast-paced team is committed to revolutionizing routine in vivo cell reprogramming.We are seeking a passionate and skilled Spatial Biology Platform Scientist to join our Platform Development Team. In this pivotal role, you will leverage your extensive knowledge in spatial biology, nucleic acid sequencing, and assay development to enhance our Deliveromics platform. As an early member of our scientific team, your collaborative efforts across biology, chemistry, and engineering will be crucial in generating high-quality data and insights driving our innovations. This full-time, in-person position is based in Cambridge, MA.

Harvard University's Department of Molecular and Cellular Biology seeks a Staff Scientist to join its research team in Cambridge. This role centers on advancing scientific understanding in molecular biology through direct involvement in research projects. Role overview The Staff Scientist will work closely with faculty and fellow researchers, contributing to the design and execution of experiments. Responsibilities include developing research strategies, conducting laboratory work, and analyzing experimental data. Collaboration Collaboration is a key part of this position. The team values open communication and shared problem-solving as they pursue new discoveries in molecular and cellular biology. Impact This role supports scientific progress by helping to shape and carry out experiments that expand the field's knowledge base. The work performed will directly influence ongoing and future research directions within the department.

Role Overview Flagship Pioneering, Inc. is on the lookout for a visionary Senior/Executive Director to serve as the Head of Biology. In this pivotal role, you will spearhead the biological strategy and target validation within our causality-driven discovery platform. Your expertise will be essential in converting human genetic data—such as GWAS, rare variants, Mendelian randomization, and functional genomics—into robust biological validations that are pertinent to disease, while also shaping preclinical programs across a range of therapeutic areas. The ideal candidate will possess extensive target validation experience across various therapeutic modalities, with a strong emphasis on neurodegenerative diseases (including Parkinson’s disease), genomic perturbation tools, and the capability to make significant contributions to cardiovascular and immune-mediated biology. You will be responsible for building and mentoring an exceptional biology team, establishing high standards for scientific rigor and decision-making quality, and collaborating closely with data science, chemistry, and platform operations to progress targets to development readiness.