Senior Scientist, Computational Chemistry Specialist

Amylyx Pharmaceuticals Inc. is on a bold mission to innovate the treatment landscape for diseases with significant unmet needs. Instead of viewing challenges as roadblocks, we embrace them as opportunities to advance solutions with urgency, scientific rigor, and a steadfast commitment to the communities we serve. As a clinical-stage company, we are currently addressing conditions such as post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).Our mission thrives on the passion of our people. We embody core values of audacity, curiosity, authenticity, engagement, and accountability, fostering a culture of care. With a seasoned team ready to make impactful changes, we invite you to join us in this endeavor if you share our enthusiasm for tackling some of the most challenging issues in medicine.The OpportunityAmylyx Pharmaceuticals Inc. is seeking a seasoned Senior Director of Chemistry, Manufacturing, and Controls (CMC) to lead our CMC organization in the development of our pipeline, including Phase III synthetic peptide Avexitide and Phase I antisense oligonucleotide AMX0114. The CMC team partners with external CDMOs to implement robust, scalable, and compliant processes for clinical and commercial supply. This role may involve direct leadership or managing leads of internal matrix CMC Asset teams, serving as the CMC representative on Asset program teams. This leader will collaborate across functions to drive technical excellence and ensure CMC alignment with program objectives.The ideal candidate will exhibit strong strategic leadership while actively engaging in hands-on execution as needed. This position reports to the Senior Vice President of Global CMC and External Manufacturing.

Your Impact at Lila Sciences The Director of Discovery Chemistry will spearhead the design, synthesis, and optimization of small molecules across Lila’s discovery platform, emphasizing organic synthesis, molecular design, and scalable chemistry execution. This pivotal role will cultivate and expand a premier molecular chemistry program that translates AI-generated molecular hypotheses into high-quality, synthetically viable, and functionally validated chemical entities. Collaboration is key, as you will work closely with Lila’s AI, automation, computational biology, and platform teams to establish the chemistry infrastructure necessary to swiftly advance novel molecules from conception to validated candidates across diverse discovery initiatives. You will drive synthetic strategy, route design, analog generation, molecular property optimization, and chemistry-enabled innovation while ensuring seamless integration with robotic synthesis and platform-based experimentation. This leadership position is crucial in shaping Lila’s molecular discovery engine by leveraging deep expertise in synthetic organic chemistry, molecular design, and data-driven experimentation to expedite the discovery of high-value molecules for therapeutic and broader platform applications. What You Will Be Building Lead the discovery chemistry strategy across programs, focusing on small molecule design, synthetic innovation, analog generation, and optimization of chemical matter. Oversee the design and implementation of synthetic routes for novel small molecules, prioritizing speed, robustness, scalability, and compatibility with automated synthesis platforms. Develop and enhance efficient workflows for molecular design, compound prioritization, analog generation, and iterative design–make–test cycles in partnership with AI and computational teams. Collaborate closely with automation and platform teams to establish robotic and high-throughput chemistry capabilities that expand accessible chemical space and accelerate molecule generation. Guide the selection of reagents, reaction modalities, and synthetic methodologies to facilitate rapid exploration of structurally diverse and functionally relevant chemical entities.

Company Overview Fulcrum Therapeutics, Inc. (NASDAQ: FULC) is a pioneering clinical-stage biopharmaceutical company dedicated to developing innovative small molecules aimed at enhancing the quality of life for patients with genetically defined rare diseases. We are steadfast in our mission to provide hope and new treatment alternatives for individuals afflicted by rare hematologic disorders and are actively expanding our pipeline of clinical and preclinical assets. Our flagship clinical asset, pociredir, represents a groundbreaking small molecule engineered to boost fetal hemoglobin expression, offering potential treatment for sickle cell disease and other hemoglobinopathies. We are seeking a dynamic and strategic leader to direct our Analytical Chemistry function as we grow our portfolio of clinical-stage assets. Position Overview In this pivotal role, reporting to the Head of Technical Operations, the Director of Analytical Chemistry will spearhead the formulation and implementation of control strategies for the manufacture of drug substances and products within Fulcrum’s developmental programs. The successful candidate will provide expert oversight of all Quality Control (QC) operations at contract manufacturers for drug substances (DS) and drug products (DP). Responsibilities include collaborating with pharmaceutics on pre-formulation tasks, engaging with Quality Assurance (QA) on Out of Specification (OOS) and Out of Trend (OOT) investigations, managing CMC risks, and assisting Regulatory CMC in drafting essential sections of regulatory submissions. Key Responsibilities Deliver technical leadership to Contract Manufacturing Organizations (CMOs) and Contract Research Organizations (CROs) for drug substance and product development, incorporating cGMP method development, validation, method transfer, method remediation, data analysis, and reporting to uphold compliance with GCP, GLP, and cGMP standards. Collaborate with cross-functional teams including Drug Substance, Drug Product, QA, and Regulatory CMC to ensure plans are cohesive, phase-appropriate, and timely. Design and oversee stability studies, including managing shelf-life and retest dates, to guarantee uninterrupted clinical supply. Lead and manage strategies for reference standards, in-process controls, and specifications throughout the asset pipeline. Review and approve a diverse array of documents, such as Test Methods, Qualification/Validation Protocols, Specifications, and Reports at CMOs. Generate, review, and authorize documentation related to the control of DS and DP for Regulatory submissions (IND/IMPD and NDA/MAA). Travel to contract manufacturing sites both domestically and internationally to support crucial production milestones and foster strong business relationships.

Scholar Rock is a pioneering biopharmaceutical company dedicated to discovering, developing, and delivering transformative therapies for individuals battling serious diseases with significant unmet needs. Renowned as a global authority in the biology of the transforming growth factor beta (TGFβ) superfamily, our clinical-stage organization is passionately focused on advancing innovative treatments that are fundamentally reliant on protein growth factors. Over the last decade, we have cultivated a robust pipeline aimed at elevating the standard of care for neuromuscular diseases, cardiometabolic disorders, cancer, and various conditions where growth factor-targeted drugs can have a revolutionary impact. Scholar Rock proudly stands as the sole company to have demonstrated clinical proof of concept for a muscle-targeted therapy in spinal muscular atrophy (SMA). Our commitment to unlocking novel therapeutic avenues is driven by the extensive application of a proprietary platform that has developed unique monoclonal antibodies designed to modulate protein growth factors with remarkable precision. By leveraging cutting-edge science in disease areas that have traditionally been overlooked by conventional therapies, we strive each day to create new possibilities for patients. To learn more about our innovative approach, visit ScholarRock.com and follow us on Twitter and LinkedIn.Position Overview:We are actively seeking a highly experienced and driven Senior Director of Global Quality Control to join our team. This pivotal role reports directly to the Head of Global Quality and serves as the senior leader responsible for establishing and maintaining a scalable, phase-appropriate, and inspection-ready global QC strategy across a fully outsourced development and manufacturing network. The Senior Director will provide both strategic and technical leadership for Quality Control activities carried out through external contract laboratories, CMOs, and other testing partners, supporting drug substance, drug product, raw materials, in-process, release, and stability programs.

Scholar Rock is a pioneering biopharmaceutical organization dedicated to the discovery, development, and provision of transformative therapies aimed at addressing significant unmet medical needs for individuals suffering from serious health conditions. As a frontrunner in understanding the biology of the transforming growth factor beta (TGFβ) superfamily of cell proteins, our clinical-stage company is devoted to advancing innovative treatments that leverage the fundamental role of protein growth factors. Over the last decade, we have established a robust pipeline that aims to elevate the standard of care for conditions such as neuromuscular diseases, cardiometabolic disorders, cancer, and other illnesses where growth factor-targeted therapies can make a substantial difference. Scholar Rock is distinctively positioned as the only company to showcase clinical proof of concept for a muscle-targeted therapy in spinal muscular atrophy (SMA). Our unwavering commitment to exploring fundamentally novel therapeutic strategies is fueled by our proprietary platform, which has successfully developed innovative monoclonal antibodies designed to modulate protein growth factors with remarkable selectivity. By applying cutting-edge scientific advancements in traditionally under-addressed disease areas, we strive daily to forge new possibilities for patients. Discover more about our approach at ScholarRock.com and follow us on @ScholarRock and LinkedIn.Position Overview:Scholar Rock is actively seeking a highly skilled and technically adept Senior Director of Drug Product External Manufacturing to spearhead the external manufacturing of drug products across our portfolio of biologics, which includes monoclonal antibodies, fusion proteins, and bispecifics. In this pivotal role, you will lead and supervise all drug product manufacturing operations conducted through external contract manufacturing organizations (CMOs). This position is essential for ensuring the efficient production, quality assurance, and timely delivery of both clinical and commercial products, in alignment with our organizational objectives and stringent regulatory requirements. The ideal candidate will possess extensive expertise in biopharmaceutical manufacturing, demonstrate strategic leadership capabilities, and exhibit a strong aptitude for managing complex global operations.

Your Impact at LilaThe Senior Scientist in Analytical Chemistry will spearhead the development and application of cutting-edge analytical and characterization techniques to bolster Discovery Chemistry initiatives across Lila’s innovative platform. This role is pivotal in facilitating the swift design, synthesis, screening, and optimization of small molecules and related molecular entities. You will be instrumental in producing high-quality, informative experimental data that guides chemistry decisions and enhances platform learning.By collaborating closely with teams in Discovery Chemistry, automation, AI/computational fields, and screening, you will establish and scale multimodal characterization workflows that surpass conventional analytical chemistry methodologies. Your expertise will help create an integrated analytical framework that includes compound characterization, reaction monitoring, molecular profiling, and rapid data generation to support fast-paced design–make–test–analyze cycles.Your contributions will be vital in molding Lila’s next-generation discovery engine, merging profound analytical chemistry knowledge with high-throughput experimentation and AI-driven workflows.

Flagship Pioneering’s Pioneering Medicines (PM) initiative focuses on creating new therapies for serious diseases by integrating multiple scientific platforms. The team aims to address significant unmet medical needs through advanced biopharmaceutical R&D. Role overview The Executive Director, CMC (Chemistry, Manufacturing & Controls) will provide both strategic and operational leadership across the full PM portfolio, spanning research through late-stage clinical development. This position reports to the SVP, CMC & Technical Operations and plays a central role in shaping CMC as a core strength for Pioneering Medicines. This leader will develop long-term CMC strategies, resolve technical challenges at both the portfolio and program levels, and define approaches for emerging modalities. Building and managing a top-tier network of external Contract Development and Manufacturing Organizations (CDMOs) is a key part of the role. The Executive Director will also guide resource allocation and promote adoption of innovative, including AI-enabled, CMC tools. Key responsibilities Serve as a senior member of the Technical Operations leadership team, overseeing CMC areas such as Drug Substance Development, Drug Delivery/Pre-formulation, Analytical Development, Product Development, and Regulatory CMC. Responsible for CMC strategy and portfolio deliverables. Grow and guide the CMC organization by recruiting, developing, and retaining talent. Foster a culture focused on excellence, accountability, and ongoing improvement. Lead end-to-end CMC processes for a diverse and expanding portfolio of multimodality compounds. Ensure timely advancement of programs and proactively identify and manage portfolio-level CMC risks. What sets this role apart This position sits at the intersection of science, strategy, and operations. The Executive Director will influence how Pioneering Medicines approaches new therapeutic modalities and will be recognized as a thought leader in the field, especially in adopting innovative methodologies and digital tools.

About Lila Sciences Lila Sciences stands at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory, dedicated to life sciences, chemistry, and materials science. Our mission is to revolutionize the scientific method by harnessing AI capabilities to tackle humanity's most pressing challenges in health, climate, and sustainability. Discover more about our vision at www.lila.ai. At Lila, we foster a culture of collaboration and inclusivity, encouraging diverse perspectives and creative problem-solving within our teams. We believe that all contributions matter and strive to create an environment where every voice is valued. If you resonate with our values and are excited about the possibility of contributing, we encourage you to apply even if you meet only some of the qualifications below. Your Impact at Lila As a Scientist on our Physical Sciences team, you will play a pivotal role in developing innovative flow chemistry workflows. You will design, construct, and optimize cutting-edge flow chemistry platforms, seamlessly integrating real-time analytics and AI-driven decision-making. Collaborating closely with systems engineers and AI scientists, you will enhance our autonomous chemistry capabilities and expedite discovery processes at an unprecedented scale. What You Will Create Design & Commission: Architect and develop versatile flow chemistry platforms for autonomous synthesis, ensuring seamless integration with the Lila platform.

Your Impact at LilaAs an intern in Analytical Chemistry, you will play a vital role in our analytical lab operations. You will be responsible for developing analytical methods, acquiring precise data, and working collaboratively with scientists and engineers to advance the field of autonomous chemistry. Your contributions will directly support closed-loop optimization campaigns, significantly expediting the transition from concept to discovery. This position emphasizes hands-on involvement.What You Will Be DevelopingDesign and implement high-throughput optimization cycles for chemical analysis.Employ Process Analytical Technology (PAT) to monitor reaction progress and final products (solids, liquids, gases), while refining methods for analytical screening.Collaborate with scientists to review and benchmark product profiles, propose subsequent closed-loop cycles, and carry out quality controls, with reporting on findings.Maintain a digital log of experimental conditions, metadata, and outcomes to ensure data integrity for AI-driven analysis.Adhere to Environmental Health and Safety (EHS) protocols when handling reagents, maintaining flow equipment, and calibrating analytical instruments.

Relay Therapeutics is seeking a dynamic and experienced Director of Analytical Development and Quality Control to lead our analytical efforts in drug development. In this leadership role, you will oversee the development and implementation of analytical methods to support our innovative drug discovery pipeline. You will work closely with cross-functional teams to ensure optimal quality control processes and regulatory compliance.Your expertise will play a critical role in driving our mission to improve the lives of patients through cutting-edge therapies.

Join Isomorphic Labs as the Head of Chemistry in Drug Design, where you will be at the forefront of innovative drug discovery. You will lead a talented team of chemists, collaborating with interdisciplinary groups to design and optimize drug candidates. Your expertise will guide the development of cutting-edge pharmaceutical solutions that have the potential to transform patient outcomes.

Join our dynamic team at Turner Townsend as a Cost/Senior Cost Controller in a collaborative hybrid working environment. We are looking for a skilled individual who is adept at managing project costs, ensuring financial accuracy, and providing insightful analysis to enhance decision-making.Your role will involve close collaboration with project teams, offering financial guidance and oversight to ensure projects are delivered on time and within budget. You will leverage your expertise in cost management to facilitate effective financial reporting and forecasting.

Your Impact at Lila The Scientist I/II, Process Chemistry will utilize cutting-edge process chemistry methodologies to enhance Discovery Chemistry initiatives across Lila’s diverse platform. This role emphasizes reaction and reactor engineering, process design, high-throughput experimentation, and digital chemistry workflows aimed at small molecules and associated molecular constructs. We seek a hands-on scientist who possesses a robust background in synthetic and process chemistry, complemented by an engineering mindset and experience in developing scalable, data-driven experimental workflows. Collaboration is key in this role; you will work closely with teams in Discovery Chemistry, analytical chemistry, automation, platform engineering, and AI/computational science to design, implement, and refine reaction and process workflows. These improvements will enhance the speed, reliability, and scalability of chemical transformations. The Scientist I/II will play a crucial role in bridging early-stage discovery chemistry with contemporary process development by establishing efficient, digitally enabled, and automation-friendly methods for reaction screening, process optimization, and chemistry execution. This position is perfect for a scientist passionate about the convergence of chemistry, engineering, high-throughput technologies, process intensification, and digital experimentation and eager to contribute to the evolution of next-generation process chemistry capabilities beyond traditional methods. What You Will Be Building Design, execute, and optimize process-relevant chemical transformations that advance Discovery Chemistry programs and the creation of small molecules. Develop reaction and process workflows with a focus on engineering rigor, scalability, reproducibility, throughput, and data integrity. Implement high-throughput experimentation (HTE) for reaction screening, process optimization, condition scouting, and assessment of process-relevant variables. Create and execute workflows that integrate reaction setup, process screening, workup, analytical readout, and data capture into streamlined experimental cycles. Contribute to the design of digitally enabled process chemistry workflows, including structured experimental data generation, electronic documentation, and the integration of chemistry data into computational and AI-ready systems. Collaborate with automation and platform teams to refine reaction and process workflows for robotics-enabled experimentation.

Join Flagship Pioneering Inc. as the Director/Senior Director of Compensation, where you will lead the strategic development and execution of our compensation programs. Your role will involve designing competitive compensation structures, ensuring alignment with industry standards, and driving initiatives that enhance employee engagement and performance. You will collaborate with senior leadership to shape compensation policies that reflect our commitment to attracting and retaining top talent.

About Flagship Pioneering, Inc. Flagship Pioneering is at the forefront of innovation, dedicated to inventing and nurturing platform companies that have the potential to revolutionize human health, sustainability, and more. Since our inception in 2000, we have successfully launched over 100 companies that tackle some of the world's most pressing challenges, such as vaccinating billions against COVID-19, curing difficult diseases, enhancing human health, preventing illness, and improving agricultural resilience and sustainability. Our commitment to impactful innovation has earned us recognition on FORTUNE's 'Change the World' list, highlighting companies that make a significant social and environmental impact, and we have appeared on Fast Company's annual list of the World’s Most Innovative Companies. Position Summary: We are looking for a passionate and experienced individual to join our Communications and Public Affairs team as the Senior Director of Communications. In this role, you will spearhead the development and implementation of communications and branding strategies for a selection of companies within Flagship Pioneering's diverse portfolio. The ideal candidate will possess a robust background in biotech corporate communications and excel in a fast-paced, startup atmosphere. This is a remarkable opportunity to influence the trajectory of groundbreaking life sciences and technology firms across human health, agriculture, and AI sectors. This full-time role requires in-office presence four days a week in Cambridge, MA. Key Responsibilities: Provide strategic counsel to the founders and leadership of emergent Flagship companies (Flagship NewCos) in developing their brand, voice, foundational messaging, and overall communication strategies. Oversee brand development, visual identity, and website design for NewCos, collaborating with external agencies. Create and implement tailored, integrated communication strategies for company launches, encompassing all written content, media engagement, and social media components. Manage PR agency support as necessary. Develop and execute communication strategies for both NewCos and more established companies (Flagship GrowthCos), including milestone announcements, internal communications, social and digital media strategies, speaking opportunities, and issue management, in close collaboration with company leadership.

Your Impact at Lila As a Scientist I/II in Organic Chemistry, you will play a pivotal role in the development, execution, and optimization of cutting-edge chemical transformations that enhance Discovery Chemistry initiatives across Lila Sciences. Your focus will be on the rapid synthesis of small molecules and a diverse range of chemical compounds. This position is tailored for an experimental organic chemist who possesses a robust foundation in synthetic chemistry, complemented by practical experience in high-throughput experimentation (HTE), reaction workup, and analytical characterization. Collaborating closely with teams specializing in Discovery Chemistry, analytical chemistry, automation, screening, and AI/computational methods, you will aid in constructing and implementing efficient chemistry workflows designed to expedite molecular design–make–test–analyze cycles. The Scientist II will be integral to reaction development, analog generation, and route execution utilizing contemporary organic chemistry techniques that are compatible with scalable, data-driven, and increasingly automated discovery environments. This role is ideal for a chemist passionate about addressing synthetic challenges at the intersection of reaction innovation, high-throughput experimentation, process efficiency, and analytical insight, and who is driven to contribute to the evolution of next-generation discovery workflows that extend beyond conventional bench chemistry. What You'll Be Building Design and optimize chemical transformations pertinent to Discovery Chemistry programs, with a strong emphasis on the swift synthesis of small molecules and analog series. Utilize modern synthetic organic chemistry methodologies to facilitate efficient exploration of a wide spectrum of structurally diverse and medicinally relevant chemical spaces. Plan and execute multi-step synthesis, reaction optimization, workup, purification, and compound characterization to support molecular discovery campaigns. Develop and implement HTE workflows aimed at reaction screening, condition optimization, reagent evaluation, and rapid assessment of transformation scopes. Establish robust methodologies for reaction setup, workup, sample preparation, and analytical readout to support rapid and information-rich experimentation. Employ analytical tools such as chromatography, NMR, and other related methods to evaluate reaction performance, characterize products, and inform synthetic strategies. Contribute to the evolution of practical and scalable chemistry workflows that integrate reaction discovery, optimization, and downstream compound generation.

Lila Sciences, located in Cambridge, MA, develops technology for chemical discovery through its autonomous science platform. The company’s projects include advanced synthesis, new catalyst development, and sustainable molecular design for applications in energy and industry. The Chemistry experiment team is searching for a Technical Program Manager to coordinate complex scientific programs in close partnership with the Chemistry domain lead and teams across the organization. Role overview This position centers on managing the daily operations and long-term planning for the Chemistry experiment team. The Technical Program Manager will keep project plans up to date, monitor milestones, and help ensure scientific programs meet both deadlines and quality standards. Acting as the main point of contact between Chemistry and platform partners, such as Automation, Machine Learning, and Engineering, the role involves communicating needs, aligning priorities, and making sure dependencies are clear and managed. What you will do Maintain project plans, track progress, and ensure delivery of scientific programs on schedule and to quality expectations. Coordinate with cross-functional partners to communicate requirements, align on priorities, and track dependencies. Break down scientific goals into actionable workstreams to support scalable autonomous experimentation. Lead program routines, including sprint planning, stand-ups, and retrospectives, with a focus on purposeful meetings and clear documentation. Work with Chemistry leads to surface and address blockers, risks, and interdependencies early in the process. Support execution of commercial contracts by collaborating with the Product & Revenue team, ensuring commitments are defined, tracked, and communicated. Assist with capacity planning and resource coordination alongside scientific leadership. Requirements At least 10 years of program or project management experience in chemistry, pharmaceuticals, or deep tech sectors. Bachelor’s degree in Chemistry, Chemical Engineering, or a related discipline. Proven ability to manage several programs in complex, evolving environments. Experience building programs from the ground up and working in early-stage startups is a strong plus. Skilled in coordinating with both scientific and operational teams, and managing cross-functional groups.

Role overview Lila Sciences seeks a Scientist I/II in Drug Delivery Chemistry for its Cambridge, MA location. This role centers on advancing drug delivery systems that align with the company’s broader research objectives. Key responsibilities Collaborate with fellow researchers to design and refine drug delivery technologies. Apply chemistry expertise to enhance scientific strategies and laboratory processes. Contribute to projects focused on improving patient outcomes through innovative drug delivery solutions. Location This position is based in Cambridge, Massachusetts.

Scholar Rock is a pioneering biopharmaceutical entity dedicated to the discovery, development, and delivery of transformative therapies aimed at addressing significant unmet medical needs. As a recognized leader in the biology of the transforming growth factor beta (TGFβ) superfamily, and inspired by the structural resemblance of a scholar rock to protein formations, our clinical-stage company is devoted to advancing groundbreaking treatments that leverage protein growth factors. Over the last decade, we have established a robust pipeline designed to redefine the standard of care for conditions such as neuromuscular diseases, cardiometabolic disorders, and cancer, where growth factor-targeted therapies can make a substantial impact. Scholar Rock stands out as the sole organization demonstrating clinical proof of concept for a muscle-targeted therapy in spinal muscular atrophy (SMA). Our commitment to unlocking innovative therapeutic pathways is underscored by the extensive application of our proprietary platform, which has yielded novel monoclonal antibodies to selectively modulate protein growth factors. By harnessing cutting-edge scientific advancements in traditionally underserved disease areas, we strive each day to create new possibilities for patients. Discover more about our mission at ScholarRock.com and connect with us on @ScholarRock and LinkedIn.Position Overview:As Scholar Rock embarks on a pivotal phase with the impending launch of our inaugural commercial product, we are in search of a strategic and operationally-savvy Senior Director of Global Facilities. This role transcends purely administrative functions; we require a visionary builder who comprehends the intricacies of scaling infrastructure within a rapidly evolving biotech setting while adeptly navigating day-to-day operational challenges.With facilities strategically located worldwide and poised for future growth, you will be responsible for ensuring our environments are safe, compliant, efficient, and conducive to supporting both research and commercial initiatives. If you are a proactive self-starter who thrives in dynamic, transformative organizations and is eager to contribute significantly, this opportunity allows you to apply your expertise, learn extensively, and make a meaningful impact.