Senior Research Associate in Formulation Development

Join our innovative team at Flagship Pioneering, Inc., where we are dedicated to advancing biopharmaceutical technologies. We are seeking a Senior Scientist in LNP Formulations who will play a key role in the development of lipid nanoparticle (LNP) formulations. This position offers the opportunity to work on cutting-edge research and contribute to the creation of next-generation therapeutics.

We are seeking a highly motivated Associate Scientist specializing in LNP (Lipid Nanoparticle) formulations. The ideal candidate will be involved in the development and optimization of LNP delivery systems for mRNA therapeutics. You will work collaboratively within our dynamic team to design experiments, analyze data, and contribute to innovative solutions in the biotechnology field.

Join Nuvalent as the Senior Manager of Formulation Sciences, where you will play a pivotal role in advancing our innovative drug development pipeline. In this leadership position, you will oversee the formulation and development of new therapeutic candidates, guiding projects from conception through to clinical phases. Collaborate with cross-functional teams to ensure the successful translation of scientific research into viable products.

Join GT Biosciences, a pioneering techbio startup based in Cambridge, MA, dedicated to revolutionizing drug delivery through our innovative Deliveromics platform. We are seeking a passionate and multidisciplinary LNP Scientist to join our team, focusing on the advancement of cutting-edge non-viral delivery technologies.In this pivotal role, you will spearhead the design and development of novel ionizable lipids and engineer ligand-conjugated lipid nanoparticle formulations. Your expertise will support in vivo screening for Deliveromics and evaluate performance through both in vitro assays and in vivo animal models. You will be responsible for experimental planning, execution, data analysis, interpretation, and effectively communicating results.As one of the earliest scientific hires at this innovative startup, you will play a crucial role in shaping platform development and collaborating across various disciplines to create transformative solutions for genetic medicine delivery. This is a full-time, in-person position based in Cambridge, MA.

Your Contribution at Lila Sciences Lila Sciences is actively seeking a dedicated (Senior) Research Associate to become an integral part of our dynamic Life Sciences team. This pivotal role will be centered around the formulation of lipid nanoparticles (LNPs), their functionalization with targeting ligands, and the characterization of the resulting targeted LNPs (tLNPs). The ideal candidate will possess substantial hands-on experience in LNP formulation and characterization, bioconjugation, protein characterization, and automation technologies. Your expertise will significantly enhance our understanding of the delivery space, enabling a high-throughput closed-loop screening cascade for tLNPs. You will work collaboratively with professionals across protein, cell biology, automation, chemistry, machine learning, and data science teams to establish advanced tools for targeted nucleic acid delivery. Your Key Responsibilities Design, execute, and characterize LNP formulations utilizing various scales and mixing modalities (e.g., DLS, ribogreen, TNS). Develop and optimize high-throughput ligand conjugation and purification methodologies, leveraging automation and robotics to maximize throughput. Collaborate with cell assay and antibody experts to screen candidates across diverse tissue targets in in vivo models. Engage with chemists, biologists, engineers, and data scientists to document processes, share insights, and refine best practices in autonomous flow chemistry. Create, implement, and uphold Standard Operating Procedures (SOPs) for both existing and emerging lab processes. Your Qualifications for Success MSc in Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences, or a closely related field with 3+ years of hands-on experience in targeted LNP production or a BSc with 5+ years of relevant experience. Industry experience is highly desirable. Strong proficiency in bioanalytical techniques (e.g., DLS, fluorescence spectroscopy, electrophoresis, in vitro assays). Experience in protein and antibody design and characterization. Familiarity with automation and high-throughput workflows is preferred. Exceptional troubleshooting, communication, and collaboration skills, with a proven ability to work effectively across interdisciplinary teams. About Lila Sciences Lila Sciences is at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory focused on life sciences, chemistry, and materials science. We are pioneering a new era of limitless discovery by harnessing AI capabilities to enhance every facet of the scientific method. Our mission is to leverage scientific superintelligence to address humanity's most pressing challenges.

Join our innovative team as a Senior Scientist where you'll drive critical research projects and make a significant impact in the field. We are seeking a highly motivated individual with a passion for scientific discovery and a strong background in relevant disciplines.

Company Overview Flagship Labs 110 Inc. (FL110) is an innovative, privately held technology company at the forefront of developing a fully integrated, end-to-end platform that revolutionizes proteomics. Our cutting-edge platform combines advanced bioengineering, machine learning, and bespoke microelectronics to deliver unparalleled precision and insights. Backed by Flagship Pioneering, we possess the vision, courage, and resources to achieve extraordinary results. Our culture fosters collaboration and creativity, making it essential for team members to embrace diverse perspectives and an inclusive mindset. If you are excited by the prospect of working in such an environment and possess some of the qualifications listed below, we encourage you to apply. Position Overview: We are looking for a passionate and skilled (Senior) Scientist, Nanopore to become part of our dynamic team. The level for this position is flexible based on experience. Your primary focus will be on the advancement of nanopore sensing technologies, contributing to the development of a nanopore-based protein reading system. As a key member of a cross-functional team, you will collaborate closely with chemists, bioinformaticians, software developers, and hardware engineers. The ideal candidate will have a robust background in nanopore technology, particularly in protein translocation, along with either relevant experience in the biotechnology sector or a proven record of scientific accomplishment.

Join us as a Senior Scientist in Computational Biology at Flagship Pioneering, Inc. In this pivotal role, you will leverage your expertise to drive innovative research and development in computational biology, contributing to groundbreaking discoveries and advancements in the field.

Join Artech Information Systems LLC as a Scientist in Cambridge, where you will contribute to groundbreaking research and innovative solutions in a collaborative environment. Your expertise will help drive scientific advancements and enhance our projects.

Are you passionate about advancing the field of machine learning? Join our team at Altos Labs as a Machine Learning Scientist or Senior Machine Learning Scientist. In this role, you will leverage your expertise to drive innovation and development in cutting-edge research projects. Collaborate with a multidisciplinary team to push the boundaries of machine learning technology.

Role overview Bicycle Therapeutics seeks a Senior Scientist specializing in Computational Chemistry to join the team in Cambridge. The position focuses on using computational methods to design and optimize new therapeutic candidates, directly supporting the company’s goal of developing new medicines. What you will do Lead molecular modeling studies for ongoing drug discovery projects. Use advanced simulation techniques to analyze and predict molecular behavior. Collaborate with scientists from various disciplines to integrate computational insights into laboratory research. Share research findings through publications and presentations at scientific meetings and conferences. Requirements Extensive experience with computational chemistry methods and tools. Strong foundation in molecular modeling and simulation. Proven ability to work effectively within cross-functional teams. Drive to advance drug discovery using computational science.

Your Impact at LilaThe Senior Scientist in Analytical Chemistry will spearhead the development and application of cutting-edge analytical and characterization techniques to bolster Discovery Chemistry initiatives across Lila’s innovative platform. This role is pivotal in facilitating the swift design, synthesis, screening, and optimization of small molecules and related molecular entities. You will be instrumental in producing high-quality, informative experimental data that guides chemistry decisions and enhances platform learning.By collaborating closely with teams in Discovery Chemistry, automation, AI/computational fields, and screening, you will establish and scale multimodal characterization workflows that surpass conventional analytical chemistry methodologies. Your expertise will help create an integrated analytical framework that includes compound characterization, reaction monitoring, molecular profiling, and rapid data generation to support fast-paced design–make–test–analyze cycles.Your contributions will be vital in molding Lila’s next-generation discovery engine, merging profound analytical chemistry knowledge with high-throughput experimentation and AI-driven workflows.

Company Summary:At FL122, we are at the forefront of pioneering genomic technologies that redefine human health and assisted reproduction. Founded by the innovative Flagship Pioneering, we are dedicated to creating, funding, and nurturing first-in-category life sciences companies. Our portfolio includes over 100 groundbreaking companies developed over the past two decades, such as Moderna (MRNA), Generate Biomedicines, Tessera Therapeutics, and Quotient Therapeutics. We pride ourselves on being an equal opportunity employer.Position Summary:We are in search of our inaugural Computational Genomics Scientist to spearhead vital research that will underpin our scientific platform. As an early-stage team member, you will enjoy significant ownership of your work, shaping our analytical strategy from the ground up by integrating genomics, statistical genetics, and advanced modeling techniques. Your responsibilities will encompass the comprehensive delivery of computational research projects, including design, execution, interpretation, and communication of results to senior leadership. We seek a resourceful individual who thrives in a fast-paced, agile environment and possesses a proactive mindset. The ideal candidate will combine technical expertise with a growth-oriented approach, meticulous attention to detail, and a relentless drive for excellence. Collaboration is essential in our startup environment, where all team members work closely to push the boundaries of scientific discovery.

Company Overview: At Flagship Labs 103, Inc., we are revolutionizing healthcare by shifting the paradigm of disease diagnosis and intervention. Our innovative technological and computational platforms are designed to detect cellular dynamics from minimally invasive biospecimens, allowing us to connect individuals with the most effective interventions to prevent the onset and progression of diseases. We are dedicated to enhancing patient outcomes through advanced research methodologies. Position Summary: We are looking for a dynamic and experienced Senior Scientist to lead our bioconjugation initiatives and propel FL103’s programs to new heights. The ideal candidate is a self-starter with a strong commitment to producing high-quality data in a fast-paced, innovative research environment. You will play a pivotal role in supporting our ongoing bioconjugation projects across various research and development domains. Key Responsibilities: Design, synthesize, purify, and analyze oligonucleotide-conjugates for antibodies and other modalities, while developing and optimizing conjugation protocols utilizing both established and novel chemistries and technologies as part of our assay development platform. Work collaboratively with the assay development team to refine and enhance conjugates to support FL103’s scientific endeavors. Participate in a cross-functional team to oversee project timelines, deliver regular updates, and communicate progress effectively within the team. Establish and nurture strong working relationships with key collaborators across the company to further discovery research activities toward pre-clinical development. Contribute to the creation of research reports and presentations for internal project teams, leadership, and external stakeholders. Maintain organized and detailed lab notebooks and batch records.

Innovate and Create Models from Scratch! At Flagship Pioneering, we are dedicated to launching pioneering companies that challenge the status quo. Within our Flagship Labs, small, agile teams develop new technical theses, rigorously test them, and build ventures around groundbreaking concepts. We are assembling an exceptional machine learning team within our newly established venture, Flagship Labs 120. Our focus is on uncovering hidden structures from complex measurement data of intricate physical systems, often necessitating mechanism-informed modeling, carefully designed inductive biases, and principled methodologies for inverse problems. This is a pioneering role dedicated to innovative modeling, moving beyond standard optimization tasks. You will have the opportunity to design, prototype, test, and refine novel approaches that establish the technical foundation of our platform starting from day one.

About Serif Biomedicines, Inc. Serif Biomedicines, Inc. is a privately held biotechnology company in Cambridge, MA. The team is developing new approaches to gene therapy for diseases that current medical solutions cannot address. Serif Biomedicines was founded by Flagship Pioneering, known for launching over 100 innovative life sciences organizations focused on human health and sustainability. Role Overview The Senior Scientist, Molecular Biology will design and develop next-generation DNA constructs for programmable medicine. This position suits scientists experienced in synthetic biology, high-throughput cloning, and computational sequence engineering. The role centers on building scalable platforms for plasmid DNA design, construction, and optimization, using automation, algorithm-driven sequence design, and data-centric workflows. This scientist will report to the Director of Molecular Biology and may supervise a direct report. Collaboration with other scientists and group leaders across the R&D team is a key part of the job. What You Will Do Lead the design and construction of plasmid DNA constructs, including vector architecture, gene synthesis strategies, and high-efficiency cloning (such as Gibson, Golden Gate, and recombination-based methods). Advance automated and computational sequence design by applying advanced tools and pipelines for codon optimization, regulatory element tuning, and multi-parameter construct optimization. Establish and manage vendor relationships to support both internal and external capabilities, helping projects move forward efficiently and minimizing disruptions.

Join AbbVie, a global biopharmaceutical company, as a Senior Scientist I in our Neuroscience division specializing in Biologics Screening. In this role, you will lead innovative research efforts to develop therapies that address unmet medical needs in the field of neuroscience.

Imagine... being part of an innovative organization that cultivates and develops life sciences companies dedicated to pioneering groundbreaking technologies aimed at revolutionizing health care and sustainability. Company Overview Expedition Medicines is a dynamic, privately held, early-stage biotechnology company at the forefront of the Protein Editing field. We specialize in creating small molecules that modify protein structure and function to target currently undruggable options across various therapeutic strategies. Our advanced platform combines cutting-edge small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to facilitate generative design. Backed by Flagship Pioneering, we leverage their vision, courage, and resources to propel Expedition Medicines from platform validation to impactful patient solutions. We seek passionate, collaborative, and determined problem solvers to join our mission! Role Overview: The Senior/Principal Scientist in Structural Biology will concentrate on determining protein-ligand complex structures using X-ray crystallography and cryo-electron microscopy (cryo-EM). This role involves delivering structural insights and collaborating with project teams to advance structure-based drug design and uncover the mechanisms of action of small molecules. Key Responsibilities: Design and implement structural biology strategies for multiple projects. Oversee the design, expression, and purification of protein constructs for structural determination. Develop and execute protocols to achieve high-quality crystals for X-ray crystallography. Create and implement protocols for grid optimization, data collection, and analysis in cryo-EM. Refine and communicate structures of protein-ligand complexes, collaborating with project teams to drive hit-to-lead and lead optimization processes. Manage contract research organizations (CROs) to ensure efficient delivery of protein expression and structural biology services. Enhance our capabilities and serve as a trusted authority in the field of structural biology.

Company Overview: Korro Bio is a pioneering biopharmaceutical company dedicated to the development of innovative genetic medicines targeting both rare and common diseases through its proprietary RNA editing technology. Our mission is to revolutionize the field of genetic medicine by utilizing RNA editing to create precise and temporary modifications at the RNA level rather than DNA, thereby enhancing specificity and long-term tolerability. With a portfolio of unique programs, we aim to leverage our expertise in oligonucleotide-based approaches to deliver therapies that improve patient outcomes. Based in Cambridge, Massachusetts, we are committed to combining cutting-edge science with a collaborative spirit to achieve transformative results in human health.At Korro, we thrive on collaboration, driven by our vision to create impactful genetic solutions for widespread health challenges. Our core values—Rewrite the Future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity—are woven into every aspect of our work culture, guiding our hiring practices and daily interactions. Join our team to help redefine the possibilities in genetic medicine and contribute to lasting health advancements.Position Overview: We are searching for a Senior Scientist to enhance our growing CMC team at Korro Bio. This role will involve overseeing the management of CMO analytical labs as well as the development of analytical methods, impurity characterization, degradation pathway analysis, and the transfer, qualification, and validation of methods for RNA-based therapies. You will play a crucial role in maintaining the quality and stability of drug substances and products throughout their development lifecycle. Collaborating closely with cross-functional teams and external partners, you will ensure that analytical data meets regulatory filing requirements and supports clinical trial progress.