Senior Program Manager, Commercial

KAYAK, a proud member of Booking Holdings (NASDAQ: BKNG), stands as a prominent leader in the travel search engine industry. With billions of search queries across our platforms, we excel at helping travelers discover their ideal flights, accommodations, rental vehicles, and vacation packages. Additionally, we're redefining business travel through our innovative corporate travel solution, KAYAK for Business.As part of the KAYAK team, you will join a dynamic travel organization that encompasses a portfolio of globally recognized metasearch brands, including momondo, Cheapflights, and HotelsCombined. From our humble beginnings to our current status as an industry power, innovation is at our core, and every employee has the chance to leave a lasting impact. Our commitment is to create the best travel search engine, simplifying the process for everyone to explore the world.We are on the lookout for a Senior Director of Flight Commercial Partnerships to spearhead and expand our North American flight commercial strategy. This pivotal role is crucial for driving revenue growth, optimizing margins, and establishing long-term strategic value across various partnerships, including airlines, OTAs, consolidators, ancillary services, and distribution channels throughout the region.You will oversee the entire commercial lifecycle for flight partnerships in North America — from strategic planning and deal structuring to execution, optimization, and ongoing relationship management. The ideal candidate will possess in-depth expertise in travel distribution, coupled with robust analytical skills and a sophisticated grasp of airline revenue management, OTA economics, and fare systems infrastructure.If you are an astute problem solver who challenges assumptions, identifies structural inefficiencies, and devises commercially viable solutions that drive revenue and competitive advantages, we are eager to connect with you!This role requires in-office presence at our Cambridge, MA location for at least 3 days a week.

Join KAYAK, a leading travel search engine, part of Booking Holdings (NASDAQ: BKNG), where billions of queries across our platforms help travelers discover their ideal flight, accommodation, rental car, and vacation package. We're also innovating business travel with KAYAK for Business.At KAYAK, you will engage with a renowned portfolio of global metasearch brands, including momondo, Cheapflights, and HotelsCombined. Our journey from startup to industry leader is driven by innovation, empowering every employee to leave their mark. We are dedicated to developing the ultimate travel search engine to simplify global exploration.We are looking for a Senior Director of Flight Commercial Partnerships to spearhead and expand our North American flight commercial strategy. This pivotal role focuses on driving revenue growth, enhancing margins, and delivering long-term strategic value through airline, OTA, consolidator, ancillary, and distribution partnerships throughout the region.In this role, you will manage the complete commercial lifecycle for flight partnerships in North America—encompassing strategy, deal structuring, execution, optimization, and sustained relationship management. The ideal candidate will possess profound travel distribution knowledge, exceptional analytical skills, and a deep understanding of airline revenue management, OTA economics, and fare systems infrastructure.If you are a pragmatic problem solver who challenges assumptions, identifies structural inefficiencies, and devises commercially viable solutions that unlock revenue and competitive advantages, we would love to hear from you!This position requires presence in our Cambridge, MA office three days a week.

Amylyx Pharmaceuticals, Inc. is a clinical-stage company in Cambridge, MA, dedicated to developing treatments for diseases with significant unmet needs. The current pipeline focuses on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). The team values urgency, scientific rigor, boldness, curiosity, authenticity, engagement, and accountability. Role overview The Senior Director of Human Resources Business Partner – Commercial will report to the SVP of Human Resources and Talent Acquisition. This leader will work closely with the Chief Commercial Officer and the Commercial Leadership Team to shape, scale, and strengthen a high-performing commercial group. The role centers on aligning HR strategies with business needs as Amylyx prepares for commercial scale-up and key data milestones. Key responsibilities Advise the Chief Commercial Officer and Commercial Leadership Team to ensure HR initiatives support business objectives. Lead efforts to build and enhance the commercial function, supporting both corporate and field-based teams. Provide broad HR Business Partner support across the company, including Clinical, Technical Operations, and G&A functions as needed during the initial phase. Balance strategic leadership with hands-on HR work in a resource-limited and adaptive setting. Adapt responsibilities as the company grows, transitioning from broad HRBP support to a more specialized commercial HR leadership focus as milestones are achieved. What success looks like HR strategies effectively aligned with commercial and company-wide goals. Strong partnerships built with commercial and cross-functional leaders. Ability to navigate and support a streamlined, evolving organization. Demonstrated flexibility and willingness to handle both strategic and operational HR responsibilities. Location This position is based in Cambridge, MA.

Join Harvard University as a Senior Partnerships Manager, where you will play a vital role in fostering collaborations that drive innovation and impact. You will be responsible for strategizing, managing, and enhancing partnerships across various sectors. Your expertise will help in identifying opportunities, negotiating agreements, and ensuring mutual benefits for all stakeholders involved.

Amylyx Pharmaceuticals is on a bold mission to revolutionize the treatment of diseases that have significant unmet needs. We view challenges as opportunities to pursue with urgency, scientific rigor, and an unwavering commitment to the communities we serve. As a clinical-stage company, we are dedicated to tackling complex conditions including post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).Powered by our dedicated team, our core values—be audacious, be curious, be authentic, be engaged, and be accountable—foster a caring culture. We are seeking passionate individuals who are eager to confront some of medicine’s most pressing challenges. If you are ready to take action, we invite you to explore the opportunity below and apply.The OpportunityThe Senior Director of Market Insights is a pivotal leadership role that will drive the comprehensive insights strategy to facilitate U.S. commercialization and global expansion. As the strategic owner of the insights function, you will ensure the integration of market intelligence, analytics, and evidence generation into corporate decision-making throughout the product lifecycle.Reporting to the Vice President of Commercial Operations, you will be a key advisor to both commercial and executive leadership, shaping strategies with insights that guide launch readiness, lifecycle management, and portfolio prioritization. This role requires adeptness at both strategic and operational levels, building scalable frameworks to support a multi-asset, multi-market organization.

Your Impact at Lila Sciences Lila Sciences is seeking a highly experienced Director of Federal Strategy and Capture to leverage senior agency relationships and deep knowledge of policy to establish impactful government partnerships and achieve funding successes. As a key member of our Government Partnerships team, you will play a crucial role in shaping the competitive landscape before formal opportunities arise, assessing the trajectory of the federal funding environment, and facilitating connections that require authentic scientific and policy expertise. This position focuses on capture strategy rather than policy development, and requires an individual with extensive federal experience. What You Will Be Building Named Account Ownership - Cultivate, manage, and elevate senior relationships with agencies such as DOE, ARPA-E, NIH, and other relevant U.S. mission agencies, ensuring the health and growth of these connections over time. Opportunity Shaping - Engage with agencies proactively to influence the development of funding opportunities before they are released as RFPs, aligning them with Lila’s strategic goals. Cross-Agency Narrative Development - Collaborate with the Head of Government Partnerships to connect Lila’s initiatives with national science priorities and create a prioritized federal funding pipeline. Institution Building - Assist in establishing Lila’s federal capture function, including tracking relationships, managing the pipeline, and systematically engaging with agencies over time. What You’ll Need to Succeed Extensive U.S. federal experience at the intersection of science, policy, and strategy, including roles within agencies, the National Security Council, interagency, or equivalent backgrounds. Strong scientific understanding in life sciences, biotechnology, or related fields. A proven ability to translate relationships into tangible outcomes, such as funded programs, formal partnerships, or procurement channels. Experience in establishing new government functions, programs, or divisions from the ground up. Ability to thrive in a dynamic, resource-limited environment where you are building processes as you go. Bonus Points For Familiarity with federal funding mechanisms—such as OTAs, cooperative agreements, SBIRs, and BAAs—and adeptness at positioning a company favorably within each. Established relationships within DOE, ARPA-E, DARPA, BARDA, DoD, NSC, or interagency networks in bioeconomy and biosecurity. Experience in startup environments, particularly within government contracting or partnerships. Salary Range: $168,000 - $238,000 annually.

Join Flagship Pioneering Inc. as the Director/Senior Director of Compensation, where you will lead the strategic development and execution of our compensation programs. Your role will involve designing competitive compensation structures, ensuring alignment with industry standards, and driving initiatives that enhance employee engagement and performance. You will collaborate with senior leadership to shape compensation policies that reflect our commitment to attracting and retaining top talent.

About Flagship Pioneering, Inc. Flagship Pioneering is at the forefront of innovation, dedicated to inventing and nurturing platform companies that have the potential to revolutionize human health, sustainability, and more. Since our inception in 2000, we have successfully launched over 100 companies that tackle some of the world's most pressing challenges, such as vaccinating billions against COVID-19, curing difficult diseases, enhancing human health, preventing illness, and improving agricultural resilience and sustainability. Our commitment to impactful innovation has earned us recognition on FORTUNE's 'Change the World' list, highlighting companies that make a significant social and environmental impact, and we have appeared on Fast Company's annual list of the World’s Most Innovative Companies. Position Summary: We are looking for a passionate and experienced individual to join our Communications and Public Affairs team as the Senior Director of Communications. In this role, you will spearhead the development and implementation of communications and branding strategies for a selection of companies within Flagship Pioneering's diverse portfolio. The ideal candidate will possess a robust background in biotech corporate communications and excel in a fast-paced, startup atmosphere. This is a remarkable opportunity to influence the trajectory of groundbreaking life sciences and technology firms across human health, agriculture, and AI sectors. This full-time role requires in-office presence four days a week in Cambridge, MA. Key Responsibilities: Provide strategic counsel to the founders and leadership of emergent Flagship companies (Flagship NewCos) in developing their brand, voice, foundational messaging, and overall communication strategies. Oversee brand development, visual identity, and website design for NewCos, collaborating with external agencies. Create and implement tailored, integrated communication strategies for company launches, encompassing all written content, media engagement, and social media components. Manage PR agency support as necessary. Develop and execute communication strategies for both NewCos and more established companies (Flagship GrowthCos), including milestone announcements, internal communications, social and digital media strategies, speaking opportunities, and issue management, in close collaboration with company leadership.

Scholar Rock is a pioneering biopharmaceutical entity dedicated to the discovery, development, and delivery of transformative therapies aimed at addressing significant unmet medical needs. As a recognized leader in the biology of the transforming growth factor beta (TGFβ) superfamily, and inspired by the structural resemblance of a scholar rock to protein formations, our clinical-stage company is devoted to advancing groundbreaking treatments that leverage protein growth factors. Over the last decade, we have established a robust pipeline designed to redefine the standard of care for conditions such as neuromuscular diseases, cardiometabolic disorders, and cancer, where growth factor-targeted therapies can make a substantial impact. Scholar Rock stands out as the sole organization demonstrating clinical proof of concept for a muscle-targeted therapy in spinal muscular atrophy (SMA). Our commitment to unlocking innovative therapeutic pathways is underscored by the extensive application of our proprietary platform, which has yielded novel monoclonal antibodies to selectively modulate protein growth factors. By harnessing cutting-edge scientific advancements in traditionally underserved disease areas, we strive each day to create new possibilities for patients. Discover more about our mission at ScholarRock.com and connect with us on @ScholarRock and LinkedIn.Position Overview:As Scholar Rock embarks on a pivotal phase with the impending launch of our inaugural commercial product, we are in search of a strategic and operationally-savvy Senior Director of Global Facilities. This role transcends purely administrative functions; we require a visionary builder who comprehends the intricacies of scaling infrastructure within a rapidly evolving biotech setting while adeptly navigating day-to-day operational challenges.With facilities strategically located worldwide and poised for future growth, you will be responsible for ensuring our environments are safe, compliant, efficient, and conducive to supporting both research and commercial initiatives. If you are a proactive self-starter who thrives in dynamic, transformative organizations and is eager to contribute significantly, this opportunity allows you to apply your expertise, learn extensively, and make a meaningful impact.

The Opportunity: Join Relay Therapeutics as a Senior Medical Director, where you will be pivotal in propelling our clinical pipeline from IND to proof of concept and ultimately to registration. In this role, you will partner with senior medical staff to shape clinical strategies, design clinical trials, and ensure successful execution. Collaborating across various functions including clinical project management, regulatory affairs, clinical operations, biostatistics, data management, and medical writing, you will significantly contribute as Relay Therapeutics continues to advance product candidates into clinical settings. You will provide clinical leadership to R&D teams and closely collaborate with Development leadership. We are open to remote employees

Your Role at Lila Sciences Lila Sciences stands at the forefront of scientific innovation, operating as the world’s first scientific superintelligence platform and autonomous laboratory dedicated to life sciences, chemistry, and materials science. Our mission is to revolutionize the process of scientific discovery by seamlessly integrating AI into every facet of the scientific method, empowering researchers to address humanity’s most pressing challenges in health, climate change, and sustainability at unprecedented speed and scale. Position Overview As the Director/Senior Director of Applied AI, you will spearhead the establishment of our foundational Applied AI team, responsible for refining and adapting our AI models for practical product deployment. You will ensure their safe integration with diverse customer datasets and oversee the development of high-performance interfaces, including chat experiences and inference endpoints like gRPC, HTTP, and PCP servers. Reporting directly to the CTO, you will manage the complete roadmap from data acquisition to model deployment, collaborating closely with Research, Product, Software, Application, Safety, and Security teams to deliver models that are functional, quantifiable, and dependable. Key Responsibilities Lead and mentor a high-performing Applied AI team to produce exceptional scientific reasoning models for consumer applications. Manage an end-to-end model customization pipeline to generate impactful models from Lila’s base models for high-value applications, including inference, chat, and API integration. Develop a comprehensive evaluation framework to facilitate ongoing model enhancement and performance optimization. Collaborate with cross-functional teams to define project requirements, deliver customer proofs of concept (POCs), and transition successful pilots into scalable products. Establish technical standards, documentation, and incident response protocols for AI systems in production. Recruit, mentor, and foster a diverse and inclusive team environment. Qualifications for Success 8+ years of experience in applied machine learning or ML systems, with a minimum of 3 years in a leadership role; proven track record of deploying large language models (LLMs) into production. Extensive experience in fine-tuning and evaluating large-scale models for customer interactions. Production inference expertise, including familiarity with serving frameworks (Triton, vLLM, TGI, Ray, Kubernetes), GPU orchestration, caching, and observability. Strong understanding of data privacy and security best practices in multi-tenant systems. Preferred Qualifications Experience with instruction fine-tuning and optimization techniques. Proficiency in developing chat user experiences, implementing guardrails, tool/function calling, and managing long-context interactions.

Your Impact at Lila Sciences As a pivotal member of the legal team at Lila Sciences, the Commercial Counsel (Director/Associate Director) will play a crucial role in developing and expanding our legal capabilities within a rapidly evolving technology landscape. This position is characterized by high levels of ownership and engagement, focusing on the structuring and negotiation of diverse commercial agreements while providing expert legal guidance on matters involving artificial intelligence, scientific research, and advanced technology development. You will collaborate cross-functionally with teams in science, engineering, business development, and operations to support Lila's mission of accelerating discovery through AI. We are seeking an experienced and entrepreneurial attorney with 6–10 years of legal experience—someone who is passionate about operating at the intersection of law, AI, and science. You should excel in environments requiring both accuracy and innovation, be adept at navigating uncertainty, and possess strong judgment and empathy in collaborative problem-solving. If you are enthusiastic about constructing scalable legal frameworks, deeply engaging with emerging technologies, and transforming the legal practice through AI, this opportunity is for you.

Company Overview:Atavistik Bio is a leading, privately-held biotechnology firm at the forefront of developing groundbreaking precision allosteric therapeutics aimed at addressing significant unmet medical needs. With our innovative AMPS™ platform, we swiftly uncover functional cryptic pockets across various target classes, enhancing the speed of medicine development. Our growing portfolio of allosteric therapeutics shows promise for superior efficacy and tolerability, leveraging the unique advantages of allostery.Atavistik Bio is spearheaded by a team of seasoned drug hunters with extensive experience in bringing marketed small molecule therapies to fruition, backed by distinguished investors including The Column Group, Nextech Invest, Lux Capital, and Regeneron Ventures.Position Overview:We are on the lookout for a dynamic and strategic Senior Director of Toxicology to become a vital member of our development team. This role involves collaborating with a passionate group of adept scientists within a vibrant, rapidly evolving organization. Reporting directly to the Chief Scientific Officer, the successful candidate will oversee the design, execution, and analysis of all nonclinical safety studies essential for discovery, IND-enabling, and late-stage clinical development. This position will lead toxicology efforts across diverse programs, ensuring the delivery of high-quality data packages for regulatory submissions. Join us in shaping a pioneering toxicology function in an exhilarating clinical-stage environment.

Join Amylyx Pharmaceuticals, Inc. as the Senior Director of Patient Services, where you will lead initiatives aimed at enhancing patient experience and access to our innovative treatments. You will be responsible for developing and implementing strategic plans that prioritize patient needs, while collaborating with cross-functional teams to ensure the highest quality of services is delivered.

Scholar Rock is a pioneering biopharmaceutical company dedicated to discovering, developing, and delivering transformative therapies for patients with serious diseases that exhibit significant unmet needs. Renowned globally for our expertise in the biology of the transforming growth factor beta (TGFβ) superfamily, we are committed to advancing innovative treatments where protein growth factors are critical. Over the last decade, we have built a robust pipeline that has the potential to redefine the standard of care for neuromuscular diseases, cardiometabolic disorders, cancer, and various other conditions where growth factor-targeted therapies can make a significant impact.Scholar Rock uniquely demonstrated clinical proof of concept for a muscle-targeted treatment in spinal muscular atrophy (SMA). Our dedication to exploring fundamentally different therapeutic avenues is driven by the innovative application of our proprietary platform, which has produced novel monoclonal antibodies that modulate protein growth factors with remarkable precision. By leveraging cutting-edge scientific research in disease areas historically underserved by conventional treatments, we work tirelessly to create new opportunities for patients. Discover more about our approach at ScholarRock.com and follow us on @ScholarRock and on LinkedIn.Position Overview:The Director or Senior Director of Regulatory Strategy, reporting directly to the Senior Vice President, Global Head of Regulatory Affairs, will be responsible for formulating and executing the global regulatory strategy for designated clinical and pipeline programs. As a subject matter expert, this individual will engage with program teams to identify regulatory risks and opportunities, thereby informing strategic direction and planning. The ideal candidate will spearhead interactions with regulatory authorities, overseeing the preparation and submission of all regulatory documentation and correspondence.

Join AbbVie as a Senior Director of Search & Evaluation in Neuroscience, where you will lead transformative initiatives in drug discovery and development. You will play a pivotal role in evaluating innovative neuroscience projects and establishing strategic partnerships that will drive our mission to improve patient outcomes.

Scholar Rock is a pioneering biopharmaceutical firm dedicated to discovering, developing, and delivering transformative therapies for individuals facing serious diseases with significant unmet medical needs. Renowned globally for its expertise in the biology of the transforming growth factor beta (TGFβ) superfamily, Scholar Rock is committed to advancing innovative treatments that leverage protein growth factors. Over the last decade, the company has built a robust pipeline poised to elevate the standard of care for neuromuscular diseases, cardiometabolic disorders, cancer, and other conditions where growth factor-targeted therapies can make a significant impact. Notably, Scholar Rock is the sole entity to demonstrate clinical proof of concept for a muscle-targeted treatment for spinal muscular atrophy (SMA). This commitment to pioneering unique therapeutic approaches is supported by a proprietary platform that has engineered novel monoclonal antibodies to selectively modulate protein growth factors. By applying state-of-the-art science in disease areas that have traditionally been overlooked by conventional therapies, Scholar Rock strives every day to forge new possibilities for patients. Discover more about the company's innovative approach at ScholarRock.com and follow @ScholarRock and on LinkedIn.Position Overview:The Senior Director of Patient Marketing (U.S.) will assume a pivotal leadership role in the strategic preparation and execution of Scholar Rock's inaugural U.S. commercial launch. This position is responsible for formulating and implementing the U.S. marketing strategy aimed at patients and caregivers for apitegromab, the first and only muscle-targeted therapy for spinal muscular atrophy (SMA).This individual will spearhead the U.S. patient brand strategy from launch through commercialization, ensuring a thoroughly patient-centric approach encompassing education, engagement, and community outreach. The Senior Director will oversee the creation of integrated, compliant, multi-channel patient programs designed to foster awareness, understanding, and empowerment throughout the patient journey.As a key member of the U.S. Marketing Team, this role will collaborate closely with Patient Services, Medical Affairs, Advocacy, Market Access, Legal, Regulatory, and Compliance teams to guarantee a cohesive and high-quality experience for patients and caregivers. This position is high-impact and high-visibility, requiring a strategic mindset and a passion for patient advocacy.

Role overview The Senior Director of Business Analytics at Scholar Rock will play a central role in shaping the company's analytics strategy. Based in Cambridge, MA, this leader will drive efforts to support business growth and enable data-informed decision-making throughout the organization. What you will do Create and implement analytics strategies that support Scholar Rock’s goals Work closely with teams across the company to move data-driven projects forward Encourage and foster a strong analytics mindset among colleagues Use business analytics expertise to help set strategic direction and find ways to improve how the company operates Location This role is located in Cambridge, MA.

At Iterative Health, we are pioneering healthcare technology and services that accelerate clinical research to enhance patient outcomes. Our Iterative Health Site Network comprises over 70 premier clinical research facilities across the US and Europe, dedicated to expediting the market introduction of innovative therapies for gastrointestinal (GI) and hepatology conditions. We are committed to bolstering the success of our partner sites by equipping them with tech-driven services. By merging extensive expertise in clinical trials with advanced AI technology, we empower research teams and study sponsors to broaden and accelerate access to groundbreaking therapeutics for patients in need.About the RoleWe are redefining clinical trial methodologies in Inflammatory Bowel Disease (IBD), and we are on the lookout for a dynamic commercial leader to amplify our impact. As the Director of Life Sciences, you will steer the next phase of Iterative Health’s growth within the biopharma and biotech sectors, cultivating and expanding relationships with our key sponsors.This role is highly visible and client-centric, tailored for a strategic builder who excels at creating value within intricate partnerships, influencing senior stakeholders, and achieving significant outcomes. You will serve as the crucial link between sponsors and Iterative Health’s internal teams, ensuring we meet all commitments while adapting our solutions to the evolving landscape of clinical research.This position is perfect for a relationship-focused commercial leader who thrives in fast-paced environments and enjoys fostering deep, strategic collaborations within the life sciences domain.