Senior / Principal Scientist in Structural Biology

Charles River Analytics, a proud member of the GRVTY family, is at the forefront of developing innovative solutions and advanced technologies designed to address some of the most challenging issues faced globally. Our dynamic team of tech entrepreneurs collaborates to enhance AI, robotics, intelligent sensing, and human-centered computing. The research and technology we develop not only propel government initiatives but also unveil new opportunities in the commercial sector. At Charles River, we take immense pride in cultivating a workplace that attracts and retains top-tier talent and creative problem-solvers in the industry. Join us as we strive to accelerate our mission-driven innovations!We are currently seeking a dedicated Senior/Principal Scientist with expertise in Human-Systems Integration, Human Factors, or Human-Computer Interaction. In this role, you will spearhead the development of cutting-edge tools and interfaces that empower users to effectively collaborate with technology in demanding environments.Your responsibilities will include leading and expanding teams of researchers, designers, and engineers to assess work domains and user needs, create novel human-AI interaction concepts, and evaluate interactive prototypes. You will also be responsible for defining and directing technical projects, while fostering robust relationships with clients, sponsors, and collaborators. As a subject matter expert in Human Systems, you will work alongside multidisciplinary teams to explore and pursue research opportunities across various technical domains.

Charles River Analytics, a proud member of the GRVTY family, is dedicated to developing innovative solutions and cutting-edge technology to address some of the world’s most pressing challenges. Our dynamic team of tech entrepreneurs collaborates to lead advancements in artificial intelligence, robotics, smart sensing, and human-centered computing. Our research and development initiatives not only enhance government programs but also unlock new opportunities within the commercial sector. As part of GRVTY, we are excited to expand our capabilities while maintaining our commitment to excellence in national security domains. Are you ready to join us in accelerating our mission-driven innovations? We would love to hear from you! We are currently seeking a motivated and experienced senior researcher who specializes in Human-Systems Integration, Human Factors, or Human-Computer Interaction. In this role, you will create groundbreaking tools and interfaces that enable users to effectively collaborate with technology in demanding work environments. As a leader, you will guide and expand teams of researchers, designers, and engineers to analyze work contexts and user requirements, develop innovative human-AI interaction concepts, and demonstrate and evaluate interactive prototypes. Your role will involve defining and directing technical projects, fostering strong partnerships with customers, sponsors, and collaborators. Additionally, you will share your expertise in Human Systems, working alongside cross-disciplinary teams to explore new research opportunities in exciting technical fields.

Join us as a Senior Scientist in Computational Biology at Flagship Pioneering, Inc. In this pivotal role, you will leverage your expertise to drive innovative research and development in computational biology, contributing to groundbreaking discoveries and advancements in the field.

Company Summary:At FL122, we are at the forefront of pioneering genomic technologies that redefine human health and assisted reproduction. Founded by the innovative Flagship Pioneering, we are dedicated to creating, funding, and nurturing first-in-category life sciences companies. Our portfolio includes over 100 groundbreaking companies developed over the past two decades, such as Moderna (MRNA), Generate Biomedicines, Tessera Therapeutics, and Quotient Therapeutics. We pride ourselves on being an equal opportunity employer.Position Summary:We are in search of our inaugural Computational Genomics Scientist to spearhead vital research that will underpin our scientific platform. As an early-stage team member, you will enjoy significant ownership of your work, shaping our analytical strategy from the ground up by integrating genomics, statistical genetics, and advanced modeling techniques. Your responsibilities will encompass the comprehensive delivery of computational research projects, including design, execution, interpretation, and communication of results to senior leadership. We seek a resourceful individual who thrives in a fast-paced, agile environment and possesses a proactive mindset. The ideal candidate will combine technical expertise with a growth-oriented approach, meticulous attention to detail, and a relentless drive for excellence. Collaboration is essential in our startup environment, where all team members work closely to push the boundaries of scientific discovery.

Role overview Bicycle Therapeutics seeks a Senior Scientist specializing in Computational Chemistry to join the team in Cambridge. The position focuses on using computational methods to design and optimize new therapeutic candidates, directly supporting the company’s goal of developing new medicines. What you will do Lead molecular modeling studies for ongoing drug discovery projects. Use advanced simulation techniques to analyze and predict molecular behavior. Collaborate with scientists from various disciplines to integrate computational insights into laboratory research. Share research findings through publications and presentations at scientific meetings and conferences. Requirements Extensive experience with computational chemistry methods and tools. Strong foundation in molecular modeling and simulation. Proven ability to work effectively within cross-functional teams. Drive to advance drug discovery using computational science.

ABOUT PIONEERING INTELLIGENCEPioneering Intelligence extends Flagship Pioneering's tradition of launching innovative scientific and computational initiatives. By leveraging the latest advancements in AI, machine learning, and data analytics, we aim to expedite fundamental research and build a diverse portfolio of AI-first companies. As a key player in Flagship's integrated approach to science, entrepreneurship, and investment, we transform groundbreaking concepts into transformative enterprises that enhance AI innovations in human health, sustainability, and more.THE ROLEWe are on the lookout for a Principal Scientist specializing in Embedded Machine Learning and Computational Techniques to spearhead various AI/ML and computational initiatives across early-stage ventures in our company origination process. You will be responsible for defining and executing practical AI strategies, overseeing the development of methodologies and platforms such as systems design, drug design, molecular modeling, systems biology, protein design, and LLM-driven workflows while ensuring the utmost rigor in model development, benchmarking, scaling, and reporting. You will manage cross-functional contributors as necessary, influence the strategic direction of the company, and represent Pioneering Intelligence to venture teams and external partners. The ideal candidate is a proactive, deep thinker who can seamlessly transition between protein design one week and mass spectrometry or docking pipelines the next, while also developing LLM-based agents to automate scientific workflows.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence continues the legacy of Flagship Pioneering by creating innovative scientific and computational ventures. Utilizing advancements in AI, machine learning, and data analytics, our mission is to expedite fundamental research and establish a diverse portfolio of AI-first companies. We integrate science, entrepreneurship, and capital to transform groundbreaking concepts into impactful companies, furthering AI advancements in human health, sustainability, and more. THE ROLE We are on the lookout for a Principal Scientist in Embedded Machine Learning/Computational to spearhead multiple AI/ML and computational projects within early-stage ventures as part of Flagship’s origination process. Your responsibilities will include defining and executing effective AI strategies, leading method and platform advancements (such as systems design, drug design, molecular modeling, systems biology, protein design, and LLM/agentic workflows), and ensuring excellence in model development, benchmarking, scaling, and reporting. You'll collaborate with cross-functional teams, shape the direction of the company, and represent Pioneering Intelligence to both venture teams and external partners. The ideal candidate is a proactive deep diver, capable of transitioning from protein design to mass spectrometry or docking pipelines, and then developing LLM-based agents to streamline scientific workflows.

Position Overview Join our innovative team at Apriori Bio, where we harness the power of computational and data-centric methods to craft groundbreaking antigens and assess vaccine efficacy. Our cutting-edge AI/ML platform, Octavia™, allows us to navigate viral fitness landscapes, anticipate immune evasion patterns, and engineer vaccines that prime the immune system for future challenges. In this role, you will leverage computational techniques—including structural modeling, machine learning, and statistical inference—to enhance our vaccine design initiatives based on insights from Octavia™. Proficiency in protein engineering and immunological datasets is advantageous, alongside a keen interest or background in high-throughput functional genomics, virology, or vaccinology. The Scientist will collaborate closely with both computational and experimental teams to analyze outcomes, formulate hypotheses, and aid in antigen development. This position is perfect for scientists who are eager to engage in a unique learning environment characterized by innovation and interdisciplinary collaboration within a fast-paced startup.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence is a forward-thinking initiative that builds upon Flagship Pioneering's rich history of establishing groundbreaking scientific and computational enterprises. By leveraging cutting-edge advancements in artificial intelligence, machine learning, and data science, we aim to accelerate fundamental research and cultivate a dynamic portfolio of AI-first companies. As an integral part of Flagship's unique model that intertwines science, entrepreneurship, and investment, we transform revolutionary concepts into impactful companies, enhancing AI innovations that contribute to human health, sustainability, and more. THE ROLE We are on the lookout for a Principal Scientist specializing in Embedded Machine Learning and Computational Methods to spearhead various AI/ML and computational initiatives across early-stage ventures within our company origination framework. Your responsibilities will include defining and executing practical AI strategies, overseeing the development of methodologies and platforms (including systems design, drug design, molecular modeling, systems biology, protein design, and LLM-based workflows), and ensuring a high standard of rigor in model development, benchmarking, scaling, and reporting. You will also manage cross-functional teams as necessary, influence the strategic direction of our initiatives, and represent Pioneering Intelligence to venture teams and external collaborators. The ideal candidate is a self-motivated individual with a diverse skill set, capable of transitioning seamlessly from protein design to mass spectrometry or docking pipelines, and then creating LLM-based agents to streamline scientific workflows.

Join our innovative team as a Senior Scientist where you'll drive critical research projects and make a significant impact in the field. We are seeking a highly motivated individual with a passion for scientific discovery and a strong background in relevant disciplines.

Senior Designer, Visual Interaction Design Position Overview: IDEO is seeking a passionate Visual Interaction Designer to join our Cambridge Studio. This role is ideal for individuals who are dedicated to creating thoughtful and elegant user experiences while showcasing strong visual design skills in the interactions people have with intricate systems, software, and services. As a Visual Interaction Designer at IDEO, you will play a key role in shaping the aesthetics, functionality, and behavior of user experiences. You will transform human-centered insights into engaging interactions and interfaces that are not only functional but also visually striking and meaningful. Your work will involve balancing visual excellence with usability, bringing a unique visual voice to each design challenge, and collaborating with a diverse team of multidisciplinary experts. This position is a fantastic opportunity for designers who are self-directed, eager to tackle complex challenges, and committed to continually honing their craft. Key Responsibilities: Contribute to a varied portfolio of projects across numerous industries, encompassing data, experience, interaction, digital product, and service design. Engage in all phases of a project, from research synthesis and concept development to prototyping, refinement, and production-ready execution. Transform human-centered insights into interaction models, visual systems, and polished digital interfaces. Create both “looks-like” and “works-like” prototypes to explore ideas, test assumptions, and communicate concepts effectively to teammates and stakeholders. Collaborate closely with designers from various backgrounds, including design research, business design, industrial design, and communication design, to develop cohesive and holistic user experiences. Design across diverse mediums and contexts such as mobile applications, websites, digital/physical systems, AR/VR, and voice interfaces, always guided by user needs and context. Advocate for high-quality visual and interaction design, fostering a culture of strong craftsmanship, curiosity, and experimentation. Qualifications: A background in visual, interaction, or graphic design related to digital products or experiences is essential. A robust portfolio that showcases visual excellence, thoughtful interaction design, and a clear perspective on typography, color, layout, and motion. Comfortable working at various fidelity levels, from rough explorations to refined, production-ready designs. Experience in producing both low and high fidelity prototypes. Proficiency in contemporary design and prototyping tools (e.g., Figma, Adobe Creative Suite).

Role overview Harvard University seeks a Principal Research Scientist for the Sciences - Chemistry and Chemical Biology department in Cambridge. This role leads research efforts, working closely with faculty and other researchers to advance scientific understanding in chemistry and chemical biology. What you will do Direct research projects in chemistry and chemical biology Collaborate with faculty and research teams on experimental design and analysis Apply innovative methods to address complex scientific questions Contribute to scientific publications and presentations

Our MissionAt Altos Labs, our mission is to rejuvenate cell health and resilience, aiming to reverse diseases, injuries, and the associated disabilities that arise throughout life.For further details, visit our website at altoslabs.com.Our ValuesWe embrace a singular value at Altos: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe hold a firm belief that diverse perspectives are crucial to scientific advancement and inquiry. At Altos, outstanding scientists and industry leaders collaborate from across the globe to further our shared mission. We prioritize creating a sense of belonging, ensuring that every employee feels valued for their unique contributions. We are collectively responsible for maintaining a diverse and inclusive workplace.Your Contributions to AltosIn the role of Senior or Principal Machine Learning Scientist, you will be instrumental in the development of generative AI/ML models for multi-modal, multiscale biology, spanning from virtual cells to agentic target assessment. We seek a hands-on, innovative, and collaborative individual to join our multidisciplinary team of scientists and engineers dedicated to transforming the treatment of aging and disease. The ideal candidate will flourish in a dynamic environment that values teamwork, transparency, scientific excellence, originality, rigor, and integrity.

Company Overview Flagship Labs 110 Inc. (FL110) is an innovative, privately held technology company at the forefront of developing a fully integrated, end-to-end platform that revolutionizes proteomics. Our cutting-edge platform combines advanced bioengineering, machine learning, and bespoke microelectronics to deliver unparalleled precision and insights. Backed by Flagship Pioneering, we possess the vision, courage, and resources to achieve extraordinary results. Our culture fosters collaboration and creativity, making it essential for team members to embrace diverse perspectives and an inclusive mindset. If you are excited by the prospect of working in such an environment and possess some of the qualifications listed below, we encourage you to apply. Position Overview: We are looking for a passionate and skilled (Senior) Scientist, Nanopore to become part of our dynamic team. The level for this position is flexible based on experience. Your primary focus will be on the advancement of nanopore sensing technologies, contributing to the development of a nanopore-based protein reading system. As a key member of a cross-functional team, you will collaborate closely with chemists, bioinformaticians, software developers, and hardware engineers. The ideal candidate will have a robust background in nanopore technology, particularly in protein translocation, along with either relevant experience in the biotechnology sector or a proven record of scientific accomplishment.

Join our dynamic team at Ramboll as a Senior / Principal Electrical Engineer. In this role, you will lead innovative projects, collaborate with a talented team, and contribute to the development of sustainable electrical solutions. Your expertise will be pivotal in driving forward our commitment to excellence in engineering.

Join Harvard University as a Senior Human Resources Consultant, where you will play a pivotal role in shaping the HR strategies that support our diverse and dynamic community. In this full-time position, you will collaborate with various departments to enhance HR practices, drive employee engagement, and ensure compliance with federal and state regulations.

Join Artech Information Systems LLC as a Scientist in Cambridge, where you will contribute to groundbreaking research and innovative solutions in a collaborative environment. Your expertise will help drive scientific advancements and enhance our projects.

Are you passionate about advancing the field of machine learning? Join our team at Altos Labs as a Machine Learning Scientist or Senior Machine Learning Scientist. In this role, you will leverage your expertise to drive innovation and development in cutting-edge research projects. Collaborate with a multidisciplinary team to push the boundaries of machine learning technology.

Your Impact at LilaThe Senior Scientist in Analytical Chemistry will spearhead the development and application of cutting-edge analytical and characterization techniques to bolster Discovery Chemistry initiatives across Lila’s innovative platform. This role is pivotal in facilitating the swift design, synthesis, screening, and optimization of small molecules and related molecular entities. You will be instrumental in producing high-quality, informative experimental data that guides chemistry decisions and enhances platform learning.By collaborating closely with teams in Discovery Chemistry, automation, AI/computational fields, and screening, you will establish and scale multimodal characterization workflows that surpass conventional analytical chemistry methodologies. Your expertise will help create an integrated analytical framework that includes compound characterization, reaction monitoring, molecular profiling, and rapid data generation to support fast-paced design–make–test–analyze cycles.Your contributions will be vital in molding Lila’s next-generation discovery engine, merging profound analytical chemistry knowledge with high-throughput experimentation and AI-driven workflows.