Senior Engineer, Polysaccharide Downstream Process Development

Join Our Mission to Safeguard Humanity!At Vaxcyte, we are pioneering vaccine innovation to safeguard humankind against the severe health impacts of bacterial diseases. Our efforts aim to eradicate or treat infections such as invasive pneumococcal disease, Group A Strep, and Shigella. With a clear and structured path to success, Vaxcyte is poised to make a profound impact in the realm of healthcare. Our Approach: We believe that the manner in which we achieve our goals is as critical as the goals themselves. Our collaborative efforts are anchored by four foundational values: *Rethink Convention: We embrace creativity and diverse perspectives to innovate and continuously improve vaccine delivery methods. *Aim High: We strive to achieve audacious goals, tackling the most complex biologics to protect humanity. *Lead with Heart: Leadership at Vaxcyte is characterized by kindness, inclusivity, and constructive debate to further our business objectives. *Model Excellence: We are committed to integrity, accountability, and clarity in all communications and decision-making processes.Position Summary:The Development organization consists of four specialized Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product, supported by Analytical Development and Formulation Development teams. Vaxcyte is seeking a Senior Associate Scientist (contract) with expertise in microbial fermentation and upstream processing to join our Upstream Polysaccharide Process Development team. The successful candidate will lead experimental design and execution to enhance and optimize polysaccharide manufacturing processes involving microorganisms. A hands-on laboratory background in microbial fermentation is essential, along with a keen willingness to acquire new laboratory skills. This role mandates over 50% of time spent in the lab, requiring the ability to independently document experimental procedures and results in both written and presentation formats. Additionally, the candidate will work closely with cross-functional teams, drafting technical reports and presenting experimental findings.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine development company dedicated to creating high-fidelity vaccines aimed at safeguarding humanity from the dire consequences of bacterial diseases. Our mission is not just to combat but to eradicate or effectively treat serious bacterial infections including invasive pneumococcal disease, Group A Strep, and Shigella. We have a clear, structured path to success, and Vaxcyte is prepared to lead the charge. Our Approach: Our work is defined by our commitment to four core values: *Challenge the Norm: We infuse creativity and diverse perspectives into all aspects of our endeavors to revolutionize vaccine delivery. *Aim High: We strive to achieve our ambitious goal of developing the most complex biologics ever created to protect humanity. *Lead with Empathy: Every team member at Vaxcyte fosters a collaborative environment that prioritizes kindness and constructive debate, propelling our objectives forward. *Exemplify Excellence: The challenges we face demand a collective commitment to integrity, accountability, and transparent communication.Position Overview:We are on the lookout for a highly motivated and detail-oriented Senior Associate Scientist (Contract) to join our Polysaccharide Analytical Development team. The primary focus of this role is to support the analytical testing and characterization of polysaccharide-based drug candidates. The successful candidate will execute and refine various biochemical and chromatographic assays, contribute to method development initiatives, and ensure the generation of high-quality data in alignment with our research and development programs.This position demands robust hands-on experience with HPLC-based techniques, biochemical assays, and analytical software platforms, alongside a steadfast commitment to data integrity, meticulous documentation, and collaborative efforts across functions.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine development company dedicated to engineering high-fidelity vaccines aimed at protecting humanity from the severe and expensive health repercussions of bacterial diseases. Our mission extends to eradicating or effectively treating bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella. With a clear and strategic path to success, Vaxcyte is poised for significant achievements in this critical field. Our Approach Matters! We are driven by four fundamental core values: *RETHINK CONVENTION: We embrace creativity and intellectual diversity across all aspects of our work to innovate and continuously improve vaccine delivery methods. *AIM HIGH: We are committed to achieving our bold goal of developing the most complex biologics ever created for the protection of humanity. *LEAD WITH HEART: At Vaxcyte, we prioritize a kindness-first, inclusive approach to collaboration and rigorous debate to further our business objectives. *MODEL EXCELLENCE: The challenges we face demand our collective commitment to integrity, accountability, equality, and clarity in communications and decision-making.Position Overview:The Development organization consists of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product, all supported by Analytical and Formulation Development teams. Vaxcyte is looking for an Associate Engineer II with a solid foundation in vaccine or biologics process development and manufacturing to join our Polysaccharide Clinical Manufacturing/Process Development team.The successful candidate will provide essential technical support for manufacturing activities in collaboration with our CDMO partners, while actively contributing to process development and validation efforts. This role demands a significant laboratory presence (over 50%) and the capacity to independently execute and document experiments, analyze data, and convey results through technical reports and presentations. The ideal candidate will work collaboratively across departments and may also engage with external CDMO partners to facilitate manufacturing campaigns and process transfers.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine company dedicated to developing high-fidelity vaccines aimed at combating the far-reaching impacts of bacterial diseases. Our mission is not only to eradicate but also to treat serious bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella. Our roadmap to success is clear and meticulously defined, positioning Vaxcyte to make significant strides in global health. At Vaxcyte, what we do is just as important as how we do it! Our collaborative efforts are driven by four core values: *RETHINK CONVENTION: We embrace creativity and intellectual diversity in every aspect of our work to innovate and continuously improve vaccine delivery methods. *AIM HIGH: We embody an audacious ambition to develop the most complex biologics ever attempted for the protection of humanity. *LEAD WITH HEART: At Vaxcyte, everyone leads with kindness and inclusivity, fostering collaboration and spirited debate to advance our business objectives. *MODEL EXCELLENCE: The magnitude of our challenges calls for a collective commitment to integrity, accountability, equality, and clear communication in all decisions.Position Overview:We are on the lookout for a highly skilled Senior Software Engineer with robust full-stack expertise and a strong DevOps inclination. This role is critical in designing, developing, testing, and maintaining scalable web applications that underpin essential business operations.The ideal candidate will demonstrate a solid combination of frontend and backend development skills and a disciplined approach to automation, testing, CI/CD, and production reliability. This position requires technical leadership, architectural foresight, and the capability to promote engineering excellence throughout the software lifecycle.Key Responsibilities:Full-Stack Application DevelopmentDesign, architect, and implement scalable applications using Next.js and React.Create and manage backend services and GraphQL APIs, focusing on schema design and performance enhancement.Maintain high standards of code quality, security, performance, and maintainability.Engage in architectural design reviews and participate in technical decision-making processes.

Join Our Innovative Team at Swift SolarAt Swift Solar, we are dedicated to harnessing the immense potential of solar energy. Our belief is that solar energy can power lives, drive economies, and enhance supply chains while safeguarding our planet against climate change. Although today's solar technology is commendable, we strive for something even better.We are pioneering advancements in solar technology with our revolutionary tandem approach, utilizing perovskite materials to deliver solutions that are not only more efficient than conventional technologies but also adaptable for diverse applications, from space solar to large-scale power generation.As a mission-oriented startup, supported by the US government and backed by esteemed investors, we are committed to a long-term journey in bringing clean energy innovations to the market. Join us in our quest to create cutting-edge solar technologies that will redefine the future of the global solar industry.A Day in the LifeAs a Process Technician on the night shift (10:00 PM – 6:30 AM PST), you will be instrumental in propelling the next wave of solar technology. Your role will involve the operation, refinement, and scaling of our thin-film deposition processes, directly aiding our transition from research and development to high-throughput manufacturing systems.Your night will commence with a detailed review of the previous shift’s notes, executing experimental plans using the lab tools you’ve mastered, and meticulously documenting your findings for the incoming team. Given the nature of the role, you will often need to exercise independent judgment—identifying when to troubleshoot independently or seek assistance from an on-call engineer, ensuring that experiments progress safely and accurately.The position will also entail repetitive, detail-oriented tasks involving procedure adherence, parameter recording, and tool performance monitoring to maintain consistent output. As you gain experience, your responsibilities will expand to include tracking supplies, identifying workflow challenges, refining processes, and preparing comprehensive shift handoff logs to ensure continuity for the day team.Being part of an early-stage startup means your involvement will span various company aspects. You will learn to adapt to new tools, experiments, and processes while contributing to Swift’s growing technical capabilities. In this dynamic environment, you will discover numerous opportunities to enhance your skills and we actively encourage you to seize them.

We are seeking a highly skilled Senior Scientist to join our Research and Development team at Natera in San Carlos, California. In this pivotal role, you will lead innovative projects that contribute to groundbreaking advancements in genetic testing and diagnostics. You will collaborate with cross-functional teams, driving research initiatives that enhance our product offerings and improve patient outcomes.

Supplier Development Engineer, Motors & Magnets | Supply ChainLocation: San Carlos, CA (on-site)About 1XAt 1X, we are revolutionizing the future of work by developing humanoid robots designed to assist humans in overcoming labor shortages and driving efficiency.Role OverviewAs a Supplier Development Engineer focusing on Motors and Magnetic Systems, you will play a pivotal role in ensuring supplier readiness and product quality for the components that power our cutting-edge humanoid robots. Your responsibilities will involve cross-functional collaboration to guarantee that all critical components meet our stringent standards for performance, reliability, and scalability.ResponsibilitiesCollaborate with engineering and sourcing teams to identify and select suppliers based on their capabilities in motor and magnetic component manufacturing.Conduct thorough evaluations of suppliers’ motor winding, rotor/stator assembly, and magnet bonding processes.Ensure suppliers maintain consistency in torque-speed characteristics, thermal performance, and EMI compliance.Assist with rotor balancing, bearing preload setups, and encoder integration.Lead the supplier industrialization process from design through production ramp-up.Support suppliers in tooling, equipment, and process qualifications.Evaluate supplier readiness for vehicle builds and manage production risk effectively.Drive the Advanced Product Quality Planning (APQP) process and support Production Part Approval Process (PPAP) leading up to production initiation.Train suppliers on 1X’s quality systems and review quality documentation for parts.Lead root cause analysis and corrective action initiatives for supplier quality challenges.Monitor and report on supplier quality metrics to ensure ongoing improvement.Utilize lean and quality tools to foster continuous improvement across the supply chain.Willingness to travel up to 40%, domestically and internationally, sometimes on short notice.

Join our dynamic team at Natera, a leading genetics company, as a Senior Network Engineer. In this pivotal role, you will be responsible for designing, implementing, and maintaining our network infrastructure. This position demands a strategic thinker skilled in problem-solving and capable of adapting to the fast-paced environment of a rapidly growing organization.

Join Robust AI as a Senior Robotics Software Engineer specializing in Controls. In this pivotal role, you will design and develop advanced control algorithms for robotics applications, contributing to the next generation of autonomous systems. Collaborate with cross-functional teams to drive innovation and implement cutting-edge solutions that enhance robotic functionality and performance.

Role overview Natera is hiring a Senior Scientist to drive In Vitro Diagnostic (IVD) Product Development at its San Carlos, CA location. This position takes ownership of major projects that shape diagnostic technology and contribute to improvements in patient care. Key responsibilities Guide IVD product development from initial concept through to final implementation. Work closely with cross-functional teams to enhance and refine development processes. Maintain strict adherence to relevant regulatory standards throughout all phases of work. Collaboration and impact This role partners with colleagues from various disciplines to strengthen Natera’s product pipeline and maintain high quality at every stage of development.

Join Our Mission to Protect Humanity!Vaxcyte is a pioneering clinical-stage vaccine development company dedicated to engineering high-fidelity vaccines aimed at safeguarding humanity from the dire impacts of bacterial diseases. Our goal is to eradicate or effectively manage bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella. With a clear and well-defined path to success, Vaxcyte is positioned to achieve remarkable advancements in public health. Our Approach: What we do is just as important as how we do it! Our collaborative efforts are driven by four enduring core values: *RETHINK CONVENTION: We embrace creative and intellectual diversity in our work, innovating and re-innovating the delivery of vaccines. *AIM HIGH: We embody our audacious goal of courageously developing the most complex biologics ever created to protect humanity. *LEAD WITH HEART: Every team member at Vaxcyte leads with a kindness-first, inclusive approach, fostering collaboration and robust discussion that propels our business forward. *MODEL EXCELLENCE: The scale of our challenge necessitates a shared commitment to integrity, accountability, equality, and clarity in communication and decision-making.Position Summary:Vaxcyte is currently seeking a Senior Associate Scientist (Contract) specializing in Conjugation Development. This role will support the development of a robust process for generating our proprietary pneumococcal conjugate vaccine. Responsibilities include reviewing analytical data and electronic notebook entries for accuracy and compliance with standard operating procedures (SOPs). This is a remote, part-time position offering flexible working hours, requiring exceptional organizational skills, clear communication, and meticulous attention to detail.

Founded in 2015, 1X is a pioneering company focused on the development of sophisticated humanoid robots for domestic use. Our vision is to revolutionize labor supply through safe and intelligent humanoids. At 1X, you will take on essential responsibilities, have the opportunity to innovate within our talent acquisition processes, and receive recognition based on your contributions and achievements.We are seeking a Senior Technical Recruiter specializing in Mechanical Engineering to enhance our hiring initiatives across mechanical, electrical, and systems engineering disciplines. This position will involve close collaboration with hardware teams, providing day-to-day recruitment support while expanding your role and influence.Key ResponsibilitiesManage the complete recruiting lifecycle for mechanical, electrical, and systems engineering positions.Collaborate with hiring managers to comprehend technical requirements and team dynamics.Develop and implement effective sourcing strategies targeting hardware and engineering talent.Assist in candidate assessments and facilitate interview calibration across engineering roles.Oversee the entire candidate experience, ensuring a positive and engaging process.Work closely with hiring teams to ensure consistent and effective communication.Continuously refine recruiting processes and enhance candidate pipelines.

About Swift SolarAt Swift Solar, we are dedicated to realizing the immense potential of solar energy. Our vision is to harness solar power to transform lives, energize economies, and bolster supply chains, all while safeguarding the environment against the challenges of climate change. While current solar technologies offer a solid foundation, we believe there is much room for improvement.We are pioneering advanced solar solutions with our innovative tandem technology, utilizing perovskite materials to develop systems that outshine traditional methods in efficiency and versatility. This technology is applicable across a spectrum of settings, from space solar applications to large-scale utility power generation.As a mission-driven startup with support from the US government and premier investors, we are committed to a long-term journey to commercialize groundbreaking clean energy technology. Join our exceptional team as we engineer the next generation of solar technology that will drive the global solar industry forward.A Night in the Life as a Senior Equipment EngineerIn your role as a Senior Equipment Engineer on the night shift, your primary responsibility will be to ensure the seamless operation of Swift's laboratory facilities during off-hours. You will provide hands-on support for our deposition tools and process equipment, ensuring that the morning team arrives to a fully operational lab.Your typical night will involve monitoring SPC dashboards and deposition parameters, promptly identifying and notifying relevant team members of any abnormalities. When equipment specifications are not met, you will decide whether to continue operations, pause, or shut down the machinery, taking the lead on troubleshooting issues such as vacuum instability, plasma fluctuations, or deposition uniformity challenges. You will also restart vacuum systems, review thin-film metrology results, adjust processes, and collaborate with controls engineers to analyze tool logs and PLC data. Throughout your shift, you will mentor and guide process technicians through real-time troubleshooting, helping them gain confidence under pressure.Additionally, you will oversee maintenance of facility equipment, including compressors, gloveboxes, and chilled water systems, manage spare part tracking and consumable forecasts, and recommend operational enhancements. As one of the key night shift team members, you will play a vital role in shaping Swift's continuous operations.

About 1X 1X develops humanoid robots designed to work alongside people, helping address labor shortages and support economic growth. Role Overview The Supplier Development Engineer - Structural Die Casting will strengthen 1X’s supply chain by ensuring suppliers deliver high-quality precision structural components for advanced bipedal humanoids. This role is based on-site in San Carlos, CA. The engineer will play a key part in both launching new products and supporting ongoing production. What You Will Do Work with engineering and sourcing teams to identify and select suppliers skilled in die casting, machining, and structural assembly. Source and assess vendors for castings, extrusions, machined parts, and sheet metal components. Validate supplier processes for surface treatments, welding, heat treatments, and coatings. Review GD&T on complex structural parts and verify accuracy with metrology tools. Support lightweighting and design optimization projects. Oversee supplier industrialization from early design through production ramp-up. Help suppliers qualify tooling, equipment, and processes. Assess supplier readiness for vehicle production and manage related risks. Facilitate APQP and support PPAP at production launch. Educate suppliers on 1X’s quality management systems and review part quality documentation. Lead root cause analysis and corrective actions for supplier quality issues. Track and report supplier quality metrics, driving ongoing improvement. Apply lean and quality tools to improve supply chain performance. Travel up to 40% domestically and internationally, often with short notice.

Be Part of Our Life-Saving Mission!At Vaxcyte, we are at the forefront of vaccine innovation, dedicated to creating high-fidelity vaccines designed to safeguard humankind from the severe health implications of bacterial diseases. Our commitment to combating bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella, is just the beginning. We have a clear and robust roadmap for our success, and we are poised to make a significant impact.Our Approach: The impact of our work is matched only by the values that guide us:*RETHINK CONVENTION: We embrace creativity and intellectual diversity in every aspect of our work to revolutionize vaccine delivery.*AIM HIGH: We strive courageously toward our ambitious goal of developing the most complex biologics in history for humanity's protection.*LEAD WITH HEART: At Vaxcyte, every individual is a leader, fostering an inclusive and kind environment where collaboration and constructive debate drive our business objectives forward.*MODEL EXCELLENCE: Our challenges require a shared commitment to integrity, accountability, equality, and clarity in all communications and decision-making processes.Position Overview:We are looking for a dedicated Engineer I to join our Upstream Process Development team within the Protein Development and CMC group. This role offers an exciting opportunity to work alongside a highly skilled team focused on bacterial fermentation development.The ideal candidate will possess the following skills and attributes:Hands-on experience in operating and maintaining bioreactors, including Ambr® 250, at laboratory scale.Familiarity with pilot-scale fermentation and recovery equipment is advantageous.Proficiency in data analysis and presentation for process enhancement, troubleshooting, and optimization.A true team player who collaborates effectively, communicates openly, and is committed to achieving optimal outcomes aligned with company objectives.Exceptional organizational and planning skills.

About the Company At Swift Solar, we are dedicated to unlocking the vast potential of solar energy. Our belief is that solar energy can power our lives, energize economies, and fortify supply chains while safeguarding our planet amidst global climate challenges. While today’s solar technologies are functional, we are committed to improving them. Swift Solar is advancing solar technology with our innovative tandem systems that utilize perovskite materials. This enables us to create solar solutions that are more efficient and versatile, suitable for various applications from space solar to utility-scale power generation. As a mission-driven startup, we are backed by the U.S. government and esteemed investors. Our journey to introduce groundbreaking clean energy technology to the market is long-term, and we invite you to join our exceptional team in revolutionizing the global solar landscape. A Night in the Life In your role as the night shift's controls technical authority, your primary objective will be to ensure the reliability of all deposition equipment, control systems, and facility infrastructure during the night. You will diagnose and resolve electrical and PLC-related issues safely, while effectively communicating with the day shift team when required. Your night typically begins at 10 PM, starting with a review of handoff notes from the day team. You may troubleshoot a Beckhoff PLC-based control system that has raised an alarm during the evening run. Your tasks will involve analyzing I/O states and control logic, diagnosing electrical faults using schematics, and collaborating with the equipment engineer to replace components such as sensors, valves, MFCs, RF components, or pumps as necessary. If equipment malfunctions, you will work alongside the equipment engineer to restore functionality, supporting mechanical repairs while leading electrical and controls recovery efforts. You will also assist with facility issues that may arise overnight, from cooling water interruptions to gas supply concerns. When operations are stable, you will shift focus to proactive initiatives. You will design and enhance HMI systems for deposition tools, develop automation routines, and construct documented troubleshooting guides to expedite the resolution of common failures. Implementing predictive maintenance checks during off-peak hours, improving PLC alarm clarity and diagnostics, and ensuring spare parts readiness will be part of your responsibilities. Over your first 12–18 months, your goal will be to independently resolve 90% or more of tool-down incidents during your shift, significantly reduce repair times, and consistently leave equipment in optimal condition.

About 1XAt 1X, we are pioneering advancements in AI and robotics from our base in Palo Alto, California. Our mission is to create an abundantly automated society using general-purpose robots that can autonomously handle any type of work.We envision a future where humanoid robots not only understand the world but also grow in intelligence by living and learning alongside us. This is why we are dedicated to developing friendly home robots that seamlessly integrate into our daily lives.If you are a curious, driven, and passionate individual eager to influence the future of robotics and AI, we would love to hear from you and discuss how you can join our innovative journey.Role Overview:The Senior Harness Manufacturing Engineer will oversee the complete lifecycle of wiring systems essential to powering every subsystem of a humanoid robot, managing everything from initial prototypes to high-volume production. The primary objective is to transform intricate harness designs and engineering specifications into consistent, repeatable assembly processes that can be scaled across thousands of robots.

Join Our Mission to Protect Humanity!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines that aim to safeguard humanity from the severe health implications of bacterial diseases. We are committed to eradicating or effectively treating bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella, with a clear and defined path toward success. Our Approach: What we do is just as vital as how we do it! Our collaborative efforts are anchored by four core values: *RETHINK CONVENTION: We infuse creativity and intellectual diversity into every aspect of our work to innovate and re-innovate vaccine delivery. *AIM HIGH: We embody our ambitious goal to courageously tackle the most complex biologics designed to protect mankind. *LEAD WITH HEART: At Vaxcyte, everyone leads with kindness and inclusiveness, fostering collaboration and spirited debate that drives our business objectives forward. *MODEL EXCELLENCE: The magnitude of our challenge necessitates our collective commitment to integrity, accountability, equality, and clarity in communications and decision-making.Position Overview:The Associate Director of Process Validation and Risk Management will spearhead and facilitate commercial process validation and risk management activities throughout Vaxcyte's comprehensive manufacturing processes. This role is pivotal in shaping technical strategies, executing plans, and coordinating across functions to ensure commercial readiness, regulatory compliance, and effective lifecycle management.The successful candidate will provide leadership to ensure our organization is adept at designing, executing, and communicating process validation and risk management strategies to internal stakeholders, external partners, and regulatory bodies.This position reports to the Senior Director of Process Validation within the Global MSAT organization and collaborates on the overarching validation strategy, with primary accountability for process validation execution and risk management frameworks supporting commercial manufacturing.

Role overview Natera seeks a Senior Manager of Research and Development to join the Oncology Product Development team in San Carlos, CA. This leader will oversee the development and optimization of next-generation sequencing (NGS)-based oncology diagnostic assays. The role also includes supporting product lifecycle management after launch. Success depends on technical leadership, strong collaboration across teams, and attention to product performance and scalability. What you will do Direct the technical development of NGS-based oncology assays, including project planning, execution, and coordination with multiple teams. Lead assay development from feasibility through verification and validation within a regulated CLIA environment. Work in partnership with Research, Informatics, Statistics, Software, Regulatory, Quality, and Commercial teams to bring products from concept to launch. Support post-launch activities such as process improvements, troubleshooting, and collaboration with Operations on commercialized assays. Prepare and review technical documents, including study protocols, reports, and validation materials to meet regulatory and product requirements. Mentor and manage team members, fostering their professional growth. Lead and oversee data analysis using statistical methods. Requirements PhD in Molecular Biology or a related field with at least 6 years of relevant industry experience, or BS/MS with a minimum of 8 years in biotech, including at least 2 years in management. Hands-on experience developing NGS-based assays in a regulated setting; CLIA experience preferred. Familiarity with CLIA laboratory workflows and implementing assays in production. Track record of leading projects and collaborating across functions; people management experience is a plus. Experience with high-throughput workflows or automation is beneficial. Knowledge and skills Strong technical background in oncology diagnostics and NGS technologies. Analytical thinking and problem-solving abilities. Proficiency in technical writing and documentation for regulated environments. Understanding of regulatory standards and design control processes, including LDT, CAP/CLIA, product development lifecycle, and change management. Excellent collaboration, communication, and interpersonal skills.