About the job
Job Summary
Iambic Therapeutics is looking for an exceptional and driven Senior Associate Scientist to enhance our Chemistry team at our San Diego headquarters. This exciting position allows you to thrive in a vibrant, cross-disciplinary environment, where you will collaborate closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning experts, and software engineers. You will engage in every phase of the discovery process, from hit identification and lead optimization to candidate selection. This role is laboratory-focused and demands robust technical skills in organic synthesis, catalysis, and medicinal chemistry, alongside hands-on experience in the drug discovery process and a proven “drug hunter” mentality.
Key Responsibilities
Design, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) utilizing cutting-edge analytical techniques including LCMS, HPLC, and NMR, implementing both manual and automated parallel synthesis techniques.
Identify and optimize reaction conditions through the use of screening kits and other efficient methodologies.
Collaborate with the high-throughput experimentation team to guarantee successful execution of parallel chemistry experiments.
Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.
Work alongside computational chemists to harness machine learning insights for the effective execution of the design–make–test cycle and platform development.
Present findings to project teams and senior leadership, effectively communicating data, implications, and recommendations.
Qualifications
BS in Chemistry with 5+ years of experience in the pharmaceutical or biotechnology sector, or MS in Chemistry with 3+ years of relevant experience.
Demonstrated expertise in multi-step organic synthesis, reaction optimization, Structure-Activity Relationship (SAR) analysis, and effective scientific presentation skills.
Adeptness in a fast-paced, highly collaborative research atmosphere.
Willingness to work onsite in San Diego.
Preferred Qualifications
Experience in high-throughput experimentation is advantageous.
Familiarity with ADME-PK principles is a plus.
5+ years of experience contributing to drug discovery projects is preferred.

