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Senior Associate Scientist I or II, Medicinal Chemistry

On-site Full-time

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Experience Level

Mid to Senior

Qualifications

Minimum qualifications include a BS in Chemistry with over 5 years of experience in the pharmaceutical or biotech field, or an MS in Chemistry with a minimum of 3 years of relevant experience. Candidates should exhibit proven skills in multi-step organic synthesis, reaction optimization, SAR analysis, and the ability to present scientific findings effectively. The ideal candidate will thrive in a collaborative and fast-paced research environment and must be available for onsite work in San Diego.

About the job

Job Summary

Iambic Therapeutics is looking for an exceptional and driven Senior Associate Scientist to enhance our Chemistry team at our San Diego headquarters. This exciting position allows you to thrive in a vibrant, cross-disciplinary environment, where you will collaborate closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning experts, and software engineers. You will engage in every phase of the discovery process, from hit identification and lead optimization to candidate selection. This role is laboratory-focused and demands robust technical skills in organic synthesis, catalysis, and medicinal chemistry, alongside hands-on experience in the drug discovery process and a proven “drug hunter” mentality.

Key Responsibilities

  • Design, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) utilizing cutting-edge analytical techniques including LCMS, HPLC, and NMR, implementing both manual and automated parallel synthesis techniques.

  • Identify and optimize reaction conditions through the use of screening kits and other efficient methodologies.

  • Collaborate with the high-throughput experimentation team to guarantee successful execution of parallel chemistry experiments.

  • Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.

  • Work alongside computational chemists to harness machine learning insights for the effective execution of the design–make–test cycle and platform development.

  • Present findings to project teams and senior leadership, effectively communicating data, implications, and recommendations.

Qualifications

  • BS in Chemistry with 5+ years of experience in the pharmaceutical or biotechnology sector, or MS in Chemistry with 3+ years of relevant experience.

  • Demonstrated expertise in multi-step organic synthesis, reaction optimization, Structure-Activity Relationship (SAR) analysis, and effective scientific presentation skills.

  • Adeptness in a fast-paced, highly collaborative research atmosphere.

  • Willingness to work onsite in San Diego.

Preferred Qualifications

  • Experience in high-throughput experimentation is advantageous.

  • Familiarity with ADME-PK principles is a plus.

  • 5+ years of experience contributing to drug discovery projects is preferred.

About Iambic Therapeutics

Iambic Therapeutics is a forward-thinking biotechnology company dedicated to innovative drug discovery and development. Our commitment to collaboration and excellence drives our success in creating transformative therapeutic solutions.

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