Scientist

Company Overview Flagship Labs 110 Inc. (FL110) is an innovative, privately held technology company at the forefront of developing a fully integrated, end-to-end platform that revolutionizes proteomics. Our cutting-edge platform combines advanced bioengineering, machine learning, and bespoke microelectronics to deliver unparalleled precision and insights. Backed by Flagship Pioneering, we possess the vision, courage, and resources to achieve extraordinary results. Our culture fosters collaboration and creativity, making it essential for team members to embrace diverse perspectives and an inclusive mindset. If you are excited by the prospect of working in such an environment and possess some of the qualifications listed below, we encourage you to apply. Position Overview: We are looking for a passionate and skilled (Senior) Scientist, Nanopore to become part of our dynamic team. The level for this position is flexible based on experience. Your primary focus will be on the advancement of nanopore sensing technologies, contributing to the development of a nanopore-based protein reading system. As a key member of a cross-functional team, you will collaborate closely with chemists, bioinformaticians, software developers, and hardware engineers. The ideal candidate will have a robust background in nanopore technology, particularly in protein translocation, along with either relevant experience in the biotechnology sector or a proven record of scientific accomplishment.

Join our innovative team as a Senior Scientist where you'll drive critical research projects and make a significant impact in the field. We are seeking a highly motivated individual with a passion for scientific discovery and a strong background in relevant disciplines.

Join us as a Senior Scientist in Computational Biology at Flagship Pioneering, Inc. In this pivotal role, you will leverage your expertise to drive innovative research and development in computational biology, contributing to groundbreaking discoveries and advancements in the field.

Are you passionate about advancing the field of machine learning? Join our team at Altos Labs as a Machine Learning Scientist or Senior Machine Learning Scientist. In this role, you will leverage your expertise to drive innovation and development in cutting-edge research projects. Collaborate with a multidisciplinary team to push the boundaries of machine learning technology.

Role overview Bicycle Therapeutics seeks a Senior Scientist specializing in Computational Chemistry to join the team in Cambridge. The position focuses on using computational methods to design and optimize new therapeutic candidates, directly supporting the company’s goal of developing new medicines. What you will do Lead molecular modeling studies for ongoing drug discovery projects. Use advanced simulation techniques to analyze and predict molecular behavior. Collaborate with scientists from various disciplines to integrate computational insights into laboratory research. Share research findings through publications and presentations at scientific meetings and conferences. Requirements Extensive experience with computational chemistry methods and tools. Strong foundation in molecular modeling and simulation. Proven ability to work effectively within cross-functional teams. Drive to advance drug discovery using computational science.

Your Impact at LilaThe Senior Scientist in Analytical Chemistry will spearhead the development and application of cutting-edge analytical and characterization techniques to bolster Discovery Chemistry initiatives across Lila’s innovative platform. This role is pivotal in facilitating the swift design, synthesis, screening, and optimization of small molecules and related molecular entities. You will be instrumental in producing high-quality, informative experimental data that guides chemistry decisions and enhances platform learning.By collaborating closely with teams in Discovery Chemistry, automation, AI/computational fields, and screening, you will establish and scale multimodal characterization workflows that surpass conventional analytical chemistry methodologies. Your expertise will help create an integrated analytical framework that includes compound characterization, reaction monitoring, molecular profiling, and rapid data generation to support fast-paced design–make–test–analyze cycles.Your contributions will be vital in molding Lila’s next-generation discovery engine, merging profound analytical chemistry knowledge with high-throughput experimentation and AI-driven workflows.

Company Summary:At FL122, we are at the forefront of pioneering genomic technologies that redefine human health and assisted reproduction. Founded by the innovative Flagship Pioneering, we are dedicated to creating, funding, and nurturing first-in-category life sciences companies. Our portfolio includes over 100 groundbreaking companies developed over the past two decades, such as Moderna (MRNA), Generate Biomedicines, Tessera Therapeutics, and Quotient Therapeutics. We pride ourselves on being an equal opportunity employer.Position Summary:We are in search of our inaugural Computational Genomics Scientist to spearhead vital research that will underpin our scientific platform. As an early-stage team member, you will enjoy significant ownership of your work, shaping our analytical strategy from the ground up by integrating genomics, statistical genetics, and advanced modeling techniques. Your responsibilities will encompass the comprehensive delivery of computational research projects, including design, execution, interpretation, and communication of results to senior leadership. We seek a resourceful individual who thrives in a fast-paced, agile environment and possesses a proactive mindset. The ideal candidate will combine technical expertise with a growth-oriented approach, meticulous attention to detail, and a relentless drive for excellence. Collaboration is essential in our startup environment, where all team members work closely to push the boundaries of scientific discovery.

Company Overview: At Flagship Labs 103, Inc., we are revolutionizing healthcare by shifting the paradigm of disease diagnosis and intervention. Our innovative technological and computational platforms are designed to detect cellular dynamics from minimally invasive biospecimens, allowing us to connect individuals with the most effective interventions to prevent the onset and progression of diseases. We are dedicated to enhancing patient outcomes through advanced research methodologies. Position Summary: We are looking for a dynamic and experienced Senior Scientist to lead our bioconjugation initiatives and propel FL103’s programs to new heights. The ideal candidate is a self-starter with a strong commitment to producing high-quality data in a fast-paced, innovative research environment. You will play a pivotal role in supporting our ongoing bioconjugation projects across various research and development domains. Key Responsibilities: Design, synthesize, purify, and analyze oligonucleotide-conjugates for antibodies and other modalities, while developing and optimizing conjugation protocols utilizing both established and novel chemistries and technologies as part of our assay development platform. Work collaboratively with the assay development team to refine and enhance conjugates to support FL103’s scientific endeavors. Participate in a cross-functional team to oversee project timelines, deliver regular updates, and communicate progress effectively within the team. Establish and nurture strong working relationships with key collaborators across the company to further discovery research activities toward pre-clinical development. Contribute to the creation of research reports and presentations for internal project teams, leadership, and external stakeholders. Maintain organized and detailed lab notebooks and batch records.

Innovate and Create Models from Scratch! At Flagship Pioneering, we are dedicated to launching pioneering companies that challenge the status quo. Within our Flagship Labs, small, agile teams develop new technical theses, rigorously test them, and build ventures around groundbreaking concepts. We are assembling an exceptional machine learning team within our newly established venture, Flagship Labs 120. Our focus is on uncovering hidden structures from complex measurement data of intricate physical systems, often necessitating mechanism-informed modeling, carefully designed inductive biases, and principled methodologies for inverse problems. This is a pioneering role dedicated to innovative modeling, moving beyond standard optimization tasks. You will have the opportunity to design, prototype, test, and refine novel approaches that establish the technical foundation of our platform starting from day one.

Join our innovative team at Flagship Pioneering, Inc., where we are dedicated to advancing biopharmaceutical technologies. We are seeking a Senior Scientist in LNP Formulations who will play a key role in the development of lipid nanoparticle (LNP) formulations. This position offers the opportunity to work on cutting-edge research and contribute to the creation of next-generation therapeutics.

About Serif Biomedicines, Inc. Serif Biomedicines, Inc. is a privately held biotechnology company in Cambridge, MA. The team is developing new approaches to gene therapy for diseases that current medical solutions cannot address. Serif Biomedicines was founded by Flagship Pioneering, known for launching over 100 innovative life sciences organizations focused on human health and sustainability. Role Overview The Senior Scientist, Molecular Biology will design and develop next-generation DNA constructs for programmable medicine. This position suits scientists experienced in synthetic biology, high-throughput cloning, and computational sequence engineering. The role centers on building scalable platforms for plasmid DNA design, construction, and optimization, using automation, algorithm-driven sequence design, and data-centric workflows. This scientist will report to the Director of Molecular Biology and may supervise a direct report. Collaboration with other scientists and group leaders across the R&D team is a key part of the job. What You Will Do Lead the design and construction of plasmid DNA constructs, including vector architecture, gene synthesis strategies, and high-efficiency cloning (such as Gibson, Golden Gate, and recombination-based methods). Advance automated and computational sequence design by applying advanced tools and pipelines for codon optimization, regulatory element tuning, and multi-parameter construct optimization. Establish and manage vendor relationships to support both internal and external capabilities, helping projects move forward efficiently and minimizing disruptions.

Join AbbVie, a global biopharmaceutical company, as a Senior Scientist I in our Neuroscience division specializing in Biologics Screening. In this role, you will lead innovative research efforts to develop therapies that address unmet medical needs in the field of neuroscience.

Imagine... being part of an innovative organization that cultivates and develops life sciences companies dedicated to pioneering groundbreaking technologies aimed at revolutionizing health care and sustainability. Company Overview Expedition Medicines is a dynamic, privately held, early-stage biotechnology company at the forefront of the Protein Editing field. We specialize in creating small molecules that modify protein structure and function to target currently undruggable options across various therapeutic strategies. Our advanced platform combines cutting-edge small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to facilitate generative design. Backed by Flagship Pioneering, we leverage their vision, courage, and resources to propel Expedition Medicines from platform validation to impactful patient solutions. We seek passionate, collaborative, and determined problem solvers to join our mission! Role Overview: The Senior/Principal Scientist in Structural Biology will concentrate on determining protein-ligand complex structures using X-ray crystallography and cryo-electron microscopy (cryo-EM). This role involves delivering structural insights and collaborating with project teams to advance structure-based drug design and uncover the mechanisms of action of small molecules. Key Responsibilities: Design and implement structural biology strategies for multiple projects. Oversee the design, expression, and purification of protein constructs for structural determination. Develop and execute protocols to achieve high-quality crystals for X-ray crystallography. Create and implement protocols for grid optimization, data collection, and analysis in cryo-EM. Refine and communicate structures of protein-ligand complexes, collaborating with project teams to drive hit-to-lead and lead optimization processes. Manage contract research organizations (CROs) to ensure efficient delivery of protein expression and structural biology services. Enhance our capabilities and serve as a trusted authority in the field of structural biology.

Company Overview: Korro Bio is a pioneering biopharmaceutical company dedicated to the development of innovative genetic medicines targeting both rare and common diseases through its proprietary RNA editing technology. Our mission is to revolutionize the field of genetic medicine by utilizing RNA editing to create precise and temporary modifications at the RNA level rather than DNA, thereby enhancing specificity and long-term tolerability. With a portfolio of unique programs, we aim to leverage our expertise in oligonucleotide-based approaches to deliver therapies that improve patient outcomes. Based in Cambridge, Massachusetts, we are committed to combining cutting-edge science with a collaborative spirit to achieve transformative results in human health.At Korro, we thrive on collaboration, driven by our vision to create impactful genetic solutions for widespread health challenges. Our core values—Rewrite the Future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity—are woven into every aspect of our work culture, guiding our hiring practices and daily interactions. Join our team to help redefine the possibilities in genetic medicine and contribute to lasting health advancements.Position Overview: We are searching for a Senior Scientist to enhance our growing CMC team at Korro Bio. This role will involve overseeing the management of CMO analytical labs as well as the development of analytical methods, impurity characterization, degradation pathway analysis, and the transfer, qualification, and validation of methods for RNA-based therapies. You will play a crucial role in maintaining the quality and stability of drug substances and products throughout their development lifecycle. Collaborating closely with cross-functional teams and external partners, you will ensure that analytical data meets regulatory filing requirements and supports clinical trial progress.

Join AbbVie as a Senior Scientist I in the field of siRNA in vitro biology. In this role, you will leverage your extensive knowledge and skills in molecular biology to contribute to innovative research and development projects. Collaborate with a team of dedicated scientists to explore new therapeutic avenues and advance our understanding of RNA interference.

Charles River Analytics, a proud member of the GRVTY family, is at the forefront of developing innovative solutions and advanced technologies designed to address some of the most challenging issues faced globally. Our dynamic team of tech entrepreneurs collaborates to enhance AI, robotics, intelligent sensing, and human-centered computing. The research and technology we develop not only propel government initiatives but also unveil new opportunities in the commercial sector. At Charles River, we take immense pride in cultivating a workplace that attracts and retains top-tier talent and creative problem-solvers in the industry. Join us as we strive to accelerate our mission-driven innovations!We are currently seeking a dedicated Senior/Principal Scientist with expertise in Human-Systems Integration, Human Factors, or Human-Computer Interaction. In this role, you will spearhead the development of cutting-edge tools and interfaces that empower users to effectively collaborate with technology in demanding environments.Your responsibilities will include leading and expanding teams of researchers, designers, and engineers to assess work domains and user needs, create novel human-AI interaction concepts, and evaluate interactive prototypes. You will also be responsible for defining and directing technical projects, while fostering robust relationships with clients, sponsors, and collaborators. As a subject matter expert in Human Systems, you will work alongside multidisciplinary teams to explore and pursue research opportunities across various technical domains.

We are seeking a highly motivated and experienced Senior Scientist I to join our Pipeline Development & Targeted Delivery team at AbbVie. In this pivotal role, you will lead innovative research efforts aimed at advancing our therapeutics pipeline. You will collaborate with cross-functional teams to design experiments, analyze data, and contribute to strategic decision-making processes.

COMPANY DESCRIPTION Flagship Pioneering is a leading bioplatform innovation firm dedicated to inventing and building transformative companies that aim to make a significant impact on the world. By merging top-tier scientific talent with entrepreneurial visionaries, we mobilize the resources necessary to support bold innovations. Our endeavors in human health, sustainability, and beyond accelerate scientific advancements across a spectrum of fields, including disease detection and treatment, nature-positive agriculture, and cutting-edge AI applications. What distinguishes Flagship is our unique capacity to propel science and technology forward by integrating innovation, company formation, and capital investment under one roof—an approach that is largely unprecedented. Our scientific pioneers, entrepreneurial leaders, and expert capital managers are aligned in a structured process that facilitates transformative innovation for the benefit of both humanity and the planet. We have founded companies that tackle some of society's most pressing challenges, including delivering vaccines to billions during the COVID-19 pandemic, finding cures for chronic diseases, enhancing health outcomes, and fostering sustainable agricultural practices. Flagship Pioneering has been recognized twice on FORTUNE’s “Change the World” list, acknowledging our positive social and environmental contributions, and we have also been honored on Fast Company’s annual list of the World’s Most Innovative Companies. THE ROLE We are on the lookout for a Senior Scientist to spearhead the design, characterization, and optimization of aerosolizable particle systems. This pivotal role involves developing a comprehensive understanding of engineered particles during their generation, dispersion, and transport in air, and translating that knowledge into robust and scalable material and system designs. The Senior Scientist will operate at the intersection of materials science, aerosol physics, and experimental engineering. You will lead the development of aerosol testing capabilities, shape experimental strategies, and connect particle design with airborne performance. This individual will play a vital role in establishing core methodologies and driving projects from concept to validation. In this highly collaborative position, you will work closely with formulation, process development, and hardware teams to ensure seamless integration between particle design, production processes, and real-world deployment challenges.

Join AbbVie as a Senior Scientist II in our Assay Development team, focusing on innovative research in Discovery Psychiatry. This role involves designing, developing, and optimizing assays to advance our understanding of psychiatric disorders. You will collaborate with cross-functional teams to drive research initiatives and contribute to the discovery of effective treatments.The ideal candidate will possess strong scientific expertise, a passion for psychiatric research, and the ability to thrive in a dynamic environment.