About the job
Your Impact at Lila
In this pivotal role, you will spearhead the innovation and validation of advanced pooled assays utilizing mammalian cells. Your work will encompass everything from proof of concept to automated screening processes, enabling the generation of intricate, high-dimensional datasets. This position involves collaboration across cell biology, protein design, and nucleic acid teams to facilitate biologic development programs, focusing on the rapid assessment of binding, stability, function, and immunogenicity of diverse biologics.
What You'll Be Building
- Create next-generation mammalian display-based assays for binding, stability, function, and immunogenicity.
- Implement cutting-edge multiomic, single-cell, and in situ sequencing workflows to design innovative, highly multiplexed assays.
- Collaborate with protein design, nucleic acid, and automation teams to leverage these workflows in biologics development.
- Closed-Loop Experimentation and Execution: Work closely with engineering and automation teams to architect automated, high-throughput experimentation platforms that yield data-rich workflows. Join forces with the AI team to conduct iterative experiments in real time, facilitating rapid optimization and discovery cycles.
- Collaborate, Lead & Communicate: Engage with cell biologists, synthetic biologists, automation engineers, protein design scientists, and data scientists to document systems, share insights, and refine best practices in autonomous science. Mentor junior scientists, align project milestones with internal and external collaborators, contribute to intellectual property and publications, and present findings across the organization.
What You’ll Need to Succeed
- Ph. D. in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, Immunology, or a related discipline (or M. S./B. S. with 5–8+ years of relevant industry experience).
- Proficiency in the development and/or application of mammalian display or similar pooled mammalian systems (perturb-seq, MPRA, etc.).
- Experience in designing, executing, and analyzing single-cell, in situ, or multiomic sequencing experiments.
- Expertise in creating complex libraries of defined sequences in mammalian cells.
- Experience in designing, executing, and analyzing flow cytometry and sorting experiments.
- Familiarity with next-generation sequencing (NGS) based experimental design and analysis.
