Principal Software Engineer I, Full Stack

Operating Principal – Summit PBU THE ROLE Join Summit, an innovative Business Unit within Flagship Pioneering, as an Operating Principal dedicated to launching and scaling our NewCos. In this pivotal role, you will oversee operations and strategy across multiple companies, spearhead corporate development efforts, and collaborate closely with scientific leaders to transform groundbreaking ideas into tangible outcomes. This position is perfectly suited for an entrepreneurial leader who excels in uncertain environments, effortlessly navigates between scientific and business realms, and is passionate about building organizations from the ground up to achieve significant growth. KEY RESPONSIBILITIES Lead the strategic and operational planning for one or more NewCos. Drive corporate development initiatives, including partnerships, financing, and strategic alliances, while engaging with the Board of Directors and other key stakeholders. Work directly with scientists and company leaders to align technical advancements with operational objectives. Recruit, mentor, and manage high-performing teams across various functions. Collaborate with Flagship's central teams (Finance, Talent, Legal/IP, HR) to implement best-in-class infrastructure for each company. Develop and execute operational and long-range plans, ensuring timely and budget-compliant achievement of milestones. Establish and maintain strong relationships with investors, partners, and key opinion leaders. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Who you are: You are a dynamic operator and strategist who blends business leadership with scientific insight. You thrive in fast-paced, entrepreneurial settings and are driven by the mission of building organizations that leverage innovative science. Qualifications: 10+ years of experience in biotech, pharmaceuticals, or life sciences strategy/operations; prior management consulting experience is advantageous. Demonstrated success in strategic, operational, or corporate development roles, preferably in early-stage biotech. Strong scientific acumen; ability to rapidly comprehend novel scientific concepts and translate them into actionable plans. Proven track record in assembling and inspiring high-performing teams. Exceptional communication skills, capable of influencing and motivating investors, partners, and internal teams. Proficient problem solver; adept at bringing order to chaos and quickly iterating to find effective solutions. Entrepreneurial, resilient, and hands-on; able to adapt and execute with urgency, unafraid to roll up sleeves and get involved.

Are you ready to make a significant impact on the environment by joining a team of skilled ecologists? We invite you to become a vital member of our innovative Nature team as a Principal Ecologist in our expanding offices located in Cambridge, Basingstoke, Croydon, Leeds, Nottingham, Newcastle, Manchester, Birmingham, Glasgow, Edinburgh, Bristol, and Liverpool (other locations may also be considered). Enjoy the benefits of our flexible hybrid working model at AECOM, where we lead the way in delivering an exceptional portfolio of Ecology programs and projects through long-standing partnerships with key clients.We are currently engaged in a diverse array of projects across the power, renewables, infrastructure, environment, and transport sectors. Our collaborative efforts extend to other technical disciplines, including landscape, GIS, engineering, sustainability, and drainage. Recent projects include some of the largest solar farms in the UK, a cable tunnel beneath the River Thames, electricity network upgrades in Kent and Suffolk, and master planning for new residential developments.Your Responsibilities:Lead and support the delivery of high-quality ecological consultancy and advisory services to both internal and external clients.Oversee, plan, schedule, and organize all phases of ecological project work, ensuring that necessary resources, budgets, and controls are in place to meet program and budget requirements.Develop technically robust and pragmatic solutions to complex ecological challenges.Lead the production of ecology chapters for environmental statements and protected species license applications and ensure the high quality of project deliverables.Contribute to the ongoing development of our technical capabilities.Join Us in Our Growth Journey. Become part of our dynamic Nature business, which comprises around 230 professionals specializing in arboriculture, forestry, groundwater, surface water, and ecology. Our team includes national and global leaders in species licensing, impact assessment, habitat creation, ecosystem restoration, enhancement, and management. At AECOM, you will flourish in an inclusive and forward-thinking environment where your contributions are valued.Don't forget the amazing perks at AECOM! You will enjoy a variety of core and personalized benefits tailored to support your future and well-being, including career development opportunities, a flexible hybrid working model to enhance your work-life balance, technical practice networks, and access to AECOM University.

As a Principal Terrestrial Ecologist at dev2, you will play a pivotal role in leading and managing ecological projects that contribute to sustainable environmental practices. You will be responsible for conducting extensive field studies, analyzing ecological data, and providing expert guidance on terrestrial ecosystems. Your insights will help shape strategies that promote biodiversity and conservation.

Join our dynamic team at Ramboll as a Senior / Principal Electrical Engineer. In this role, you will lead innovative projects, collaborate with a talented team, and contribute to the development of sustainable electrical solutions. Your expertise will be pivotal in driving forward our commitment to excellence in engineering.

Join our dynamic team at Integrated Resources, Inc. as a Principal Application Administrator. In this pivotal role, you will oversee and manage our application systems, ensuring optimal performance and user satisfaction. You will collaborate with various departments to implement innovative solutions and enhance our technology infrastructure.

Role Overview Lila Sciences is seeking a Principal Engineer with expertise in AI Security for its Cambridge, MA office. This senior individual contributor will help define and drive the technical strategy to secure AI applications across the organization. The role involves close collaboration with IT and business teams to ensure AI tools and platforms are implemented safely and in compliance with internal and external requirements. Securing both third-party and in-house AI tools is central to this position. The work will focus on protecting sensitive data, intellectual property, and scientific processes as AI becomes increasingly embedded in Lila's operations. What You Will Do Enterprise AI Security Strategy: Develop and roll out security controls and guidelines for using AI tools throughout the company, covering LLM APIs and SaaS AI platforms. AI Gateway & Agentic Gateway Security: Design and enforce controls for AI gateways, monitoring and managing access to AI systems. Ensure agentic workflows are secured with strong identity and authorization measures. AI Red Teaming & Adversarial Testing: Lead red teaming and adversarial testing efforts to uncover vulnerabilities in AI usage, such as prompt injection and data exfiltration risks. Data Protection for AI Usage: Establish and maintain safeguards to prevent sensitive data exposure through AI systems, with a focus on input/output filtering and secure data management. Multi-Layer AI Security: Integrate AI security practices with the organization's broader security framework, maintaining visibility and control over AI service access and data flows. AI Threat Modeling: Build and maintain threat models tailored to enterprise AI applications, addressing risks like data leaks and unauthorized agent actions. Vendor & Platform Security: Assess and advise on secure integration of third-party AI vendors, with close attention to their data handling practices and model behavior.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence is a forward-thinking initiative that builds upon Flagship Pioneering's rich history of establishing groundbreaking scientific and computational enterprises. By leveraging cutting-edge advancements in artificial intelligence, machine learning, and data science, we aim to accelerate fundamental research and cultivate a dynamic portfolio of AI-first companies. As an integral part of Flagship's unique model that intertwines science, entrepreneurship, and investment, we transform revolutionary concepts into impactful companies, enhancing AI innovations that contribute to human health, sustainability, and more. THE ROLE We are on the lookout for a Principal Scientist specializing in Embedded Machine Learning and Computational Methods to spearhead various AI/ML and computational initiatives across early-stage ventures within our company origination framework. Your responsibilities will include defining and executing practical AI strategies, overseeing the development of methodologies and platforms (including systems design, drug design, molecular modeling, systems biology, protein design, and LLM-based workflows), and ensuring a high standard of rigor in model development, benchmarking, scaling, and reporting. You will also manage cross-functional teams as necessary, influence the strategic direction of our initiatives, and represent Pioneering Intelligence to venture teams and external collaborators. The ideal candidate is a self-motivated individual with a diverse skill set, capable of transitioning seamlessly from protein design to mass spectrometry or docking pipelines, and then creating LLM-based agents to streamline scientific workflows.

Join Cambridge Mobile Telematics (CMT), the world's leading telematics service provider, dedicated to enhancing road safety and improving driver behavior. Our cutting-edge AI platform, DriveWell Fusion®, integrates sensor data from millions of IoT devices—including smartphones, proprietary Tags, connected vehicles, dashcams, and third-party devices—melding it with contextual information to deliver a comprehensive analysis of vehicle and driver interactions. Our insights empower auto insurers, automotive manufacturers, mobility companies, and public sector organizations to optimize risk assessment, safety protocols, claims processing, and driver improvement initiatives. Based in Cambridge, MA, with global offices in Budapest, Chennai, Seattle, Tokyo, and Zagreb, CMT actively monitors and safeguards millions of drivers worldwide every day.As a Principal Software Engineer within our Trip Processing team, you will play a crucial role in delivering innovative technical solutions at the core of our advanced telematics pipeline. Collaborating closely with product and research teams, you will design, develop, and implement new features while mentoring junior engineers and enhancing our codebase. Your contributions will be vital in upholding our high standards of software quality to meet the expectations of our insurance partners.We seek a collaborative, customer-focused, and imaginative Principal Software Engineer II - Backend who is eager to help make roads safer and drivers more responsible!

ABOUT PIONEERING INTELLIGENCEPioneering Intelligence extends Flagship Pioneering's tradition of launching innovative scientific and computational initiatives. By leveraging the latest advancements in AI, machine learning, and data analytics, we aim to expedite fundamental research and build a diverse portfolio of AI-first companies. As a key player in Flagship's integrated approach to science, entrepreneurship, and investment, we transform groundbreaking concepts into transformative enterprises that enhance AI innovations in human health, sustainability, and more.THE ROLEWe are on the lookout for a Principal Scientist specializing in Embedded Machine Learning and Computational Techniques to spearhead various AI/ML and computational initiatives across early-stage ventures in our company origination process. You will be responsible for defining and executing practical AI strategies, overseeing the development of methodologies and platforms such as systems design, drug design, molecular modeling, systems biology, protein design, and LLM-driven workflows while ensuring the utmost rigor in model development, benchmarking, scaling, and reporting. You will manage cross-functional contributors as necessary, influence the strategic direction of the company, and represent Pioneering Intelligence to venture teams and external partners. The ideal candidate is a proactive, deep thinker who can seamlessly transition between protein design one week and mass spectrometry or docking pipelines the next, while also developing LLM-based agents to automate scientific workflows.

POS-4092 Team and Product Focus The Data Hub team at HubSpot connects scattered data sources to deliver practical insights for Revenue Operations, marketing, sales, and customer teams. By integrating information from various channels and tools, the team improves data quality and makes this data actionable within HubSpot. This enables teams to run AI-powered demand generation, optimize campaigns, and produce reliable reports, without requiring deep expertise in data systems. Product engineering here blends data engineering, machine learning, applied AI, and market strategy. The group prioritizes reliability, cost efficiency, and scalability, while always considering usability for marketers and sales professionals. Role Overview HubSpot is seeking a Lead Principal Software Engineer to steer the next phase of Data Hub's development. This platform is evolving into the central engine for data-driven demand generation company-wide. Key Responsibilities Take ownership of critical components in the data lake and analytics architecture, working with technologies such as Iceberg, Spark, and both batch and streaming data pipelines. These systems underpin large-scale demand generation, segmentation, and scoring. Design and refine data systems to achieve the right balance between cost, latency, data freshness, and reliability. Apply principles like the CAP theorem, efficient partitioning, and thoughtful storage layout to guide decisions. Collaborate closely with Product Management, product analytics, and go-to-market leaders to deliver solutions that drive business outcomes: improved lead scoring, enhanced funnel visibility, audience segmentation, and campaign attribution for marketing and sales. Contribute to transforming Data Hub into an AI-powered platform, aiming for curated, always-available datasets that support AI agents and reporting tools, eliminating the need for manual integrations or custom pipelines. This is a hands-on principal engineering position. The role involves building systems, working alongside product and design, and amplifying the impact of HubSpot's broader engineering community.

As a Principal Medical Writer at Sobi, you will leverage your expertise in communication to spearhead a strategy-oriented approach in crafting pivotal clinical and regulatory documents. Your role will be crucial in ensuring clarity, credibility, and consistency of clinical information across submission packages and clinical programs, thereby facilitating regulatory assessment and achieving product labels that meet commercial needs.Key Responsibilities:Lead an effective strategy for authoring clinical components of regulatory submissions, ensuring that the scientific content is clear, concise, complete, credible, and compelling, aligned with regulatory document objectives.Take the lead in preparing essential clinical and regulatory documents, including those that support major regulatory submissions and responses to regulatory agencies/health authorities.Provide leadership and project coordination to cross-functional authoring teams, ensuring timely delivery, high quality, and compliance with regulatory standards for clinical documents.Collaborate with senior project staff to develop a storyboard for submissions and plan document development to optimally support the proposed prescribing information.Serve as a Product Medical Writer, offering strategic medical writing expertise and support across multiple projects within a clinical development program.Ensure that all documents meet high technical quality standards in accordance with in-house technical requirements.Mentor and develop less experienced Medical Writers.Oversee and coordinate the contributions of all Medical Writers involved in documents under your purview, including in-house consultants and Medical Writers at Contract Research Organizations (CROs).

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence continues the legacy of Flagship Pioneering by creating innovative scientific and computational ventures. Utilizing advancements in AI, machine learning, and data analytics, our mission is to expedite fundamental research and establish a diverse portfolio of AI-first companies. We integrate science, entrepreneurship, and capital to transform groundbreaking concepts into impactful companies, furthering AI advancements in human health, sustainability, and more. THE ROLE We are on the lookout for a Principal Scientist in Embedded Machine Learning/Computational to spearhead multiple AI/ML and computational projects within early-stage ventures as part of Flagship’s origination process. Your responsibilities will include defining and executing effective AI strategies, leading method and platform advancements (such as systems design, drug design, molecular modeling, systems biology, protein design, and LLM/agentic workflows), and ensuring excellence in model development, benchmarking, scaling, and reporting. You'll collaborate with cross-functional teams, shape the direction of the company, and represent Pioneering Intelligence to both venture teams and external partners. The ideal candidate is a proactive deep diver, capable of transitioning from protein design to mass spectrometry or docking pipelines, and then developing LLM-based agents to streamline scientific workflows.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence builds on the legacy of Flagship Pioneering, leveraging the latest advancements in artificial intelligence, machine learning, and data analytics to expedite groundbreaking research and establish a portfolio of AI-centric companies. As an integral part of Flagship’s innovative model that merges science, entrepreneurship, and capital, we transform revolutionary ideas into transformative enterprises, enhancing the AI breakthroughs occurring within the realms of human health, sustainability, and beyond. THE ROLE Pioneering Intelligence represents a strategic initiative of Flagship Pioneering, dedicated to positioning our organization at the forefront of global innovation through the fusion of human, machine, and nature’s intelligence – a concept we refer to as Polyintelligence. We are currently on the lookout for a Principal Product Manager to collaborate across various disciplines including UX design, AI research, engineering, legal, communications, marketing, and scientific research teams, as well as venture creation units, to address the most significant challenges in AI within the life sciences sector. We are establishing a state-of-the-art digital infrastructure that integrates computational science, AI/ML technologies, knowledge engineering, data platforms, and workflow automation. These capabilities are essential in supporting Flagship’s distinctive approach to exploring uncharted territories and translating scientific insights into transformative enterprises. The Principal Product Manager, Agentic AI will be a key individual contributor responsible for owning a specific product area from conception to execution, translating intricate user and scientific requirements into a coherent strategy, quantifiable outcomes, and widely adopted solutions aligned with our business objectives. As part of a multidisciplinary team, you will closely partner with scientists and business stakeholders to drive impactful innovations from agentic systems that redefine workflows and business capabilities within a dynamic startup environment. KEY RESPONSIBILITIES Own and articulate the product vision, strategy, and roadmap. Define Objectives and Key Results (OKRs) and drive measurable outcomes. Lead discovery processes with scientists, synthesize insights, and develop wireframes. Facilitate cross-functional decision-making and alignment among machine learning, engineering, and scientific stakeholders. Drive product adoption, including spearheading user enablement initiatives.

Join Lila Sciences as a Staff or Principal Engineer specializing in Technical Mitigations Research. This role offers an exciting opportunity to leverage your engineering expertise to develop innovative solutions in the field of technical mitigations.

Your Role at Lila Sciences Lila Sciences is on the lookout for an experienced Principal Software Engineer specializing in Instrument Simulations. In this pivotal position, you will spearhead the architecture and development of our cutting-edge laboratory automation platform. Your expertise will be crucial in designing the simulation framework and integration layer that links AI-driven experimental design with physical robotic systems, enabling groundbreaking scientific discoveries at an unparalleled scale. Key Responsibilities Design and implement high-fidelity simulation environments that accurately model intricate laboratory instrumentation, fluidics, and robotic processes. Establish and maintain robust integration frameworks between diverse hardware systems, ensuring the safe and reliable execution of fully automated experiments. Lead the development of APIs and interfaces to facilitate seamless interaction between scientists and AI agents with complex automation infrastructures. Champion best practices in hardware-software integration, system monitoring, and continuous integration/deployment (CI/CD) within laboratory automation contexts. Provide mentorship to engineers, likely overseeing a small, agile team.

Join Cambridge Mobile Telematics (CMT), the globe’s leading telematics service provider, dedicated to enhancing road safety for drivers worldwide. Our innovative AI-powered platform, DriveWell Fusion®, collects sensor data from millions of IoT devices—including smartphones, proprietary Tags, connected vehicles, dashcams, and third-party devices—and integrates it with contextual data to provide a comprehensive overview of vehicle and driver behavior. Auto insurers, automakers, commercial mobility firms, and public sector organizations leverage insights from CMT’s platform to enhance risk assessment, optimize safety, streamline claims, and develop driver improvement initiatives. With headquarters in Cambridge, MA, and additional offices located in Budapest, Chennai, Seattle, Tokyo, and Zagreb, we are committed to safeguarding tens of millions of drivers globally every day.As the Principal Product Manager, you will spearhead the strategy and execution of our Drivewell Crash product, with an initial emphasis on Openroad—a direct-to-consumer mobile application that delivers advanced crash detection and assistance. Utilizing state-of-the-art technology, the app provides real-time alerts, automatic emergency response, and comprehensive incident reports. We are seeking a self-motivated, imaginative, and customer-centric mobile app Product Manager to take charge of the app and drive its continuous innovation, ensuring it remains a reliable resource for our users.CMT is in search of a collaborative, customer-focused, and inventive Principal Product Manager II, Crash & Claims who is eager to contribute to our mission of making roads safer by improving driver behavior!

POS-9034About Our TeamThe Commerce Hub at HubSpot is revolutionizing how businesses sell, bill, and manage revenue seamlessly within our platform. Handling billions in customer transactions, our focus on accuracy, clarity, and reliability is paramount. We are developing an AI-first commerce ecosystem that integrates flawlessly with HubSpot’s CRM, offering a streamlined, consistent, and adaptable experience for both sellers and buyers.About the RoleWe are in search of a Principal Software Engineer to drive the technical evolution of Commerce Hub. This pivotal role demands hands-on involvement, where you will engage in coding, exploring services, evaluating complex designs, troubleshooting intricate systems, and taking ownership of the architecture for critical components in CPQ, Billing, Payments, and Revenue OS.Your ResponsibilitiesDevelop a Cohesive, Scalable PlatformInfluence the technical roadmap for CPQ, Billing, and Payments using strong, decisive patterns.Define and enhance core domain models to ensure consistent and predictable behavior for pricing, products, contracts, invoices, and payments.Create frameworks that facilitate easy extensions without increasing complexity.Be a Proactive, Impactful BuilderRegularly write code, lead design reviews, and construct impactful systems from start to finish.Manage extensive multi-team projects that encompass CPQ, Billing, and Payments.Transform prototypes into scalable production-ready solutions.Guide Architectural DirectionEstablish patterns for extensibility, contract boundaries, financial accuracy, event-driven consistency, and safe interactions between AI/agents and commerce objects.Advocate for simplicity in complex domains while maintaining consistency across surfaces.Collaborate Closely with Product LeadershipShape product strategies across CPQ, Buyer Portal, and Revenue OS.Assist teams in navigating trade-offs between speed, accuracy, compliance, and long-term platform sustainability.Elevate Organizational StandardsMentor senior engineers and technical leads.Drive informed design choices and facilitate learning from incidents and significant migrations.Encourage teams to align on best practices and strategic goals.

Imagine... being part of an innovative organization that cultivates and develops life sciences companies dedicated to pioneering groundbreaking technologies aimed at revolutionizing health care and sustainability. Company Overview Expedition Medicines is a dynamic, privately held, early-stage biotechnology company at the forefront of the Protein Editing field. We specialize in creating small molecules that modify protein structure and function to target currently undruggable options across various therapeutic strategies. Our advanced platform combines cutting-edge small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to facilitate generative design. Backed by Flagship Pioneering, we leverage their vision, courage, and resources to propel Expedition Medicines from platform validation to impactful patient solutions. We seek passionate, collaborative, and determined problem solvers to join our mission! Role Overview: The Senior/Principal Scientist in Structural Biology will concentrate on determining protein-ligand complex structures using X-ray crystallography and cryo-electron microscopy (cryo-EM). This role involves delivering structural insights and collaborating with project teams to advance structure-based drug design and uncover the mechanisms of action of small molecules. Key Responsibilities: Design and implement structural biology strategies for multiple projects. Oversee the design, expression, and purification of protein constructs for structural determination. Develop and execute protocols to achieve high-quality crystals for X-ray crystallography. Create and implement protocols for grid optimization, data collection, and analysis in cryo-EM. Refine and communicate structures of protein-ligand complexes, collaborating with project teams to drive hit-to-lead and lead optimization processes. Manage contract research organizations (CROs) to ensure efficient delivery of protein expression and structural biology services. Enhance our capabilities and serve as a trusted authority in the field of structural biology.

Your Impact at Lila As a Senior or Principal Research Engineer specializing in Synthetic Data, you will play a pivotal role in shaping the vision, roadmap, and execution of our synthetic data initiatives. Your responsibilities will span from asset generation and simulation to integrating machine learning training and achieving measurable enhancements in model performance. Collaborating closely with our Research Engineering team, you will design, generate, and implement artificial datasets aimed at training, testing, and refining Lila’s platform to achieve our strategic objectives. What You Will Build Define and refine the synthetic data strategy along with a comprehensive multi-quarter roadmap. Create evaluation frameworks that effectively connect synthetic interventions with genuine model performance. Establish high standards for asset quality, diversity, thorough documentation, and reproducibility while fostering a robust review culture. What You Will Need to Succeed Over 6 years of experience in applied ML/ML systems, with at least 3 years leading industry initiatives, showcasing a strong track record in advanced algorithms and frameworks designed for large-scale synthetic data generation. More than 8 years of experience working with contemporary ML workflows, including Python, PyTorch, dataset tools, training loops, and evaluation frameworks; adept at profiling and optimizing GPU-intensive pipelines. Bonus Points For A proven history of constructing synthetic datasets from source data to significantly enhance model performance in specific domains. Experience with instruction fine-tuning and hill-climbing techniques. Ability to translate product requirements and feedback into a scalable synthetic data generation pipeline. Knowledge of quantization, distillation, routing, mixture-of-experts, and cost optimization at scale. Experience in compliance-heavy settings (HIPAA, PCI, FedRAMP) and with on-premises/VPC deployments. About Lila Lila Sciences stands at the forefront of innovation as the world’s first scientific superintelligence platform and autonomous lab, dedicated to life sciences, chemistry, and materials science. We are ushering in an era of limitless discovery by harnessing AI to enhance every facet of the scientific method. Our mission is to empower scientists to tackle humanity's most pressing challenges in health, climate, and sustainability at an unprecedented pace and scale. Discover more about our mission at www.lila.ai. If this sounds like an environment in which you would thrive, we encourage you to apply even if your experience doesn't perfectly align with every requirement listed.