Principal Research Scientist II in Lipid Chemistry

We are on the lookout for exceptional scientists to join our Discovery Machine Learning team at Iambic Therapeutics. This position will play a pivotal role in utilizing cutting-edge machine learning techniques to enhance our drug discovery initiatives. You will collaborate with drug discovery teams focused on developing innovative therapeutics for a variety of conditions. Your work will center around our leading machine learning models, such as Enchant, our multimodal transformer model designed for predicting drug-target interactions and molecular properties. This opportunity is based at our headquarters in San Diego.

JOB SUMMARYiambic therapeutics is on the lookout for a talented and motivated Analytical/Bioanalytical Scientist specializing in chromatography-based purification to enhance our drug discovery initiatives. The chosen candidate will be instrumental in facilitating high-throughput purification and assay workflows, supporting a weekly design-make-test-analysis cycle driven by our proprietary AI-based drug discovery engine. The ideal individual will possess extensive expertise in chromatographic purification, particularly in SFC and/or LC purification of small molecules, along with demonstrated skills in instrument troubleshooting, workflow optimization, and a solid understanding of ADME/DMPK assay design and execution.KEY RESPONSIBILITIESAct as the authority in chromatography-based purification, leveraging significant experience in SFC and LC purification of small molecules within a drug discovery context.Create, implement, and refine purification workflows, including preparative chromatography methods, fraction collection strategies, and post-purification data integration.Design and sustain automated purification workflows to enhance throughput, reproducibility, and sample quality.Work collaboratively with medicinal chemistry, purification, and DMPK teams to supply high-quality purified compounds, aiding in lead optimization and screening.Provide direct support, preventive maintenance, and troubleshooting for LC, LC/MS, and SFC instruments to reduce downtime and ensure continuous lab operations.Engage with vendors and automation partners for service, upgrades, installations, and workflow integration.Potentially assist with ADME/DMPK and physicochemical assays, contributing to method development, troubleshooting, and execution as required.Document purification workflows, maintenance activities, and troubleshooting in line with laboratory best practices.QUALIFICATIONSPossession of an advanced degree (M.S. or Ph.D.) in Analytical Chemistry, Chemistry, Chemical Engineering, or a related discipline; or equivalent industry experience.A minimum of a Ph.D. with 2 years of relevant experience OR an M.S. with 6 years of relevant experience.Extensive hands-on experience with chromatography-based purification, particularly SFC and/or LC purification of small molecules.Strong proficiency in operating, maintaining, and troubleshooting chromatography and mass spectrometry instruments.

At Genesis Molecular AI, we are creating an elite team of experts in computational chemistry to transform the landscape of drug discovery through advanced machine learning and biophysical simulations. We invite a Senior Computational Aided Drug Discovery (CADD) Scientist to join us in our mission, collaborating closely with scientists in our advanced wet lab and our distributed teams in computational chemistry across the United States.Key ResponsibilitiesEmploy a mix of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse array of targets, including innovative targets with limited chemical history.Utilize techniques such as virtual screening, molecular simulations, and ADMET prediction to facilitate critical decision-making during drug discovery.Work closely with medicinal chemists on molecular design and the creation of tailored computational methodologies for specific projects.Serve as a liaison across teams, effectively bridging communication between our computational and medicinal chemistry departments to ensure smooth information exchange and collaborative strategies.Thrive in a fast-paced environment that encourages innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. Candidates with a PhD in organic or medicinal chemistry and substantial laboratory experience transitioning into industry roles in CADD are also encouraged to apply.Extensive knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools, including MOE, PyMOL, and Schrodinger Suite.A minimum of 2 years of experience in the pharmaceutical or biotech industry as a CADD scientist, with practical involvement in active drug discovery projects.While onsite presence at our San Diego lab is preferred for collaboration, we are open to considering remote team members as well.What We OfferAttractive SalaryComprehensive Health Care Plans (Medical, Dental, and Vision fully covered for employees)An opportunity to work in a pioneering environment with the latest technologies in drug discovery.

At Genesis Molecular AI, we are on a mission to transform the landscape of drug discovery by forming a premier computational chemistry team that leverages advanced machine learning techniques and biophysical simulations. We are actively looking for a Principal CADD Scientist to collaborate with our scientists in our cutting-edge wet lab and coordinate with our remote computational chemistry and CADD science teams throughout the United States.Key ResponsibilitiesEmploy both established and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse range of targets, including innovative targets with minimal chemical precedents.Implement strategies such as virtual screening, molecular simulations, and predictive analytics for potency and ADMET to inform critical decision-making in drug development.Work collaboratively with medicinal chemists on molecular design and the formulation of project-specific computational methodologies.Serve as a liaison among teams, ensuring effective communication between computational chemistry and medicinal chemistry groups to facilitate seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that fosters innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. This role is also suitable for PhD-level professionals in organic or medicinal chemistry with substantial lab experience who have transitioned into CADD roles.In-depth knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.A minimum of 5 years of relevant industry experience as a CADD scientist in pharmaceuticals or biotechnology, with direct involvement in active drug discovery projects.While onsite presence in our San Diego lab is preferred for collaboration, we welcome applicants interested in remote opportunities.What We OfferCompetitive salary and benefits packageComprehensive health care plans (including medical, dental, and vision, fully covered for employees)Eligibility for stock options

Join Veracyte, a leader in transforming cancer care through innovative diagnostics that empower patients and clinicians alike. At Veracyte, we provide an inspiring work environment where you can make a significant impact on patients' lives while advancing your career. Our culture, known as the Veracyte way, emphasizes collaboration, resilience, and a commitment to excellence.Our Core Values:We Seek A Better Way: We boldly innovate and learn from challenges to improve cancer care.We Make It Happen: We prioritize urgency, quality, and enjoyment in our work.We Are Stronger Together: We foster open collaboration and celebrate our collective successes.We Care Deeply: We honor our diverse backgrounds and support each other in doing what is right.The Role:We are on the lookout for an enthusiastic Bioinformatics Research Scientist to join our Translational Bioinformatics group within the Bioinformatics and Data Science Team. This pivotal role involves leveraging computational and statistical techniques on extensive transcriptomic and genomic datasets, particularly focusing on prostate cancer biology and its clinical implications. The ideal candidate will play a key role in identifying clinically relevant molecular signatures that enhance disease stratification, prognosis, and the development of diagnostics, while effectively communicating findings to both scientific and clinical audiences. This position offers a unique opportunity to bridge the realms of data science, biology, and clinical research through close collaboration with scientists, clinicians, and cross-functional teams to convert complex data into actionable insights.

Our MissionAt Altos Labs, our mission is to rejuvenate cellular health and resilience, aiming to reverse diseases, injuries, and age-related disabilities.For further details, visit our website at altoslabs.com.Our ValueWe believe in a single core value: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe embrace diverse perspectives as essential to scientific innovation. Our team comprises exceptional scientists and industry leaders from around the globe, unified in advancing our mission. We prioritize belonging, ensuring every employee feels valued for their unique insights. Together, we are accountable for fostering a diverse and inclusive workplace.Your Contributions to AltosAs a member of our team, you will play a crucial role in accelerating our development of multi-modal generative foundation models for multiscale biology. We are looking to hire either a Machine Learning Scientist or a Machine Learning Engineer.In either capacity, you will be an essential part of our multidisciplinary teams, building computational platforms that help Altos achieve its mission. Collaborating with fellow Machine Learning Scientists and Engineers within the Institute of Computation, you will contribute to the Altos research and translation ecosystem. Your focus will be on designing and constructing cutting-edge multimodal foundation models that address biological challenges and facilitate the discovery of innovative interventions for aging and disease.The ideal candidate will thrive in a dynamic environment that values teamwork, transparency, scientific excellence, originality, and integrity.

Join our dynamic team as a Scientist II, where you will leverage your expertise to drive innovation and contribute to cutting-edge research projects. You will work collaboratively with a team of professionals in a stimulating environment that fosters growth and creativity.

Join AbbVie as a Principal Research Scientist II in our Analytical Development team, where you will play a pivotal role in advancing our therapeutic solutions. Your expertise will be crucial in developing and validating analytical methods, ensuring our products meet the highest standards of quality and efficacy.This position offers a unique opportunity to collaborate with cross-functional teams, driving innovation and excellence in our research initiatives. If you are passionate about scientific discovery and eager to contribute to impactful projects, we invite you to apply.

Join AbbVie as a Scientist II specializing in In Vitro Pharmacology. In this pivotal role, you will collaborate with a dynamic team of scientists to drive innovative research that advances our understanding of pharmacological compounds. Your expertise will contribute to the development of groundbreaking therapies aimed at improving patient outcomes.

Job Overview: We are seeking a dedicated Bench Scientist II to join our dynamic team in San Diego. This role entails collaborating with fellow scientists to advance translational pharmacology research focusing on various clinical candidate compounds and late-stage assets. Key responsibilities include performing tissue culture, conducting cell-based assays, and executing western blot analysis. The ideal candidate will possess a solid background in cancer biology and relevant laboratory experience while demonstrating strong communication and teamwork skills.Key Responsibilities: Conduct tissue culture, cell-based assays, and western blot analysisWork with unscreened blood, human tissue, or human cell lines

Genesis Molecular AI is on a mission to transform drug discovery through innovative computational chemistry solutions. We are building a premier team of experts in computational chemistry, and we invite you to join us as a Senior CADD Scientist. In this pivotal role, you will collaborate closely with our cutting-edge wet lab scientists and work alongside our distributed computational chemistry and CADD science teams throughout the United States.Key Responsibilities:Employ a blend of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a varied target landscape, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and potency and ADMET prediction to facilitate critical decision-making processes in drug discovery.Work collaboratively with medicinal chemists to design molecules and develop tailored computational strategies for specific projects.Serve as a bridge among teams, effectively communicating between our computational chemistry and medicinal chemistry groups to promote seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that encourages innovation and rapid iteration.

Join our innovative team at Artech Information Systems LLC as a Research Scientist. We are seeking a dedicated individual to contribute to groundbreaking research initiatives. You will engage in scientific inquiry, data analysis, and collaborative projects that push the boundaries of knowledge in your field.

Join LanceSoft, Inc. as a Research Scientist I in the vibrant city of San Diego, California. In this entry-level role, you will play a crucial part in supporting scientific research initiatives, collaborating with senior scientists, and contributing to innovative projects within our dynamic team.

Join our dynamic team at Integrated Resources, Inc. as a Research Scientist I. In this role, you will contribute to cutting-edge research initiatives, collaborating with multidisciplinary teams to innovate and develop groundbreaking solutions.

Scismic is proud to partner with a leading global consulting firm renowned for its collaborative and inclusive culture that nurtures creativity, growth, and innovation. With a dedicated team of over 1,000 professionals operating across 50 international markets, this organization collaborates with prestigious clients to tackle intricate business challenges spanning various industries. The company embraces a 'builder’s mindset,' empowering employees to devise innovative solutions, create a lasting impact, and advance their careers in a supportive environment.We are currently seeking a talented Senior Data Scientist who possesses extensive expertise in Natural Language Processing and Large Language Models to join our consulting practice. You will collaborate directly with Fortune 500 clients, leveraging cutting-edge AI technologies to address complex business challenges across diverse sectors.

JOB SUMMARYIambic Therapeutics is on the lookout for a talented and highly motivated Senior/Principal Scientist specializing in Computational Chemistry to join our innovative Computational Sciences team at our San Diego headquarters. As a vital contributor, you will leverage advanced ligand and structure-based methodologies to propel our drug discovery initiatives. You will actively engage with research teams focused on developing groundbreaking therapeutics across various indications. Collaborating closely with experts in machine learning, medicinal chemistry, and biology, you will implement state-of-the-art Structure-Based Drug Design (SBDD) techniques throughout hit identification, lead optimization, and candidate selection phases. This hands-on position demands robust expertise in computational chemistry, a keen interest in co-folding applications, and a proactive drug-hunter mindset.KEY RESPONSIBILITIESUtilize diverse ligand and structure-based strategies during the hit identification, lead optimization, and candidate selection phases (including cheminformatics, pharmacophore modeling, docking, shape-based virtual screening, de novo molecular design, and molecular dynamics simulations).Lead design cycles by identifying structure-activity relationships and integrating computational predictions with bioactivity data.Collaborate with medicinal chemists to design, assess, and prioritize virtual libraries, proposing concrete molecular designs.Work alongside machine learning scientists to meld SBDD methodologies with our proprietary transformer-based property prediction technology (Enchant).Enhance and utilize our proprietary protein-ligand co-folding technology (NeuralPLexer) to generate novel and actionable structural hypotheses.Translate scientific inquiries into computational workflows, delivering actionable insights.Present findings to project teams, elucidating methods, implications, and recommendations.Develop, validate, and maintain computational workflows and tools.QUALIFICATIONSRequired:PhD or equivalent in Computational Chemistry (or a related field) with a minimum of 5 years of experience in an industrial drug discovery setting.Proven experience in supporting active small molecule drug discovery programs.Experience with ligand and structure-based drug design methodologies.

Join AbbVie as a Senior Scientist II in Analytical Development, where your expertise will contribute to innovative solutions in biopharmaceuticals. You will collaborate with a dynamic team, leveraging your analytical skills to drive research and development efforts. This role is pivotal in advancing our mission to improve patient outcomes through groundbreaking therapies.

Role Overview ServiceNow is hiring a Staff Machine Learning Engineer focused on VoIP Infrastructure in San Diego. This position centers on applying machine learning expertise within telecommunications to strengthen and expand ServiceNow’s VoIP offerings. What You Will Do Develop and refine machine learning models tailored for VoIP systems Optimize algorithms to improve performance and reliability Work closely with cross-functional teams to bring advanced technology into production VoIP environments Contribute solutions that shape customer experiences and influence the direction of ServiceNow’s services About the Team This engineering group collaborates across disciplines to deliver high-quality, innovative solutions for clients using ServiceNow’s VoIP infrastructure.

Join Genesis Molecular AI as a Senior / Principal ADME Scientist in San Diego, CA!At Genesis Molecular AI, we are at the forefront of utilizing artificial intelligence to revolutionize rational drug design and tackle significant unmet medical needs. We are looking for an enthusiastic and adaptable ADME Scientist to become a vital part of our Non-Clinical Development team, facilitating the progression of our innovative compounds through both preclinical and clinical phases.This full-time role is set in a dynamic biotech environment where collaboration thrives among a talented team of professionals, all working towards clear scientific objectives. We offer an attractive benefits package, including comprehensive medical and dental insurance, flexible working hours, generous vacation time, and the chance to engage deeply with the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in various ADME-related assays such as metabolic stability, protein binding, drug-drug interactions, and more. They will be skilled in developing, executing, and troubleshooting assays both independently and in collaboration with external partners. As the subject matter expert in in-vitro ADME, you will provide critical strategic input to our project teams. Experience in bioanalytical assays and method development is a plus.