Principal CADD Scientist

AbbVie is seeking a highly skilled Principal Research Scientist II specializing in Lipid Chemistry to join our innovative team in San Diego. This role is pivotal in advancing our research efforts and driving the development of novel lipid-based therapies. The ideal candidate will possess a robust background in lipid biochemistry, with a proven track record of impactful research and development.

Role Overview iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams focused on automated experimentation, AI-driven molecular design, property prediction, and bioassay data generation. What You Will Do Design and refine strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties, using multivariate SAR analysis and hypothesis-driven design. Apply a broad range of modern organic chemistry transformations and synthetic methodologies, including parallel experimentation, to advance project goals. Work closely with colleagues in molecular and cellular biology, pharmacology, computational chemistry, ADME, and related groups to drive discovery efforts. Shape the use of computational approaches, automated synthesis, and high-throughput experimentation in medicinal chemistry projects. Collaborate with AI and machine learning teams to build and apply predictive models for novel molecule design. Clearly communicate project updates and findings to the broader team and stakeholders. Contribute to the Chemistry research group, supporting a culture of scientific rigor, innovation, and teamwork. Qualifications BS, MS, or PhD in chemistry, with a focus on synthetic organic chemistry. Direct experience in small molecule drug discovery within biotech or pharma: minimum 15+ years with a BS, 12+ years with an MS, or 8+ years with a PhD. Documented success advancing drug discovery programs from lead identification through advanced candidate stages. Deep experience optimizing lead compounds for potency, selectivity, ADME, and pharmacokinetics. Expert knowledge of modern synthetic organic chemistry methods, supported by publications and patents. Hands-on familiarity with target protein degradation and modalities such as molecular glues and PROTACs. This position is based onsite at our San Diego HQ.

Join AbbVie as a Principal Research Scientist II in our Analytical Development team, where you will play a pivotal role in advancing our therapeutic solutions. Your expertise will be crucial in developing and validating analytical methods, ensuring our products meet the highest standards of quality and efficacy.This position offers a unique opportunity to collaborate with cross-functional teams, driving innovation and excellence in our research initiatives. If you are passionate about scientific discovery and eager to contribute to impactful projects, we invite you to apply.

As a Staff Scientist at Scripps Research, you will have the opportunity to contribute to cutting-edge research in organic chemistry. Your responsibilities will be tailored to the specific laboratory and the Principal Investigator's needs. You will engage in laboratory management, assist in grant editing and reporting, maintain LC-MS systems, support collaborations with the Principal Investigator and graduate students, and organize chemical libraries while developing click chemistry methodologies.

At Bee Genius, we are pioneering the future of work, today.This post was generated on behalf of our client:Job Description: We are seeking a highly accomplished and motivated Principal Scientist to become an integral part of our innovative team. In this role, you will spearhead groundbreaking scientific research and development initiatives, offer expert technical guidance, and catalyze innovation within our organization.Responsibilities:Lead and oversee scientific research projects from conception through to execution.Design and refine scientific methodologies and protocols for optimal outcomes.Conduct thorough analysis and interpretation of intricate data, effectively presenting insights to stakeholders.Mentor and provide technical support to junior scientists, fostering their professional growth.Collaborate with cross-functional teams to convert scientific discoveries into actionable applications.Remain abreast of the latest advancements and industry trends in your field.

JOB SUMMARYIambic Therapeutics is on the lookout for a talented and highly motivated Senior/Principal Scientist specializing in Computational Chemistry to join our innovative Computational Sciences team at our San Diego headquarters. As a vital contributor, you will leverage advanced ligand and structure-based methodologies to propel our drug discovery initiatives. You will actively engage with research teams focused on developing groundbreaking therapeutics across various indications. Collaborating closely with experts in machine learning, medicinal chemistry, and biology, you will implement state-of-the-art Structure-Based Drug Design (SBDD) techniques throughout hit identification, lead optimization, and candidate selection phases. This hands-on position demands robust expertise in computational chemistry, a keen interest in co-folding applications, and a proactive drug-hunter mindset.KEY RESPONSIBILITIESUtilize diverse ligand and structure-based strategies during the hit identification, lead optimization, and candidate selection phases (including cheminformatics, pharmacophore modeling, docking, shape-based virtual screening, de novo molecular design, and molecular dynamics simulations).Lead design cycles by identifying structure-activity relationships and integrating computational predictions with bioactivity data.Collaborate with medicinal chemists to design, assess, and prioritize virtual libraries, proposing concrete molecular designs.Work alongside machine learning scientists to meld SBDD methodologies with our proprietary transformer-based property prediction technology (Enchant).Enhance and utilize our proprietary protein-ligand co-folding technology (NeuralPLexer) to generate novel and actionable structural hypotheses.Translate scientific inquiries into computational workflows, delivering actionable insights.Present findings to project teams, elucidating methods, implications, and recommendations.Develop, validate, and maintain computational workflows and tools.QUALIFICATIONSRequired:PhD or equivalent in Computational Chemistry (or a related field) with a minimum of 5 years of experience in an industrial drug discovery setting.Proven experience in supporting active small molecule drug discovery programs.Experience with ligand and structure-based drug design methodologies.

Join Veracyte, a leader in transforming cancer care through innovative diagnostics that empower patients and clinicians alike. At Veracyte, we provide an inspiring work environment where you can make a significant impact on patients' lives while advancing your career. Our culture, known as the Veracyte way, emphasizes collaboration, resilience, and a commitment to excellence.Our Core Values:We Seek A Better Way: We boldly innovate and learn from challenges to improve cancer care.We Make It Happen: We prioritize urgency, quality, and enjoyment in our work.We Are Stronger Together: We foster open collaboration and celebrate our collective successes.We Care Deeply: We honor our diverse backgrounds and support each other in doing what is right.The Role:We are on the lookout for an enthusiastic Bioinformatics Research Scientist to join our Translational Bioinformatics group within the Bioinformatics and Data Science Team. This pivotal role involves leveraging computational and statistical techniques on extensive transcriptomic and genomic datasets, particularly focusing on prostate cancer biology and its clinical implications. The ideal candidate will play a key role in identifying clinically relevant molecular signatures that enhance disease stratification, prognosis, and the development of diagnostics, while effectively communicating findings to both scientific and clinical audiences. This position offers a unique opportunity to bridge the realms of data science, biology, and clinical research through close collaboration with scientists, clinicians, and cross-functional teams to convert complex data into actionable insights.

Job SummaryIambic Therapeutics is looking for an exceptional and driven Senior Associate Scientist to enhance our Chemistry team at our San Diego headquarters. This exciting position allows you to thrive in a vibrant, cross-disciplinary environment, where you will collaborate closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning experts, and software engineers. You will engage in every phase of the discovery process, from hit identification and lead optimization to candidate selection. This role is laboratory-focused and demands robust technical skills in organic synthesis, catalysis, and medicinal chemistry, alongside hands-on experience in the drug discovery process and a proven “drug hunter” mentality.Key ResponsibilitiesDesign, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) utilizing cutting-edge analytical techniques including LCMS, HPLC, and NMR, implementing both manual and automated parallel synthesis techniques.Identify and optimize reaction conditions through the use of screening kits and other efficient methodologies.Collaborate with the high-throughput experimentation team to guarantee successful execution of parallel chemistry experiments.Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.Work alongside computational chemists to harness machine learning insights for the effective execution of the design–make–test cycle and platform development.Present findings to project teams and senior leadership, effectively communicating data, implications, and recommendations.QualificationsBS in Chemistry with 5+ years of experience in the pharmaceutical or biotechnology sector, or MS in Chemistry with 3+ years of relevant experience.Demonstrated expertise in multi-step organic synthesis, reaction optimization, Structure-Activity Relationship (SAR) analysis, and effective scientific presentation skills.Adeptness in a fast-paced, highly collaborative research atmosphere.Willingness to work onsite in San Diego.Preferred QualificationsExperience in high-throughput experimentation is advantageous.Familiarity with ADME-PK principles is a plus.5+ years of experience contributing to drug discovery projects is preferred.

Join our dynamic team as a Scientist II, where you will leverage your expertise to drive innovation and contribute to cutting-edge research projects. You will work collaboratively with a team of professionals in a stimulating environment that fosters growth and creativity.

JOB SUMMARYiambic therapeutics is on the lookout for a talented and motivated Analytical/Bioanalytical Scientist specializing in chromatography-based purification to enhance our drug discovery initiatives. The chosen candidate will be instrumental in facilitating high-throughput purification and assay workflows, supporting a weekly design-make-test-analysis cycle driven by our proprietary AI-based drug discovery engine. The ideal individual will possess extensive expertise in chromatographic purification, particularly in SFC and/or LC purification of small molecules, along with demonstrated skills in instrument troubleshooting, workflow optimization, and a solid understanding of ADME/DMPK assay design and execution.KEY RESPONSIBILITIESAct as the authority in chromatography-based purification, leveraging significant experience in SFC and LC purification of small molecules within a drug discovery context.Create, implement, and refine purification workflows, including preparative chromatography methods, fraction collection strategies, and post-purification data integration.Design and sustain automated purification workflows to enhance throughput, reproducibility, and sample quality.Work collaboratively with medicinal chemistry, purification, and DMPK teams to supply high-quality purified compounds, aiding in lead optimization and screening.Provide direct support, preventive maintenance, and troubleshooting for LC, LC/MS, and SFC instruments to reduce downtime and ensure continuous lab operations.Engage with vendors and automation partners for service, upgrades, installations, and workflow integration.Potentially assist with ADME/DMPK and physicochemical assays, contributing to method development, troubleshooting, and execution as required.Document purification workflows, maintenance activities, and troubleshooting in line with laboratory best practices.QUALIFICATIONSPossession of an advanced degree (M.S. or Ph.D.) in Analytical Chemistry, Chemistry, Chemical Engineering, or a related discipline; or equivalent industry experience.A minimum of a Ph.D. with 2 years of relevant experience OR an M.S. with 6 years of relevant experience.Extensive hands-on experience with chromatography-based purification, particularly SFC and/or LC purification of small molecules.Strong proficiency in operating, maintaining, and troubleshooting chromatography and mass spectrometry instruments.

Join AbbVie as a Scientist II specializing in In Vitro Pharmacology. In this pivotal role, you will collaborate with a dynamic team of scientists to drive innovative research that advances our understanding of pharmacological compounds. Your expertise will contribute to the development of groundbreaking therapies aimed at improving patient outcomes.

Job Overview: We are seeking a dedicated Bench Scientist II to join our dynamic team in San Diego. This role entails collaborating with fellow scientists to advance translational pharmacology research focusing on various clinical candidate compounds and late-stage assets. Key responsibilities include performing tissue culture, conducting cell-based assays, and executing western blot analysis. The ideal candidate will possess a solid background in cancer biology and relevant laboratory experience while demonstrating strong communication and teamwork skills.Key Responsibilities: Conduct tissue culture, cell-based assays, and western blot analysisWork with unscreened blood, human tissue, or human cell lines

Join our innovative team at Artech Information Systems LLC as a Research Scientist. We are seeking a dedicated individual to contribute to groundbreaking research initiatives. You will engage in scientific inquiry, data analysis, and collaborative projects that push the boundaries of knowledge in your field.

We are on the lookout for exceptional scientists to join our Discovery Machine Learning team at Iambic Therapeutics. This position will play a pivotal role in utilizing cutting-edge machine learning techniques to enhance our drug discovery initiatives. You will collaborate with drug discovery teams focused on developing innovative therapeutics for a variety of conditions. Your work will center around our leading machine learning models, such as Enchant, our multimodal transformer model designed for predicting drug-target interactions and molecular properties. This opportunity is based at our headquarters in San Diego.

Join LanceSoft, Inc. as a Research Scientist I in the vibrant city of San Diego, California. In this entry-level role, you will play a crucial part in supporting scientific research initiatives, collaborating with senior scientists, and contributing to innovative projects within our dynamic team.

Join our dynamic team at Integrated Resources, Inc. as a Research Scientist I. In this role, you will contribute to cutting-edge research initiatives, collaborating with multidisciplinary teams to innovate and develop groundbreaking solutions.

Genesis Molecular AI is on a mission to transform drug discovery through innovative computational chemistry solutions. We are building a premier team of experts in computational chemistry, and we invite you to join us as a Senior CADD Scientist. In this pivotal role, you will collaborate closely with our cutting-edge wet lab scientists and work alongside our distributed computational chemistry and CADD science teams throughout the United States.Key Responsibilities:Employ a blend of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a varied target landscape, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and potency and ADMET prediction to facilitate critical decision-making processes in drug discovery.Work collaboratively with medicinal chemists to design molecules and develop tailored computational strategies for specific projects.Serve as a bridge among teams, effectively communicating between our computational chemistry and medicinal chemistry groups to promote seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that encourages innovation and rapid iteration.

At Genesis Molecular AI, we are assembling a premier computational chemistry team dedicated to transforming drug discovery through state-of-the-art machine learning and biophysical simulations. We invite applications for the role of Principal CADD Scientist, who will collaborate closely with our scientists in the advanced wet lab and our distributed computational chemistry and CADD teams located across the United States.Key ResponsibilitiesEmploy a mix of industry-leading and proprietary AI-driven CADD tools to steer small molecule drug discovery projects across a wide array of targets, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and ADMET prediction to facilitate critical decision-making during the drug discovery process.Work in tandem with medicinal chemists in molecular design and the formulation of project-specific computational strategies.Serve as an effective liaison among the computational and medicinal chemistry teams, ensuring smooth communication and collaborative decision-making.Thrive in a fast-paced environment that champions innovation and rapid iteration.QualificationsPh.D. in Computational Chemistry, Structural Biology, or a closely related discipline. Candidates with a Ph.D. in organic or medicinal chemistry and substantial laboratory experience transitioning to industry roles in CADD may also be considered.Comprehensive understanding of structure-based drug design and protein-ligand interactions.Expertise in industry-standard CADD software such as MOE, PyMOL, and Schrödinger Suite.A minimum of 5 years of experience as a CADD scientist in the pharmaceutical or biotechnology sector, with direct involvement in active drug discovery projects.While onsite collaboration in our San Diego lab is preferred, we are open to accommodating remote team members.What We OfferCompetitive salary and benefitsComprehensive health care plans, including medical, dental, and vision insurance fully covered for employeesEligibility for stock options

We are seeking a dedicated and detail-oriented Research Associate II to join our dynamic team in San Diego. In this role, you will be responsible for conducting research, analyzing data, and contributing to the development of innovative solutions. You will work collaboratively with senior researchers and other team members to support ongoing projects and initiatives.