Senior Bioinformatics Scientist

Join Veracyte, a trailblazing organization dedicated to revolutionizing cancer care for patients worldwide. At Veracyte, our team members have the opportunity to make a significant difference in patients' lives while thriving in a mission-driven environment. We embrace the Veracyte way, which emphasizes collaboration, guided by our core values, to equip clin…

Join Veracyte, a leader in transforming cancer care through innovative diagnostics that empower patients and clinicians alike. At Veracyte, we provide an inspiring work environment where you can make a significant impact on patients' lives while advancing your career. Our culture, known as the Veracyte way, emphasizes collaboration, resilience, and a commitment to excellence.Our Core Values:We Seek A Better Way: We boldly innovate and learn from challenges to improve cancer care.We Make It Happen: We prioritize urgency, quality, and enjoyment in our work.We Are Stronger Together: We foster open collaboration and celebrate our collective successes.We Care Deeply: We honor our diverse backgrounds and support each other in doing what is right.The Role:We are on the lookout for an enthusiastic Bioinformatics Research Scientist to join our Translational Bioinformatics group within the Bioinformatics and Data Science Team. This pivotal role involves leveraging computational and statistical techniques on extensive transcriptomic and genomic datasets, particularly focusing on prostate cancer biology and its clinical implications. The ideal candidate will play a key role in identifying clinically relevant molecular signatures that enhance disease stratification, prognosis, and the development of diagnostics, while effectively communicating findings to both scientific and clinical audiences. This position offers a unique opportunity to bridge the realms of data science, biology, and clinical research through close collaboration with scientists, clinicians, and cross-functional teams to convert complex data into actionable insights.

Join Veracyte as a Senior Computational Development Scientist, where you will play a pivotal role in our mission to transform patient care through innovative genomics. In this remote position, you will leverage cutting-edge computational techniques to analyze complex genomic data, contributing to groundbreaking discoveries in cancer diagnostics.

Join our dynamic team at Artech Information Systems LLC as a Bioinformatics Software Engineer! In this pivotal role, you will leverage your expertise in bioinformatics and software development to create innovative solutions that drive advancements in biotechnology.

About Xaira TherapeuticsXaira Therapeutics is a cutting-edge biotechnology startup dedicated to harnessing the power of artificial intelligence to revolutionize the fields of drug discovery and development. Our mission is to innovate generative AI models that facilitate the design of protein and antibody therapeutics, paving the way for effective treatments against traditionally challenging molecular targets. In addition, we are advancing foundational biological models to enhance target identification and patient stratification. These pioneering technologies are designed to continuously uncover novel therapies and boost the success rates in drug development. Our headquarters are strategically located in the San Francisco Bay Area, Seattle, and London.About the RoleWe are seeking an AI Scientist to become an integral part of our team at the convergence of machine learning and single-cell biology. In this pivotal role, you will focus on the development and application of foundational models to large-scale perturb-seq and single-cell datasets, revealing new biological mechanisms and therapeutic potentials. You will be responsible for designing scalable machine learning architectures that can extract insights from high-dimensional perturbation data and integrate across multi-omic modalities.

About Us: Calico Life Sciences LLC, a cutting-edge research and development firm founded by Alphabet, is dedicated to unraveling the complexities of human aging through advanced technologies and innovative model systems. Our mission is to leverage this understanding to create interventions that promote longer, healthier lives. With state-of-the-art technology labs, a culture of curiosity-driven discovery, and a robust pipeline of drug development in collaboration with both academic and industry partners, Calico is an inspiring environment for catalyzing medical breakthroughs. Job Overview: We are on the lookout for a dynamic and passionate Scientist/Senior Scientist in Aging Biology to become a pivotal member of our Translational Medicine team. In this vital role, you will investigate the mechanisms of action (MOA) of therapeutic targets within our aging biology pipeline. The successful candidate will define the molecular and cellular pathways integral to our research programs, translating novel in vivo findings into a profound mechanistic understanding that will guide clinical development. The ideal candidate will possess substantial expertise in cell biology, MOA studies, and complex signaling pathways. Key Responsibilities: Design and implement experimental strategies to elucidate the molecular and cellular mechanisms of action for aging-related targets and biomarkers, providing insights that steer program direction. Execute in vitro and ex vivo studies to explore target biology in significant aging-related processes, such as stem cell function, tissue repair, and signaling or transcriptional regulation. Analyze acute and chronic pathway modulation in tissue injury and aging models to comprehend the evolution of stress responses and repair mechanisms in aging. Investigate the molecular drivers of in vivo phenotypes in preclinical aging models to identify biomarkers and translatable mechanisms for clinical development. Collaborate with in vivo pharmacology and biomarker teams to select optimal preclinical models that effectively probe target biology. Engage with cross-functional teams (e.g., Biomarkers, Genomics, Protein Sciences) to integrate multi-omic datasets and construct a comprehensive mechanistic framework. Analyze, interpret, and present complex data along with strategic recommendations to internal project teams and senior leadership. Maintain rigorous experimental documentation and contribute to internal reports, publications, and regulatory submissions.

About Us:Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of human aging through cutting-edge technologies and model systems. Our mission is to leverage this knowledge to develop interventions that promote longer, healthier lives. At Calico, we foster a culture of curiosity-driven science, supported by a robust drug-development pipeline in collaboration with leading academic and industry partners, making us a dynamic environment for medical innovation.Position Overview:We are on the lookout for a seasoned Scientist to join our mass spectrometry proteomics team. The ideal candidate will exhibit enthusiasm, attention to detail, and exceptional organizational skills while tackling complex scientific challenges. This role focuses on employing chemoproteomics techniques via mass spectrometry to facilitate drug discovery, involving extensive sample handling and optimization of proteomics methodologies to propel our drug discovery initiatives forward.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development firm with the mission to leverage cutting-edge technologies and experimental systems to deepen our understanding of the biology behind human aging. Our goal is to translate this knowledge into innovative interventions that enhance the quality and longevity of life. With a vibrant drug-development pipeline and a commitment to curiosity-driven scientific exploration, Calico offers a dynamic environment where medical breakthroughs are catalyzed and realized. Position Overview: We are on the lookout for a dedicated in vivo scientist to propel our neurodegenerative disease research forward, specifically targeting Parkinson's disease. This role is vital for designing, executing, and interpreting experiments utilizing rodent models to explore neurological and aging disorders while evaluating potential therapeutic interventions. The successful candidate will enhance our Translational Neuroscience team's capacity for in vivo research, establish sophisticated models for thorough investigation, and assess novel drug mechanisms of action. Additionally, the scientist will contribute to modeling innovative aspects of neurodegenerative diseases, integrate insights from human cohorts, and develop mechanistic models for hypothesis testing stemming from new target discoveries. Key Responsibilities: Develop and characterize novel in vivo models related to neurodegeneration and age-associated biology. Design and implement in vivo functional experiments for target validation and mechanistic biology studies. Conduct comprehensive animal behavioral assessments to delineate neurological phenotypes. Analyze, interpret, and effectively communicate data and results to the team. Maintain meticulous records of experiments, data, and findings in compliance with Calico guidelines. Participate in experimental design, data interpretation, and results presentation. Foster collaboration across multiple functional teams. Ensure adherence to all animal welfare regulations and institutional guidelines.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of the biological mechanisms of human aging. Our mission is to leverage cutting-edge technologies and innovative model systems to create interventions that promote longer, healthier lives. With our state-of-the-art laboratories, commitment to curiosity-driven discovery, collaborative partnerships across academia and industry, and a dynamic drug development pipeline, Calico is an inspiring environment for driving impactful medical breakthroughs. Position Overview: The Cellular Models and Assay Technologies (CMAT) laboratory and the Microscopy group at Calico are in search of a highly skilled and driven bench Scientist to join our innovative teams. This position is at the forefront of spatial biology, concentrating on the intricate mapping of molecular environments involving proteins and protein complexes within both live and fixed cells and tissues. The ideal candidate will spearhead the creation and application of Laser Capture Microdissection (LCM) workflows integrated with various proximity biotinylation techniques to achieve exceptional resolution in multiomics experiments specific to cells and tissues. As a crucial member of our drug discovery and fundamental research initiatives, the successful applicant will play a significant role in identifying and validating novel therapeutic targets and biomarkers. This hands-on position necessitates a profound understanding of cell and tissue biology, biochemistry, microscopy, and image analysis, along with the capability to develop or adapt novel methodologies as required. We seek an independent, adaptable, and proactive scientist with outstanding communication skills who can effectively manage complex studies in a fast-paced environment.

Lead the analytical development and product characterization activities for our diverse drug development portfolios independently. Oversee, provide technical guidance, and direct analytical method development, transfer, validation, release, and stability testing activities at contract development and manufacturing organizations (CDMOs). Serve as a subject matter expert for comprehensive physical and chemical characterization of new chemical entities (NCEs) at contract research organizations (CROs).Independently design, conceptualize, and execute experiments while interpreting and presenting data and conclusions to a variety of audiences, including senior leadership. Tackle complex problems utilizing traditional and innovative analytical techniques. Ensure accurate and timely lab records in compliance with good documentation practices and all applicable laboratory, safety, quality, and regulatory standards.Develop and implement strategic project plans for internal and external projects, ensuring that product requirements are accurately designed and delivered on schedule for all stakeholders throughout the drug development continuum—from discovery through preclinical, clinical, and commercial stages. Provide technical support during investigations at CDMOs and CROs in collaboration with quality teams.Author and review technical reports, data packages, and relevant sections for health authority submissions including INDs, NDAs, and annual reports, while supporting due diligence and partnership efforts.Exhibit excellent communication skills in project management, including budget planning, overseeing progress and periodic accruals, and coordinating contracts, purchase orders, and invoices with finance; ensure follow-ups and maintain project timelines to meet high-quality deliverables.

At Veracyte, we are thrilled to invite talented individuals to join our innovative team dedicated to revolutionizing cancer care for patients worldwide. Being part of Veracyte empowers our employees to make a profound impact on patient lives while fostering personal and professional growth in a mission-driven environment. This embodies the Veracyte way: a collaborative approach guided by our core values, enabling clinicians with insights to help patients make transformative decisions.Our Values:We Seek A Better Way: We boldly innovate, learn from setbacks, and remain resilient in our mission to transform cancer care.We Make It Happen: We act swiftly, uphold quality, and infuse enjoyment into our hard work.We Are Stronger Together: We foster open collaboration, strive for understanding, and celebrate our achievements.We Care Deeply: We embrace diversity, act ethically, and support one another. The Position:We are seeking an enthusiastic and driven individual to become a vital member of our Product Development team as a Senior Scientist. This role is focused on the development of assays for high-throughput operations, contributing to Veracyte's groundbreaking diagnostic products. You will play a key role in study design and documentation, executing bench studies while adhering to rigorous design control standards.

AbbVie is seeking a dedicated Senior Scientist II specializing in Occupational and Environmental Toxicology to join our innovative team in South San Francisco. In this pivotal role, you will leverage your expertise to assess and mitigate the risks associated with chemical exposure in various environments, ensuring the safety and health of populations.

Join Alumis Inc., a pioneering precision medicines company dedicated to transforming the lives of patients suffering from autoimmune diseases. Despite significant advancements in treatment over the past two decades, many individuals with immunologic conditions still struggle; our mission is to fundamentally improve their outcomes.The CMC team at Alumis is on the lookout for a driven and highly skilled Senior Scientist I in Analytical Development. In this role, you will contribute significantly to our research efforts, utilizing your expertise to develop and validate analytical methods, ensuring the quality and efficacy of our innovative therapeutics.

About Us:Calico Life Sciences LLC, a research and development firm backed by Alphabet, is dedicated to exploring advanced technologies and model systems to deepen our understanding of the biological mechanisms governing human aging. Our goal is to leverage this knowledge to create interventions that empower individuals to enjoy longer, healthier lives. With cutting-edge technology labs and a vibrant drug-development pipeline in collaboration with both academic institutions and industry partners, Calico fosters an inspiring environment for driving medical breakthroughs.Position Overview:We are on the lookout for a passionate and skilled neuroscientist to join our dynamic research team, specifically focusing on the biology of Parkinson’s Disease. This is an exciting opportunity for an innovative scientist eager to explore and validate new mechanistic and therapeutic hypotheses through the design of specialized in vivo models. The ideal candidate will possess a comprehensive background in systems neuroscience and neurophysiology, and will work synergistically with experts in translational neuroscience, research physiology, genomics, data science, and advanced imaging methodologies. This role may involve leading research initiatives from initial exploratory biology to early stages of drug development.Key Responsibilities:Design, execute, and interpret complex in vivo experiments, including but not limited to stereotactic surgeries, viral delivery methods, and pharmacological assessments.Provide scientific leadership across projects involving Contract Research Organizations (CROs), external collaborators, and internal teams.Oversee model creation, licensing, and maintenance of biological colonies, coordinating with Laboratory Animal Resources and associated vendors.

Position SummaryCellares is on the lookout for a dynamic and driven Senior Scientist with a strong background in cell therapy manufacturing to become a vital member of our Process Development team. This role offers a unique opportunity to collaborate with various departments and make substantial contributions to the advancement of our innovative cell therapy manufacturing platform.In this pivotal position, you will be responsible for designing, coordinating, executing, and analyzing experiments related to cell therapy process development. Your efforts will be instrumental in enhancing and optimizing the Cellares platform. The ideal candidate will exhibit exceptional organizational skills, demonstrate technical leadership, and possess a proven track record in developing robust autologous and allogeneic cell therapy processes.We seek individuals who thrive in a fast-paced, mission-driven environment and are eager to embrace a diverse range of challenges as Cellares continues to expand.

Join AbbVie as a Senior Scientist I in our Machine Learning team dedicated to advancing Biologics Drug Substance Development and Cell Culture Development. In this key role, you will leverage your expertise in machine learning to drive innovations that enhance our drug development processes.

Join AbbVie as a Senior Scientist I in our Quality Control team focused on Biologics Analytical Research & Development. In this pivotal role, you will leverage your expertise in analytical methods to ensure the quality and compliance of our biologic products. Collaborate with cross-functional teams to drive innovative solutions and contribute to the advancement of our research initiatives.

Join our dynamic team at Mindlance as an Associate Scientist. In this pivotal role, you will contribute to groundbreaking research initiatives and assist in the development of innovative solutions within the scientific community. Your expertise and analytical skills will help drive forward our mission to advance scientific knowledge and technology.

Join Artech Information Systems, a leader in innovative technology solutions, as a Scientist. In this role, you will engage in cutting-edge research and development to advance our projects. Your expertise will contribute to impactful scientific endeavors that shape the future.

Join Xaira Therapeutics as a Senior Research Associate Scientist specializing in Display Technologies. In this pivotal role, you will be at the forefront of groundbreaking research and development initiatives that are shaping the future of therapeutic solutions. Your expertise will directly contribute to the innovation of our display technology, enhancing our product offerings and impacting the lives of patients worldwide.