Senior Principal Machine Learning Scientist jobs in San Francisco – Browse 3,966 openings on RoboApply Jobs

Senior Principal Machine Learning Scientist jobs in San Francisco

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companyAltos Labs logo
Full-time|$317.1K/yr - $509.4K/yr|On-site|San Francisco Bay Area, CA;San Diego, CA

Our MissionAt Altos Labs, we are dedicated to restoring cell health and resilience through advanced cell rejuvenation techniques aimed at reversing diseases, injuries, and age-related disabilities.For more information, please visit our website at altoslabs.com.Our ValueWe embrace a singular value at Altos: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe recognize that diverse perspectives are vital to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders collaborate from around the globe, united by a common mission. Our commitment to fostering a sense of belonging ensures that every employee feels valued for their unique insights. We all share the responsibility of maintaining a diverse and inclusive workplace.What You Will Contribute To AltosAs a Senior or Principal Machine Learning Scientist, you will be pivotal in developing groundbreaking generative AI/ML models that address multi-modal, multiscale biological challenges—from virtual cell simulations to agentic target assessments. We seek an innovative, hands-on individual who thrives in a collaborative and fast-paced environment, emphasizing teamwork, transparency, scientific excellence, originality, rigor, and integrity.

Feb 19, 2026
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Full-time|On-site|San Francisco

About Wispr FlowAt Wispr Flow, we strive to make device interaction as seamless as conversing with a friend.Wispr Flow has revolutionized voice dictation, now preferred by users over traditional keyboards due to its unparalleled accuracy on the first attempt. Our platform is context-aware, personalized, and effective across all devices, whether desktop or mobile.By 2026, we aim to expand beyond dictation to develop native actions within an agentic framework that comprehends and responds to user needs reliably.Our diverse team comprises AI researchers, designers, growth specialists, and engineers dedicated to reimagining human-computer interaction. We value team members who prioritize open communication, exhibit a user-centric mindset, and pay meticulous attention to detail. Our collaborative environment fosters spirited discussions, truth-seeking, and tangible impact.Having achieved a remarkable 150% revenue growth quarterly for the past year, we have successfully raised $81 million from top-tier venture capitalists and renowned angel investors.

Aug 4, 2025
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companySentiLink logo
Full-time|$200K/yr - $240K/yr|Hybrid|United States

SentiLink is at the forefront of delivering cutting-edge identity and risk management solutions, providing both individuals and institutions the ability to transact with assurance. We are revolutionizing identity verification within the United States, replacing outdated, inefficient, and costly practices with solutions that are ten times faster, smarter, and more precise.Our rapid growth is a testament to our innovative approach; our real-time APIs have successfully verified hundreds of millions of identities, initially focusing on the financial sector and quickly expanding into various new markets. SentiLink enjoys the support of prestigious investors including Craft Ventures, Andreessen Horowitz, NYCA, and Max Levchin.We are proud to have received accolades from TechCrunch, CNBC, Bloomberg, Forbes, Business Insider, PYMNTS, and American Banker, and we have been featured in the Forbes Fintech 50 list every year since 2023. Notably, we made history as the first company to deploy the eCBSV and have testified before the United States House of Representatives regarding the future of identity verification.SentiLink accommodates a flexible work environment, ranging from fully remote positions to in-office roles. As a digital-first company, we emphasize collaboration across teams in the U.S. and India. We have physical locations in Austin, San Francisco, New York City, Seattle, Los Angeles, and Chicago in the U.S., alongside offices in Gurugram (Delhi) and Bengaluru in India. For those near our offices, we encourage regular office attendance. Certain roles, such as our engineering team in India, are designed to be primarily in-office.Role Overview:As a Senior Applied ML Scientist at SentiLink, you will be instrumental in developing our core products: advanced models aimed at identifying fraudulent activities while enhancing our expanding array of financial risk solutions. Your expertise as a seasoned researcher will be essential, making you the authoritative figure in your domain. You will frequently engage in high-impact projects that necessitate a profound understanding of the field, critical analytical skills, and robust technical capabilities. Collaboration with various teams across the organization will be key as you investigate new fraud types, innovate product offerings, and conduct analyses to support our sales and marketing efforts.

Mar 13, 2026
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companyLaurel logo
Full-time|On-site|San Francisco Office

Join our dynamic team at Laurel as a Senior Machine Learning Data Scientist specializing in Analytics. In this pivotal role, you will leverage your expertise in machine learning and data analysis to drive innovative solutions that enhance our decision-making processes. You will collaborate with cross-functional teams to design and implement predictive models, analyze complex datasets, and translate insights into actionable strategies.Your contributions will be key in shaping the future of our analytics framework, enabling us to better serve our clients and stakeholders. If you’re passionate about data science and eager to make a significant impact, we want to hear from you!

Feb 3, 2026
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companyCausal Labs logo
Full-time|On-site|San Francisco

At Causal Labs, we are on a groundbreaking mission to develop general causal intelligence—artificial intelligence that not only predicts future events but also determines the most effective actions to influence those outcomes.To achieve this monumental goal, we are constructing a Large Physics Foundation Model (LPM). Our focus is on domains governed by physical laws, which inherently exhibit cause-and-effect relationships, setting them apart from traditional visual or textual data.Weather serves as the ideal training environment for our LPM, being one of the most extensively observed physical systems available. It provides immediate, objective feedback from sensory observations and boasts data scales significantly larger than those currently employed to train existing language models.Our team at Causal Labs includes leading researchers and engineers with backgrounds in self-driving technology, drug discovery, and robotics, hailing from prestigious organizations such as Google DeepMind, Cruise, Waymo, Meta, Nabla Bio, and Apple. We firmly believe that achieving general causal intelligence will represent one of the most critical technological advancements for our civilization.We are seeking innovative researchers eager to confront unsolved challenges in the field.This role presents an opportunity to create powerful models rooted in observable feedback and verifiable ground truths. If you possess experience in pioneering research and training large-scale models from the ground up in areas such as language and vision models, robotics, or biology, we invite you to join our mission.

Oct 29, 2025
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companyLila Sciences logo
Full-time|On-site|San Francisco, CA USA

Lila Sciences is seeking a Principal Machine Learning Engineer based in San Francisco, CA. This position centers on designing and building advanced machine learning algorithms to support scientific progress in healthcare and agriculture. Role overview The Principal Machine Learning Engineer will develop and implement new algorithms that strengthen Lila Sciences’ product capabilities and support data-driven decisions. The work will directly affect both internal business outcomes and broader scientific initiatives. Collaboration and impact This role involves close collaboration with engineers and data scientists on projects that address a range of technical and scientific challenges. The solutions created will have a direct influence on the future of healthcare and agriculture by applying advanced analytics and machine learning techniques.

Apr 28, 2026
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companyHandshake logo
Full-time|Remote|San Francisco, CA

Join Handshake as a Machine Learning Research Scientist and contribute to groundbreaking projects that leverage advanced algorithms and data analysis to drive innovation. In this role, you will collaborate with a dynamic team to design, implement, and evaluate machine learning models that enhance our products and services. Your expertise will be pivotal in unlocking new insights from data, improving user experiences, and shaping the future of our technology.

Mar 19, 2026
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companyJobs for Humanity logo
Full-time|Remote|San Francisco

Join our dynamic team at Jobs for Humanity as a Machine Learning Data Scientist, where you will harness the power of data to drive innovative solutions for underserved communities. Your expertise will play a crucial role in developing algorithms and models that enhance accessibility and improve lives.As a key member of our team, you will collaborate with cross-functional teams to identify opportunities for leveraging data to create impactful products. If you are passionate about using your data science skills for a greater good, we want to hear from you!

Sep 23, 2024
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companyDatabricks logo
Full-time|On-site|San Francisco, California

Role overview The Principal Research Scientist – Scaling at Databricks leads research projects that advance how the company’s data analytics platform handles large workloads. This San Francisco-based role focuses on designing and improving algorithms that enable efficient large-scale data processing and machine learning. Collaboration is central, with regular work alongside engineering, product, and research teams. What you will do Lead research to develop algorithms that scale for data analytics applications. Work with colleagues across engineering, product, and research to strengthen machine learning capabilities. Use deep expertise to shape the direction and architecture of the Databricks platform. Drive new ideas and solutions that influence the future of data science and analytics at Databricks. Location This role is based in San Francisco, California.

Apr 23, 2026
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companyAltos Labs logo
Full-time|$251.7K/yr - $330K/yr|On-site|San Francisco Bay Area, CA

Our MissionAt Altos Labs, we are dedicated to restoring cell health and resilience through innovative cell rejuvenation techniques aimed at reversing diseases, injuries, and disabilities that can arise throughout life.For further insights, please visit our website at altoslabs.com.Our ValueOur singular Altos Value is: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe firmly believe that diverse perspectives are crucial for scientific innovation. At Altos, exceptional scientists and industry leaders collaborate globally to further our shared mission. We prioritize Belonging, ensuring all employees feel valued for their unique perspectives, and we hold ourselves accountable for maintaining a diverse and inclusive environment.Your Contributions to AltosAs a member of our team, you will accelerate and enhance our efforts in developing unified, multi-modal generative foundation models tailored for multiscale biology. You will be a key player in multidisciplinary teams that create the computational platforms essential for Altos to fulfill its mission.In this position, you will collaborate with other scientists and engineers across the Institute of Computation to design, develop, and scale cutting-edge foundation models that address biological inquiries and assist in discovering novel interventions for aging and disease. Your focus will be on synthesizing unstructured multimodal signals with structured relational data and knowledge graphs that depict biological realities.The ideal candidate will excel in a dynamic environment that values teamwork, transparency, scientific excellence, originality, and integrity.

Feb 19, 2026
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companyHilbert logo
Full-time|On-site|San Francisco

Join Hilbert, a pioneering data science-driven growth engine that empowers B2C teams with predictive insights into user behaviors, revenue drivers, and sustainable growth strategies. Our innovative approach compresses lengthy decision-making processes into mere minutes.Trusted by Fortune 10 enterprises and beloved brands like FreshDirect, Blank Street, and Levain Bakery, Hilbert is the backbone of their growth strategies. We are also collaborating with leading AI companies to push the boundaries of what’s possible.We are seeking a talented Data Scientist who possesses a deep understanding of B2C business challenges, develops actionable models using real-world data, and delivers impactful analyses that facilitate significant growth outcomes — all with the initiative and urgency typical of a founder.This is not a role where you simply receive tasks; you will take ownership of problems from start to finish — from problem framing and modeling to measuring impact — for enterprise clients where the stakes are high and feedback is rapid. If you understand the nuances of churn analysis for different sectors, can create effective recommendation systems from sparse data, and can clearly communicate your causal analysis to clients, we want to meet you.ROLE OVERVIEWYou will closely collaborate with the founding team, engineering, product, and go-to-market teams to enhance the data science systems integral to Hilbert. Daily responsibilities include building models, conducting experiments, analyzing data, and producing analyses that influence key decisions. Our focus is B2C, and the challenges we tackle — such as demand forecasting, customer lifecycle management, personalization, and activation — require an individual who can translate business contexts into effective modeling choices. You will thrive in a high-autonomy, high-ambiguity environment where data is often messy, incomplete, or scarce.Key Responsibilities:Develop ML models that enhance core product features: recommendation systems, search relevance, customer segmentation, demand forecasting, and activation optimization.Contribute to configurable, multi-tenant model architectures that adapt to various customer contexts and business needs, avoiding the need for custom solutions for each case.Build effective models using available data — leveraging limited, noisy, or sparse datasets while determining the appropriate level of complexity.Design and implement rigorous A/B tests and recognize when causal inference methods are necessary.

Feb 26, 2026
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companyPhysical Intelligence logo
Full-time|On-site|San Francisco

Join us at Physical Intelligence as a Research Scientist, where you will be at the forefront of innovation in machine learning and robotics. We are in search of exceptional researchers across all experience levels who demonstrate a strong track record of impactful research results. Ideal candidates will possess a solid foundation in both practical implementation and theoretical frameworks, showcasing a blend of system-building capabilities and significant conceptual, algorithmic, or theoretical advancements. We value diverse backgrounds and encourage applications from both traditional academic researchers and those with unique, unconventional experiences.We are committed to fostering a diverse and inclusive workplace. In accordance with the San Francisco Fair Chance Ordinance, we welcome applications from qualified individuals with arrest and conviction records.

Aug 24, 2024
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companySentiLink logo
Full-time|$200K/yr - $240K/yr|Hybrid|United States

SentiLink is at the forefront of transforming identity verification and risk management, enabling both institutions and individuals to conduct transactions with confidence. We are committed to revolutionizing the outdated and inefficient identity verification landscape in the United States, offering solutions that are ten times faster, more intelligent, and more precise.Our rapid growth reflects the significant traction we've garnered, with our real-time APIs successfully verifying hundreds of millions of identities, especially within the financial services sector, while swiftly expanding into other markets. SentiLink enjoys the backing of top-tier investors such as Craft Ventures, Andreessen Horowitz, NYCA, and Max Levchin.We have received accolades from major publications including TechCrunch, CNBC, Bloomberg, Forbes, Business Insider, PYMNTS, and American Banker, and have consistently ranked on the Forbes Fintech 50 list since 2023. Notably, we made history by being the first company to implement the eCBSV and provided testimony before the United States House of Representatives regarding the future of identity verification.SentiLink promotes a flexible working environment, offering various work arrangements ranging from fully remote to in-office. As a digital-first organization, we emphasize strong collaboration across teams in the U.S. and India. Our offices are located in cities including Austin, San Francisco, New York City, Seattle, Los Angeles, and Chicago in the U.S., along with Gurugram (Delhi) and Bengaluru in India. If you are near any of these locations, we encourage regular in-office engagement. Some positions are designed to be hybrid or in-office. For instance, our engineering team in India primarily operates from our Gurugram office.

Mar 13, 2026
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companySesame logo
Full-time|On-site|San Francisco

About SesameAt Sesame, we envision a future where computers possess lifelike qualities, enabling them to see, hear, and interact with us in natural and human-like ways. We are dedicated to creating innovative voice agents that seamlessly integrate into our daily lives. Our talented team comprises founders from Oculus and Ubiquity6, along with seasoned professionals from Meta, Google, and Apple, boasting extensive expertise in both hardware and software development. Join us as we redefine the boundaries of technology and create a world where computers come to life.About the RoleAs a Machine Learning Scientist at Sesame, you will play a pivotal role in advancing our product goals through innovative research. We seek a detail-oriented individual with a strong background in Natural Language Processing (NLP), Speech Recognition, and/or Computer Vision, particularly with a focus on deep learning methodologies. You will stay abreast of the latest research and leverage your creativity and intuition to devise novel solutions tailored to our unique applications.Responsibilities:Contribute to the design and enhancement of machine learning models across diverse modalities.Engage with the complete ML stack, including model architecture, data curation, evaluation metrics, and training and inference infrastructure, while conducting research and experimentation.Identify and adopt promising techniques from existing literature, while innovating new methods as necessary to meet our distinct objectives.Required Qualifications:Demonstrated ability to work independently in environments characterized by high ambiguity.Published research in NLP, Speech Recognition, or Computer Vision focused on large-scale deep learning projects.Proficient understanding of cutting-edge advancements in artificial intelligence.Bachelor’s degree or higher in Computer Science or a related field.Preferred Qualifications:Master’s or PhD degree is preferred.Experience working on product development.Familiarity with startup environments.Sesame is committed to fostering a workplace that values, respects, and empowers everyone. We welcome applicants from diverse backgrounds, embracing all aspects of identity, race, gender, orientation, and ability. We also provide reasonable accommodations for individuals with disabilities — please contact careers@sesame.com for assistance.

Feb 19, 2026
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companyAltos Labs logo
Full-time|Remote|San Francisco Bay Area, CA;San Diego, CA

Join Altos Labs as a Machine Learning Scientist or Senior Machine Learning Scientist and be at the forefront of innovative research in the virtual cell space. Our team is dedicated to advancing the field of machine learning and its applications in biological research.

Mar 11, 2026
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companySoFi logo
Full-time|$153.6K/yr - $240K/yr|On-site|CA - San Francisco

Employee Applicant Privacy Notice SoFi is a national bank and financial services company that creates mobile-first tools to help people manage their money and reach their financial goals. The team values direct impact and aims to make a positive difference for members. Role overview The Senior Marketing Data Scientist - Machine Learning joins the Marketing Data Science team in San Francisco, CA. This position supports SoFi’s Marketing organization through analytics, model building, experimentation, and performance measurement to help drive marketing and growth initiatives. Work centers on designing, building, and scaling machine learning models that improve customer acquisition, conversion, retention, and lifetime value across SoFi’s products. The role draws on behavioral, transactional, and credit data to create predictive models and actionable insights. Collaboration with cross-functional teams is key for identifying business needs, managing model development end-to-end, implementing models in production, and monitoring their ongoing performance. Regulatory compliance is a consistent focus. Main responsibilities Design, develop, and deploy machine learning models to optimize customer acquisition, onboarding, and engagement for products such as loans, credit cards, investments, and cryptocurrency. Build predictive models for outcomes including customer lifetime value, conversion rates, cross-sell and upsell effectiveness, and retention across channels like email, direct mail, in-app, and Operations. Work with structured and unstructured data, such as behavioral signals, transaction data, and credit attributes, to enable audience segmentation and large-scale personalization. Maintain a feature store to streamline model development. Set up A/B testing frameworks to evaluate marketing strategies and measure their impact.

Apr 20, 2026
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companyEight Sleep logo
Full-time|$150K/yr - $150K/yr|On-site|San Francisco

Become a Pioneer in Sleep FitnessAt Eight Sleep, we're dedicated to unlocking human potential through optimal sleep. As the world's first sleep fitness company, we are revolutionizing what it means to be well-rested by creating the most advanced hardware, software, and AI technology. Our innovative products enhance mental, physical, and emotional performance by transforming each night into a personalized, data-driven recovery journey. Trusted by high achievers, professional athletes, and health-conscious individuals across over 30 countries, we have been recognized by Fast Company as one of the Most Innovative Companies in 2019, 2022, and 2023, and honored twice by TIME's “Best Inventions of the Year.” Our high-performance team operates with speed, focus, and a commitment to impact. We don't just create; we refine and obsess over every detail to ensure our members sleep better and wake up stronger.Every position at Eight Sleep offers the opportunity to innovate cutting-edge technology, collaborate with exceptional talent, and contribute to a future where sleep is a powerful tool for well-being. If you're ready to break away from the ordinary and eager to build at the forefront of possibility, this is your chance to join us in reshaping how the world sleeps and what we can achieve upon waking.Our Culture: High Standards, No CompromiseOur mission demands intensity, and at Eight Sleep, we embody the mindset of the world's top performers: focused, relentless, and committed to being in the top 1% of our field. Inspired by the relentless drive of legends like Kobe Bryant, we apply that mentality to bold ideas, next-gen technology, and impeccable execution. This is not a standard 9-to-5 role; our team is dedicated, often working 60+ hours per week—not out of obligation, but out of passion. If you thrive under pressure and seek to do the most meaningful work of your career, you'll find a home here. If you prefer an easier path, this position is not for you.Your RoleAs a Machine Learning Research Scientist at Eight Sleep, you will be at the cutting edge of sleep innovation. Your mission will be to leverage innovative technology, minimalistic design, and proven clinical science to personalize and enhance sleep experiences, fundamentally changing how people sleep for the better.Our revolutionary temperature-regulated technology, the Pod, has been recognized as a game changer, enhancing health and happiness by transforming sleep. Join us in making sleep count for more.

Oct 30, 2025
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companyArena Intelligence logo
Full-time|On-site|Bay Area

Join Arena Intelligence as a Machine Learning ScientistAt Arena Intelligence, we are revolutionizing how AI models are evaluated in real-world scenarios. Founded by innovative researchers from UC Berkeley’s SkyLab, our mission is to push the boundaries of AI evaluation and ensure its practical application.With millions of users engaging with our platform each month, we prioritize community feedback to develop transparent, rigorous, and human-centered model evaluations. Our leaderboards serve as the benchmark for AI performance, gaining the trust of leading enterprises and AI labs to understand the reliability, alignment, and impact of AI systems.Our diverse team comprises experts from esteemed institutions such as UC Berkeley, Google, Stanford, DeepMind, and Discord. We foster a culture that values truth, agility, craftsmanship, curiosity, and impact over hierarchy. We are committed to creating an environment where talented individuals from all backgrounds can excel in their work.Role OverviewWe are seeking a passionate Machine Learning Scientist to spearhead our open-source research initiatives, including the development of open datasets and code releases. You will be instrumental in advancing how AI models are evaluated and understood globally.In this position, you will operationalize our dedication to openness by curating impactful datasets, developing innovative methodologies, and establishing reproducible benchmarks. Your contributions will enhance our public leaderboards, empower community tools, and promote transparency in AI evaluation on a global scale.This interdisciplinary role involves collaboration with engineers, product teams, marketing, and the broader research community to refine model comparisons, analyze preference data, and explore dimensions like style, reasoning, and robustness. You will also work closely with our go-to-market teams to advocate for our open research initiatives, strengthen research partnerships, and encourage community engagement.If you are excited by complex challenges, rigorous evaluation processes, and scientific outreach, we invite you to apply!

Dec 18, 2025
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companyHilberts logo
Full-time|On-site|San Francisco

Join Hilberts as a Machine Learning Engineer / Data Scientist in our San Francisco office, where you will leverage cutting-edge technology to drive enterprise-level solutions. You will work collaboratively with cross-functional teams to design, develop, and implement machine learning models that enhance our data-driven decision-making processes.

Mar 3, 2026
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companyFaire logo
Full-time|$192K/yr - $264K/yr|On-site|San Francisco, CA

About FaireFaire is a dynamic online wholesale marketplace dedicated to empowering local businesses. We believe in a future where independent retailers can thrive and compete against retail giants like Walmart and Amazon. By harnessing technology, data, and machine learning, we connect a vibrant community of entrepreneurs globally. Imagine helping your favorite local boutique source outstanding products from around the world to enhance their offerings. Our mission is to provide the tools and insights that enable small businesses to succeed in a competitive landscape.By championing the growth of independent businesses, Faire fosters positive economic impacts within communities worldwide. We are on the lookout for intelligent, resourceful, and passionate individuals to join our team as we drive the shop local movement. If you share our commitment to community, we invite you to be part of ours.About this roleAt Faire, we leverage advanced machine learning and data insights to transform the wholesale industry, enabling local retailers to stand strong against larger competitors. The Data Science team is pivotal in developing and sustaining a variety of algorithms and models that enhance our marketplace. We focus on creating innovative machine learning models that empower our customers to succeed.As a member of the Brand Data Science team focused on Listing Quality, your role will involve enhancing the quality of product listings, enabling retailers to effectively discover and assess products on Faire. You will apply ML and AI to address key challenges, including improving image and text quality, extracting structured product attributes, and accurately identifying duplicates and product variants. Utilizing deep learning, multi-modal LLMs, and a human-in-the-loop approach, you'll deliver high-performance solutions. In this rapidly evolving domain, you will be at the forefront of applying cutting-edge technology to drive tangible outcomes. You will independently design and implement solutions while collaborating with the cross-functional Listing Quality pod, which includes product, design, engineering, analytics, and operations, to tackle challenges comprehensively.

Mar 4, 2026

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