Principal Mechanical Engineer – Advanced Automation & Systems Integration

Vivodyne: Innovating Human Data for Clinical Trials.At Vivodyne, we revolutionize the discovery, design, and development of human therapeutics. By utilizing large, lab-grown human organ tissues at unprecedented scale, we propel technological advancements at the intersection of cutting-edge biology, robotics, and artificial intelligence. Our innovative approach allows us to identify and validate new therapeutic targets while de-risking therapeutic assets through the generation of clinically translatable multi-omic data. This capability enables the production of more human data than all clinical trials in the U.S. combined. We are supported by some of the most prestigious venture funds and have established partnerships with many of the world's leading pharmaceutical companies to enhance drug discovery and development while significantly reducing reliance on animal testing.www.vivodyne.comRole OverviewAs the Principal Mechanical Engineer at Vivodyne, you will collaborate within a dynamic, multi-disciplinary team, pioneering advancements in automated, large-scale "organ-on-a-chip" robotics and associated manufacturing systems. Your primary focus will be on the development and optimization of hardware and software that coordinates robotic arms, embedded controllers, and microfluidic systems to facilitate high-throughput and high-precision biological workflows.This position demands a strong expertise in hardware, although knowledge in software is beneficial. You will engage with high-level motion control, machine vision, and robotics programming, working primarily with Python, while occasionally interacting with C# and C++ codebases to ensure seamless system integration and optimal performance.As an expert in mechanical design, you have a deep understanding of concepts like kinematic docking, material selection (440 vs 316), finite element analysis (FEA), and error budgets. You are well-acquainted with suppliers such as McMaster-Carr, Misumi, and Grainger.Collaboration is essential in this role; you will work closely with mechanical engineers, biologists, immunologists, AI scientists, and process engineers to design and enhance automation workflows that lead to groundbreaking discoveries. We seek a problem-solver who thrives in a fast-paced, innovative environment that prioritizes continuous learning and technical excellence.This is a full-time, onsite position located in San Francisco, where you will be integral to designing, building, and testing transformative technologies.

Role Overview The City and County of San Francisco's Department of Technology is hiring a Principal System Integration Engineer focused on enterprise systems with Python expertise. This position leads major integration projects that connect and enhance a wide range of internal systems. What You Will Do Design, develop, and implement integration solutions for enterprise systems Lead complex projects that require coordination across multiple platforms and teams Work closely with colleagues from different departments to solve technical challenges Improve system performance and reliability through thoughtful integration work Collaboration and Impact This role works at the intersection of technology and city operations. Projects often require input from diverse stakeholders and have a direct impact on how services run across the organization.

Join the innovative team at Kobold Metals as a Mechanical Engineer in our Advanced Technology Group. In this role, you will be responsible for designing and developing state-of-the-art mechanical systems that drive our cutting-edge projects forward. You will collaborate closely with cross-functional teams to ensure that our technology meets both performance and reliability standards.

Join Cloudflare as a Principal Systems Engineer, Data, where you will lead innovative projects that enhance our data processing capabilities. You will work collaboratively with cross-functional teams to design, implement, and optimize systems that efficiently handle large-scale data. This role requires a deep understanding of systems engineering principles, strong analytical skills, and a passion for leveraging data to drive decisions. Your contributions will be pivotal in shaping the future of our data infrastructure.

Role Overview The Department of Technology at the City and County of San Francisco is hiring a Principal System Integration Engineer (Enterprise Systems). This position leads integration efforts for enterprise systems, focusing on Oracle BPEL and SOA methodologies. The work directly supports technology projects that strengthen city operations and public services. Key Responsibilities Guide the integration of complex enterprise systems across city departments Apply Oracle BPEL and SOA practices to ensure reliable, efficient system connections Support technology initiatives that improve how city services are delivered Location This role is based in San Francisco.

Role overview Pinterest is seeking a Principal Engineer to join the Online Systems team, based in either San Francisco or Palo Alto. This position centers on designing and building scalable systems that serve millions of users. The focus is on enhancing user engagement and optimizing the performance of Pinterest's online platforms. What you will do Architect and develop large-scale applications built for high-traffic environments Collaborate with engineering, product, and design teams to deliver reliable solutions Lead technical decisions that influence the direction of Pinterest's online systems

At Mechanize, we specialize in developing reinforcement learning (RL) environments that empower AI models to execute real-world tasks efficiently. Our mission is to drive the complete automation of the economy, providing innovative solutions to leading AI laboratories. Discover more about our work at mechanize.work.As a Senior Software Engineer at Mechanize, you will contribute to the creation of RL environments that are pivotal in the field of AI model training. Ideal candidates will have 2-5 years of software engineering experience with proficiency in Python programming. Previous experience in machine learning or AI is not a prerequisite.For insights on our interview process, visit: Interview Process at Mechanize.

At Mechanize, we are pioneering the development of Reinforcement Learning (RL) environments tailored to train AI models for real-world applications. Our ambition is to facilitate the complete automation of the economy, partnering with leading AI laboratories. Discover more at mechanize.work.As a Software Engineering Intern at Mechanize, you will play a pivotal role in assisting our team to develop these groundbreaking RL environments. If you have a solid command of Python programming and possess a keen intellect, we would love to hear from you.We are currently seeking interns for Winter 2026, Spring 2026, and Summer 2026.No prior experience in machine learning or AI is necessary.Curious about our interview process? Learn more here: https://www.mechanize.work/how-our-interview-process-works/

Join mechanize as a Senior Software Engineer, where you'll contribute to innovative software solutions that shape the future of technology. In this role, you will lead projects, mentor junior developers, and collaborate with cross-functional teams to deliver high-quality software products. Your expertise will drive architectural decisions and enhance our development processes.

Join Cloudflare as a Principal Systems Engineer specializing in Internet Protocol Communication (IPC). In this pivotal role, you will lead and innovate within our engineering team, playing a crucial part in enhancing our systems to support seamless communication over the internet. Your expertise will help shape our infrastructure and drive our mission to help build a better internet.

Join Anthropic as a Finance Systems Integration Engineer, where you will play a vital role in streamlining our financial systems and enhancing integration processes. In this position, you will collaborate with cross-functional teams to design, implement, and optimize finance-related systems, ensuring robust data flow and accuracy. Your expertise will contribute to our mission of building safe and beneficial AI systems.

Join Cloudflare as a Principal Systems Engineer and play a pivotal role in shaping the future of our cutting-edge technology solutions. In this hybrid position, you will leverage your extensive expertise to design and implement innovative systems that enhance our service offerings.

Astranis is at the forefront of space innovation, developing state-of-the-art satellites that extend humanity's exploration capabilities into high orbits. Our satellites deliver reliable and secure communication networks to a diverse clientele, including large corporations, government entities, and military organizations. With five satellites currently in orbit and several more on the horizon, we are addressing a substantial backlog of over $1 billion in commercial contracts.As the preferred satellite communications partner for clients with rigorous demands for uptime, data integrity, and customized solutions, Astranis has successfully secured over $750 million in funding from esteemed investors like Andreessen Horowitz, Blackrock, and Fidelity. Our dedicated team of 450 engineers and entrepreneurs works passionately from our expansive 153,000 sq. ft. headquarters in Northern California, USA, to design, build, and operate our cutting-edge satellites.Mechanical Integration EngineerJoin our Mechanical Integration team at Astranis and play a pivotal role in constructing components, subsystems, and complete satellites. Collaborate closely with designers, technicians, and testing teams to shape the future of satellite communication while also having the chance to redefine our manufacturing processes.

CoreWeave develops cloud infrastructure tailored for AI workloads. Since launching in 2017, the company has expanded rapidly and is now listed on Nasdaq (CRWV, as of March 2025). CoreWeave works with AI labs, startups, and large enterprises, providing high-performance compute resources and technical support. More information is available at www.coreweave.com. Role overview The Integration Engineer - Enterprise Systems will design and implement integrations across Finance and Supply Chain platforms. This position is part of the Strategy & Transformation team, which focuses on scaling and improving CoreWeave’s internal systems. Team members work closely with Finance, Accounting, Procurement, IT, and Engineering to modernize workflows and support data-driven decisions. What you will do Architect and build integrations for Finance and Supply Chain systems. Develop automated workflows using Workato and/or Boomi. Create and maintain APIs to support real-time data movement between business platforms. Collaborate with cross-functional teams to automate processes and improve system interoperability. Ensure data reliability and contribute to GenAI-enabled automation initiatives. Location This role is based in Livingston, NJ; New York, NY; Sunnyvale, CA; San Francisco, CA; or Bellevue, WA.

About Our TeamAt OpenAI, our Hardware team specializes in developing cutting-edge silicon and system-level solutions tailored to meet the rigorous demands of advanced AI applications. We are at the forefront of creating the next generation of AI-native silicon and collaborate closely with our software and research partners to ensure our hardware is seamlessly integrated with AI models. Our mission extends beyond just delivering production-grade silicon for OpenAI’s supercomputing infrastructure; we are also dedicated to innovating custom design tools and methodologies that enhance hardware optimized for AI.About the PositionWe are seeking a highly skilled Mechanical Engineer with a minimum of 7 years of experience in the design of IT hardware, encompassing everything from chip/package to system levels. In this role, you will collaborate with a team of experts across thermal, mechanical, electrical, software, and systems engineering to support the design, analysis, and validation of mechanical and thermal systems that guarantee the reliability, efficiency, and longevity of critical hardware. A strong analytical mindset, hands-on testing experience, and the ability to thrive in a fast-paced, multidisciplinary environment are essential for success in this role.This position is based in San Francisco, CA, and follows a hybrid work model, requiring 3 days in the office per week. We also offer relocation assistance for new hires.Key ResponsibilitiesLead mechanical designs for AI supercomputer products within data center applications.Collaborate with cross-functional teams to design and enhance thermal solutions for data center hardware, including chips, power modules, and system-level cooling architectures.Integrate thermal management strategies into hardware designs from concept through to mass production.Design and validate mechanical systems such as chassis, enclosures, and cooling systems while ensuring compliance with performance and reliability standards.Conduct 3D modeling, finite element analysis (FEA), tolerance analysis, and prototyping to ensure manufacturability and adherence to stringent quality requirements.Perform mechanical testing, including vibration, shock, and thermal cycling, to ensure long-term reliability under extreme operating conditions.Identify and assess new technologies and methodologies to enhance mechanical and thermal performance in product designs, contributing expertise in mechanical design to new product development initiatives.

About Atomic SemiAtomic Semi is pioneering the creation of a compact and rapid semiconductor fabrication facility.Our vision leverages contemporary technology and innovative simplifications to realize this goal. By developing our own tools, we aim for swift iterations and enhancements.We are assembling a small cadre of outstanding, hands-on engineers across various disciplines including mechanical, electrical, hardware, computer science, and process engineering. Our ambition is to master the entire stack—from the atomic level to architectural designs. Our team is driven by optimism and a commitment to pushing the boundaries of technology.We embrace the philosophy that smaller, faster, and self-built solutions are superior.Our belief in our capabilities is unwavering; our lab is equipped with 3D printers, an array of sophisticated microscopes, e-beam writers, general fabrication tools, and we are ready to invent anything that we find lacking.Founded by Sam Zeloof and Jim Keller, Atomic Semi is led by pioneers in the semiconductor industry, with Sam recognized for producing chips in his garage, and Jim boasting a 40-year legacy of leadership in the field.About the TeamOur automation engineering team is tasked with developing robotic systems to efficiently produce semiconductor packaging devices. We engage in designing, prototyping, building our own fabrication equipment, and innovating novel manufacturing processes. Our specialized team, skilled in electrical, mechanical, physics, and chemistry, collaborates closely to achieve our objectives.About the RoleAs a Mechanical Engineer - Automation at Atomic Semi, you will be responsible for generating and prototyping robotic components and systems from the ground up. Your projects will encompass precision small motion manipulation, integrating automation into existing machines, and overseeing complete system development and implementation.

We are seeking a passionate and skilled Automation Engineer to join our innovative team in San Francisco. In this role, you will be responsible for designing, developing, and implementing automated systems that enhance operational efficiency and product quality. You will collaborate with cross-functional teams to identify automation opportunities and drive process improvements.

About Multiply LabsMultiply Labs is an innovative startup located in the vibrant city of San Francisco, California. Supported by prestigious tech and life science investors, including Casdin Capital, Lux Capital, and Y Combinator, our mission is to construct the most advanced robots globally and utilize them to democratize access to cutting-edge, life-saving therapies.We are at the forefront of transforming cell therapy manufacturing by creating state-of-the-art robotic systems that automate and scale the production of these critical treatments. Our robots enable biopharma companies to produce cell therapies efficiently while minimizing alterations to their existing processes, thus mitigating regulatory hurdles and risks. Unlike traditional methods that are often labor-intensive and exorbitantly costly (typically exceeding $1M per patient), our robotic solutions are designed to make these transformative therapies more accessible and affordable to patients in need.To discover more and to watch a video showcasing our robots in action, please visit us at www.multiplylabs.com and connect with us on LinkedIn.About the RoleIn the capacity of Senior Systems Integration Engineer, you will play a pivotal role as a technical leader, enhancing system reliability and ensuring that our automated manufacturing clusters operate with the precision essential for cell therapy production. You will take ownership of the robustness pipeline for our current systems, analyzing robot data to assess performance proactively. Your responsibilities will include driving system enhancements and resolving errors by investigating complex electromechanical issues that affect operational uptime. As we evolve, you will oversee the validation and approval process for new software releases prior to their deployment. Additionally, you will collaborate closely with hardware engineers to confirm that new designs incorporate testability and resilience from the outset of our next generation of technology.

ABOUT JUUL LABS: At Juul Labs, our mission is to revolutionize the landscape of smoking by guiding a billion adult smokers away from combustible cigarettes. We are dedicated to eradicating the use of these harmful products while also addressing underage consumption of our offerings. Our commitment to exceptional quality, innovative research, and design empowers us to tackle one of the world’s most challenging public health issues. Supported by notable technology investors, we are equally dedicated to attracting and hiring top-tier talent. Our diverse team is united by a shared purpose, and we are actively seeking the best engineers, scientists, designers, product managers, operations specialists, and customer service professionals. If you're looking for a fulfilling opportunity to advance your career while making a positive impact, we encourage you to explore this position further. ROLE OVERVIEW: We are in search of an Enterprise Systems Engineer who will leverage AI as a core element of our enterprise systems implementation, integration, and operations. This role will take charge of the technical execution of our Workday and ERP ecosystem, utilizing advanced AI technologies such as Claude, Gemini, and Cursor to enhance implementation speed, integration quality, and ongoing system improvement. The ideal candidate will not only connect systems but will also create a robust, autonomous integration layer, combining deep platform expertise with the discernment to know when to configure, code, or let AI handle processes. KEY RESPONSIBILITIES: Act as a cross-functional technical authority within the Workday and ERP ecosystems, ensuring data integrity and alignment with evolving business demands. Identify and implement low-friction AI use cases across Enterprise Systems, optimizing internal operations. Lead Workday and ERP implementations using AI-enhanced methodologies, from requirements gathering to post-launch support. Utilize Cursor with LLM-pair programming (Claude/Gemini) to significantly enhance development speed for integrations, transformation scripts, and API documentation. Create and maintain UAT test scripts, data migration mappings, and functional specifications using AI tools to minimize manual documentation efforts. Produce comprehensive technical documentation to support all aspects of system integration and operation.

Join the dynamic team at DoorDash Labs, the forefront of innovation within DoorDash, dedicated to transforming last-mile logistics through cutting-edge automation and robotics. We are on the lookout for a passionate Senior Mechanical Engineer who will be instrumental in designing, developing, and validating mechanical systems for our advanced unmanned platforms. Ideal candidates will possess substantial experience in mechanical design, structural analysis, CAD, and rapid prototyping, with a history of delivering effective solutions in fast-paced production environments.