Senior Director of Medicinal Chemistry

Genesis Therapeutics is seeking a highly experienced Senior Director of Medicinal Chemistry to lead our innovative research team in San Diego, California. In this pivotal role, you will drive the advancement of our drug discovery initiatives, leveraging your extensive expertise in medicinal chemistry to develop novel therapeutic compounds that address unmet medical needs.As a key member of our leadership team, you will collaborate closely with cross-functional teams to guide the design and optimization of small molecules. Your strategic vision and scientific acumen will be crucial in shaping our research agenda and ensuring the successful progression of projects from concept to clinical development.

We are seeking a highly skilled Senior Director of Medicinal Chemistry to join our innovative team at Genesis Molecular AI. In this pivotal role, you will leverage our cutting-edge platform to spearhead medicinal chemistry initiatives that drive drug discovery from Hit Identification to candidate nomination. You will be a key collaborator and leader in multidisciplinary drug discovery projects, shaping the medicinal chemistry strategy for each project. As a recognized leader in medicinal chemistry, you will possess exceptional communication skills, facilitating collaboration with both internal teams and external partners.Key ResponsibilitiesDevelop and implement medicinal chemistry strategies utilizing the Genesis platform to effectively manage drug discovery programs from Hit ID through to candidate nomination.Apply Structure-Based Drug Design (SBDD) principles, optimize physicochemical properties, and interpret in vitro and in vivo ADME/PK/Toxicology data to advance projects.Employ data visualization software and metrics-driven analysis to formulate medicinal chemistry hypotheses and prioritize project strategies.Engage and collaborate with industry partners on various drug discovery projects.Work closely with other drug discovery disciplines, including biology, DMPK, software engineering, and computational chemistry, to foster hypothesis-driven decisions and enhance platform capabilities.Maintain regular communication and engagement with project teams and management to ensure alignment and progress.Mentor and guide internal chemists and other scientific professionals on medicinal chemistry best practices.

Role Overview iambic therapeutics seeks a Director or Senior Director of Medicinal Chemistry to guide drug discovery efforts from our San Diego headquarters. This leadership role calls for deep experience in medicinal chemistry and a strong record of moving drug discovery programs forward. The position sits at the center of scientific strategy and team leadership within a multidisciplinary setting. What You Will Do Oversee drug discovery projects from early-stage concepts through key milestones Lead, mentor, and develop a team of medicinal chemists Coordinate resources across internal teams and external partners Work closely with groups specializing in automated experimentation, machine learning-based molecular design, property prediction, and bioassay data analysis Location This role is based onsite at our San Diego headquarters.

Genesis Therapeutics is seeking an innovative and experienced Associate Director/Director of Medicinal Chemistry to join our dynamic team in San Diego, CA. In this leadership role, you will spearhead the design and optimization of novel therapeutic compounds, driving the discovery process from initial concept through to clinical candidates.The ideal candidate will have a robust background in medicinal chemistry and a proven track record of leading successful drug discovery projects. You will collaborate closely with cross-functional teams, fostering an environment of creativity and scientific excellence.

Join Genesis Molecular AI as an Associate Director/Director of Medicinal Chemistry, where you will play a pivotal role in utilizing our cutting-edge AI platform to spearhead drug discovery initiatives, guiding projects from Hit Identification through to candidate nomination. Collaborate with multidisciplinary teams to shape the medicinal chemistry vision and drive innovative solutions in drug development.Key Responsibilities:Develop and implement medicinal chemistry strategies using the Genesis platform for drug discovery from Hit ID through to candidate nomination.Apply Structure-Based Drug Design (SBDD) methodologies, optimize physicochemical properties, and analyze in vitro and in vivo ADME/PK/Toxicology data to advance programs.Leverage data visualization tools and metrics to formulate medicinal chemistry hypotheses and prioritize approaches effectively.Foster communication and collaboration with industry partners on drug discovery initiatives.Engage with diverse drug discovery teams (biology, DMPK, software engineers, computational chemists) to drive data-driven decisions, enhance platform capabilities, and uphold scientific excellence.Maintain regular communication with project team members and management to ensure alignment and progress.

Role Overview iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams focused on automated experimentation, AI-driven molecular design, property prediction, and bioassay data generation. What You Will Do Design and refine strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties, using multivariate SAR analysis and hypothesis-driven design. Apply a broad range of modern organic chemistry transformations and synthetic methodologies, including parallel experimentation, to advance project goals. Work closely with colleagues in molecular and cellular biology, pharmacology, computational chemistry, ADME, and related groups to drive discovery efforts. Shape the use of computational approaches, automated synthesis, and high-throughput experimentation in medicinal chemistry projects. Collaborate with AI and machine learning teams to build and apply predictive models for novel molecule design. Clearly communicate project updates and findings to the broader team and stakeholders. Contribute to the Chemistry research group, supporting a culture of scientific rigor, innovation, and teamwork. Qualifications BS, MS, or PhD in chemistry, with a focus on synthetic organic chemistry. Direct experience in small molecule drug discovery within biotech or pharma: minimum 15+ years with a BS, 12+ years with an MS, or 8+ years with a PhD. Documented success advancing drug discovery programs from lead identification through advanced candidate stages. Deep experience optimizing lead compounds for potency, selectivity, ADME, and pharmacokinetics. Expert knowledge of modern synthetic organic chemistry methods, supported by publications and patents. Hands-on familiarity with target protein degradation and modalities such as molecular glues and PROTACs. This position is based onsite at our San Diego HQ.

Job SummaryIambic Therapeutics is looking for an exceptional and driven Senior Associate Scientist to enhance our Chemistry team at our San Diego headquarters. This exciting position allows you to thrive in a vibrant, cross-disciplinary environment, where you will collaborate closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning experts, and software engineers. You will engage in every phase of the discovery process, from hit identification and lead optimization to candidate selection. This role is laboratory-focused and demands robust technical skills in organic synthesis, catalysis, and medicinal chemistry, alongside hands-on experience in the drug discovery process and a proven “drug hunter” mentality.Key ResponsibilitiesDesign, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) utilizing cutting-edge analytical techniques including LCMS, HPLC, and NMR, implementing both manual and automated parallel synthesis techniques.Identify and optimize reaction conditions through the use of screening kits and other efficient methodologies.Collaborate with the high-throughput experimentation team to guarantee successful execution of parallel chemistry experiments.Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.Work alongside computational chemists to harness machine learning insights for the effective execution of the design–make–test cycle and platform development.Present findings to project teams and senior leadership, effectively communicating data, implications, and recommendations.QualificationsBS in Chemistry with 5+ years of experience in the pharmaceutical or biotechnology sector, or MS in Chemistry with 3+ years of relevant experience.Demonstrated expertise in multi-step organic synthesis, reaction optimization, Structure-Activity Relationship (SAR) analysis, and effective scientific presentation skills.Adeptness in a fast-paced, highly collaborative research atmosphere.Willingness to work onsite in San Diego.Preferred QualificationsExperience in high-throughput experimentation is advantageous.Familiarity with ADME-PK principles is a plus.5+ years of experience contributing to drug discovery projects is preferred.

JOB SUMMARYIambic Therapeutics is on the lookout for a talented and highly motivated Senior/Principal Scientist specializing in Computational Chemistry to join our innovative Computational Sciences team at our San Diego headquarters. As a vital contributor, you will leverage advanced ligand and structure-based methodologies to propel our drug discovery initiatives. You will actively engage with research teams focused on developing groundbreaking therapeutics across various indications. Collaborating closely with experts in machine learning, medicinal chemistry, and biology, you will implement state-of-the-art Structure-Based Drug Design (SBDD) techniques throughout hit identification, lead optimization, and candidate selection phases. This hands-on position demands robust expertise in computational chemistry, a keen interest in co-folding applications, and a proactive drug-hunter mindset.KEY RESPONSIBILITIESUtilize diverse ligand and structure-based strategies during the hit identification, lead optimization, and candidate selection phases (including cheminformatics, pharmacophore modeling, docking, shape-based virtual screening, de novo molecular design, and molecular dynamics simulations).Lead design cycles by identifying structure-activity relationships and integrating computational predictions with bioactivity data.Collaborate with medicinal chemists to design, assess, and prioritize virtual libraries, proposing concrete molecular designs.Work alongside machine learning scientists to meld SBDD methodologies with our proprietary transformer-based property prediction technology (Enchant).Enhance and utilize our proprietary protein-ligand co-folding technology (NeuralPLexer) to generate novel and actionable structural hypotheses.Translate scientific inquiries into computational workflows, delivering actionable insights.Present findings to project teams, elucidating methods, implications, and recommendations.Develop, validate, and maintain computational workflows and tools.QUALIFICATIONSRequired:PhD or equivalent in Computational Chemistry (or a related field) with a minimum of 5 years of experience in an industrial drug discovery setting.Proven experience in supporting active small molecule drug discovery programs.Experience with ligand and structure-based drug design methodologies.

As a Staff Scientist at Scripps Research, you will have the opportunity to contribute to cutting-edge research in organic chemistry. Your responsibilities will be tailored to the specific laboratory and the Principal Investigator's needs. You will engage in laboratory management, assist in grant editing and reporting, maintain LC-MS systems, support collaborations with the Principal Investigator and graduate students, and organize chemical libraries while developing click chemistry methodologies.

Chemistry InternJoin Genesis Molecular AI, where we are revolutionizing drug design through artificial intelligence to meet critical medical needs. Our cutting-edge laboratory in San Diego invites passionate and proactive individuals to become part of our chemistry team. As a Chemistry Intern, you will gain hands-on experience with laboratory techniques while tackling current chemistry challenges.Your ResponsibilitiesAcquire and apply essential laboratory skills in chemistry.Maintain thorough documentation of all laboratory findings.Participate in project meetings with mentors and effectively communicate your findings.Compile a comprehensive report of your findings at the conclusion of the internship.Perform additional tasks and responsibilities as assigned.Your QualificationsCurrently pursuing a Bachelor’s degree in Organic Chemistry, Biochemistry, Medicinal Chemistry, or a related field.Prior experience in an organic chemistry lab is preferred.Strong organizational, communication, and multitasking skills, with an ability to thrive in a collaborative environment.Demonstrated enthusiasm, integrity, self-motivation, and meticulous attention to detail.

AbbVie is seeking a highly skilled Principal Research Scientist II specializing in Lipid Chemistry to join our innovative team in San Diego. This role is pivotal in advancing our research efforts and driving the development of novel lipid-based therapies. The ideal candidate will possess a robust background in lipid biochemistry, with a proven track record of impactful research and development.

We are seeking an experienced and visionary Senior Director of Accounting to join our dynamic team at Veracyte. In this role, you will lead our accounting department, overseeing financial reporting, compliance, and strategic financial planning. Your expertise will be essential in driving our financial performance and ensuring adherence to regulatory requirements.As a Senior Director, you will collaborate with cross-functional teams to enhance our financial processes and systems, contributing to Veracyte's commitment to innovation in the medical diagnostics field.

Capricor Therapeutics focuses on developing cell and exosome-based therapies for rare diseases. The company’s lead candidate, Deramiocel (CAP-1002), is in late-stage development for Duchenne muscular dystrophy. Capricor also advances its proprietary StealthX™ exosome platform to pursue new possibilities in targeted delivery and vaccinology. Role overview The Senior Director of Quality leads both strategic and operational quality functions for Capricor’s clinical and commercial-stage activities. This position oversees the design, implementation, and continuous improvement of the Quality Management System (QMS). Ensuring regulatory compliance, inspection readiness, and strong quality governance are central to this role, spanning development, manufacturing (including cell therapy production), and the potential commercialization of Deramiocel and StealthX™-based programs. Key responsibilities Provide leadership for all quality-related activities across the organization. Maintain and enhance the QMS to meet regulatory standards and support inspection readiness. Oversee quality governance for development, manufacturing, and commercialization efforts. Support late-stage development, BLA submissions, and responses, with a focus on quality aspects of Deramiocel. Collaboration This role works closely with executive leadership and teams in Regulatory Affairs, CMC, Clinical, and Manufacturing. The Senior Director of Quality helps drive cross-functional efforts for late-stage development and commercial readiness, while promoting a proactive, risk-based quality culture throughout Capricor.

Ensure adherence to all relevant local and international pharmaceutical regulations.Lead Quality Chemistry, Manufacturing, and Controls (CMC) operations, overseeing batch disposition, manufacturing, packaging, labeling, and testing to guarantee product integrity and timely material release.Provide decisive leadership to enhance quality-related processes including batch disposition, investigations, analytical data reviews, supply chain management, and risk assessment.Act as the primary contact for complex and high-stakes quality challenges and resolutions.Proactively assess and manage quality risks throughout the product lifecycle, recommending and implementing effective mitigation strategies.Collaborate closely with ORIC's technical operations team, Contract Manufacturing Organizations (CMOs), contract testing labs, and distribution centers to ensure rigorous quality reviews of all process and analytical data, supporting informed program decisions.Work synergistically with Regulatory Affairs to facilitate timely and precise submission reviews.Engage actively with clinical program teams, contributing to clinical development meetings to ensure ongoing quality support.Design and implement performance-driven quality metrics and trend analyses to foster continuous improvement.Conduct and present Annual Product Reviews for advanced-stage programs.Lead, mentor, and cultivate a high-performing Quality team, scaling effectively to support transitions from clinical to commercial phases.Serve as Chair or a key member of various governance committees, including ORIC’s Stability Review Board, Material Review Board, and Change Review Board.Represent ORIC Quality in discussions with CDMOs, regulatory authorities, and strategic leadership meetings as required.Exhibit a high degree of adaptability in fast-paced environments, adjusting strategies and priorities according to evolving business needs, technologies, and stakeholder expectations.Develop new functional Standard Operating Procedures (SOPs), policies, and plans for late-phase and commercial readiness as required.

About Acadia Pharmaceuticals Acadia Pharmaceuticals focuses on turning scientific discoveries into meaningful treatments for people with neurological and rare diseases. The company’s commercial portfolio includes the first and only FDA-approved therapies for Parkinson’s disease psychosis and Rett syndrome. Acadia continues to expand its pipeline, with mid- to late-stage programs in Alzheimer’s disease psychosis and Lewy body dementia psychosis, as well as earlier-stage research targeting additional unmet needs. Location and Hybrid Work Model This Senior Director of Portfolio Management role may be based in Princeton, NJ, San Diego, CA, or South San Francisco, CA. Acadia uses a hybrid work model, with an average of three days per week in the office required for this position. Role Overview The Senior Director of Portfolio Management shapes and executes the strategic direction of Acadia’s development and commercialization portfolio. Working in a matrixed environment, this leader drives portfolio prioritization across the enterprise, builds cross-functional partnerships, and supports effective decision-making to maximize value. The role requires close collaboration with teams in Finance, R&D, and Commercial to ensure portfolio investments align with scientific goals, market needs, and financial discipline. Key Responsibilities Create and apply portfolio prioritization frameworks that balance scientific innovation, commercial opportunity, and financial impact. Partner with Finance to assess investment scenarios, improve resource allocation, and support financially sound portfolio decisions. Work alongside R&D leadership to align pipeline strategy with overall portfolio objectives, focusing on scientific feasibility and milestone-based progress. Collaborate with Commercial teams to incorporate market insights, competitive analysis, and launch planning into product positioning strategies.

Who We AreAt Stealth Fintech, we are on a transformative journey to reshape B2B payments. As a well-funded, innovative startup operating in stealth mode, we are dedicated to crafting advanced solutions that will redefine the financial landscape for businesses. If you are passionate about addressing significant challenges and making a substantial impact from the outset, we would love to connect with you.Role OverviewWe are seeking an experienced Senior Director of Product and Growth Marketing to join our dynamic Sales and Marketing team. In this pivotal role, you will lead product marketing efforts and drive demand generation. This is a unique opportunity to shape the go-to-market strategy of our fintech platform at a critical juncture, reporting directly to the Chief Sales Officer.Your ResponsibilitiesDevelop and execute a comprehensive integrated marketing strategy that aligns with our business goals, encompassing brand, product marketing, and demand generation.Implement initial priorities within the first year to establish our core value proposition, messaging, high-impact content assets, and a website that resonates with our target audience, aiming to generate $5 million in pipeline within the first year.Manage the marketing budget and performance metrics; intelligently allocate resources to optimize return and pipeline results.Lead demand generation initiatives, including events, while continuously refining strategies based on data analysis.Oversee hands-on execution of marketing materials, external communications, and web presence.Ideal Qualifications7+ years of experience in B2B marketing with demonstrated success in product marketing and demand generation.In-depth knowledge of demand generation strategies, performance marketing, account-based marketing (ABM), and funnel analytics.Proven ability to create compelling product narratives for executive-level audiences.Exceptional verbal and written communication skills, capable of thriving in a fast-paced, collaborative environment.

Veracyte, Inc. is seeking an accomplished Senior Director of Strategic Alliance Management to lead our strategic partnerships and alliances initiatives. This role is pivotal in driving collaboration with key stakeholders and fostering innovative solutions that enhance our market presence.The ideal candidate will possess exceptional leadership skills, a strong background in alliance management, and a track record of successfully managing partnerships to achieve mutual goals. You will be responsible for developing and executing strategies that align with our business objectives and drive growth.

Join Our Team as a High School Science TeacherHigh Tech High Schools - General PoolReports To: School DirectorFLSA Classification: Certificated, 188-dayFull Time/Part Time Status: Salary, full time, exemptRegular/Temporary: RegularSalary: Teacher Framework (Steps 1-29) Range: $64,735.44-$115,369.76, commensurate with experience and education.Application Opening: 2/26/26Application Closing: 4/30/26High Tech High, established in 2000, is an innovative network of sixteen charter schools in San Diego County, providing a unique educational experience to over 6,350 students from grades K-12. Our mission is to foster equity, personalization, authentic work, and collaborative design in education. If you are passionate about these principles, we invite you to apply!JOB SUMMARYAs a High School Science Teacher at HTH, you will design engaging learning experiences centered around equity, personalization, and authentic work. You will collaborate with your school community and director to create an inclusive environment where students explore their identities, cultivate their passions, and become innovative thinkers and problem solvers.You'll be responsible for preparing lesson plans, facilitating meaningful project work, and creating a supportive learning atmosphere.

Fate Therapeutics is seeking a dynamic and experienced Senior Manager or Associate Director of Project Management to become a vital member of our Global Business Operations team. In this pivotal role, you will collaborate closely with the Development and Technical Operations departments to oversee the complete lifecycle of intricate projects. This position acts as a crucial bridge between operational execution, program development strategies, and portfolio direction across our clinical stage programs. This is a full-time, exempt position based at our corporate headquarters in San Diego, CA, reporting directly to the Vice President of Global Operations.

Join Janux Therapeutics as the Senior Director of Business Development and Alliance Management, where you will spearhead strategic initiatives to discover, assess, and secure partnerships that enhance Janux's pipeline and platform capabilities. This pivotal role merges business development acumen with alliance management to influence corporate strategy and uphold a competitive advantage in the dynamic biotech sector.