Senior Computational Aided Drug Discovery Scientist

At Genesis Molecular AI, we are creating an elite team of experts in computational chemistry to transform the landscape of drug discovery through advanced machine learning and biophysical simulations. We invite a Senior Computational Aided Drug Discovery (CADD) Scientist to join us in our mission, collaborating closely with scientists in our advanced wet lab and our distributed teams in computational chemistry across the United States.Key ResponsibilitiesEmploy a mix of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse array of targets, including innovative targets with limited chemical history.Utilize techniques such as virtual screening, molecular simulations, and ADMET prediction to facilitate critical decision-making during drug discovery.Work closely with medicinal chemists on molecular design and the creation of tailored computational methodologies for specific projects.Serve as a liaison across teams, effectively bridging communication between our computational and medicinal chemistry departments to ensure smooth information exchange and collaborative strategies.Thrive in a fast-paced environment that encourages innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. Candidates with a PhD in organic or medicinal chemistry and substantial laboratory experience transitioning into industry roles in CADD are also encouraged to apply.Extensive knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools, including MOE, PyMOL, and Schrodinger Suite.A minimum of 2 years of experience in the pharmaceutical or biotech industry as a CADD scientist, with practical involvement in active drug discovery projects.While onsite presence at our San Diego lab is preferred for collaboration, we are open to considering remote team members as well.What We OfferAttractive SalaryComprehensive Health Care Plans (Medical, Dental, and Vision fully covered for employees)An opportunity to work in a pioneering environment with the latest technologies in drug discovery.

JOB SUMMARYIambic Therapeutics is on the lookout for a talented and highly motivated Senior/Principal Scientist specializing in Computational Chemistry to join our innovative Computational Sciences team at our San Diego headquarters. As a vital contributor, you will leverage advanced ligand and structure-based methodologies to propel our drug discovery initiatives. You will actively engage with research teams focused on developing groundbreaking therapeutics across various indications. Collaborating closely with experts in machine learning, medicinal chemistry, and biology, you will implement state-of-the-art Structure-Based Drug Design (SBDD) techniques throughout hit identification, lead optimization, and candidate selection phases. This hands-on position demands robust expertise in computational chemistry, a keen interest in co-folding applications, and a proactive drug-hunter mindset.KEY RESPONSIBILITIESUtilize diverse ligand and structure-based strategies during the hit identification, lead optimization, and candidate selection phases (including cheminformatics, pharmacophore modeling, docking, shape-based virtual screening, de novo molecular design, and molecular dynamics simulations).Lead design cycles by identifying structure-activity relationships and integrating computational predictions with bioactivity data.Collaborate with medicinal chemists to design, assess, and prioritize virtual libraries, proposing concrete molecular designs.Work alongside machine learning scientists to meld SBDD methodologies with our proprietary transformer-based property prediction technology (Enchant).Enhance and utilize our proprietary protein-ligand co-folding technology (NeuralPLexer) to generate novel and actionable structural hypotheses.Translate scientific inquiries into computational workflows, delivering actionable insights.Present findings to project teams, elucidating methods, implications, and recommendations.Develop, validate, and maintain computational workflows and tools.QUALIFICATIONSRequired:PhD or equivalent in Computational Chemistry (or a related field) with a minimum of 5 years of experience in an industrial drug discovery setting.Proven experience in supporting active small molecule drug discovery programs.Experience with ligand and structure-based drug design methodologies.

Genesis Molecular AI is on a mission to transform drug discovery through innovative computational chemistry solutions. We are building a premier team of experts in computational chemistry, and we invite you to join us as a Senior CADD Scientist. In this pivotal role, you will collaborate closely with our cutting-edge wet lab scientists and work alongside our distributed computational chemistry and CADD science teams throughout the United States.Key Responsibilities:Employ a blend of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a varied target landscape, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and potency and ADMET prediction to facilitate critical decision-making processes in drug discovery.Work collaboratively with medicinal chemists to design molecules and develop tailored computational strategies for specific projects.Serve as a bridge among teams, effectively communicating between our computational chemistry and medicinal chemistry groups to promote seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that encourages innovation and rapid iteration.

We are on the lookout for exceptional scientists to join our Discovery Machine Learning team at Iambic Therapeutics. This position will play a pivotal role in utilizing cutting-edge machine learning techniques to enhance our drug discovery initiatives. You will collaborate with drug discovery teams focused on developing innovative therapeutics for a variety of conditions. Your work will center around our leading machine learning models, such as Enchant, our multimodal transformer model designed for predicting drug-target interactions and molecular properties. This opportunity is based at our headquarters in San Diego.

Role Overview Iambic Therapeutics is seeking an Associate Director or Director of Biology to advance oncology drug discovery efforts at our San Diego headquarters. This leader will shape scientific strategy and guide teams through every stage, from hit identification to IND submission. The position requires a strong record of leading oncology drug discovery programs and experience collaborating across disciplines, including Chemistry, DMPK, Safety, and Computational teams. Impact and Scope Work directly with computational and machine learning scientists to apply AI/ML tools that support data interpretation, hypothesis generation, and decision-making in biology workflows. This role plays a central part in steering portfolio strategy and advancing key programs. Key Responsibilities Program Leadership: Design and oversee biology strategies that align with medicinal chemistry and translational goals across all discovery phases, including hit-to-lead, lead optimization, candidate selection, and IND-enabling studies. Cross-Functional Integration: Lead or co-chair initiatives that coordinate assay design with SAR hypotheses, DMPK/PD needs, and safety or translational biomarker requirements. Collaboration Leadership: Drive major scientific partnerships, both internal and external, ensuring effective data sharing and strategic alignment. Assay Strategy and Data Integrity: Develop, validate, and supervise in vitro and ex vivo assays (such as signaling, binding, trafficking, imaging, and mechanism of action) to evaluate potency, selectivity, and efficacy. Establish acceptance criteria, controls, and quality standards. External Execution: Oversee and mentor CROs and partners, define statements of work, manage timelines and budgets, and ensure adherence to internal SOPs and GLP-adjacent practices. People Leadership and Development: Build and support a team of scientists and associates by setting goals, offering feedback, and fostering professional growth. Decision-Making: Lead stage-gate reviews, maintain risk registers, develop mitigation plans, and prepare decision memos for leadership and governance bodies.

At Genesis Molecular AI, we are on a mission to transform the landscape of drug discovery by forming a premier computational chemistry team that leverages advanced machine learning techniques and biophysical simulations. We are actively looking for a Principal CADD Scientist to collaborate with our scientists in our cutting-edge wet lab and coordinate with our remote computational chemistry and CADD science teams throughout the United States.Key ResponsibilitiesEmploy both established and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse range of targets, including innovative targets with minimal chemical precedents.Implement strategies such as virtual screening, molecular simulations, and predictive analytics for potency and ADMET to inform critical decision-making in drug development.Work collaboratively with medicinal chemists on molecular design and the formulation of project-specific computational methodologies.Serve as a liaison among teams, ensuring effective communication between computational chemistry and medicinal chemistry groups to facilitate seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that fosters innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. This role is also suitable for PhD-level professionals in organic or medicinal chemistry with substantial lab experience who have transitioned into CADD roles.In-depth knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.A minimum of 5 years of relevant industry experience as a CADD scientist in pharmaceuticals or biotechnology, with direct involvement in active drug discovery projects.While onsite presence in our San Diego lab is preferred for collaboration, we welcome applicants interested in remote opportunities.What We OfferCompetitive salary and benefits packageComprehensive health care plans (including medical, dental, and vision, fully covered for employees)Eligibility for stock options

At Genesis Molecular AI, we are assembling a premier computational chemistry team dedicated to transforming drug discovery through state-of-the-art machine learning and biophysical simulations. We invite applications for the role of Principal CADD Scientist, who will collaborate closely with our scientists in the advanced wet lab and our distributed computational chemistry and CADD teams located across the United States.Key ResponsibilitiesEmploy a mix of industry-leading and proprietary AI-driven CADD tools to steer small molecule drug discovery projects across a wide array of targets, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and ADMET prediction to facilitate critical decision-making during the drug discovery process.Work in tandem with medicinal chemists in molecular design and the formulation of project-specific computational strategies.Serve as an effective liaison among the computational and medicinal chemistry teams, ensuring smooth communication and collaborative decision-making.Thrive in a fast-paced environment that champions innovation and rapid iteration.QualificationsPh.D. in Computational Chemistry, Structural Biology, or a closely related discipline. Candidates with a Ph.D. in organic or medicinal chemistry and substantial laboratory experience transitioning to industry roles in CADD may also be considered.Comprehensive understanding of structure-based drug design and protein-ligand interactions.Expertise in industry-standard CADD software such as MOE, PyMOL, and Schrödinger Suite.A minimum of 5 years of experience as a CADD scientist in the pharmaceutical or biotechnology sector, with direct involvement in active drug discovery projects.While onsite collaboration in our San Diego lab is preferred, we are open to accommodating remote team members.What We OfferCompetitive salary and benefitsComprehensive health care plans, including medical, dental, and vision insurance fully covered for employeesEligibility for stock options

Join Veracyte as a Senior Computational Development Scientist, where you will play a pivotal role in our mission to transform patient care through innovative genomics. In this remote position, you will leverage cutting-edge computational techniques to analyze complex genomic data, contributing to groundbreaking discoveries in cancer diagnostics.

Join Genesis Molecular AI as a Senior / Principal ADME Scientist in San Diego, CA!At Genesis Molecular AI, we are at the forefront of utilizing artificial intelligence to revolutionize rational drug design and tackle significant unmet medical needs. We are looking for an enthusiastic and adaptable ADME Scientist to become a vital part of our Non-Clinical Development team, facilitating the progression of our innovative compounds through both preclinical and clinical phases.This full-time role is set in a dynamic biotech environment where collaboration thrives among a talented team of professionals, all working towards clear scientific objectives. We offer an attractive benefits package, including comprehensive medical and dental insurance, flexible working hours, generous vacation time, and the chance to engage deeply with the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in various ADME-related assays such as metabolic stability, protein binding, drug-drug interactions, and more. They will be skilled in developing, executing, and troubleshooting assays both independently and in collaboration with external partners. As the subject matter expert in in-vitro ADME, you will provide critical strategic input to our project teams. Experience in bioanalytical assays and method development is a plus.

JOB SUMMARYiambic therapeutics is on the lookout for a talented and motivated Analytical/Bioanalytical Scientist specializing in chromatography-based purification to enhance our drug discovery initiatives. The chosen candidate will be instrumental in facilitating high-throughput purification and assay workflows, supporting a weekly design-make-test-analysis cycle driven by our proprietary AI-based drug discovery engine. The ideal individual will possess extensive expertise in chromatographic purification, particularly in SFC and/or LC purification of small molecules, along with demonstrated skills in instrument troubleshooting, workflow optimization, and a solid understanding of ADME/DMPK assay design and execution.KEY RESPONSIBILITIESAct as the authority in chromatography-based purification, leveraging significant experience in SFC and LC purification of small molecules within a drug discovery context.Create, implement, and refine purification workflows, including preparative chromatography methods, fraction collection strategies, and post-purification data integration.Design and sustain automated purification workflows to enhance throughput, reproducibility, and sample quality.Work collaboratively with medicinal chemistry, purification, and DMPK teams to supply high-quality purified compounds, aiding in lead optimization and screening.Provide direct support, preventive maintenance, and troubleshooting for LC, LC/MS, and SFC instruments to reduce downtime and ensure continuous lab operations.Engage with vendors and automation partners for service, upgrades, installations, and workflow integration.Potentially assist with ADME/DMPK and physicochemical assays, contributing to method development, troubleshooting, and execution as required.Document purification workflows, maintenance activities, and troubleshooting in line with laboratory best practices.QUALIFICATIONSPossession of an advanced degree (M.S. or Ph.D.) in Analytical Chemistry, Chemistry, Chemical Engineering, or a related discipline; or equivalent industry experience.A minimum of a Ph.D. with 2 years of relevant experience OR an M.S. with 6 years of relevant experience.Extensive hands-on experience with chromatography-based purification, particularly SFC and/or LC purification of small molecules.Strong proficiency in operating, maintaining, and troubleshooting chromatography and mass spectrometry instruments.

Role Overview iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams focused on automated experimentation, AI-driven molecular design, property prediction, and bioassay data generation. What You Will Do Design and refine strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties, using multivariate SAR analysis and hypothesis-driven design. Apply a broad range of modern organic chemistry transformations and synthetic methodologies, including parallel experimentation, to advance project goals. Work closely with colleagues in molecular and cellular biology, pharmacology, computational chemistry, ADME, and related groups to drive discovery efforts. Shape the use of computational approaches, automated synthesis, and high-throughput experimentation in medicinal chemistry projects. Collaborate with AI and machine learning teams to build and apply predictive models for novel molecule design. Clearly communicate project updates and findings to the broader team and stakeholders. Contribute to the Chemistry research group, supporting a culture of scientific rigor, innovation, and teamwork. Qualifications BS, MS, or PhD in chemistry, with a focus on synthetic organic chemistry. Direct experience in small molecule drug discovery within biotech or pharma: minimum 15+ years with a BS, 12+ years with an MS, or 8+ years with a PhD. Documented success advancing drug discovery programs from lead identification through advanced candidate stages. Deep experience optimizing lead compounds for potency, selectivity, ADME, and pharmacokinetics. Expert knowledge of modern synthetic organic chemistry methods, supported by publications and patents. Hands-on familiarity with target protein degradation and modalities such as molecular glues and PROTACs. This position is based onsite at our San Diego HQ.

Join Our Team as a Senior / Principal ADME ScientistAt Genesis Molecular AI, we are at the forefront of revolutionizing drug discovery through innovative artificial intelligence-driven approaches. Our San Diego lab is actively seeking a dynamic and skilled Senior / Principal ADME Scientist to enhance our Non-Clinical Development team and propel our compounds through the phases of preclinical and clinical development.This full-time position offers an exciting opportunity to work in a fast-paced biotech environment alongside a collaborative team of experts, all focused on achieving clear scientific and developmental objectives. We provide comprehensive medical and dental benefits, flexible working hours, generous vacation time, and the chance to gain extensive exposure to the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in a range of ADME-related assays, including metabolic stability, protein binding, and drug-drug interactions. You will be instrumental in developing, executing, and troubleshooting assays, as well as managing outsourced work. As a subject matter expert in in-vitro ADME, your strategic input will be crucial to project teams. Experience with bioanalytical assays and method development is highly desirable.

Role Overview iambic therapeutics seeks a Director or Senior Director of Medicinal Chemistry to guide drug discovery efforts from our San Diego headquarters. This leadership role calls for deep experience in medicinal chemistry and a strong record of moving drug discovery programs forward. The position sits at the center of scientific strategy and team leadership within a multidisciplinary setting. What You Will Do Oversee drug discovery projects from early-stage concepts through key milestones Lead, mentor, and develop a team of medicinal chemists Coordinate resources across internal teams and external partners Work closely with groups specializing in automated experimentation, machine learning-based molecular design, property prediction, and bioassay data analysis Location This role is based onsite at our San Diego headquarters.

We are seeking a highly skilled Senior Director of Medicinal Chemistry to join our innovative team at Genesis Molecular AI. In this pivotal role, you will leverage our cutting-edge platform to spearhead medicinal chemistry initiatives that drive drug discovery from Hit Identification to candidate nomination. You will be a key collaborator and leader in multidisciplinary drug discovery projects, shaping the medicinal chemistry strategy for each project. As a recognized leader in medicinal chemistry, you will possess exceptional communication skills, facilitating collaboration with both internal teams and external partners.Key ResponsibilitiesDevelop and implement medicinal chemistry strategies utilizing the Genesis platform to effectively manage drug discovery programs from Hit ID through to candidate nomination.Apply Structure-Based Drug Design (SBDD) principles, optimize physicochemical properties, and interpret in vitro and in vivo ADME/PK/Toxicology data to advance projects.Employ data visualization software and metrics-driven analysis to formulate medicinal chemistry hypotheses and prioritize project strategies.Engage and collaborate with industry partners on various drug discovery projects.Work closely with other drug discovery disciplines, including biology, DMPK, software engineering, and computational chemistry, to foster hypothesis-driven decisions and enhance platform capabilities.Maintain regular communication and engagement with project teams and management to ensure alignment and progress.Mentor and guide internal chemists and other scientific professionals on medicinal chemistry best practices.

Join Veracyte, a trailblazing company dedicated to revolutionizing cancer care for patients globally. At Veracyte, our employees contribute significantly to patient outcomes while thriving in a mission-driven culture. We embody the Veracyte way—a collaborative approach rooted in our values to empower clinicians with crucial insights for transformative patient decisions.Our Core Values:We Seek A Better Way: We boldly innovate, learn from our challenges, and remain resilient in transforming cancer care.We Make It Happen: We act swiftly, commit to excellence, and infuse joy into our work.We Are Stronger Together: We foster open collaboration, seek understanding, and celebrate successes.We Care Deeply: We honor our differences, uphold integrity, and support one another.Position Overview:As the Executive Director of Discovery, you will leverage your expertise as a forward-thinking scientific leader to propel Veracyte's innovative discovery initiatives. Your focus will be on identifying and developing groundbreaking biomarkers, technologies, and platforms that further our mission in transforming cancer care. You will integrate laboratory cancer biology, genomic methodologies, and cutting-edge bioinformatics—including multi-modal artificial intelligence (MMAI)—to discover new molecular diagnostics poised for clinical application.This pivotal role aligns with Veracyte's objective of delivering impactful genomic solutions to enhance patient outcomes globally. Having served hundreds of thousands of patients, we are committed to pioneering diagnostic innovations grounded in rigorous scientific research and advanced analytics.The ideal candidate will possess extensive hands-on experience in cancer biology, genomic technologies, and computational analysis, along with a proven ability to translate complex biological signals into diagnostic product concepts. This position demands excellence in managing laboratory discovery programs, developing high-quality datasets, and guiding teams to produce robust, reproducible evidence suitable for subsequent development under stringent design controls.

About Veracyte Veracyte, Inc. is dedicated to transforming cancer care and improving patient outcomes around the world. The team works in a mission-driven environment, supporting clinicians with innovative solutions and quality insights that help guide life-changing decisions. Employees are encouraged to make a real impact and grow in a collaborative setting known as the Veracyte way. Core Values We Seek A Better Way: Innovating boldly, learning from challenges, and showing resilience to enhance cancer care. We Make It Happen: Acting with urgency, aiming for excellence, and bringing joy to hard work. We Are Stronger Together: Collaborating openly, seeking understanding, and celebrating shared achievements. We Care Deeply: Valuing differences, maintaining integrity, and supporting each other. Role Overview The Senior Bioimage Scientist will join the Discovery Research team, focusing on tissue-based oncology diagnostics. This position connects pathologists, biologists, and AI/ML teams, contributing to the development of new assays, digital pathology AI tools, biological interpretation, and diagnostic product advancement. Both wet and dry lab work are part of the role, including developing, optimizing, and validating imaging assays and quantitative image analysis. The goal is to link biological and clinical questions with clear, interpretable image-derived metrics and features. Location San Diego, California (Hybrid)

Genesis Therapeutics is seeking an innovative and experienced Associate Director/Director of Medicinal Chemistry to join our dynamic team in San Diego, CA. In this leadership role, you will spearhead the design and optimization of novel therapeutic compounds, driving the discovery process from initial concept through to clinical candidates.The ideal candidate will have a robust background in medicinal chemistry and a proven track record of leading successful drug discovery projects. You will collaborate closely with cross-functional teams, fostering an environment of creativity and scientific excellence.

Millennium Health LLC is a highly regarded specialty laboratory with over a decade of expertise in medication monitoring and drug testing services. We empower healthcare professionals to effectively monitor both the use and misuse of prescription medications and illicit substances. Our testing solutions provide clinicians with objective insights into patients' recent drug usage, enhancing the effectiveness of treatment plans.We are seeking a Clinical Scientist who will take the lead in developing clinical LC-MS/MS assays. This role involves independently conducting original scientific research and creating innovative analytical technologies while managing project resources and timelines effectively.The responsibilities of this position include, but are not limited to: Acting as a technical leader to design, develop, and validate high-quality LC-MS/MS assays/products/technologies within established timelines. Providing formal and informal scientific mentoring to team members. Leveraging technical expertise to design experiments and independently contribute to multiple projects concurrently. Serving as a critical technical and scientific resource within the organization. Drafting, reviewing, and finalizing technical documentation essential for various stages of product development. Maintaining meticulous experimental records in compliance with company SOPs. Ensuring adherence to HIPAA, confidentiality, and compliance policies, procedures, and standards. Upholding administrative, physical, and technical cybersecurity controls. Consistent and reliable attendance is a must.

JOB SUMMARYIambic Therapeutics is actively seeking a Director of Drug Product Development to spearhead formulation and process development for small molecule programs, guiding them from late discovery/IND-enabling stages through clinical phases, with a clear trajectory towards later-stage development, global registrations, and commercialization. This pivotal role will define the drug product strategy within the CMC framework and drive its execution, supervising scale-up, technology transfer, and manufacturing readiness at Contract Development and Manufacturing Organizations (CDMOs), while ensuring top-tier quality CMC documentation to support global regulatory submissions.The ideal candidate will possess extensive expertise in formulation design and process development, delivering robust, scalable, patient-centric, and cost-effective drug products throughout various phases of clinical development. This role will collaborate closely with teams across Discovery, Analytical Development, Process Chemistry, Project Management, Quality, Regulatory, Clinical Pharmacology, Clinical Operations, and Supply Chain to synchronize development plans, mitigate risks, and meet program timelines.This position is based on-site at our San Diego Headquarters.KEY RESPONSIBILITIESAct as the drug product lead in a cross-functional matrix team, defining and executing formulation and manufacturing process strategies in alignment with key stakeholders to achieve program goals.Oversee small-molecule formulation design and development from late discovery through clinical stages, converting biopharmaceutic requirements into patient-centric, clinically viable dosage forms that are manufacturable, stable, and compliant with global regulatory standards.Collaborate with Chemical Process R&D to enhance Active Pharmaceutical Ingredients (APIs) with optimal physicochemical properties into clinical development.Lead process development and optimization using Quality by Design (QbD) principles to establish phase-appropriate control strategies and scalable manufacturing processes.Manage CDMO selection and provide comprehensive technical oversight throughout formulation/process development, clinical manufacturing, scale-up, and technology transfer.Work with Chemistry, DMPK, and Toxicology teams to evaluate compound developability and establish appropriate nonclinical formulations.Draft, review, and approve Module 3 drug product sections for IND/IMPD submissions.

Join AbbVie as a Senior Scientist II in Analytical Development, where your expertise will contribute to innovative solutions in biopharmaceuticals. You will collaborate with a dynamic team, leveraging your analytical skills to drive research and development efforts. This role is pivotal in advancing our mission to improve patient outcomes through groundbreaking therapies.