Submit Your Resume for Future Opportunities at Vaxcyte

Join Our Mission to Protect Humankind!At Vaxcyte, we are a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines aimed at safeguarding humanity from the serious health implications of bacterial diseases. Our efforts focus on eradicating or treating bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella, marking the beginning of our ambitious journey. Our roadmap to success is clear and robust, positioning Vaxcyte for long-term achievements. Our Approach: The significance of WHAT we do is matched only by the importance of HOW we do it! Our collaborative efforts are anchored in four enduring core values: *Rethink Convention: We inject creative and intellectual diversity into every aspect of our work, continuously innovating the delivery of vaccines. *Aim High: We are driven by an audacious collective goal to create the most complex biologics ever developed to protect humankind. *Lead with Heart: Every team member at Vaxcyte leads with a kindness-first, inclusive approach that fosters collaboration and robust debate, propelling us towards our business objectives. *Model Excellence: The magnitude of our challenges demands our shared commitment to integrity, accountability, equality, and clarity in our communications and decision-making processes.We are always on the lookout for bright, dedicated, and innovative individuals who are passionate about making a difference. If you don’t find a suitable role on our Careers Page, we invite you to submit your resume to join our Talent Community for future opportunities. We encourage you to frequently check our Careers Page as we expand our team and add more opportunities.Vaxcyte is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine innovation firm focused on engineering high-fidelity vaccines aimed at protecting humanity from the severe and costly repercussions of bacterial diseases. Our commitment extends to eradicating or treating bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella. Our roadmap to success is well-defined, and Vaxcyte is poised for long-term impact. Our Approach: What we do is as crucial as how we do it! Our collaborative efforts are guided by four enduring core values: *RETHINK CONVENTION: We embrace creative and intellectual diversity across all aspects of our work to innovate and transform vaccine delivery. *AIM HIGH: We embody an audacious goal to tackle the most intricate biologics ever conceived to protect humanity. *LEAD WITH HEART: Everyone at Vaxcyte leads with kindness, fostering an inclusive atmosphere conducive to collaboration and vigorous debate that furthers our business aspirations. *MODEL EXCELLENCE: The scale of our challenge demands a collective commitment to integrity, accountability, and clarity in our communications and decision-making processes.Role Summary:We are in search of a dynamic, proactive, and self-motivated Lab Manager to join our expanding Facilities and Lab Operations Team. This role is highly hands-on, overseeing the daily operations of Vaxcyte laboratories, including vendor management, lab supply inventory, equipment maintenance, and new equipment orders. As a pivotal point of contact for lab personnel, the Lab Manager will handle service requests, prioritize and assign tasks, provide training, and nurture a culture of safety and compliance. This role also involves supporting the design of lab space equipment layouts, collaborating with various departments to develop essential SOPs for training, maintenance, calibration, and repair. The Lab Manager will work closely with procurement and lab teams on CAPEX/OPEX budgeting and management of lab assets and service contracts, support installation in lab spaces, and oversee any qualification and validation activities. Additionally, this role will involve providing feedback on lab efficiency, operations, and policies and making recommendations for improvements.

About Vaxcyte Vaxcyte, Inc. is a biotechnology company based in San Carlos, California, focused on advancing vaccine development. Role Overview The Project Manager will oversee and execute projects that support Vaxcyte’s mission to develop new vaccine solutions. This role guides cross-functional teams, moving projects from initial concept through to completion. The Project Manager ensures each project aligns with company goals and strategic plans.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine company dedicated to developing high-fidelity vaccines aimed at combating the far-reaching impacts of bacterial diseases. Our mission is not only to eradicate but also to treat serious bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella. Our roadmap to success is clear and meticulously defined, positioning Vaxcyte to make significant strides in global health. At Vaxcyte, what we do is just as important as how we do it! Our collaborative efforts are driven by four core values: *RETHINK CONVENTION: We embrace creativity and intellectual diversity in every aspect of our work to innovate and continuously improve vaccine delivery methods. *AIM HIGH: We embody an audacious ambition to develop the most complex biologics ever attempted for the protection of humanity. *LEAD WITH HEART: At Vaxcyte, everyone leads with kindness and inclusivity, fostering collaboration and spirited debate to advance our business objectives. *MODEL EXCELLENCE: The magnitude of our challenges calls for a collective commitment to integrity, accountability, equality, and clear communication in all decisions.Position Overview:We are on the lookout for a highly skilled Senior Software Engineer with robust full-stack expertise and a strong DevOps inclination. This role is critical in designing, developing, testing, and maintaining scalable web applications that underpin essential business operations.The ideal candidate will demonstrate a solid combination of frontend and backend development skills and a disciplined approach to automation, testing, CI/CD, and production reliability. This position requires technical leadership, architectural foresight, and the capability to promote engineering excellence throughout the software lifecycle.Key Responsibilities:Full-Stack Application DevelopmentDesign, architect, and implement scalable applications using Next.js and React.Create and manage backend services and GraphQL APIs, focusing on schema design and performance enhancement.Maintain high standards of code quality, security, performance, and maintainability.Engage in architectural design reviews and participate in technical decision-making processes.

Vaxcyte, a clinical-stage vaccine company in San Carlos, California, develops vaccines targeting serious bacterial diseases such as invasive pneumococcal disease, Group A Strep, and Shigella. The team is committed to protecting people from bacterial infections and advancing vaccine technology. The company values creative thinking, ambitious goals, and a collaborative, inclusive culture. Integrity, accountability, and clear communication guide all decisions and actions at Vaxcyte. Role overview The Accounting Summer Intern position gives students the chance to apply academic knowledge to real-world accounting and finance projects. Interns will gain hands-on experience and develop practical skills that support future career growth. What you will do Assist with financial analysis and accounting tasks, such as variance analysis, manufacturing accounting, SOX compliance, and preparing financial statements. Research and benchmark finance and accounting tools, including AI-enabled solutions, to identify opportunities for process improvement, automation, and improved reporting. Help maintain and update financial documentation, including process flows, Standard Operating Procedures (SOPs), training materials, and internal controls documentation. Apply AI and advanced Excel tools to support data analysis, streamline reporting, and maintain accuracy in line with company policies and controls. This internship is based in San Carlos, CA.

Join Our Mission to Protect Humankind!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines designed to safeguard humanity from the severe health impacts of bacterial diseases. Our mission encompasses the eradication and treatment of bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella. With a clear and well-defined path to success, Vaxcyte is committed to making a meaningful difference. Our Approach is as vital as our Results! Our collective work is driven by four core values: *Rethink Convention: We embrace creative and intellectual diversity to innovate and continually improve vaccine delivery. *Aim High: We strive to achieve audacious goals to develop the most complex biologics aimed at protecting humankind. *Lead with Heart: Everyone at Vaxcyte leads with kindness, fostering an inclusive environment that promotes collaboration and healthy debate to meet our business objectives. *Model Excellence: Our challenge demands a shared commitment to integrity, accountability, equality, and clarity in communication and decision-making.Position Summary:Vaxcyte is thrilled to offer an exciting opportunity for a dynamic and skilled individual to join our Analytical Development team. The Associate Scientist II, Analytical Development will be responsible for executing analytical testing and supporting method development activities for our biologics and vaccine development programs. This role will entail performing both routine and non-routine analytical assays utilizing modern analytical techniques and contributing to method optimization, troubleshooting, and continuous improvement initiatives under supervision. Candidates should possess demonstrated hands-on laboratory experience, strong technical execution, and the ability to work independently on routine tasks while supporting more complex development activities.Essential Functions:Analytical Testing & Data GenerationConduct routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical or biophysical techniques).Prepare samples, reagents, standards, and controls for testing.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine innovation enterprise dedicated to engineering high-fidelity vaccines aimed at protecting humanity from the dire consequences of bacterial diseases. Our efforts to eradicate or treat significant bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella, are just the beginning. With a clear and well-defined path to success, Vaxcyte is poised to make a lasting impact. Our Approach is as crucial as Our Mission! We are guided by four core values that shape our collaborative efforts: *RETHINK CONVENTION: We embrace creative and intellectual diversity to innovate and continuously improve vaccine delivery methods. *AIM HIGH: Our audacious goal drives us to develop the most complex biologics ever devised to protect humankind. *LEAD WITH HEART: Collaboration and vigorous debate are fostered through a kindness-first, inclusive approach. *MODEL EXCELLENCE: Our challenge requires a shared commitment to integrity, accountability, equality, and clear communication in decision-making.Position Summary:Vaxcyte is looking for a distinguished Director of Immunoassay Development to spearhead and lead a dedicated analytical function focused on immunoassay development for intricate conjugated vaccines. This role will involve building and managing a laboratory team tasked with the development, maintenance, and continuous enhancement of potency- and antigenicity-based immunoassays to support CMC development from preclinical stages through BLA-stage programs and commercialization.A primary focus for this role will be the stewardship of the VAX-31 MSD immunoassay platform, which has advanced to Phase 3 due to extensive internal leadership in clinical serology, GLP studies, and immunoassay development. The ideal candidate will collaborate closely with the current immunoassay leadership to ensure effective knowledge transfer, maintain scientific and execution excellence, and ensure the long-term sustainability of the immunoassay strategy as accountability transitions into Analytical Development.This is a hands-on scientific leadership position embedded within CMC execution.

Join Our Mission to Safeguard Humanity!Vaxcyte is at the forefront of vaccine innovation, dedicated to developing high-fidelity vaccines aimed at protecting humanity from serious bacterial diseases. Our commitment to eradicating or effectively treating infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. With a clear and well-defined path ahead, Vaxcyte is positioned for long-term success. Our approach is defined by our core values: *RETHINK CONVENTION: We embrace creative and intellectual diversity to innovate and continuously improve vaccine delivery. *AIM HIGH: We pursue our collective audacious goal of developing the most complex biologics to protect humanity. *LEAD WITH HEART: At Vaxcyte, we lead with kindness and inclusivity, fostering collaborative discussions that propel our business objectives. *MODEL EXCELLENCE: Our significant challenges demand a shared commitment to integrity, accountability, equality, and clear communication.Role Summary:The Senior Manager for Drug Substance (DS) Commercialization will oversee the launch readiness and commercial supply of the conjugate drug substance. This role will facilitate the transition of the conjugate product strategy from the Process Development team to Manufacturing Science and Technology (MSAT) during the late stages of product development. Key responsibilities include technical launch planning and execution, implementing best practices, and coordinating cross-functional efforts for regulatory submissions, facility preparations, and launch materials.The successful candidate will provide leadership to ensure effective communication of the scientific and commercial rationale for the conjugation process to internal stakeholders, relevant Contract Manufacturing Organizations (CMOs), and regulatory bodies. Exceptional written communication skills are essential, particularly in authoring submissions to Health Authorities (IND/BLA). The ability to collaborate with individuals from diverse backgrounds and perspectives is crucial for success in this role.

Become a Champion for Global Health!At Vaxcyte, we are at the forefront of vaccine innovation, developing cutting-edge vaccines designed to combat the severe and costly impacts of bacterial diseases. Our mission is to eliminate or effectively manage bacterial infections, including invasive pneumococcal disease, Group A Streptococcus, and Shigella. We have a clear trajectory towards success, and Vaxcyte is well-equipped to achieve our ambitious goals. Our Approach: What we do is equally as significant as how we accomplish it! Our collaborative efforts are driven by four core values: *RETHINK CONVENTION: We introduce creativity and diverse perspectives into every aspect of our work to innovate and continuously improve vaccine delivery methods. *AIM HIGH: We strive for excellence with a bold ambition to create some of the most intricate biologics ever developed to safeguard human health. *LEAD WITH HEART: Kindness and inclusivity are at the forefront of our leadership style, fostering collaboration and robust discussions that propel our business forward. *MODEL EXCELLENCE: We share an unwavering commitment to integrity, accountability, and clarity in all our communications and decisions.Position Overview:Vaxcyte is in search of a Senior Director, Product Launch Lead for VAX-31, who will spearhead the strategic planning and execution of our inaugural launch. This pivotal role involves coordinating cross-departmental initiatives from late-stage development through market introduction, ensuring readiness across supply chain, regulatory, medical affairs, and commercial operations. You will collaborate with senior leadership to outline launch strategies, manage timelines, address risks, and synchronize efforts among internal and external stakeholders to successfully introduce our products to the global market.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines aimed at protecting humankind from the dire consequences of bacterial diseases, which can lead to severe and costly health issues if not addressed. Our efforts to combat and potentially eliminate bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella are just the beginning of our journey towards success. Vaxcyte is strategically positioned to achieve its goals. Our Work Philosophy: We believe that what we do is as crucial as how we go about it! Our collaborative efforts are guided by four foundational core values: *RETHINK CONVENTION: We embrace intellectual diversity and creativity at every level to innovate and continuously improve vaccine delivery methods. *AIM HIGH: We strive to achieve our ambitious goal of creating the most complex biologics ever developed to protect humanity. *LEAD WITH HEART: Every team member at Vaxcyte approaches leadership with kindness and inclusivity, fostering collaboration and constructive debate to meet our business objectives. *MODEL EXCELLENCE: The scale of our mission demands a unified commitment to integrity, accountability, equality, and clear communication in all our decisions. Position Overview:Vaxcyte is seeking an enthusiastic and skilled Senior Engineer to join our Polysaccharide Development and Manufacturing team within the CMC group. The successful candidate will play a pivotal role in developing a multi-valent polysaccharide-based conjugate vaccine, utilizing a novel carrier protein produced via the Xpress CF platform. With a strong emphasis on downstream purification for early-stage development and late-stage process characterization, the ideal candidate should possess significant experience in these areas. Familiarity with Design of Experiments (DOE) methodologies and proficiency in statistical software (e.g., JMP) are essential. Proven leadership in project initiatives and team management is required. The candidate must be eager to acquire new lab skills, as they will collaborate on experimental designs and execute experiments to advance our polysaccharide development and manufacturing initiatives. This role entails over 50% laboratory time, and the candidate should be capable of working independently and in collaboration with cross-functional teams.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines aimed at protecting humanity from the severe repercussions of bacterial diseases, which can lead to significant health complications and financial burdens if left unaddressed. Our commitment to eradicating or treating bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the start. With a clear and well-defined path to success, Vaxcyte is poised to make a lasting impact. Our Approach: What we do is equally as critical as how we do it! Our collaborative efforts are anchored by four guiding core values: *RETHINK CONVENTION: We infuse creative and intellectual diversity into every aspect of our work to innovate and continuously improve the delivery of vaccines. *AIM HIGH: We embody our audacious goal to courageously tackle the most complex biologics designed to protect humanity. *LEAD WITH HEART: Everyone at Vaxcyte adopts a kindness-first, inclusive approach to collaboration and spirited debate that drives our business objectives forward. *MODEL EXCELLENCE: The scale of our challenge demands our collective commitment to integrity, accountability, equality, and transparency in our communications and decision-making.Position Overview:Vaxcyte’s Legal team is on the lookout for a driven and innovative AI Implementation Consultant to assist in the design, evaluation, and deployment of cutting-edge AI solutions within the Legal and Compliance sectors. This project-based position is ideal for a graduate student pursuing their MS or PhD, who possesses strong technical skills, a keen interest in legal operations, and a passion for utilizing AI to solve real-world business challenges. You will collaborate with cross-functional teams to prototype, test, and implement AI tools that enhance efficiency, improve compliance workflows, and bolster the team’s capacity to provide strategic support to the business.Key Responsibilities:Bot Development: Create and prototype an AI-driven chatbot to assist Legal and Compliance functions (e.g., FAQs, SOP references, or workflow routing).Legal Dashboard Enhancements: Upgrade the existing Legal Dashboard utilizing Box AI and related integrations to enhance automation, visibility, and user experience.Tool Evaluation: Research, assess, and recommend emerging AI tools and products; coordinate and participate in their implementation.

Join Our Mission to Safeguard Humanity!At Vaxcyte, we are a pioneering clinical-stage vaccine innovation company committed to developing high-fidelity vaccines aimed at protecting humanity from the severe health impacts of bacterial diseases. Our mission is to eradicate or effectively treat bacterial infections like invasive pneumococcal disease, Group A Streptococcus, and Shigella, and we have a clear and well-defined path to achieving this goal. Our Approach: What we do is as vital as how we do it! Our collaborative efforts are anchored by four core values: *RETHINK CONVENTION: We embrace creative and intellectual diversity, driving innovation and enhancing vaccine delivery methods. *SET HIGH ASPIRATIONS: We strive to tackle the most complex biologics challenges to protect humankind. *LEAD WITH COMPASSION: Our leadership is rooted in kindness and inclusivity, fostering collaboration and constructive debate to meet our business goals. *MODEL EXCELLENCE: We are dedicated to demonstrating integrity, accountability, and clarity in our communications and decision-making processes.Position Overview:Vaxcyte is on the lookout for an Associate Director of Real-World Evidence & Epidemiology to play a pivotal role in advancing and enhancing our epidemiology and real-world evidence (RWE) capabilities throughout the vaccine lifecycle. Joining our purpose-driven team means contributing to the science of prevention across all stages of life. This role presents a unique opportunity to establish a robust epidemiology and RWE function, offering significant ownership, mentorship, and opportunities for growth.This dynamic, hands-on position is ideal for an early-to-mid-career epidemiologist who thrives on both executing tasks and building functions. The role integrates operational leadership (including study start-up, vendor management, and IRB submissions) with scientific execution, encompassing study design, data analysis, evidence synthesis, and interpretation.As this individual progresses, they will evolve into a scientific epidemiology lead, assuming greater responsibility for study design, analytical strategy, and external scientific collaboration.

Be Part of Our Mission to Safeguard Humanity!Vaxcyte is at the forefront of vaccine innovation, dedicated to developing high-fidelity vaccines aimed at protecting people from bacterial diseases that can have severe and costly health impacts if not addressed. Our commitment to eradicating or treating bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning of our journey. With a clear and strategic roadmap, Vaxcyte is poised for significant impact in global health. Our Approach Matters: We are guided by four core values that shape our collaborative efforts: *RETHINK CONVENTION: We promote creative and intellectual diversity in all our endeavors to continuously innovate the delivery of vaccines. *AIM HIGH: Our ambitious goal is to develop the most complex biologics ever conceived to defend humanity. *LEAD WITH HEART: At Vaxcyte, everyone contributes to leadership through a kindness-first, inclusive collaboration approach that fosters vigorous debate and drives our business objectives forward. *MODEL EXCELLENCE: Our mission's scale requires a shared commitment to integrity, accountability, equality, and clarity in communications and decision-making.Position Overview:Vaxcyte is looking for a dynamic Manager of Quality Assurance and Compliance to oversee daily operational governance and strategic oversight of vital Quality System processes. This role will primarily focus on leading Change Control governance and managing deviation/investigation oversight, ensuring consistent, risk-based decision-making, inspection readiness, and cross-functional accountability across quality systems. The Manager will serve as a pivotal governance leader for cross-functional quality processes, proactively identifying systemic risks, ensuring compliance with procedures, driving performance metrics through KPIs, and presenting insights on quality system health and trends during Management Review.

Join Our Mission to Safeguard Humanity!Vaxcyte is at the forefront of vaccine innovation, developing high-fidelity vaccines aimed at protecting humanity from the dire consequences of bacterial diseases. Our commitment to eradicating or treating infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. With a clear and actionable pathway to success, Vaxcyte is perfectly positioned to make a lasting impact. Our Approach is as crucial as Our Goals! We are guided by four enduring core values: *RETHINK CONVENTION: We foster creative and intellectual diversity in every aspect of our work to continuously innovate the delivery of vaccines. *AIM HIGH: Our audacious collective goal drives us to tackle the most complex biologics ever created for the benefit of humankind. *LEAD WITH HEART: At Vaxcyte, we prioritize kindness and inclusivity in our collaborations and vigorous discussions that propel our business objectives forward. *MODEL EXCELLENCE: The magnitude of our challenge demands a shared commitment to integrity, accountability, equality, and transparency in our communications and decision-making processes. Position Overview:We are seeking a dynamic and skilled individual to join our Drug Product Development team. The ideal candidate will possess a solid understanding and hands-on experience in analyzing and characterizing biomolecules (proteins, polysaccharide conjugates, vaccines) utilizing various methods, particularly immunoassays and multiplexed formats. Experience with vaccine and adjuvant-containing formulations is a significant advantage.Additionally, we value flexibility and the ability to manage multiple projects simultaneously while adeptly prioritizing tasks to meet aggressive deadlines. This laboratory-based role demands excellent scientific judgment, independence, rigor, and meticulous record-keeping.Key Responsibilities:Perform both routine and non-routine analyses of internal release, development, and stability samples utilizing a diverse range of analytical techniques, ensuring the production of high-quality data and comprehensive reporting.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine development company dedicated to creating high-fidelity vaccines aimed at safeguarding humanity from the dire consequences of bacterial diseases. Our mission is not just to combat but to eradicate or effectively treat serious bacterial infections including invasive pneumococcal disease, Group A Strep, and Shigella. We have a clear, structured path to success, and Vaxcyte is prepared to lead the charge. Our Approach: Our work is defined by our commitment to four core values: *Challenge the Norm: We infuse creativity and diverse perspectives into all aspects of our endeavors to revolutionize vaccine delivery. *Aim High: We strive to achieve our ambitious goal of developing the most complex biologics ever created to protect humanity. *Lead with Empathy: Every team member at Vaxcyte fosters a collaborative environment that prioritizes kindness and constructive debate, propelling our objectives forward. *Exemplify Excellence: The challenges we face demand a collective commitment to integrity, accountability, and transparent communication.Position Overview:We are on the lookout for a highly motivated and detail-oriented Senior Associate Scientist (Contract) to join our Polysaccharide Analytical Development team. The primary focus of this role is to support the analytical testing and characterization of polysaccharide-based drug candidates. The successful candidate will execute and refine various biochemical and chromatographic assays, contribute to method development initiatives, and ensure the generation of high-quality data in alignment with our research and development programs.This position demands robust hands-on experience with HPLC-based techniques, biochemical assays, and analytical software platforms, alongside a steadfast commitment to data integrity, meticulous documentation, and collaborative efforts across functions.

Join Our Mission to Safeguard Humanity!Vaxcyte is a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines aimed at protecting humanity from the dire consequences of bacterial diseases. Our mission to combat and eradicate bacterial infections—including invasive pneumococcal disease, Group A Strep, and Shigella—is just the beginning. With a clear and defined path to success, Vaxcyte is positioned to make a lasting impact. Our Approach: At Vaxcyte, what we do is as crucial as how we achieve it. Our work is guided by four core values: *RETHINK CONVENTION: We leverage creative and intellectual diversity to innovate and redefine the delivery of vaccines. *AIM HIGH: We pursue our ambitious goal of developing the most complex biologics ever attempted for the protection of humanity. *LEAD WITH HEART: At Vaxcyte, we prioritize kindness and inclusivity in our collaborative efforts, fostering vigorous discussions that align with our business objectives. *MODEL EXCELLENCE: Our shared challenge necessitates a commitment to integrity, accountability, equality, and clarity in all communications and decisions.Summary:Vaxcyte is seeking a dynamic and skilled individual to join our Vaccine Product Development team as a Stability Manager within the Quality Control Unit. This role is vital for managing the stability program for various projects in preclinical and clinical development.In this position, you will play an essential role in implementing and upholding cGMP Stability for all stages of clinical development. Your primary responsibilities will include overseeing stability studies for individual projects and analyzing stability data. You will collaborate closely with QC team members in a highly cooperative and cross-functional environment. The ideal candidate will bring extensive stability experience, ensure compliant operations and documentation, promote open communication, and adopt data-driven methodologies.

Join Our Mission to Protect Humanity!At Vaxcyte, we are a pioneering clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines aimed at safeguarding humanity from the dire consequences of bacterial diseases. Our goal is to combat serious bacterial infections, including invasive pneumococcal disease, Group A Strep, and Shigella. We are on a clear pathway to success, determined to make a significant impact in the world of vaccine development. Our Approach: We believe that what we do is as important as how we do it. Our collaborative work is anchored by four core values: *RETHINK CONVENTION: We embrace creative and intellectual diversity in all aspects of our work to innovate and transform vaccine delivery. *AIM HIGH: We strive to achieve audacious goals, courageously tackling the most complex biologics to protect humankind. *LEAD WITH HEART: At Vaxcyte, leadership is about kindness and inclusivity, fostering collaboration and robust discussions that further our mission. *MODEL EXCELLENCE: Our ambitious challenges necessitate a shared commitment to integrity, accountability, and clarity in our communications and decision-making processes.Position Overview:We invite a dynamic and skilled individual to become part of our Analytical Development team as a Scientist I. In this role, you will execute analytical testing and play a vital role in the development of analytical methods for our biologics and vaccine programs.This position entails performing both routine and advanced analytical assays utilizing modern techniques. You will support method optimization and troubleshooting, engage in continuous improvement initiatives with moderate supervision, and work effectively within cross-functional teams. The ideal candidate will possess hands-on laboratory experience, exceptional technical execution, and robust problem-solving abilities. You will independently plan and execute tasks, analyze and interpret data, and drive or escalate investigations as necessary. Additionally, you will author and maintain comprehensive technical documentation, including method protocols, development summaries, and SOPs, while effectively communicating experimental results to internal stakeholders.

Join Our Mission to Safeguard Humanity!Vaxcyte, a pioneering clinical-stage vaccine innovation company, is dedicated to creating high-fidelity vaccines aimed at protecting humanity from the dire consequences of bacterial diseases. Our mission is to combat serious health threats posed by bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella. Our path forward is clear and strategically defined, positioning Vaxcyte to achieve long-lasting success. Our Approach: At Vaxcyte, the WHAT we do is as significant as the HOW we do it! Our collaborative efforts are governed by four core values: *Rethink Convention: We foster creative and intellectual diversity to revolutionize vaccine delivery. *Aim High: We passionately pursue audacious goals to devise the most complex biologics for humanity's protection. *Lead with Heart: Every member leads with kindness and inclusivity, fostering collaboration and constructive debate to drive our business objectives. *Model Excellence: Our shared commitment to integrity, accountability, equality, and transparent communication is essential in overcoming challenges.Position Summary:This role presents an exciting opportunity to serve as a strategic financial partner to Vaxcyte’s R&D organization, focusing on clinical studies. You will support Clinical Operations and the Immunoassay and Non-Clinical teams by overseeing clinical trial and serology finances while adapting to broader R&D needs. This position requires close collaboration with Clinical Operations and Serology on planning, forecasting, accruals, financial reporting, and decision support across multiple development programs.Key Responsibilities:Provide strategic oversight for clinical outsourcing by collaborating with Clinical Operations, Clinical Development, Finance, and Legal to evaluate the best fit for Vaxcyte’s pipeline and outsourced scope of work.Oversee financial and commercial aspects of RFP processes, vendor selection, and budget management for the Clinical organization.Manage financial updates for clinical trials and support the annual planning process, including detailed analyses.

About Vaxcyte Vaxcyte, Inc. is advancing vaccine research in San Carlos, California, with a focus on high-fidelity vaccines targeting serious bacterial diseases. The team works to address infections such as invasive pneumococcal disease, Group A Streptococcus, and Shigella. Vaxcyte’s mission centers on reducing or managing these health threats through innovative science and a clear, strategic vision. Our Values Rethink Convention: Encourage creativity and welcome diverse perspectives to improve vaccine delivery. Aim High: Pursue ambitious goals in developing complex biologics for public health. Lead with Heart: Foster a collaborative culture rooted in kindness, inclusivity, and healthy debate. Model Excellence: Commit to integrity, accountability, and clear communication in all work. Role Overview: Associate Scientist II, Vaccine Research The Research team relies on a broad set of chromatographic techniques to purify vaccine antigens. This role calls for hands-on experience with multiple chromatography methods, including monoclonal antibody/Protein A workflows. Candidates should have worked on selecting, screening, developing, scaling up, and characterizing various chromatography techniques. Main Responsibilities Carry out AKTA FPLC chromatography, including: Immobilized metal affinity chromatography (IMAC) Ion-exchange chromatography (IEX) Hydrophobic interaction chromatography (HIC) Size-exclusion chromatography (SEC) Hydroxyapatite (CHT / HA) Design chromatography trains to reduce host cell proteins, endotoxins, and aggregates by combining complementary techniques. Apply Design of Experiments (DoE) for multimodal optimization (experience in this area is a plus). Use membrane chromatography for high-throughput contaminant analysis.

Vaxcyte seeks a Medical Science Liaison (MSL) to join its Medical Affairs team in San Carlos, California. This position focuses on immunization and pneumonia prevention, supporting the company's mission to address serious bacterial diseases. Role overview The MSL will serve as a scientific resource for healthcare providers, public health officials, and key opinion leaders. Responsibilities include supporting vaccine education, contributing to clinical development, and assisting with real-world evidence generation related to Vaxcyte’s vaccine programs. Candidates with deeper experience may be considered for the Senior MSL title, which includes additional duties in strategic leadership and mentorship within the team. What you will do Act as a scientific contact for external stakeholders, including healthcare professionals and public health officials. Support educational initiatives about immunization and pneumonia prevention. Contribute to clinical development and real-world evidence projects. What matters here Creativity and openness to new ideas in vaccine delivery. A drive to pursue ambitious goals for global health impact. Kindness, inclusivity, and a collaborative approach. Integrity, accountability, and transparency in daily work.