Scientist II, Clinical Bioinformatics

About the Role At 10x Genomics, we are pioneering advancements in diagnostics by harnessing our cutting-edge single-cell and spatial assay technologies for transformative clinical applications. We are currently looking for a Scientist II to become an integral part of our clinical bioinformatics team. The ideal candidate will be adept at translating intricate biological questions into effective computational strategies, employing computational and statistical methodologies to analyze extensive single-cell or spatial transcriptomics datasets to extract clinically relevant insights. This role necessitates a biology-first approach, expertise in large-scale bioinformatics analysis, and a strong foundation in scientific reasoning and statistical analysis. The successful candidate will have the chance to work with some of the largest biomedical datasets, using state-of-the-art 10x Genomics technologies to drive innovations in clinical diagnostics. What You Will Be Doing: Execute comprehensive computational and statistical methods for single-cell and spatial transcriptomics data analysis. Extract actionable insights from clinical and translational single-cell or in-situ spatial datasets. Design, implement, and validate biomarkers for diagnostic use. Develop and uphold bioinformatics pipelines for reproducible, large-scale data processing. Process and analyze single-cell or in-situ spatial transcriptomics datasets encompassing hundreds to thousands of samples. To Be Successful, You Will Need: A Ph.D. in bioinformatics, computational biology, genomics, or a related field, along with substantial hands-on experience in single-cell NGS data analysis. At least 2 years of relevant industry experience post-Ph.D. Proficiency in analyzing large-scale single-cell or spatial transcriptomics datasets to glean biologically significant insights and/or diagnostic biomarkers. A deep understanding of the assumptions, limitations, and caveats associated with statistical methods. Experience in developing and optimizing high-performance, scalable code. Proficiency in a Linux environment. A goal-oriented, self-driven mindset with a knack for independent problem solving. Exceptional attention to detail and a strong work ethic.

Join our dynamic and innovative team at PromptBio as a Senior Bioinformatics Scientist, where you'll play a pivotal role in leveraging AI technologies within the life sciences sector. This position also involves substantial interaction with our clients, ensuring they receive the best scientific support.Key Responsibilities:Collaborate closely with the Business Development team, acting as the primary scientific liaison for enterprise clients, fostering deep technical relationships, and assisting them in extracting biological insights.Develop and execute customized multi-omics analysis workflows, including genomics, transcriptomics, proteomics, metabolomics, and epigenomics, tailored to meet specific client needs.Continuously assess and integrate cutting-edge bioinformatics tools, algorithms, and computational techniques to maintain leadership in the field.Contribute to scientific literature through authorship and collaboration on publications, presentations, and intellectual property filings.

10x Genomics seeks a Scientist II to join the Reagents Sustaining and Applications team at the Pleasanton, California headquarters. This position centers on advancing and refining reagents that support genomic applications. Key responsibilities Contribute to product development efforts for reagents used in genomic solutions Use scientific expertise to improve and optimize reagent applications Work closely with team members from different scientific backgrounds to meet project objectives Location This role is based in Pleasanton, California.

10x Genomics is developing a diagnostics program that brings single-cell and spatial genomics technologies to clinical settings. The Clinical Laboratory Scientist (Technical Supervisor) will oversee scientific and technical operations for complex next-generation sequencing (NGS) assays in the company’s CLIA-certified laboratory at headquarters in Pleasanton, California. This position ensures that NGS testing is accurate, meets analytical and regulatory standards, and operates smoothly. As the technical lead, the supervisor acts as an expert in assay validation, quality systems, and troubleshooting, partnering with lab leadership to uphold standards and drive ongoing improvements. Main Responsibilities Direct daily operations and technical aspects of complex NGS assays to deliver accurate and reliable results. Validate and implement NGS assays in compliance with CLIA, CAP, and other regulatory requirements. Establish and monitor quality control and assurance programs by analyzing performance data, identifying trends, and initiating corrective actions as needed. Draft, review, and approve technical documents, including standard operating procedures (SOPs), validation protocols, reports, and testing methods. Maintain regulatory compliance and support both internal and external audits and inspections. Act as the primary technical contact for resolving complex issues related to assays, laboratory instruments, and bioinformatics. Review and approve changes to assays, workflows, instruments, and software, and oversee any required revalidation. Manage proficiency testing, method comparisons, and ongoing monitoring of assay performance. Provide technical training and assess competency of laboratory staff. Collaborate with teams in bioinformatics, R&D, quality, and operations to improve and optimize assays. Stay current with new technologies, regulatory updates, and best practices in NGS and molecular diagnostics.

10x Genomics is growing its diagnostics team, bringing single-cell and spatial genomics technologies into clinical practice. The Clinical Laboratory Scientist (General Supervisor) leads daily operations for high-complexity next-generation sequencing (NGS) testing in the CLIA-certified laboratory at the Pleasanton, California headquarters. This position ensures test results are accurate and timely, upholding rigorous regulatory and quality standards. The supervisor also guides technical staff and helps keep lab operations running smoothly. What you will do Oversee daily laboratory operations for high-complexity NGS assays, following established protocols and quality requirements. Supervise and mentor laboratory staff, including training, competency assessments, and performance reviews. Review quality control data and assay performance to verify accuracy and reliability of test results. Ensure compliance with CLIA, CAP, and other relevant regulatory standards. Contribute to developing, validating, implementing, and improving NGS assays and lab workflows. Monitor laboratory throughput, turnaround times, and resource usage to support efficient operations. Troubleshoot technical issues with instruments, assays, or data analysis. Maintain detailed laboratory records, including SOPs, validation documents, and quality logs. Collaborate with lab leadership on ongoing quality improvement projects. Oversee maintenance and calibration of laboratory equipment. Location This role is based at 10x Genomics headquarters in Pleasanton, California.

Calyxo, Inc. is an innovative medical device company based in Pleasanton, California, dedicated to revolutionizing kidney stone treatment since its inception in 2016. Our mission addresses the urgent need for effective solutions to a prevalent and painful health issue that significantly burdens healthcare systems annually. Our leadership team is composed of seasoned executives and investors with a successful history of bringing groundbreaking medical devices to market in the urology field.Are you prepared to reshape the future of kidney stone treatment? We invite high achievers to join our dynamic and diverse team in a collaborative and enjoyable work environment.Position Overview:The Scientist, Scientific Affairs will be a key player within the Medical and Clinical Affairs team, spearheading and contributing to various initiatives including scientific communication strategies, clinical and R&D project support, regulatory submissions, and marketing objectives. The ideal candidate will possess a robust knowledge of scientific research, clinical development, and the urology marketplace. A collaborative spirit is essential, as this role will require cross-functional teamwork with R&D, regulatory, legal, clinical operations, and marketing teams. Exceptional communication skills and the ability to thrive independently in a fast-paced environment are crucial.Key Responsibilities:Scientific Communication:Execute and manage the scientific podium and publication strategy, contributing to strategic direction.Develop and submit high-quality peer-reviewed publications, abstracts, and presentations across various categories.Establish and nurture relationships with key opinion leaders (KOLs) for research collaborations and ensure timely submissions of abstracts and publications. On-site support for KOL presentations at meetings is required.Create deliverables including white papers, opinion editorials, and clinical summaries.Clinical Pipeline Initiatives:Collaborate with clinical operations to design trials, develop protocols, and ensure clinical data aligns with the company’s scientific goals.Facilitate communication and alignment with clinical operations and stakeholders to ensure trial execution aligns with podium and publication timelines. Work cross-functionally to adjust timelines as necessary and elevate concerns to leadership when needed.R&D Projects:Engage in R&D initiatives that drive innovation and enhance the company's product offerings.

Role Overview vectoratomic is seeking a Senior Quantum Scientist in Pleasanton, California. This role focuses on research and development in quantum technologies. The position involves working closely with a skilled team to explore and advance new quantum applications. What You Will Do Lead and contribute to quantum science research projects Collaborate with colleagues to develop and test quantum technology concepts Help drive innovation in quantum applications

About the Role:Join Sajix as a Trainee Data Scientist, where you will play a pivotal role in developing predictive models and conducting experiments to extract valuable insights from intricate healthcare data.Key Responsibilities:Assist in the cleaning and preprocessing of both structured and unstructured data to ensure high-quality datasets.Support the creation and refinement of statistical and machine learning models to enhance data-driven decision-making.Engage in exploratory data analysis and feature engineering to uncover hidden patterns and improve model performance.Document your findings and effectively communicate insights to non-technical stakeholders, promoting data literacy within the organization.

Ware Malcomb is seeking an Interior Architect & Designer II for its Pleasanton, CA office. This position offers the chance to contribute to a team that values creativity and collaboration, with a focus on delivering thoughtful design solutions for a range of project sizes. Role overview The Designer II will handle a variety of interior architecture and design assignments. Projects may range from small-scale spaces to larger, more complex environments. The role involves applying established design methods to meet project objectives and client needs. Responsibilities Work on diverse design projects, applying recognized design principles and methodologies Exercise independent judgment in evaluating and implementing design strategies Collaborate with team members while receiving guidance from a licensed interior designer Requirements Experience in interior architecture or design, with the ability to work on both small and large projects Comfort making independent decisions within established guidelines Willingness to work under the supervision of a licensed professional Learn more about the company’s culture and values by visiting the Ware Malcomb company culture page.

Role Overview Vector Atomic seeks a Staff Scientist focused on Quantum Research at its Pleasanton, California office. This position centers on advancing quantum technology through hands-on research and close collaboration with a multidisciplinary team of scientists and engineers. The work aims to expand the practical limits of quantum science and its applications.

Join our dynamic and innovative team at PromptBio as a Senior AI Scientist, where we are at the forefront of integrating advanced AI solutions in the life sciences sector. We are looking for a passionate and skilled individual who thrives in a collaborative environment and is eager to push the boundaries of technology.Key Responsibilities:Design and prototype state-of-the-art autonomous AI agents and multi-agent systems with capabilities in dynamic planning, reasoning, memory management, and self-reflection.Develop and integrate essential components of AI agents, including planning modules (such as Tree-of-Thought and CoT-based planners), tool-use interfaces, and persistent long-term memory/retrieval mechanisms (RAG).Write high-quality, production-ready code in Python or Go to seamlessly integrate LLMs and other foundational models into functional agent architectures.Build and maintain scalable agent infrastructure utilizing frameworks like LangChain, ensuring smooth integration with cloud services, preferably AWS.Conduct thorough testing, evaluation, and optimization of agent performance in complex, real-world scenarios.Collaborate closely with the engineering team to define agent use cases and translate research prototypes into deployable product features that provide substantial business value.

About the Role: 10x Genomics is seeking an exceptional Senior Scientist to join our Process Development team. This pivotal role supports the development and commercial launch of innovative new products. The successful candidate will collaborate across various teams, including Chemistry, Microfluidics, custom plastic consumables, Assay Development, and Production, to develop, optimize, validate, and transfer novel chemistries and processes essential for producing 10x reagents and consumables. A comprehensive understanding of chemical processes and analytical methods related to polymer, surfactant, or surface chemistry is crucial, along with hands-on experience in custom instrumentation and a background in process development, scale-up, implementation, and validation within a commercial manufacturing environment. The ideal candidate is a self-starter, a strategic thinker, action-oriented, and adaptable to shifting priorities and methodologies. You should flourish in a dynamic environment, excel at managing multiple tasks, and effectively communicate across all organizational levels, providing immediate and impactful contributions.

Role Overview Vector Atomic is seeking a Senior Staff Scientist with expertise in Quantum technologies for its Pleasanton, California location. This position focuses on advancing research and development in quantum science. The scientist will work closely with a skilled team, applying advanced resources to address complex problems in the field. What You Will Do Lead research and development projects in quantum technologies Collaborate with other scientists and technical staff on challenging quantum science initiatives Contribute to projects that aim to solve significant technical challenges in the quantum domain

Calyxo, Inc. develops medical devices aimed at improving kidney stone treatment. Based in Pleasanton, California, the company has focused on addressing the challenges of kidney stone disease since 2016. Calyxo’s leadership team brings significant experience in launching devices for the urology field. Role overview The Clinical Project Manager leads clinical trials from planning through completion. This position coordinates all aspects of trial execution, working to ensure studies run smoothly, stay on schedule, and meet regulatory requirements. The role requires close collaboration with internal teams and external partners, including Clinical Research Associates, Contract Research Organizations, and clinical sites. The main objective is to generate strong clinical evidence that supports Calyxo’s product development and regulatory strategies. Key responsibilities Oversee day-to-day clinical trial operations from initial planning to study closeout Maintain compliance with regulatory standards at every stage of the trial Coordinate with internal staff and external partners, such as CRAs, CROs, and clinical sites Drive the collection and management of high-quality clinical data to support product and regulatory goals Contribute to a collaborative team environment and adapt to changing project priorities as needed Location This role is based in Pleasanton, CA.

Join our innovative team at Lunar Biosciences as a Senior Staff/Principal Scientist specializing in Organic Chemistry and Biochemistry. In this pivotal role, you will spearhead the development of complex chemical processes, integral to our revolutionary technology. Collaborate in a dynamic startup environment with a multidisciplinary team to create foundational chemistry solutions for our advanced sequencing technology.Key Responsibilities:Serve as both a hands-on bench scientist and a leader within the chemistry team.Devise, execute, and refine R&D strategies to innovate chemistries for our proprietary non-mass spectrometry-based proteomics workflow.Develop, validate, and optimize protocols to integrate with cross-disciplinary processes, including automation.Oversee multiple timelines across diverse projects, ensuring alignment with functional progress.Articulate the overarching chemistry strategy and its rationale to external stakeholders.Drive innovation by expanding our technology pipeline and intellectual property portfolio.Identify and cultivate internal and external resources to bolster our R&D initiatives.Establish and maintain a scientific advisory group to support ongoing research.Engage in multidisciplinary team activities, swiftly identifying and resolving challenges while advancing projects through critical review processes.Review relevant research and intellectual property literature to inform ongoing research projects.

About the Role: Join 10x Genomics in our mission to revolutionize diagnostics by leveraging our pioneering single-cell and spatial genomics technologies for impactful clinical applications. We are currently looking for a talented and driven Senior Scientist to become a key member of our Diagnostic Assay Development team. This role is a hands-on bench scientist position that involves taking scientific ownership of assay development and optimization while providing mentorship and technical guidance to junior staff. As a Senior Scientist, you will execute, troubleshoot, and enhance 10x Genomics-based assays to facilitate the development of robust Laboratory Developed Tests (LDTs). Key Responsibilities: Assay Development & Execution Independently perform complex single-cell and spatial genomics workflows, including sample processing, library preparation, and sequencing. Act as a hands-on technical authority for 10x Genomics platforms (e.g., Chromium, Xenium), ensuring high standards in assay performance. Methodically troubleshoot and refine assay workflows to enhance robustness, sensitivity, and reproducibility. Adapt, refine, and expand existing protocols to fulfill clinical, regulatory, and scalability criteria. Design and conduct feasibility studies to assess new reagents, chemistries, instrumentation, and workflow enhancements. Process a variety of challenging clinical sample types to support clinical research and validation studies. Analytical Validation & Documentation Design and implement experiments that support analytical validation, focusing on accuracy, precision, detection limits, and reproducibility. Create, review, and uphold high-quality laboratory documentation, including SOPs, validation protocols, and batch records, in compliance with Good Documentation Practices. Analyze assay performance metrics and quality control data to drive informed, data-based technical decisions. Present experimental data and scientific findings clearly in team meetings and written reports. Scientific Leadership & Mentorship Provide daily technical guidance and mentorship to junior team members. Review experimental data and assist in the interpretation of results to foster a collaborative research environment.

About the Role:The Senior Manager, Clinical Operations and Strategic Alliances, under the guidance of the Director of Business Development and Strategic Partnerships, will spearhead the operational execution and strategic oversight of pivotal alliances that are essential to 10x Genomics’ mission of advancing innovative diagnostic solutions utilizing single-cell and spatial technologies.Key responsibilities encompass managing a portfolio of academic collaborations and strategic partnerships, ensuring alignment with established milestones and outcomes. You will lead the operational execution of extensive, multi-year collaborations with leading academic institutions, generating critical evidence for future clinical applications of our technologies. Additionally, you will facilitate collaboration between internal cross-functional teams and external partners to drive desired outcomes efficiently.This position requires a distinctive combination of Clinical Operations and Alliance Management. The ideal candidate will be an action-oriented, results-driven leader with prior experience in managing clinical research studies and strategic partnerships.What You Will Be Doing:Clinical Operations and Study ExecutionStudy Execution: Oversee the operational execution of large-scale, longitudinal clinical research studies, adhering to established agreements with academic institutions.Timeline & Risk Management: Own the clinical research study timelines, deliverables, and operational plans, ensuring compliance with sampling schedules; proactively identify operational risks related to enrollment, setup, or logistics, implementing mitigation strategies to uphold study integrity.Sample Logistics & Chain of Custody: Develop and enforce auditable procedures for sample collection, tracking, and chain of custody, ensuring compliant transport from clinical sites to 10x Genomics laboratories.Budget & Resource Oversight: Manage study budgets, including oversight of reimbursements, equipment provisioning, and consumables provided to partner sites.Regulatory & Quality Compliance: Ensure full compliance of all study activities with IRB protocols, patient consent requirements, and GCLP/CLIA standards where applicable.Strategic Alliance Management

At Veeva Systems, we are a mission-driven organization at the forefront of industry cloud technology, dedicated to expediting the delivery of life-saving therapies to patients. As one of the fastest-growing SaaS companies in history, we achieved over $3 billion in revenue last fiscal year, with significant growth opportunities ahead. Our core values guide us: Do the Right Thing, Customer Success, Employee Success, and Speed. In 2021, we made history by becoming a public benefit corporation (PBC), committed to balancing the interests of our customers, employees, society, and investors. As a Work Anywhere organization, we empower our employees to choose their optimal work environment, whether from home or in the office, to foster success and well-being. Join us in transforming the life sciences industry and making a meaningful impact on our customers, employees, and communities.The RoleWe are seeking a highly motivated individual with experience in data management or the life sciences sector, particularly in software product management. In this role, you will champion customer success by leveraging our Veeva Clinical Data Management products, specifically the Veeva Clinical Database (CDB), while engaging with our North American clientele.As a member of the Clinical Data Management Product Expert team, you will be integral to our Product organization. Your key responsibilities will include:1. Acting as a representative for the Product organization and promoting our products in customer interactions, online forums, and industry events.2. Advocating for customer feedback to influence the product roadmap.3. Realizing the potential of our product innovations by creating valuable content and resources for both internal and external stakeholders.This position is ideal for candidates experienced with Veeva EDC and/or CDB applications or comparable Clinical Data Management systems and processes, who are eager to collaborate with customers and drive their success.

Role Overview Vector Atomic is hiring a Senior Facilities Technician II in Pleasanton, California. This position ensures the smooth operation and upkeep of facility systems. The technician will handle troubleshooting, repairs, and routine maintenance across a range of building systems to support a safe and efficient workplace. Key Responsibilities Troubleshoot and repair facility equipment and infrastructure Perform regular maintenance on building systems Monitor facility conditions to meet safety and operational requirements

About UsHawthorne Health stands at the forefront of clinical research as a premier community site network and home research visit solution provider, boasting over 20 sites and a workforce of more than 2,000 healthcare professionals experienced in research across the U.S. Our innovative approach leverages accessible healthcare locations, curated patient data, and advanced technology to enhance patient engagement, improve retention rates, and lower the costs associated with clinical studies. By integrating high-quality research within local communities, we make clinical trials more approachable and convenient, ultimately accelerating the delivery of improved treatments to market.About the RoleWe are looking for a highly skilled Dermatologist (1099 | PRN) to join our team and support upcoming clinical trials in Pleasanton, CA. This role offers a flexible, supplemental opportunity for a physician keen on contributing to clinical research alongside their standard practice. Candidates with prior clinical research experience are strongly preferred, and hands-on injection experience is required. You will play a critical role in ensuring exceptional participant care and protocol adherence while acquiring invaluable sponsor-backed clinical research experience.