Compute Infrastructure Engineer at Schmidt Sciences | New York

Schmidt Sciences is a nonprofit organization established in 2024 by Eric and Wendy Schmidt, dedicated to accelerating scientific advancements and breakthroughs using cutting-edge tools to promote a sustainable planet. The organization emphasizes research in impactful fields such as AI and advanced computing, astrophysics, biosciences, climate science, and space exploration while also supporting a diverse array of researchers through its science systems program.About the AI & Advanced Computing Institute (“AI Institute”) The AI Institute at Schmidt Sciences operates as a grantmaking and research entity that recognizes AI as a pivotal driver for scientific discovery and societal advancement. Over the upcoming decade, we aim to empower leading researchers focused on enhancing AI systems to be competent, trustworthy, and reliable partners for scientists in groundbreaking discoveries. Our investments will target beneficial AI domains where philanthropy can make a significant difference. By fostering enabling infrastructure, fundamental research, and specialized scientific programs, the AI and Advanced Computing Institute will cultivate an environment where AI-enabled discoveries can thrive. The AI Institute currently concentrates on three core areas:AI for Science – Utilizing AI to enhance the scientific process, including hypothesis generation, experimental execution, data analysis, and knowledge production, all aimed at accelerating discovery. Key initiatives include exploring post-transistor hardware for AI and AI applications in scientific simulation.Science of AI – Investigating and managing AI systems to address potential risks associated with advanced AI. This includes improving AI reliability and performance in less commercially viable areas. Current programs comprise AI2050 and Science of Trustworthy AI, with explorations into AI interpretability and multi-agent communication evolution.Beneficial AI – Establishing scientific foundations and datasets to comprehend the broader societal impacts of AI. This encompasses high-impact grantmaking initiatives, such as leveraging AI to expedite humanities research (Humanities and AI Virtual Institute) and assessing AI's impact on the labor market (AI@Work). These initiatives are interconnected with other Schmidt Sciences efforts, like the Virtual Institute for Scientific Software (VISS), which aims to enhance the pace of scientific discovery through the development and support of high-quality, community-focused scientific software.

Schmidt Sciences is a pioneering nonprofit organization established in 2024 by Eric and Wendy Schmidt, dedicated to propelling scientific knowledge and breakthroughs through cutting-edge tools aimed at fostering a sustainable planet. The organization emphasizes impactful research across diverse fields including AI and advanced computing, astrophysics, biosciences, climate science, and space, while also supporting researchers through its comprehensive science systems program.About the AI & Advanced Computing Institute (AI Institute) The AI Institute at Schmidt Sciences is a dynamic research and grantmaking entity that recognizes AI as a pivotal catalyst for scientific discovery and societal advancement. Our mission over the next decade is to empower key researchers who will develop AI systems that are competent, trustworthy, and reliable, enabling fruitful collaborations with human scientists to foster the next generation of discoveries. We are committed to investing in beneficial AI initiatives where our philanthropic efforts can create unique advantages, thereby establishing a robust infrastructure for AI-enabled discoveries. The AI Institute focuses on three primary areas: AI for Science – Enhancing scientific methodologies through AI, optimizing hypothesis generation, experiment conduction, data analysis, and knowledge creation to expedite the discovery process. Current exploratory projects include advancements in post-transistor hardware for AI and AI-enhanced scientific simulations.Science of AI – Investigating and managing AI systems to mitigate risks associated with advanced AI. Our efforts aim to boost AI reliability and performance in areas lacking commercial interest, with ongoing programs like AI2050 and the Science of Trustworthy AI, alongside exploratory programs focusing on AI interpretability and the evolution of multi-agent communication.Beneficial AI – Laying scientific foundations and curating datasets to understand AI's broader human impacts. This encompasses impactful grantmaking initiatives, such as the Humanities and AI Virtual Institute, which aims to leverage AI for advancements in humanities research, and the AI@Work program that quantifies AI's influence on the labor market. Schmidt Sciences encompasses various programs associated with the AI Institute, including the Virtual Institute for Scientific Software (VISS), aimed at enhancing scientific software capabilities.

Join Schmidt Entities as a Senior Engineer, where you will play a pivotal role in driving innovative engineering solutions. As an integral part of our team, you will leverage your expertise to tackle challenging projects, ensuring that our clients receive top-notch service and results. Your contributions will directly impact our growth and success in the industry.

Schmidt Sciences is a nonprofit organization established in 2024 by Eric and Wendy Schmidt with a mission to expedite scientific knowledge and breakthroughs through the application of innovative tools aimed at fostering a sustainable planet. The organization emphasizes impactful research in fields such as AI and advanced computing, astrophysics, biosciences, climate science, and space, while also supporting diverse researchers across various disciplines via its science systems program.About the AI & Advanced Computing Institute ("AI Institute")The AI Institute at Schmidt Sciences functions as a grantmaking and research entity that recognizes AI as a revolutionary catalyst for scientific discovery and societal advancement. Over the coming decade, we aspire to support leading researchers committed to developing AI systems that are not only competent and trustworthy but also capable of collaborating effectively with human scientists in driving the next wave of breakthroughs. Additionally, we will engage in select, strategic investments in beneficial AI sectors where philanthropic efforts can provide distinct advantages. By enhancing the necessary infrastructure, foundational research, and specialized programs within scientific disciplines, the AI and Advanced Computing Institute will cultivate the conditions required for AI-fueled discoveries to reach their full potential.The AI Institute currently focuses on three pivotal areas:AI for Science – leveraging AI to enhance hypothesis generation, experiment execution, data analysis, and knowledge creation, all aimed at accelerating the discovery process. Exploratory initiatives encompass post-transistor hardware for AI and AI applications in scientific simulations.Science of AI – investigating and managing AI systems to mitigate potential risks associated with advanced AI technologies. This area focuses on enhancing AI's reliability and performance in sectors with limited commercial appeal. Existing programs include AI2050 and the Science of Trustworthy AI. Emerging projects address topics like AI interpretability and the evolution of multi-agent communication.Beneficial AI – establishing scientific foundations and datasets to better understand the broader human implications of AI. This includes significant grantmaking initiatives such as our programs aimed at utilizing AI to accelerate humanities research (Humanities and AI Virtual Institute) and quantifying AI's impact on the labor market (AI@Work).

Join 10alabs as an MLOps / Infrastructure Engineer, where you will play a crucial role in streamlining the deployment and management of machine learning models. Collaborate with cross-functional teams to build robust infrastructure that supports scalable and efficient AI solutions. Your expertise will help us enhance our platform and drive innovation.

Position Summary We are looking for a dedicated Computational Biologist who is eager to leverage data-driven, scalable methodologies to uncover biological insights. The perfect candidate will be an innovative thinker with robust computational and quantitative skill sets, capable of collaborating seamlessly with both experimental and computational scientists. In this role, you will design, implement, and enhance computational pipelines tailored for single-cell perturbation datasets, while also playing a key role in model development and experimental design. This represents a unique opportunity to join a vibrant, interdisciplinary team and significantly influence Neptune Bio’s computational strategy and infrastructure.

Why Join Our Team?Tandem presents a unique opportunity to revolutionize the process of bringing new therapies to market, significantly minimizing risks through our proven strategies:Rapid Organic Growth: We have established product-market fit, experiencing swift growth while supporting thousands of new patients daily through referrals and partnerships with leading biopharma companies.AI-Driven Business Model: Our operations are fundamentally enhanced by AI, enabling us to strengthen our business as foundational models evolve, fostering durability through network effects.Leading Investors: With a compelling business model, we have secured substantial funding from top-tier investors like Thrive Capital, General Catalyst, and Accel, allowing us to attract an exceptional team of engineers and operators.Our priority is to scale according to market demand. We seek highly motivated, resourceful individuals to help us expand capacity and accelerate growth. Our pace is fast, and we aim to move even faster.All full-time positions are in-person at our New York office. Discover more about working with us at the end of this page.About the PositionAs the inaugural Infrastructure Engineer at Tandem, you will specialize in infrastructure and developer experience. You will be responsible for evolving the core systems that enhance our engineering team's efficiency, improve platform reliability, and facilitate company growth. Your role will be pivotal in various projects, from AI product development to partner integrations and high-throughput operations.You will have the chance to establish our foundational infrastructure practices, including CI/CD, observability, and cloud architecture, thereby setting the standard for our scaling efforts. You will collaborate across infrastructure, DevOps, and developer productivity to create systems that enable rapid advancement without sacrificing stability or transparency.This challenging role offers a high degree of autonomy and responsibility. You are expected to take ownership and commit to Tandem's success. If you are humble, eager to learn, and passionate about impactful work that promotes both company growth and personal career advancement, we want to hear from you.

Join Kalshi: Pioneers in Prediction MarketsKalshi is revolutionizing the financial landscape by introducing a groundbreaking concept: prediction markets. Our platform empowers individuals to trade on the outcomes of various events, transforming questions about the future into viable financial assets. After years of advocacy, we successfully legalized prediction markets in the United States, positioning ourselves as the fastest-growing financial market in the country with an extensive range of markets spanning politics, economics, finance, weather, technology, artificial intelligence, culture, and more.We envision a future where prediction markets become the largest financial marketplace, enabling anyone to convert any scenario into a financial position.Our vision: To build the largest financial market on the planet.Our mission: To enhance the world’s understanding of truth through the power of market dynamics.Our culture is straightforward: we hire top-tier talent, work diligently, and relish our journey together. We are seeking driven and exceptional individuals to join our compact team to forge the next generation of financial markets.Your Role: Infrastructure EngineerAs an Infrastructure Engineer at Kalshi, you will design, build, and scale the systems that sustain our exchange, clearinghouse, API infrastructure, and broker and market-maker connectivity. Your role is pivotal in crafting a next-generation financial ecosystem akin to the NYSE or CME but rebuilt from the ground up.Being part of a small engineering team means your responsibilities will expand quickly, and your impact will be both visible and foundational. Much of our infrastructure remains uncharted territory, granting you the opportunity to design and take ownership of entire systems. You will engage across the complete infrastructure and DevOps stack, ensuring reliability, speed, and robustness for one of the most ambitious financial platforms ever constructed.Key ResponsibilitiesEstablish and standardize the infrastructure for software building, versioning, testing, and deployment.Automate testing frameworks throughout the testing pyramid (unit, API, integration).Architect large-scale systems with strategic trade-offs pertaining to performance, risk, and long-term maintainability.Develop and uphold infrastructure for high-performance data feeds and trading APIs.Support clearing systems with high availability and stringent guarantees, including margining, collateral management, and banking integrations.Conduct stress tests and fortify critical systems for robustness and scalability.Deliver solutions swiftly and with high quality.

Supported by top-tier Silicon Valley investors, Peregrine Technologies is dedicated to assisting public safety organizations, state and local governments, federal agencies, and private-sector entities in overcoming societal challenges with unmatched speed and precision. Our AI-driven platform transforms isolated and fragmented data into actionable operational intelligence, allowing for prompt access to mission-critical information that facilitates swift decision-making and enhances outcomes at every level. Currently, Peregrine serves hundreds of clients across over 30 states and two countries, impacting more than 125 million individuals, as we broaden our influence into the enterprise sector and international markets.Role OverviewWe are seeking a Senior Infrastructure Engineer to join our dynamic team, where you will be responsible for designing and implementing the infrastructure that underlies the Peregrine platform.Within our engineering division, we believe that empathy fosters superior solutions. Observing users interact with our product is a priority that guides us toward effective answers. Engineers will collaborate closely with our onsite team to grasp the varied use cases that Peregrine addresses. We emphasize strong ownership while promoting teamwork and ongoing feedback.In this role, you will utilize a diverse range of technologies to scale our platform, ensuring secure connections to client networks, while managing vast amounts of data. You will engage with a variety of complex challenges, including:Creating highly available and secure production environmentsDesigning scalable and secure network architecturesEnhancing the ingest engine for extensive data processingStreamlining the entire engineering lifecycleOur technology stack is continually evolving, currently based on AWS GovCloud, Kubernetes, Docker, Terraform, Pulumi, PostgreSQL, Redshift, Elasticsearch, and more.

Schmidt Sciences is a pioneering nonprofit organization established in 2024 by Eric and Wendy Schmidt, dedicated to advancing scientific knowledge and breakthroughs through cutting-edge tools aimed at fostering a sustainable planet. Our focus includes impactful research in AI, advanced computing, astrophysics, biosciences, climate, and space, along with support for researchers across diverse disciplines via our science systems program.Position OverviewSchmidt Sciences is excited to invite recent PhD graduates in AI and computer science to engage in a 12-18 month fellows-in-residence program. Reporting to the Director of the AI Institute, fellows will dedicate their time to both supporting the AI Institute (including the exploration of new grantmaking initiatives) and undertaking specific research projects that align with the Institute's strategic objectives. Up to four fellows will be selected for hire in 2026, with applications being reviewed on a rolling basis.We are particularly interested in candidates with expertise in the following areas:- AI agent interoperability and emerging communication within multi-agent systems- AI applications in scientific discovery- Hardware-enabled verification of AI agreements- The influence of AI on the labor market- Research in trustworthy AI and alignment- Note: The AI Institute's research priorities will evolve with the growth of the Institute and the rapid advances in AI technologies, so future cohorts may focus on different areas.

Schmidt Sciences is a forward-thinking nonprofit organization founded in 2024 by Eric and Wendy Schmidt, dedicated to advancing scientific knowledge and fostering breakthroughs with innovative tools aimed at ensuring a sustainable planet. Our primary focus is on impactful research in key areas, including artificial intelligence (AI) and advanced computing, astrophysics, biosciences, climate science, and space exploration, while also supporting researchers across various disciplines through our science systems program.About the AI & Advanced Computing Institute (“AI Institute”) The AI Center at Schmidt Sciences is a pioneering grantmaking and research entity that recognizes AI as a transformative driver of scientific discovery and societal advancement. Our objective over the next decade is to empower key researchers dedicated to enhancing the competency, trustworthiness, and reliability of AI systems, enabling them to collaborate effectively with human scientists in groundbreaking discoveries. Additionally, we intend to strategically invest in beneficial AI sectors where philanthropy can create unique advantages. By bolstering essential infrastructure, foundational research, and targeted programs across scientific disciplines, the AI and Advanced Computing Center aims to facilitate the conditions necessary for AI-enabled discoveries to fulfill their potential. The AI Center focuses on three primary areas: 1. AI for Science – leveraging AI to enhance how scientists formulate hypotheses, conduct experiments, analyze data, and generate new knowledge, specifically accelerating the discovery process. 2. Science of AI – exploring and managing AI systems to mitigate risks associated with advanced AI, while improving reliability and performance in areas often neglected by commercial interests. Current initiatives include AI2050 and the Science of Trustworthy AI. 3. Beneficial AI – establishing scientific foundations and datasets to understand the broader human impacts of AI, including high-impact grantmaking programs aimed at utilizing AI to accelerate research in the humanities and assessing AI's effects on the labor market.

Join Claylabs as a Software Engineer, InfrastructureAt Claylabs, our goal is to empower organizations to transform innovative growth ideas into tangible realities. We view growth as a creative endeavor rather than a mere formula. Engaging your ideal customers requires unique strategies and continual refinement. Amid the rapid evolution driven by AI, creativity remains the one sustainable competitive advantage. We proudly support thousands of clients, including industry leaders like Anthropic, Notion, Google, and Ramp, to launch unique data-driven campaigns and AI research.In 2025, we celebrated surpassing $100M in revenue and secured a $100M Series C funding round, achieving a valuation of $5B thanks to our prestigious backers such as Sequoia, CapitalG, and First Round. Additionally, we executed our second employee tender offer and initiated a community equity round for our customers, agency partners, and club members.What Makes Us Unique:Our vibrant community boasts over 11,000 customers, 150+ integration partners, 125+ agencies, 50+ Clay clubs, and 30,000 Slack members.Our culture is exceptionally diverse, with team members who are also DJs, activists, writers, clowns, marathoners, skydivers, and psychedelic therapists.All employees have access to free sessions with world-class coaches specializing in creativity, management, and more.Our operating principles, including negative maintenance and non-attached action, shape our work ethics. Discover more about them here.

Join Ellipsis Labs, a thriving venture-backed startup based in New York, where we are pioneering innovative products and infrastructure in the decentralized finance sector. We are the creators of Phoenix, the leading order book spot exchange on the Solana blockchain, and a prominent decentralized exchange (DEX) that has processed over $70 billion in volume since its inception in 2023. As one of the most active on-chain market makers in the crypto space, we invite you to be part of our dynamic team.All positions are based in our office in New York City.The RoleWe are on the hunt for our inaugural full-time Infrastructure Engineer to enhance our team! Previously supported by a part-time advisor, we are ready to bring on a dedicated expert. The ideal candidate will be a generalist in infrastructure or systems, eager to address sensitive and high-performance financial technology that demands exceptional reliability, aiming for 5+ 9s of uptime.Key responsibilities include:Establishing foundational best practices and architecture for infrastructureDeveloping and managing the team’s DevOps processesEnsuring the security and monitoring of essential production systems

Role Overview Sigma Computing is building the next generation of data interaction. The platform lets users explore billions of data rows in seconds, work with data in a familiar spreadsheet-like interface, and build visualizations, applications, and workflows. Sigma is now expanding these capabilities with AI to help users create, discover insights, and make decisions faster. The Senior AI/ML Engineer will join a team focused on developing the AI infrastructure that shapes Sigma’s future. Work here directly impacts how enterprises use Sigma in their daily operations. Location This position is based in New York City, NY.

As the financial sector evolves, the integration of AI becomes essential. At Endex, we are pioneering this transformation by developing advanced digital coworkers tailored for financial services. Our mission is to connect today’s capabilities with the future of finance, collaborating closely with esteemed research institutions.Joining our infrastructure team, your expertise in deployment and security will be crucial in guaranteeing the reliability and protection our investment partners expect. You may be the right candidate if you possess:Experience in designing and implementing secure deployment pipelines within regulated, high-security, or on-premises environments.A passion for creating scalable and resilient infrastructure solutions.A drive to enable workflows that empower product teams to innovate rapidly while maintaining stringent security standards.Become part of our innovative team as we redefine the landscape of financial analysis tools, fundamentally changing how investment firms operate and compete.

About Espresso AIAt Espresso AI, we are dedicated to revolutionizing performance engineering through advanced machine learning technology. Our innovative solutions empower businesses to significantly reduce their SQL compute costs on platforms like Snowflake and Databricks by up to 70%, all while maintaining their existing workflows.As data warehouses become increasingly vital for managing complex analytics, the associated costs can escalate rapidly. Espresso AI offers a groundbreaking AI-driven approach that enables our clients to achieve substantial cost savings.We are a fast-growing, well-funded startup with significant backing from industry leaders, including Nat Friedman and Daniel Gross.About the RoleIn the role of Staff Infrastructure Engineer, you will be instrumental in designing and creating the distributed systems that drive our optimization engine. Your responsibilities will encompass real-time scheduling, workload execution, performance analysis, and the development of internal compute environments that facilitate safe and efficient workload management.You will take ownership of key architectural components, enhance reliability and performance, and work closely with our founders and engineering team to shape the long-term technical vision. This is a highly technical position focused on deep systems engineering.What You’ll Work OnDesign, develop, and scale Espresso's distributed execution and scheduling systems.Create internal compute environments to effectively manage workloads from Snowflake and Databricks.Conduct compiler-style analysis and optimization for SQL workloads.Construct infrastructure and data pipelines that support machine learning models and product functionalities.Enhance performance, reliability, and observability across the platform.Influence architectural decisions and contribute to engineering strategy as a pivotal early team member.Mentor junior engineers as the team expands, instilling strong engineering principles and ensuring high-quality delivery.What You Bring7+ years of experience in software engineering.Solid foundations in systems design, performance engineering, and debugging.Proven ability to oversee complex technical projects from inception to completion.Adept at handling a wide array of infrastructure challenges.

ElectronX™ is a U.S.-regulated marketplace focused on direct access to electricity derivatives. Headquartered in New York City, with an office in Chicago, the company builds financial infrastructure and risk management tools for the U.S. energy sector. ElectronX is backed by venture capital partners including Innovation Endeavors, Systemiq Capital, Equinor Ventures, Shell Ventures LLC, DCVC, Amplo, BoxGroup, and Lightning Capital. ElectronX operates in the competitive world of quantitative capital markets. The team values resourcefulness, curiosity, and adaptability. Collaboration and entrepreneurial thinking are central to the company’s culture, and team members are expected to demonstrate intellectual resilience and a drive for technical excellence. Role overview The Senior Systems & Infrastructure Engineer will guide and improve the core platforms that power the ElectronX exchange. This position covers cloud infrastructure, containerized environments, observability, security operations, and networking. The engineer will join a lean, high-trust team with significant autonomy and direct impact on production systems. ElectronX seeks candidates who are committed to raising organizational standards. The right person approaches architectural challenges and support requests alike with a positive, solution-focused mindset. Clear communication, reliability, and sharing technical best practices are essential. What you will do Cloud Infrastructure: Design, deploy, and maintain multi-tiered cloud environments using infrastructure-as-code tools such as Terraform and Ansible. Manage container orchestration platforms, overseeing lifecycle management, autoscaling, ingress, persistent storage, and workload isolation. Establish and enforce cloud organization policies, Identity and Access Management (IAM), and key network security measures. Apply FinOps principles to optimize cloud spending and resource allocation.

Harvey develops AI-driven solutions for legal and professional services, serving over 1,000 organizations in more than 60 countries. The company is growing rapidly and has strong support from leading investors. Harvey’s team values ownership, quick decision-making, and close collaboration. Engineers work side by side with leadership and customers to address practical challenges. The company operates in person in New York City and provides relocation support for new hires. Role overview The Staff Software Engineer - Core Infrastructure joins a team responsible for designing, building, and scaling Harvey’s core infrastructure. This platform handles billions of prompt tokens and millions of daily requests, forming the backbone of Harvey’s global legal AI services. The work involves both creating new systems and maintaining high operational standards. Reliability, scalability, and security are central as Harvey continues to expand its reach among top law firms and professional service providers. This is a full-time, in-person position based in New York City. Relocation assistance is available. What you will do Design and build scalable, fault-tolerant infrastructure systems that support Harvey’s AI platform across multiple cloud regions. Take ownership of and improve multi-cloud infrastructure (Azure, GCP), focusing on Kubernetes orchestration, networking, and container management. Lead technical projects in areas such as observability, incident response, and performance optimization.

Role Overview Sigma Computing is growing quickly, and the Technical Support Engineering team is scaling to meet the needs of a larger global user base. This team recently earned the 2024 Stevie Gold Award for Customer Service. As a Technical Support Engineer based in New York City, the work centers on helping customers solve technical, business, and data challenges using the Sigma platform. The role involves close collaboration with Product, Engineering, and Go-to-Market teams to troubleshoot complex issues, deliver solutions, and improve both the product and support experience. What You Will Do Work directly with Sigma customers and pre-sales staff to identify and resolve complex technical problems. Partner with the development team to define best practices and build tools for diagnosing issues and improving service performance. Coordinate with teams across backend, frontend, DevOps, design, product management, and marketing to support a strong user experience. Join quarterly projects, provide periodic on-call support, and take on assignments that focus on automation and process improvements.

Are you ready to revolutionize the world of finance? At Superstate, we are dedicated to crafting investment products that leverage the rapidity, programmability, and compliance benefits of blockchain tokenization, steering clear of the inefficiencies of traditional finance.As a Staff DevOps Engineer, you will play a pivotal role in constructing and sustaining a highly reliable and scalable infrastructure that underpins our innovative financial products. Your expertise will be crucial in designing robust systems that guarantee our platforms' exceptional performance, availability, and security as they scale. You'll take on diverse responsibilities, including general DevOps, security, observability, and reliability, leading these vital initiatives.