PKPD Modelling Lead - London

Isomorphic Labs is at the forefront of utilizing advanced AI to revolutionize scientific research, accelerating the discovery of transformative medicines with the ambitious goal of eradicating all diseases.The future is on the horizon—a future harnessed by the remarkable capabilities of machine learning, a future where diseases are managed or eradicated, starting with innovative drug discovery.Join our interdisciplinary team that is pioneering innovative solutions and take a significant role in helping us achieve our ambitious objectives, all while being part of an inspiring and collaborative environment.The world we envision tomorrow is being shaped today, and it begins with the culture we cultivate at Isomorphic Labs. It begins with you.About Isomorphic LabsFounded in 2021, Isomorphic Labs aims to enhance human health by building upon the Nobel-winning AlphaFold system. Our diverse team of drug discovery experts and machine learning specialists has developed cutting-edge predictive and generative AI models that expedite scientific discovery at unprecedented speeds.Our name reflects our belief in the inherent harmony between biology and information science. By leveraging AI’s extraordinary capabilities, we model complex biological processes to design novel molecules, predict drug performance, and develop pioneering medicines to combat some of the world’s most challenging diseases.We have established a world-class drug design platform featuring AI models that operate across various therapeutic areas and drug modalities. We continuously innovate our model architecture and develop state-of-the-art capabilities to propel rational drug design forward.With every breakthrough, we draw closer to realizing the potential of digital biology, pursuing our ambitious mission to ultimately conquer all diseases with the power of AI.

Role overview Funding Circle seeks a Lead Model Validation Analyst in London. This role centers on upholding the integrity and accuracy of financial models that inform business decisions and manage risk. The analyst will play a central part in ensuring models meet high standards and support the company’s goals. What you will do Develop and enhance methodologies for validating financial models. Carry out thorough reviews to evaluate model performance and dependability. Collaborate with various teams to improve analytical processes across the business. Contribute to shaping the model risk management framework to promote transparency and uphold high standards. Impact This position is vital to Funding Circle’s commitment to strong model governance and analytical quality. The analyst’s work supports clear, informed decision-making and reinforces transparency throughout the company.

About hyperexponential (hx)At hyperexponential, we are pioneering an AI-driven platform designed to facilitate critical decision-making within a $7 trillion sector. Our technology influences significant outcomes, from successful space launches to the deployment of autonomous vehicles and community recovery after natural disasters.Historically, insurers have relied on outdated systems to make billion-dollar choices. We are transforming this landscape by integrating data, AI, and human expertise to streamline the journey from submission to decision. This empowers insurers to operate with speed, intelligence, and confidence in risk management.With backing from renowned investors such as a16z, Highland Europe, and Battery Ventures, we are expanding our reach globally. Nearly 50 of the largest insurers trust our platform, experiencing zero churn and billions in premiums flowing through hx.What started as a singular product in a single market has swiftly transformed into a diverse, multi-product platform that supports every phase of pricing and underwriting. At the heart of our operation is AI, demonstrated by our development of the world’s first domain-specific AI peer programmer for insurance, akin to GitHub Copilot but specialized in actuarial science. We also create agentic workflows that redefine industry standards.What sets hx apart is our remarkable team. Here, your impact is measured not by title or tenure, but by the challenges you tackle and the dedication you bring. You'll be surrounded by peers who inspire you to excel, allowing you to produce some of the most significant work of your career in a resilient organization.If this resonates with you, we invite you to join us in shaping the future.About the Model Development TeamThe hyperexponential Model Development Team (MDT) consists of a dynamic mix of engineers, actuaries, mathematicians, and data scientists. We focus exclusively on the most challenging and intriguing problems our clients encounter, where a blend of technical expertise, market acumen, and deep knowledge of hx Renew is essential.The MDT is the go-to authority on hx Renew, possessing comprehensive knowledge and experience. You will explore its capabilities and uncover innovative techniques, shortcuts, and insights. By merging this expertise with a growing understanding of insurance technology, you will present clients with the 'art of the possible' and collaborate on cutting-edge tech, alongside some of the brightest minds in both technology and insurance.

About CartesiaAt Cartesia, we are on a mission to revolutionize artificial intelligence by creating interactive, ubiquitous intelligence that can operate seamlessly in any environment. Despite advances, current AI models struggle to process extensive streams of audio, video, and text simultaneously—an area we aim to transform.Our innovative team, which originated from the Stanford AI Lab, has developed State Space Models (SSMs)—a breakthrough in training efficient, large-scale foundation models. Merging deep knowledge of model engineering with a design-centric approach, we are dedicated to delivering cutting-edge AI models and applications.Supported by esteemed investors including Index Ventures and Lightspeed Venture Partners, alongside an array of industry experts and advisors, we are well-positioned to lead the future of AI.About the RoleAs we open our inaugural European office in London, we are eager to welcome talented individuals who share our vision for advancing real-time multimodal intelligence.Your ImpactEngage in pioneering research focused on neural network architecture design to elevate the state-of-the-art (SOTA) in alternative architectures such as state space models, efficient Transformers, and hybrid architectures.Create innovative architectures that enhance model quality, inference efficiency, and adaptability across various environments, from cloud infrastructures to on-device implementations.Investigate capabilities like statefulness, long-range memory, and advanced conditioning mechanisms to boost model expressiveness and generalization.Analyze how architectural choices affect model trade-offs, including scalability, robustness, latency, and energy consumption.Formulate new frameworks and tools to assess architectural innovations, benchmarking performance in both research and production contexts.Collaborate with multidisciplinary teams to translate architectural research into scalable, impactful systems for real-world applications.

Location: LondonCompany: H About H H is focused on building agentic AI that automates complex, multi-step tasks typically handled by people. The company’s goal is to help individuals achieve more by creating superintelligent systems that work safely and responsibly. H values openness, continuous learning, and collaboration. Every team member’s input matters here. About the Models Team The Models team develops the core models that power H’s agentic AI technology. This group works on training methods to boost model performance and efficiency, especially for agent-driven applications where inference costs matter. Projects span Large Language Models (LLMs) and Vision-Language Models (VLMs), enabling agents to interpret and interact with complex environments. Team members refine these models using advanced training approaches, including reinforcement learning and reward modeling. The focus is on better instruction following, tool use, and dynamic interaction. The team’s work bridges research and product, turning new research into practical solutions that move AI forward. Who Hires Here H seeks exceptional AI researchers and engineers from around the world who care about advancing technology safely and responsibly. The company welcomes those eager to shape the future of superintelligent AI alongside a collaborative and driven team.

About the Position We are seeking a proactive Cybersecurity Engineer to enhance the security framework of our applications, data, infrastructure, and processes within our dedicated Cybersecurity team. This role merges hands-on technical skills to identify and mitigate vulnerabilities with the ability to collaborate effectively across various teams. You will guide your peers in assessing the security implications of design choices and ensure that security is integrated into applications from inception. Utilizing your offensive security expertise, you will pinpoint potential threats and delve into intricate technical aspects to craft tailored security solutions while navigating complex challenges with innovative approaches. Practical experience in threat modeling is essential, along with the capacity to translate security principles into tangible architectural advancements. Additionally, you will engage with system owners who possess in-depth knowledge of their applications but may overlook potential vulnerabilities. Your role will involve collaborating with them to identify and resolve these issues, weighing the balance between security measures and business needs. As part of the Cybersecurity team, you'll collaborate with a talented group of programmers and security professionals dedicated to safeguarding the firm. Our work encompasses a broad spectrum of topics, including software engineering, DevOps, risk analysis, security governance, and cyber awareness.

Join our innovative team at dev2 as a Senior Data Modeller. In this role, you will be at the forefront of shaping our data architecture and modeling strategies to drive insightful decision-making across the organization. Your expertise will be critical in designing sophisticated data models that enhance our analytical capabilities and support our business objectives.

About Us At Ki Insurance, we’re in the business of insuring some of the most exciting ventures around the globe—from space shuttles and world tours to wind farms and even professional footballers’ legs.Our mission is clear: to digitally disrupt and revolutionize an industry that has remained unchanged for over 335 years. Partnering with Google and UCL, we have developed an innovative platform that leverages algorithms, machine learning, and large language models to deliver rapid insurance quotes—within seconds instead of days.As the world’s largest algorithmic insurance carrier, we are proud to be the fastest-growing syndicate in the Lloyd's of London market, achieving an unprecedented $100 million in profit within just three years.Our diverse teams work collaboratively in an agile environment, striving to provide the best possible experience for our customers. As we set our sights on ambitious future goals, we are eager to welcome brilliant minds who are ready to challenge the status quo and explore new horizons with us.Your RoleWe are seeking a Senior Analyst to join our team at Ki Insurance. In this pivotal role, you will ensure that our underwriters receive prompt, consistent, and precise service aligned with the risk aggregation strategy established with the Senior Manager (Catastrophe Modelling) and Head of Risk Aggregation.With your expertise in providing comprehensive and accurate exposure data and modelled loss information, you will facilitate timely reporting for both internal and external stakeholders, ensuring compliance with internal guidelines and regulatory standards.Your role will involve enhancing business understanding of its risk profile, enabling effective aggregate deployment, and continuously seeking opportunities to develop, streamline, and implement best practices for the risk aggregation function, while ensuring alignment across various business classes and modelling applications (e.g., ORI and Pricing). Additionally, you will oversee the daily operations, relationships, and outputs of our outsourced business partner related to relevant modelling and data entry.Key Responsibilities Collaborate with the Risk Aggregation team and relevant functions (capital modelling, actuarial, and ERM) to ensure that modelling processes and assumptions are closely aligned and meet regulatory standards.Deliver accurate pricing, analytics, management information, and reporting to stakeholders (including underwriting and ORI placement teams) in a timely manner.Oversee the quality of exposure data and the data production from Ki's processing teams.Provide subject matter expertise for broader risk aggregation projects and deliverables (e.g., Ki's risk perspective and ORI).

Join Egis Group as a BIM Modeller specializing in Bentley MEP solutions. In this pivotal role, you will be responsible for creating and modifying Building Information Models (BIM) to support our engineering projects. Your expertise will contribute to the design and visualization of mechanical, electrical, and plumbing systems, enhancing project efficiency and collaboration.

Join Monzo as an IFRS9 Modeller and play a crucial role in shaping our financial strategies. You will be responsible for developing and maintaining IFRS9 models, ensuring accurate credit risk assessments and supporting our growth in the banking sector.

Egis Group is seeking a Senior Modeller to join its Water Sector team in London. This role centers on developing and applying advanced modelling techniques for water resource management and infrastructure projects. Key responsibilities Develop and implement advanced models to address water resource and infrastructure challenges. Collaborate with colleagues from different disciplines to deliver solutions that meet client needs. Collaboration The Senior Modeller works alongside professionals from multiple backgrounds, ensuring that modelling approaches align with project goals and client requirements.

About Flagright:Flagright is an innovative AI operating system designed for financial crime compliance, trusted by Fortune 500 companies, major banks, fintechs, and rapidly growing startups worldwide. By facilitating real-time risk detection, automating investigations, and enabling intelligent decision-making, Flagright empowers compliance teams to maximize their effectiveness in combating financial crime.We pride ourselves on being a lean, high-performance team that emphasizes individual ownership and provides direct access to leadership.Role Overview:Our Marketing team plays a crucial role in enhancing our brand visibility across target markets. From engaging customers to executing integrated campaigns, they articulate Flagright's narrative, accelerate pipeline growth, and help clients appreciate our value through strategic and impactful initiatives.We are seeking a Social & Distribution Lead based in London to amplify our global marketing strategies. In this role, you will spearhead Flagright's distribution and social strategy, fostering awareness, engagement, and pipeline expansion in critical markets.This position requires both strategic insight and analytical prowess. You must possess strong editorial judgment, a data-driven approach, and a relentless focus on performance enhancement.Ideal Candidates:Resilient individuals who rise after setbacksResourceful problem solvers who leverage available toolsConfident with strong opinions they can substantiateQuick learners driven by curiosityCollaborative team players committed to meaningful workChallenges for Some:Individuals requiring excessive guidanceThose who consider high expectations as unreasonableCandidates prioritizing work-life balance over performancePeople who struggle with ambiguity or rejectionIndividuals who prefer a consistent routine over a dynamic environmentKey Responsibilities:Lead the distribution strategy for company content, executive thought leadership, product launches, webinars, reports, and significant eventsEstablish and manage the publishing schedule for the founder and executives on LinkedIn and other pertinent channelsTransform key long-form assets into multiple, high-quality distribution formats instead of relying solely on new content creation

Role Overview The London Campus Lead at Canva shapes the local office experience and builds a strong sense of community. This role focuses on growing Canva’s presence in London and making the campus a lively center for creativity. What You Will Do Lead campus initiatives that bring people together and support a positive office culture. Drive engagement among team members and encourage collaboration across departments. Work closely with cross-functional teams to help the London office thrive as a creative and innovative space.

Note: Candidates must be available to commence work in January 2026 and possess the right to work in the UK. We are unable to sponsor visas.The award-winning Film & Episodic Studio at Framestore collaborates with leading filmmakers and storytellers to design, plan, and create stunning visuals. We are committed to discovering innovative artistic solutions that enhance their vision and elevate the standards of visual effects in cinema.At Framestore, we merge creativity with cutting-edge technology to breathe life into our creations. Our mission is to redefine what is possible every day, fueled by imagination and a forward-thinking approach.As a Character & Creature Modeller, you will be instrumental in producing high-fidelity CG models for use in premium visual effects productions. You will work from various reference materials, including photographs, scan data, blueprints, and concept designs, and collaborate closely with Texture Artists to ensure model and UV specifications align with VFX pipeline requirements.

Discover Tilt At Tilt, our mission is clear: Make Commerce Alive.We are transforming the outdated landscape of commerce, moving beyond static online stores and faceless marketplaces. Our focus is on fostering engaging, personalized experiences that resonate with the new generation of merchants who thrive on community, attention, and personality.In the UK, we are proud to have welcomed millions of shoppers, including sneaker enthusiasts, Y2K fashionistas, collectors, and savvy parents. Tilt empowers sellers to achieve remarkable milestones, with many reaching over £1M+ in earnings and numerous others surpassing the median income.The journey is just beginning!Your Role As one of the pioneering product leads at Tilt, you will take charge of multiple products, overseeing the entire roadmap and execution process. Your responsibilities will encompass research, planning, development, launch, marketing, analysis, and beyond. Think of yourself as a mini-CEO, leading a cross-functional team to deliver products with outstanding impact.Key Responsibilities Oversee the product lifecycle from ideation through to growth and maintenanceDevelop roadmaps, objectives, and success metrics that align with Tilt's core missionLeverage SQL and proprietary data tools to analyze and guide product developmentEngage in technical and design discussions to refine approaches and requirementsLead your diverse team of engineers, designers, analysts, and more directlyQualifications We are seeking an ambitious, inquisitive, and collaborative problem-solver eager to shape the future of shopping. Additionally, you should possess:10+ years of product management experience with a proven record of delivering scalable, impactful mobile products from inception3+ years of experience in high-growth tech environments, startups, or sectors such as mobile gaming, eCommerce, travel, or fintechExceptional analytical skills, utilizing data and market insights to guide decisions and enhance performanceA strong grasp of UX/UI design principles coupled with an eye for outstanding product experiencesExcellent communication skills, both written and verbal, to align stakeholders and propel product vision

Marloo creates AI-powered solutions that help financial advisers guide their clients through key financial choices. Backed by Blackbird Ventures, Marloo has rapidly onboarded more than 650 firms across six countries in under a year, maintaining low churn. The team is growing to support this momentum. Role overview The Growth Lead will shape Marloo’s go-to-market approach. This position centers on designing and running experiments, measuring outcomes, and helping scale what proves effective. The role combines hands-on execution with the chance to help build the team as Marloo expands. Collaboration with co-founders Hardy and Shak is a core part of the day-to-day work. Main responsibilities Design and run growth experiments across channels, segments, and messaging. Identify and double down on strategies that deliver results, and stop those that do not. Emphasize clear, honest measurement over vanity metrics. Building growth systems Curate and enrich lead lists using tools such as Clay, Apollo, and LinkedIn Sales Navigator. Set up outbound infrastructure, including sequences, automation, attribution, and dashboards. Use AI tools to accelerate experiment deployment. Market engagement Lead introductory and discovery calls to refine messaging and qualify leads. Manage full-cycle sales for early-stage deals when needed. Share feedback to improve Marloo’s ideal customer profile, pitch, and positioning. Accountability Own growth metrics and ensure alignment with broader business goals. This position is based in London.

Join hyperexponential as a Junior Model DeveloperAt hyperexponential (hx), we are revolutionizing the insurance industry with our AI-driven platform that informs critical decisions in a $7 trillion market. We empower insurers to make informed choices about risk and pricing, impacting vital outcomes like successful space launches, the rollout of autonomous vehicles, and community recovery post-disasters.Our innovative platform integrates data, artificial intelligence, and expert insights, streamlining the decision-making process for insurers. By transforming traditional methods, we enable our clients to act swiftly and confidently, tackling greater risks.Supported by leading investors like a16z, Highland Europe, and Battery Ventures, we are expanding our reach globally, serving nearly 50 of the largest insurers worldwide with an impressive retention rate and billions in premiums.What started as a singular product in one region has blossomed into a comprehensive, multi-product platform that enhances every aspect of pricing and underwriting. Our focus on AI allows us to develop groundbreaking tools, including the world’s first domain-specific AI peer programmer for insurance.At hx, our team is our strength. Here, your impact is measured not by your title but by the challenges you embrace and the dedication you show. Working alongside talented peers, you will tackle complex problems and contribute to a resilient company culture.If you are ready to make a difference, come join us in shaping the future of insurance technology.

AECOM is seeking a Senior or Principal Civil 3D Modeller to support infrastructure projects in London. This role centers on applying advanced Civil 3D skills to produce accurate models for a range of engineering and construction initiatives. Role overview Work closely with multidisciplinary teams to develop and refine design solutions. The position involves creating detailed models that support project delivery and contribute to effective collaboration across engineering disciplines. What you will do Use Civil 3D to generate and manage models for infrastructure projects Coordinate with colleagues from various specialties to ensure integrated project outcomes Support design innovation and maintain high standards of quality in modelling work Requirements Extensive experience with Civil 3D software Background in infrastructure or related engineering projects Strong collaboration and communication skills

Join our dynamic team as a Key Lead at Hollister located on Regent Street in London. In this pivotal role, you will inspire and lead a team to create a welcoming and engaging environment for our customers. Your leadership will drive sales performance and enhance the overall shopping experience.

Role Overview Capimoney is looking for a Tech Lead in London to guide technical direction and support a team of developers. This role focuses on building scalable solutions and maintaining strong quality and performance standards within the technology stack. Key Responsibilities Lead and mentor a team of developers on project delivery Design and architect scalable technology solutions Work with cross-functional teams to develop products that meet client needs Uphold high standards for code quality and system performance What You'll Bring Experience in software development and technical leadership Ability to collaborate across teams and communicate clearly Strong problem-solving skills and attention to detail Location This position is based in London.