Principal Applied Scientist jobs in Irvine – Browse 25 openings on RoboApply Jobs

Principal Applied Scientist jobs in Irvine

Open roles matching “Principal Applied Scientist” with location signals for Irvine. 25 active listings on RoboApply Jobs.

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companyViant Technology Inc. logo
Principal Applied Scientist

Viant Technology Inc.

Full-time|$210K/yr - $250K/yr|On-site|Irvine, California, United States; Los Angeles, California, United States

WHAT YOU’LL DOJoin Viant’s pioneering Machine Learning team as we revolutionize the Ad Tech industry through advanced machine learning and AI automation. We are dedicated to replacing manual processes in digital ad creation, optimization, and measurement with autonomous, scalable systems that handle hundreds of millions of events every day. We are on the lookout for an exceptional Principal Applied Scientist who will spearhead innovative advancements in applied machine learning. In this key role, you will define our end-to-end AI strategy, craft the applied science roadmap, and develop state-of-the-art models in natural language processing (NLP), deep learning, and large-scale AI systems. Your expertise will enhance AI capabilities, driving significant business impact while cultivating a research-focused, data-driven culture at Viant.

Feb 12, 2026
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companyThe Trade Desk logo
Applied Scientist II

The Trade Desk

Full-time|On-site|Irvine

Join The Trade Desk as an Applied Scientist II, where you will leverage your analytical skills to drive impactful data-driven decisions. In this role, you will collaborate with cross-functional teams to develop and implement advanced algorithms that enhance our advertising solutions. Your work will focus on transforming complex data into actionable insights, contributing to the innovation of our platform.

Apr 8, 2026
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companyAbbVie Inc. logo
Full-time|On-site|Irvine

Join AbbVie, a global biopharmaceutical company, as a Principal Research Scientist focused on advanced modeling and simulation techniques. In this role, you will lead innovative research initiatives, developing state-of-the-art models that enhance our understanding of complex biological systems. You will collaborate with multidisciplinary teams to drive scientific advancements and contribute to our mission of delivering transformative therapies.

Oct 6, 2025
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companyCompa logo
Full-time|On-site|Orange County HQ

Join Compa as a Senior Applied AI EngineerCompa is an innovative AI startup transforming the landscape of compensation management. As a venture-backed company, we are at the forefront of harnessing artificial intelligence to provide real-time compensation data that empowers enterprises to navigate the complexities of today's job market.In an era that demands agility and precision in hiring practices, Compa stands out by equipping leading organizations with the data they need to make informed pay decisions. Our clients include industry giants such as NVIDIA, Stripe, DoorDash, OpenAI, T-Mobile, Moderna, Workday, Ulta, and Target.Headquartered in Irvine, California, we have additional offices in Denver and San Francisco. Our collaborative team prioritizes transparency, ownership, and continuous learning, fostering an environment where in-person work is encouraged.Your Role:As a Senior Applied AI Engineer, you will spearhead initiatives across our product suite, driving the development of machine learning services from concept to execution. This role will allow you to make a tangible impact on our operations and product offerings.Key Responsibilities:Develop and deploy machine learning features that empower top companies to enhance their compensation strategies.Oversee end-to-end ML projects, including scoping, planning, data collection, model training, deployment, and experimentation.Collaborate closely with product and engineering teams to quickly prototype and iterate on ML solutions based on user feedback and business needs.Construct and maintain Compa’s ML infrastructure: develop models, establish deployment pipelines, and manage production systems for both enterprise clients and internal operations.Foster technical excellence by advocating for ML best practices within the team.

Jan 9, 2026
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companyViant Technology logo
Full-time|$180K/yr - $220K/yr|On-site|Irvine, California, United States; Los Angeles, California, United States; United States

WHAT YOU’LL DOThe Machine Learning team at Viant Technology is transforming the Ad Tech landscape through cutting-edge machine learning systems. By automating the manual processes involved in creating, launching, and measuring digital advertisements, we develop autonomous systems capable of processing hundreds of millions of events daily. We are on the lookout for a seasoned and innovative Senior Manager of Applied Science to spearhead the development and execution of impactful machine learning solutions. In this role, you will shape the team’s strategic vision, nurture a high-performance engineering culture, and deliver pioneering models and systems that tackle intricate business challenges.THE DAY-TO-DAYOffer strategic and technical leadership to the Machine Learning Engineering team, fostering innovation and ensuring alignment with corporate goals.Oversee the complete lifecycle of machine learning models that empower Viant’s products and services, from development to deployment and maintenance.Mentor and develop a team of machine learning engineers, promoting a culture of excellence in engineering practices, architecture, and quality.Utilize advanced machine learning techniques, such as supervised learning and causal inference, to address challenges like content demand forecasting, incremental value measurement, and personalization.Collaborate with cross-functional teams including Product, Finance, and Content leadership to provide actionable insights that inform strategic decisions.Drive innovation through research and implementation of novel methodologies, statistical techniques, and machine learning strategies.Build and maintain relationships with stakeholders to ensure the timely delivery of impactful machine learning solutions.

Mar 11, 2026
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companyiHerb logo
Full-time|$175K/yr - $198K/yr|Remote|United States of America - Irvine, California; United States of America - Remote / Home Office

Role Overview iHerb is looking for a Pricing Data Scientist to join the Pricing team. This role focuses on hands-on pricing analytics and measurement, supporting business decisions with data-driven insights. The position is open to candidates based in Irvine, California or working remotely from within the United States. What You Will Do Validate competitive pricing and support pricing decisions with clear analysis Measure the impact of pricing tests and experiments Analyze promotions and discounts to understand performance and effectiveness Assess price elasticity and provide actionable recommendations Translate complex pricing data into executive-ready insights for senior leadership What We Look For Strong quantitative skills and experience with predictive modeling Proficiency in SQL and Python for analytics workflows Ability to turn data findings into practical, clearly communicated recommendations Sound judgment and a proactive approach to problem-solving Comfort working independently and presenting insights to senior decision-makers Location Irvine, California Remote / Home Office (United States)

Apr 17, 2026
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companyePlus inc. logo
Full-time|On-site|Irvine, CA

Role Overview ePlus inc. is hiring a Principal Technologist in Irvine, CA. This senior role shapes the direction of technology services across the company. The Principal Technologist leads major initiatives and guides the development of advanced solutions for clients. What You Will Do Lead technology projects from concept through delivery Advise on strategy for technology services and solutions Apply deep technical expertise to influence company direction Ensure solutions meet high standards for clients

Apr 17, 2026
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companyTarsus Pharmaceuticals logo
Scientist in the Innovation Lab

Tarsus Pharmaceuticals

Full-time|$97.5K/yr - $136.5K/yr|On-site|Irvine, California, United States

Hello, Tarsan!Thank you for your interest in the Scientist position at Tarsus Pharmaceuticals. Please take a moment to review the details below. If you feel this role aligns with your career aspirations, we encourage you to discuss your qualifications with your current manager and HR business partner. Should everything align, we invite you to apply, and our Talent Acquisition team will reach out to you for an interview to learn more about you.- Your Human Resources TeamAbout the RoleTarsus Pharmaceuticals is on the lookout for a talented and forward-thinking Scientist to join our dynamic Innovation Lab team. In this pivotal role, you will play a key part in the design, execution, and analysis of preclinical experiments that drive innovative eye care programs, contributing to our groundbreaking pipeline. You will also assist in the operational setup of our new in-house laboratory facilities.The successful candidate will oversee external research collaborations with Contract Research Organizations (CROs) and academic institutions while engaging in hands-on experiments within our lab. Collaborating closely with the Innovation Lab team, you will convert unmet medical needs into actionable therapeutic strategies across various ophthalmology disease areas. The ideal candidate will possess scientific adaptability, exceptional project management capabilities, and the proficiency to translate research goals into pragmatic experimental plans.Key Responsibilities:Execute experimental protocols across diverse testing methods, including phantom model testing, cell and tissue culture, and ex vivo experimentation.Facilitate ongoing communication and coordinate activities with external partners (CROs, academic laboratories) under the strategic direction of the Senior Scientist.Collaborate with external partners on in vivo ophthalmology models for efficacy, pharmacokinetics, and toxicity studies.Conduct thorough literature reviews to support ongoing projects.Analyze and summarize experimental data for internal discussions and present findings to the Innovation Lab team.Provide scientific insights and support for cross-functional initiatives as required.Perform general laboratory duties, with opportunities to assume specific responsibilities as the team expands.Stay updated with scientific and medical literature relevant to the therapeutic areas.

Feb 14, 2026
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companyArtech Information Systems LLC logo
Scientist/Chemist Position

Artech Information Systems LLC

Contract|On-site|Irvine

Join our dynamic team at Artech Information Systems LLC as a Scientist/Chemist. In this role, you will be involved in innovative research and development projects, contributing to the advancement of scientific knowledge and practical applications. This is an exciting opportunity for individuals passionate about chemistry and seeking to make a significant impact in their field.

Jul 12, 2017
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companydstaff logo
Full-time|On-site|Irvine

Join our dynamic team at dstaff as a Senior or Principal Engineer specializing in Electronic Design. In this pivotal role, you will contribute to innovative projects that drive technological advancements and enhance our product offerings. We are looking for a passionate engineer with a strong background in electronic design, who thrives in a collaborative environment and is eager to tackle complex challenges.

Aug 31, 2015
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companySonSoft Inc. logo
Full-time|On-site|Irvine

We are seeking a talented and experienced SAP IS-U Principal Consultant to join our dynamic team at SonSoft Inc. This full-time position is ideal for individuals with a strong background in SAP IS-U solutions and a passion for delivering exceptional results. As a Principal Consultant, you will lead projects, mentor junior team members, and engage directly with clients to understand their needs and provide tailored solutions.

Jul 2, 2016
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companyWestern Digital Corporation logo
Full-time|On-site|Irvine

Join Western Digital Corporation as a Principal Engineer in Software Development Engineering. We seek a talented and innovative engineer who is passionate about software development and engineering excellence. In this role, you will lead technical projects, mentor junior engineers, and contribute to the design and implementation of cutting-edge software solutions.As a Principal Engineer, you will work closely with cross-functional teams to deliver high-quality software products. You will be responsible for defining architecture, driving best practices, and ensuring software reliability and performance.

Apr 8, 2026
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companyBalt logo
Full-time|$160K/yr - $170K/yr|On-site|Irvine, California, United States

Balt develops medical devices for neurovascular and peripheral vascular care. With over 45 years of experience, the company collaborates with healthcare professionals and institutions worldwide. Since introducing one of the first neurovascular intervention devices in 1977, Balt has grown to 13 offices in 11 countries and continues to expand its portfolio for stroke and vascular conditions. The team is dedicated to improving the lives of more than 150,000 patients by 2026 through ongoing innovation and collaboration. What sets Balt apart Work that directly affects patient outcomes A close-knit team united by a shared mission and strong values A culture built on recognition, respect, and diversity Comprehensive support for employees in all locations Role overview The Clinical Scientist position is based in Irvine, California. This role centers on clinical research and medical writing to advance Balt’s research goals. Key responsibilities include developing clinical investigation protocols (CIPs), preparing clinical study reports (CSRs), and supporting research and development activities. The Clinical Scientist leads clinical trials from First-in-Man (FIM) through pivotal and post-market phases. Additional duties involve authoring and reviewing scientific documents and providing leadership within the clinical department.

Apr 28, 2026
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companyAbbVie logo
Full-time|On-site|Irvine

AbbVie is hiring a Scientist I for the Biologics Drug Product Development team in Irvine. This position centers on formulating and developing biologic drug products to support new therapeutic solutions. What you will do Assist in the formulation and development of biologic drug products. Support efforts to meet quality standards and regulatory requirements for drug products. Role focus This role involves hands-on work with biologic formulations and contributes to the advancement of new therapies. The Scientist I collaborates with team members to move drug products through development while maintaining compliance and quality.

Apr 24, 2026
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companyAbbVie Inc. logo
Full-time|On-site|Irvine

Role Overview AbbVie Inc. is hiring a Senior Scientist II with a focus on Occupational and Environmental Toxicology in Irvine. This scientist will investigate how chemical exposures impact both workplace and environmental health, supporting the safety and effectiveness of pharmaceutical products. Key Responsibilities Conduct research on chemical exposures in occupational and environmental contexts. Develop risk assessments that inform product safety. Prepare and support regulatory submissions related to toxicology findings. Apply scientific principles to address practical toxicology challenges. What AbbVie Looks For Advanced expertise in occupational and environmental toxicology. Strong background in risk assessment and regulatory science. Ability to translate research into actionable safety guidance. Innovative thinking and a commitment to scientific rigor.

Apr 17, 2026
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company
Full-time|On-site|Irvine, CA

Join our innovative team at Lever as a Senior Data Scientist in Irvine, CA! We are on a mission to redefine the recruitment landscape by developing cutting-edge hiring software used by industry giants such as Netflix, Shopify, and Spotify.Lever, recognized as the #1 workplace in San Francisco, is committed to nurturing its employees and fostering a people-first culture. As we continue to scale our operations, we seek talented individuals who are eager to contribute to our success.As part of the Product team, the Senior Data Scientist will leverage data-driven insights to enhance our software solutions and improve user experiences.

Nov 27, 2019
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companyViant Technology logo
Full-time|$190K/yr - $260K/yr|On-site|Irvine, California, United States; Los Angeles, California, United States

WHAT YOU’LL DOAs a Principal Software Engineer at Viant Technology, you will play a crucial role in shaping the future of our Demand Side Platform (DSP). Our clients rely on this platform to launch, manage, and evaluate their advertising campaigns. You will lead a talented team of engineers in the design and implementation of sophisticated backend services and a user-friendly frontend UI that comprise our DSP. These solutions are deployed on a cutting-edge, cloud-based infrastructure that spans multiple regions and utilizes advanced technologies to support our clients' complex needs. Your expertise will ensure that our systems evolve to meet the demands of speed, scalability, and agility in today’s digital landscape. You will also have the chance to mentor fellow engineers and directly influence the success of Viant’s innovative products. Your primary focus will be on Viant DSP, working in collaboration with Product, Engineering, and Technical Operations teams to create specifications and provide production support.

Feb 12, 2026
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companyTarsus Pharmaceuticals logo
Full-time|$97.5K/yr - $136.5K/yr|On-site|Irvine, California, United States

About the RoleTarsus Pharmaceuticals invites applications for a dynamic and innovative Scientist to join our Innovation Lab. In this pivotal position, you will play a key role in designing, executing, and analyzing preclinical experiments aimed at developing groundbreaking eye care solutions. You will also assist in establishing our state-of-the-art in-house laboratory facilities.Your responsibilities will include managing collaborations with external research partners, including CROs and academic institutions, while executing hands-on experiments within our laboratory. Working closely with the Innovation Lab team, you will help translate unmet medical needs into effective therapeutic strategies across various ophthalmology disease areas. The ideal candidate will possess a blend of scientific versatility, excellent project management skills, and the capability to convert research objectives into practical experimental designs.

Feb 24, 2026
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companyViant Technology logo
Full-time|$200K/yr - $230K/yr|On-site|Irvine, California, United States

What You'll DoViant® (NASDAQ: DSP) is a premier advertising software company that empowers marketers to seamlessly plan, execute, and measure omnichannel advertising campaigns through a state-of-the-art cloud-based platform. As a Principal Product Manager, you will take the helm of Viant DSP's supply products, leveraging research, data analysis, and feedback from vendors and partners to uncover customer needs and develop cutting-edge supply products. You will be responsible for the product vision, strategy, definition, and market delivery.The Day-to-DayLead and execute the strategy, roadmap, and deliverables for product launches.Oversee comprehensive product management for the suite of supply products within Viant DSP.Collaborate with cross-functional teams and gather external customer insights to identify pain points and opportunities.Establish and manage differentiated product requirements, prioritizing them on the roadmap for Viant DSP's self-serve media buying platform.Monitor dependencies within the technical landscape and ensure development aligns with expected outcomes.Work with teams to continuously enhance product functionality leading to successful results.Generate strategic, innovative product ideas and drive their implementation.Conduct thorough research on competitive offerings in the DSP sector.Communicate key performance indicators effectively to stakeholders.

Mar 23, 2026
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companySonsoft Inc. logo
Full-time|On-site|Irvine

Join Sonsoft Inc. as a Principal Consultant specializing in SAP ISU. We are seeking a knowledgeable professional with a passion for delivering exceptional solutions to our clients. In this role, you will leverage your expertise to drive successful implementations and optimizations of SAP ISU functionalities.If you are a proactive problem solver and enjoy collaborating with cross-functional teams, we encourage you to apply!

Jun 22, 2016

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