Senior Scientist I, Neuroscience – Biologics Screening

Join AbbVie, a global biopharmaceutical company, as a Senior Scientist I in our Neuroscience division specializing in Biologics Screening. In this role, you will lead innovative research efforts to develop therapies that address unmet medical needs in the field of neuroscience.

Your Impact at Lila In this pivotal role, you will spearhead the innovation and validation of advanced pooled assays utilizing mammalian cells. Your work will encompass everything from proof of concept to automated screening processes, enabling the generation of intricate, high-dimensional datasets. This position involves collaboration across cell biology, protein design, and nucleic acid teams to facilitate biologic development programs, focusing on the rapid assessment of binding, stability, function, and immunogenicity of diverse biologics. What You'll Be Building Create next-generation mammalian display-based assays for binding, stability, function, and immunogenicity. Implement cutting-edge multiomic, single-cell, and in situ sequencing workflows to design innovative, highly multiplexed assays. Collaborate with protein design, nucleic acid, and automation teams to leverage these workflows in biologics development. Closed-Loop Experimentation and Execution: Work closely with engineering and automation teams to architect automated, high-throughput experimentation platforms that yield data-rich workflows. Join forces with the AI team to conduct iterative experiments in real time, facilitating rapid optimization and discovery cycles. Collaborate, Lead & Communicate: Engage with cell biologists, synthetic biologists, automation engineers, protein design scientists, and data scientists to document systems, share insights, and refine best practices in autonomous science. Mentor junior scientists, align project milestones with internal and external collaborators, contribute to intellectual property and publications, and present findings across the organization. What You’ll Need to Succeed Ph.D. in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, Immunology, or a related discipline (or M.S./B.S. with 5–8+ years of relevant industry experience). Proficiency in the development and/or application of mammalian display or similar pooled mammalian systems (perturb-seq, MPRA, etc.). Experience in designing, executing, and analyzing single-cell, in situ, or multiomic sequencing experiments. Expertise in creating complex libraries of defined sequences in mammalian cells. Experience in designing, executing, and analyzing flow cytometry and sorting experiments. Familiarity with next-generation sequencing (NGS) based experimental design and analysis.

Your Impact at Lila Join our dynamic and innovative AI safety team at Lila Sciences, where we prioritize talent and agency to mitigate risks associated with scientific superintelligence. Our mission is to craft and execute a tailored safety strategy that aligns with our unique objectives and deployment methods. This role involves creating technical safety strategies, engaging with the broader scientific community, and producing critical technical documentation, including evaluations focused on risk and capability assessments. What You’ll Be Creating Design and implement capability evaluations to assess scientific risks, particularly from cutting-edge scientific models integrated with automated physical laboratories across biological and physical sciences. Lead and coordinate threat modeling sessions with both internal and external scientific experts, keeping abreast of emerging technologies and use cases. Develop and manage high-quality training and testing datasets for evaluations and safety systems. Analyze risks associated with Lila’s capabilities and their interactions with the broader ecosystem of general-purpose frontier models and specialized scientific tools. Contribute to high-quality research initiatives focused on scientific capability evaluation and restriction as needed. Assist with external communications regarding Lila’s safety initiatives. What You’ll Need to Succeed A PhD in biological sciences (e.g., molecular biology, virology, computational biology) or physical sciences (e.g., materials science, physics, chemistry, or chemical engineering), or similar experience. Proficient in scientific computing related to biological or physical sciences. Familiarity with dual-use research and dissemination issues within relevant safety, regulatory, and governance frameworks (e.g., export control, biological and chemical conventions). Exceptional communication skills to convey complex technical concepts to non-expert audiences effectively. Proven ability to lead internal and external teams in developing Lila's perspective on biological and physical risks. Demonstrated capacity to collaborate with cross-functional stakeholders (science, AI, product, policy) in a complex environment.

Role Overview Korrobio is hiring an Associate Scientist for its Compound Management, Cell Screening, and NGS teams. This position is based at 60 First St, Cambridge, MA 02141. What You Will Do Support compound management activities and maintain accurate records. Assist with cell screening workflows to help drive research goals. Participate in Next Generation Sequencing (NGS) projects, contributing to efficient and reliable processes. About the Team The role works closely with scientists across several research areas, helping to advance ongoing projects through careful handling of compounds, cell-based assays, and sequencing tasks.

Your Contribution at Lila At Lila, we are assembling a highly skilled and proactive AI safety team that will collaborate with all core departments, including science, model training, and lab integration, to effectively address risks associated with scientific superintelligence. The primary mission of this team is to develop and execute a tailored safety strategy that aligns with Lila's unique objectives and deployment methodologies. This will encompass formulating technical safety strategies, engaging with the broader ecosystem, and producing technical documentation such as risk and capability assessments and safety measures. Your Responsibilities Establish the research and development strategy for Lila’s safety framework concerning biological and physical risks. Design and implement capability evaluations to identify scientific risks (both recognized and novel) arising from state-of-the-art scientific models integrated with automated physical laboratories across biological and physical sciences. Lead and coordinate threat modeling sessions with both internal and external scientific experts, including monitoring advancements in technologies and their applications. Create and curate high-quality training and testing datasets for evaluations and safety systems. Assess risks linked to Lila’s capabilities, considering interactions with the broader ecosystem of capabilities (including general-purpose frontier models and specialized scientific tools). Contribute to extensive, high-quality research initiatives when needed for scientific capability evaluation and restriction. Engage in external communications regarding Lila’s safety initiatives. Qualifications for Success A PhD in a biological sciences field (e.g., molecular biology, virology, computational biology) or a physical sciences field (e.g., materials science, physics, chemistry, chemical or nuclear engineering) or equivalent experience. Proven track record in setting research directions for open issues surrounding dual-use risks in biological and physical sciences. Experience in scientific computing within the biological or physical sciences. Understanding of dual-use research and dissemination issues in relation to relevant safety, regulatory, and governance frameworks (e.g., export controls, biological and chemical-related conventions). Excellent communication skills, capable of articulating complex technical concepts to non-specialist audiences. Demonstrated leadership capabilities in guiding teams of internal and external collaborators in developing Lila's perspective on biological and physical risks.

We are seeking a passionate and detail-oriented Scientist I to join our innovative team at Integrated Resources Inc. This entry-level position offers a fantastic opportunity to contribute to groundbreaking research and development projects. You will work closely with experienced scientists to support various laboratory activities, including experimental design, data collection, and analysis.

We are seeking a motivated and detail-oriented Scientist I to join our dynamic team in Cambridge. The ideal candidate will have a strong background in scientific research, with a passion for innovation and problem-solving. This entry-level role offers an exciting opportunity to contribute to groundbreaking projects and advance your career in a collaborative environment.

Join AbbVie as a Senior Director of Search & Evaluation in Neuroscience, where you will lead transformative initiatives in drug discovery and development. You will play a pivotal role in evaluating innovative neuroscience projects and establishing strategic partnerships that will drive our mission to improve patient outcomes.

Company Overview Metaphore Biotechnologies, Inc. is a pioneering biotechnology firm dedicated to developing the next generation of biological therapeutics. Our mission is to revolutionize patient care by harnessing the potential of biological therapeutics through an innovative mimic-discovery platform. Position Overview We are actively looking for a Senior Director of CMC Development & External Manufacturing to spearhead the comprehensive CMC strategy and execution for our biologics programs. This role entails significant accountability for formulating drug substance and drug product processes in collaboration with external manufacturing partners (CDMOs). The successful candidate will oversee the integrated CMC plan encompassing strategy, timelines, budgets, and risk management, while partnering with key internal stakeholders to ensure a smooth transition into late-stage CMC operations, thereby supporting regulatory submissions and clinical supply requirements.

Join Flagship Pioneering, Inc. as a Scientist specializing in Responsive Protein Engineering and Screening. In this pivotal role, you will leverage your expertise in protein design and molecular biology to innovate and optimize protein-based solutions. Your work will directly contribute to cutting-edge research and development projects aimed at addressing significant challenges in biotechnology.

At Iterative Health, we are at the forefront of healthcare technology and services, committed to revolutionizing clinical research and enhancing patient outcomes. Our renowned Iterative Health Site Network comprises over 70 clinical research sites across the U.S. and Europe, dedicated to expediting the market introduction of groundbreaking gastrointestinal (GI) and hepatology therapies. We empower our partner sites through innovative, tech-enabled services, leveraging our extensive expertise in clinical trials and advanced AI to broaden and accelerate access to vital therapeutics for patients in need.About the RoleThe Manager, Pre-Screening plays a crucial role in overseeing the initial stages of patient engagement for Iterative Health studies. This position is responsible for monitoring key performance indicators related to screenings, randomizations, and overall funnel health. You will lead a dedicated team that conducts electronic health record (EHR) chart reviews to identify potential candidates for trial enrollment, ensuring that every study supported by Iterative Health receives optimal pre-screening assistance.

Join AbbVie as a Senior Scientist I in the field of siRNA in vitro biology. In this role, you will leverage your extensive knowledge and skills in molecular biology to contribute to innovative research and development projects. Collaborate with a team of dedicated scientists to explore new therapeutic avenues and advance our understanding of RNA interference.

Join our team as a Biology Scientist, where you will engage in groundbreaking research and development in the field of biology. You will collaborate with a talented group of scientists and contribute to innovative projects that aim to advance our understanding of biological processes. This is an exciting opportunity to be part of a dynamic environment that fosters creativity and scientific inquiry.

Join our innovative team as a Senior Scientist where you'll drive critical research projects and make a significant impact in the field. We are seeking a highly motivated individual with a passion for scientific discovery and a strong background in relevant disciplines.

Join Integrated Resources Inc. as an Associate Scientist I, where you will contribute to innovative scientific research and development projects. As a pivotal part of our team, your role will involve conducting experiments, analyzing data, and collaborating with multidisciplinary teams to advance our scientific objectives.

We are seeking a highly motivated and detail-oriented Associate Scientist I to join our dynamic team in Cambridge. The ideal candidate will assist in the design and execution of experiments, analysis of data, and contribute to various projects within our research initiatives.

COMPANY DESCRIPTION Flagship Pioneering is a leading bioplatform innovation firm dedicated to inventing and building transformative companies that aim to make a significant impact on the world. By merging top-tier scientific talent with entrepreneurial visionaries, we mobilize the resources necessary to support bold innovations. Our endeavors in human health, sustainability, and beyond accelerate scientific advancements across a spectrum of fields, including disease detection and treatment, nature-positive agriculture, and cutting-edge AI applications. What distinguishes Flagship is our unique capacity to propel science and technology forward by integrating innovation, company formation, and capital investment under one roof—an approach that is largely unprecedented. Our scientific pioneers, entrepreneurial leaders, and expert capital managers are aligned in a structured process that facilitates transformative innovation for the benefit of both humanity and the planet. We have founded companies that tackle some of society's most pressing challenges, including delivering vaccines to billions during the COVID-19 pandemic, finding cures for chronic diseases, enhancing health outcomes, and fostering sustainable agricultural practices. Flagship Pioneering has been recognized twice on FORTUNE’s “Change the World” list, acknowledging our positive social and environmental contributions, and we have also been honored on Fast Company’s annual list of the World’s Most Innovative Companies. THE ROLE We are on the lookout for a Senior Scientist to spearhead the design, characterization, and optimization of aerosolizable particle systems. This pivotal role involves developing a comprehensive understanding of engineered particles during their generation, dispersion, and transport in air, and translating that knowledge into robust and scalable material and system designs. The Senior Scientist will operate at the intersection of materials science, aerosol physics, and experimental engineering. You will lead the development of aerosol testing capabilities, shape experimental strategies, and connect particle design with airborne performance. This individual will play a vital role in establishing core methodologies and driving projects from concept to validation. In this highly collaborative position, you will work closely with formulation, process development, and hardware teams to ensure seamless integration between particle design, production processes, and real-world deployment challenges.

We are seeking a highly motivated and experienced Senior Scientist I to join our Pipeline Development & Targeted Delivery team at AbbVie. In this pivotal role, you will lead innovative research efforts aimed at advancing our therapeutics pipeline. You will collaborate with cross-functional teams to design experiments, analyze data, and contribute to strategic decision-making processes.

Your Impact at Lila The Senior Director of Small Molecule Therapeutics will spearhead the biological evaluation and screening of small molecule therapeutics within Lila’s innovative discovery platform. This pivotal leader will cultivate and expand a top-tier screening organization, effectively translating AI-designed and robotically synthesized molecules into validated biological insights and promising therapeutic opportunities. Collaborating closely with Lila’s chemistry, automation, and AI/computational teams, the Senior Director will establish the biological screening infrastructure necessary for the rapid evaluation of novel chemical entities. This role involves designing and implementing high-throughput and high-content screening strategies, constructing automated assay platforms, and developing creative methodologies to explore extensive chemical libraries. As a key architect of Lila’s small molecule discovery engine, this leader will integrate biology, automation, and data science into scalable discovery workflows, significantly accelerating the identification of high-quality therapeutic candidates. What You’ll Be Building Lead and develop Lila’s small molecule biology and screening organization, focusing on hiring, mentoring, and fostering a high-performing scientific team. Design and implement automated, high-throughput screening platforms to assess small molecules generated through Lila’s AI-driven chemistry and robotic synthesis systems. Develop and refine biochemical, biophysical, and cell-based assays for the identification and validation of novel small molecule hits. Establish scalable automation-enabled workflows for assay execution, screening campaigns, and data generation. Guide the development and execution of DNA-encoded library (DEL) screening strategies and subsequent validation pipelines. Work in partnership with chemistry, computational, and automation teams to harmonize screening results with molecular design and synthesis initiatives. Define and execute screening strategies targeting new therapeutic areas, including target validation, assay design, and hit identification. Oversee large-scale screening initiatives, including hit triage, orthogonal validation, and preliminary mechanism-of-action studies. Implement data-driven methodologies to analyze screening outputs and inform iterative molecule design processes. Set best practices for screening data quality, reproducibility, and assay robustness. Collaborate across various disciplines to translate screening hits into validated chemical starting points for therapeutic development. What You’ll Need to Succeed PhD in Molecular Biology, Biochemistry, or a related field.

AbbVie is seeking a talented and motivated Associate Scientist II or Scientist I to join our dynamic In Vivo Pharmacology team in Cambridge. As part of our innovative research environment, you will play a crucial role in advancing our understanding of pharmacological mechanisms through in vivo studies. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to transform patient care.