Senior Principal Electrical Engineer jobs in Cambridge – Browse 461 openings on RoboApply Jobs

Senior Principal Electrical Engineer jobs in Cambridge

Open roles matching “Senior Principal Electrical Engineer” with location signals for Cambridge. 461 active listings on RoboApply Jobs.

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companyRamboll logo
Full-time|On-site|Cambridge

Join our dynamic team at Ramboll as a Senior / Principal Electrical Engineer. In this role, you will lead innovative projects, collaborate with a talented team, and contribute to the development of sustainable electrical solutions. Your expertise will be pivotal in driving forward our commitment to excellence in engineering.

Jul 9, 2025
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companyHarvard University logo
Full-time|On-site|Cambridge

Organizational Context/Position Summary:The Engineering & Utilities (E&U) department is responsible for the management and operation of energy supplies, district energy plants, and utility infrastructures across the Cambridge and Allston campuses. This includes a 24/7 facilities-related call center, alarm monitoring, and dispatch services, as well as providing engineering and technical support.This role encompasses senior-level electrical engineering responsibilities for the planning, design, technical support, operation, maintenance, and upgrades of the University’s utility infrastructure. This includes electric, steam, hot water, chilled water, energy/building management, and utility metering systems. The position will also involve executing special short- and long-range projects as directed.Duties & Responsibilities:Collaborate with E&U leadership to develop, refine, and uphold campus utility systems while coordinating with the needs of the University’s Schools and Units. Supervise the installation and relocation of underground utility infrastructures with minimal disruption to the University community. Assume full engineering accountability for utility distribution systems, ensuring capability, flexibility, reliability, safety, economic operation, and expansion considerations. Formulate and manage long and short-range plans and budgets regarding utility distribution upgrades. Generate distribution system statistics, records, and drawings, and contribute to the documentation of utility infrastructure for record-keeping.Maintain effective communication and relationships with governmental agencies to ensure the University’s interests are addressed safely, reliably, economically, and with minimal disruption. Stay updated with relevant government standards concerning employee environmental health and safety. Keep abreast of federal, state, municipal, industry, and University codes, regulations, practices, trends, and guidelines, along with the latest innovations in electrical design and equipment.Engage and work alongside E&U staff and partner groups to leverage systems, data, and reporting for E&U’s KPI monitoring and operational analysis. As stewards of university energy and utility systems, provide technical assistance to Campus Services personnel and support for the operation and maintenance of central energy and utility production/distribution systems as needed. Evaluate and recommend enhancements for preventive maintenance, inspection, and testing programs for the University’s electrical distribution systems, central chilled water and steam plants, and related electrical systems and equipment. Identify and develop cost control opportunities and system cost planning.

Mar 11, 2026
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companyLila Sciences logo
Full-time|$224K/yr - $336K/yr|On-site|Cambridge, MA USA; San Francisco, CA USA

Your Impact at Lila As a Senior or Principal Research Engineer specializing in Synthetic Data, you will play a pivotal role in shaping the vision, roadmap, and execution of our synthetic data initiatives. Your responsibilities will span from asset generation and simulation to integrating machine learning training and achieving measurable enhancements in model performance. Collaborating closely with our Research Engineering team, you will design, generate, and implement artificial datasets aimed at training, testing, and refining Lila’s platform to achieve our strategic objectives. What You Will Build Define and refine the synthetic data strategy along with a comprehensive multi-quarter roadmap. Create evaluation frameworks that effectively connect synthetic interventions with genuine model performance. Establish high standards for asset quality, diversity, thorough documentation, and reproducibility while fostering a robust review culture. What You Will Need to Succeed Over 6 years of experience in applied ML/ML systems, with at least 3 years leading industry initiatives, showcasing a strong track record in advanced algorithms and frameworks designed for large-scale synthetic data generation. More than 8 years of experience working with contemporary ML workflows, including Python, PyTorch, dataset tools, training loops, and evaluation frameworks; adept at profiling and optimizing GPU-intensive pipelines. Bonus Points For A proven history of constructing synthetic datasets from source data to significantly enhance model performance in specific domains. Experience with instruction fine-tuning and hill-climbing techniques. Ability to translate product requirements and feedback into a scalable synthetic data generation pipeline. Knowledge of quantization, distillation, routing, mixture-of-experts, and cost optimization at scale. Experience in compliance-heavy settings (HIPAA, PCI, FedRAMP) and with on-premises/VPC deployments. About Lila Lila Sciences stands at the forefront of innovation as the world’s first scientific superintelligence platform and autonomous lab, dedicated to life sciences, chemistry, and materials science. We are ushering in an era of limitless discovery by harnessing AI to enhance every facet of the scientific method. Our mission is to empower scientists to tackle humanity's most pressing challenges in health, climate, and sustainability at an unprecedented pace and scale. Discover more about our mission at www.lila.ai. If this sounds like an environment in which you would thrive, we encourage you to apply even if your experience doesn't perfectly align with every requirement listed.

Mar 25, 2026
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companyEngine logo
Full-time|On-site|Cambridge, MA

Join Engine as a Senior Associate in Community OperationsAt Engine, we empower visionary founders who are tackling the world's most critical challenges in areas such as climate change, health, and advanced technologies. Our commitment includes providing robust support through founder programs, access to shared infrastructure and labs, and the opportunity to connect with a diverse national network of corporate partners, investors, and industry experts.

Apr 3, 2026
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companyCambridge Mobile Telematics logo
Principal Software Engineer - Backend

Cambridge Mobile Telematics

Full-time|$167.2K/yr - $209K/yr|On-site|Cambridge, MA

Join Cambridge Mobile Telematics (CMT), the world's leading telematics service provider, dedicated to enhancing road safety and improving driver behavior. Our cutting-edge AI platform, DriveWell Fusion®, integrates sensor data from millions of IoT devices—including smartphones, proprietary Tags, connected vehicles, dashcams, and third-party devices—melding it with contextual information to deliver a comprehensive analysis of vehicle and driver interactions. Our insights empower auto insurers, automotive manufacturers, mobility companies, and public sector organizations to optimize risk assessment, safety protocols, claims processing, and driver improvement initiatives. Based in Cambridge, MA, with global offices in Budapest, Chennai, Seattle, Tokyo, and Zagreb, CMT actively monitors and safeguards millions of drivers worldwide every day.As a Principal Software Engineer within our Trip Processing team, you will play a crucial role in delivering innovative technical solutions at the core of our advanced telematics pipeline. Collaborating closely with product and research teams, you will design, develop, and implement new features while mentoring junior engineers and enhancing our codebase. Your contributions will be vital in upholding our high standards of software quality to meet the expectations of our insurance partners.We seek a collaborative, customer-focused, and imaginative Principal Software Engineer II - Backend who is eager to help make roads safer and drivers more responsible!

Apr 3, 2026
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companyHubSpot, Inc. logo
Full-time|$313.8K/yr - $502.1K/yr|Hybrid|Flex - Cambridge, Massachusetts

POS-4092 Team and Product Focus The Data Hub team at HubSpot connects scattered data sources to deliver practical insights for Revenue Operations, marketing, sales, and customer teams. By integrating information from various channels and tools, the team improves data quality and makes this data actionable within HubSpot. This enables teams to run AI-powered demand generation, optimize campaigns, and produce reliable reports, without requiring deep expertise in data systems. Product engineering here blends data engineering, machine learning, applied AI, and market strategy. The group prioritizes reliability, cost efficiency, and scalability, while always considering usability for marketers and sales professionals. Role Overview HubSpot is seeking a Lead Principal Software Engineer to steer the next phase of Data Hub's development. This platform is evolving into the central engine for data-driven demand generation company-wide. Key Responsibilities Take ownership of critical components in the data lake and analytics architecture, working with technologies such as Iceberg, Spark, and both batch and streaming data pipelines. These systems underpin large-scale demand generation, segmentation, and scoring. Design and refine data systems to achieve the right balance between cost, latency, data freshness, and reliability. Apply principles like the CAP theorem, efficient partitioning, and thoughtful storage layout to guide decisions. Collaborate closely with Product Management, product analytics, and go-to-market leaders to deliver solutions that drive business outcomes: improved lead scoring, enhanced funnel visibility, audience segmentation, and campaign attribution for marketing and sales. Contribute to transforming Data Hub into an AI-powered platform, aiming for curated, always-available datasets that support AI agents and reporting tools, eliminating the need for manual integrations or custom pipelines. This is a hands-on principal engineering position. The role involves building systems, working alongside product and design, and amplifying the impact of HubSpot's broader engineering community.

Apr 28, 2026
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companyLila Sciences logo
Full-time|$171K/yr - $230.5K/yr|On-site|Cambridge, MA USA

Role Overview Lila Sciences is seeking a Principal Engineer with expertise in AI Security for its Cambridge, MA office. This senior individual contributor will help define and drive the technical strategy to secure AI applications across the organization. The role involves close collaboration with IT and business teams to ensure AI tools and platforms are implemented safely and in compliance with internal and external requirements. Securing both third-party and in-house AI tools is central to this position. The work will focus on protecting sensitive data, intellectual property, and scientific processes as AI becomes increasingly embedded in Lila's operations. What You Will Do Enterprise AI Security Strategy: Develop and roll out security controls and guidelines for using AI tools throughout the company, covering LLM APIs and SaaS AI platforms. AI Gateway & Agentic Gateway Security: Design and enforce controls for AI gateways, monitoring and managing access to AI systems. Ensure agentic workflows are secured with strong identity and authorization measures. AI Red Teaming & Adversarial Testing: Lead red teaming and adversarial testing efforts to uncover vulnerabilities in AI usage, such as prompt injection and data exfiltration risks. Data Protection for AI Usage: Establish and maintain safeguards to prevent sensitive data exposure through AI systems, with a focus on input/output filtering and secure data management. Multi-Layer AI Security: Integrate AI security practices with the organization's broader security framework, maintaining visibility and control over AI service access and data flows. AI Threat Modeling: Build and maintain threat models tailored to enterprise AI applications, addressing risks like data leaks and unauthorized agent actions. Vendor & Platform Security: Assess and advise on secure integration of third-party AI vendors, with close attention to their data handling practices and model behavior.

Apr 16, 2026
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companyAcceleron Fusion logo
Full-time|On-site|Cambridge, MA

About Acceleron Fusion:Acceleron Fusion is at the forefront of developing muon-catalyzed fusion technology, paving the way for a sustainable and abundant energy future. Leveraging groundbreaking research backed by the U.S. Department of Energy, we have successfully secured a $24 million Series A funding round and accumulated over 100 hours of muon-catalyzed fusion testing at the prestigious Paul Scherrer Institute. Our collaborative efforts are strengthened by partnerships with renowned institutions including PSI, Oak Ridge, Argonne, Fermilab, and several esteemed universities. Become part of a dynamic team where cutting-edge physics meets practical engineering, and your innovative designs could facilitate the transition of our technology from research environments to commercial energy solutions.About This Role:We are seeking a talented High Voltage Electrical Engineer to spearhead the design of advanced beam-control hardware for our fusion experiments. You will be responsible for creating high-voltage and RF solutions that ensure precise manipulation of particle beams operating in the kilovolt to megavolt range.Key Responsibilities:Analyze, model, and address electrical breakdown and insulation issues in high-voltage structures and circuits.Design electrostatic systems ranging from kilovolts to megavolts, utilizing technologies such as Marx generators, Cockcroft-Walton stacks, and Pelletrons for particle beam acceleration and cooling.Develop RF power and energy recovery systems using Klystrons, Magnetrons, waveguides, and other relevant components.Create multiphysics models that integrate electromagnetics, heat transfer, fluid dynamics, and particle transport.Construct prototypes and conduct laboratory tests to validate designs.Produce comprehensive design documentation, test plans, and risk assessments to facilitate rapid iteration and ensure safety.Travel internationally to collaborate with team members in integrating hardware at beamline facilities and executing experiments.

Jan 22, 2026
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companyLila Sciences logo
Full-time|On-site|Cambridge, MA USA; London, UK; San Francisco, CA USA

Join Lila Sciences as a Staff or Principal Engineer specializing in Technical Mitigations Research. This role offers an exciting opportunity to leverage your engineering expertise to develop innovative solutions in the field of technical mitigations.

Apr 7, 2026
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companyHubSpot logo
Remote|Remote|Remote - USA

POS-9034About Our TeamThe Commerce Hub at HubSpot is revolutionizing how businesses sell, bill, and manage revenue seamlessly within our platform. Handling billions in customer transactions, our focus on accuracy, clarity, and reliability is paramount. We are developing an AI-first commerce ecosystem that integrates flawlessly with HubSpot’s CRM, offering a streamlined, consistent, and adaptable experience for both sellers and buyers.About the RoleWe are in search of a Principal Software Engineer to drive the technical evolution of Commerce Hub. This pivotal role demands hands-on involvement, where you will engage in coding, exploring services, evaluating complex designs, troubleshooting intricate systems, and taking ownership of the architecture for critical components in CPQ, Billing, Payments, and Revenue OS.Your ResponsibilitiesDevelop a Cohesive, Scalable PlatformInfluence the technical roadmap for CPQ, Billing, and Payments using strong, decisive patterns.Define and enhance core domain models to ensure consistent and predictable behavior for pricing, products, contracts, invoices, and payments.Create frameworks that facilitate easy extensions without increasing complexity.Be a Proactive, Impactful BuilderRegularly write code, lead design reviews, and construct impactful systems from start to finish.Manage extensive multi-team projects that encompass CPQ, Billing, and Payments.Transform prototypes into scalable production-ready solutions.Guide Architectural DirectionEstablish patterns for extensibility, contract boundaries, financial accuracy, event-driven consistency, and safe interactions between AI/agents and commerce objects.Advocate for simplicity in complex domains while maintaining consistency across surfaces.Collaborate Closely with Product LeadershipShape product strategies across CPQ, Buyer Portal, and Revenue OS.Assist teams in navigating trade-offs between speed, accuracy, compliance, and long-term platform sustainability.Elevate Organizational StandardsMentor senior engineers and technical leads.Drive informed design choices and facilitate learning from incidents and significant migrations.Encourage teams to align on best practices and strategic goals.

Dec 18, 2025
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companyExpedition Medicines logo
Full-time|$126K/yr - $214.5K/yr|On-site|Cambridge, MA USA

Imagine... being part of an innovative organization that cultivates and develops life sciences companies dedicated to pioneering groundbreaking technologies aimed at revolutionizing health care and sustainability. Company Overview Expedition Medicines is a dynamic, privately held, early-stage biotechnology company at the forefront of the Protein Editing field. We specialize in creating small molecules that modify protein structure and function to target currently undruggable options across various therapeutic strategies. Our advanced platform combines cutting-edge small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to facilitate generative design. Backed by Flagship Pioneering, we leverage their vision, courage, and resources to propel Expedition Medicines from platform validation to impactful patient solutions. We seek passionate, collaborative, and determined problem solvers to join our mission! Role Overview: The Senior/Principal Scientist in Structural Biology will concentrate on determining protein-ligand complex structures using X-ray crystallography and cryo-electron microscopy (cryo-EM). This role involves delivering structural insights and collaborating with project teams to advance structure-based drug design and uncover the mechanisms of action of small molecules. Key Responsibilities: Design and implement structural biology strategies for multiple projects. Oversee the design, expression, and purification of protein constructs for structural determination. Develop and execute protocols to achieve high-quality crystals for X-ray crystallography. Create and implement protocols for grid optimization, data collection, and analysis in cryo-EM. Refine and communicate structures of protein-ligand complexes, collaborating with project teams to drive hit-to-lead and lead optimization processes. Manage contract research organizations (CROs) to ensure efficient delivery of protein expression and structural biology services. Enhance our capabilities and serve as a trusted authority in the field of structural biology.

Jan 28, 2026
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companyLila Sciences logo
Full-time|$204K/yr - $270K/yr|On-site|Cambridge, MA USA

Your Role at Lila Sciences Lila Sciences is on the lookout for an experienced Principal Software Engineer specializing in Instrument Simulations. In this pivotal position, you will spearhead the architecture and development of our cutting-edge laboratory automation platform. Your expertise will be crucial in designing the simulation framework and integration layer that links AI-driven experimental design with physical robotic systems, enabling groundbreaking scientific discoveries at an unparalleled scale. Key Responsibilities Design and implement high-fidelity simulation environments that accurately model intricate laboratory instrumentation, fluidics, and robotic processes. Establish and maintain robust integration frameworks between diverse hardware systems, ensuring the safe and reliable execution of fully automated experiments. Lead the development of APIs and interfaces to facilitate seamless interaction between scientists and AI agents with complex automation infrastructures. Champion best practices in hardware-software integration, system monitoring, and continuous integration/deployment (CI/CD) within laboratory automation contexts. Provide mentorship to engineers, likely overseeing a small, agile team.

Mar 20, 2026
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companyCambridge Mobile Telematics logo
Full-time|$177.7K/yr - $209K/yr|On-site|Cambridge, MA

Join Cambridge Mobile Telematics (CMT), the leading telematics service provider dedicated to enhancing road safety and driver performance. Our AI-powered platform, DriveWell Fusion®, aggregates data from millions of IoT devices, including smartphones and connected vehicles, to deliver actionable insights for auto insurers, automakers, and mobility companies. Headquartered in Cambridge, MA, with a global presence in cities like Budapest, Chennai, and Tokyo, we protect millions of drivers every day.We are on the lookout for a talented Principal Software Engineer to spearhead ambitious projects while mentoring our engineering teams in developing robust and scalable full-stack solutions. This pivotal role involves setting the technical direction for our platform and contributing to its ongoing success.If you are a collaborative, innovative, and customer-focused engineer eager to make a real impact on road safety, we invite you to apply!

Apr 1, 2026
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companyCharles River Analytics logo
Full-time|$170K/yr - $225K/yr|On-site|Cambridge, MA

Charles River Analytics, a proud member of the GRVTY family, is at the forefront of developing innovative solutions and advanced technologies designed to address some of the most challenging issues faced globally. Our dynamic team of tech entrepreneurs collaborates to enhance AI, robotics, intelligent sensing, and human-centered computing. The research and technology we develop not only propel government initiatives but also unveil new opportunities in the commercial sector. At Charles River, we take immense pride in cultivating a workplace that attracts and retains top-tier talent and creative problem-solvers in the industry. Join us as we strive to accelerate our mission-driven innovations!We are currently seeking a dedicated Senior/Principal Scientist with expertise in Human-Systems Integration, Human Factors, or Human-Computer Interaction. In this role, you will spearhead the development of cutting-edge tools and interfaces that empower users to effectively collaborate with technology in demanding environments.Your responsibilities will include leading and expanding teams of researchers, designers, and engineers to assess work domains and user needs, create novel human-AI interaction concepts, and evaluate interactive prototypes. You will also be responsible for defining and directing technical projects, while fostering robust relationships with clients, sponsors, and collaborators. As a subject matter expert in Human Systems, you will work alongside multidisciplinary teams to explore and pursue research opportunities across various technical domains.

Apr 13, 2026
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companyHubSpot logo
On-site|On-site|Cambridge, MA, USA

POS-31591About Our TeamThe Prospecting Solutions team is revolutionizing the way B2B SMB and mid-market sales teams cultivate their pipeline. The current outbound sales approach is often inefficient and outdated, with representatives dedicating excessive time to research, tool integration, and uncertain contact strategies. Our focus transcends mere outreach execution; we prioritize intelligent sourcing, prioritization, and trust.This team is developing a comprehensive, signal-driven prospecting ecosystem that aligns with contemporary B2B purchasing behavior: account-centered, aware of buying groups, and trust-oriented. Our mission is to merge human discernment with automation, enabling sales teams to generate consistent, high-quality pipeline without compromising their brand integrity or their representatives' well-being.About the RoleWe are seeking a Principal Software Engineer to serve as a pivotal technical leader for Prospecting Solutions. This role is highly hands-on, perfect for an innovator who excels in dynamic, product-defining environments.As a Principal Engineer within our team, you will play a crucial role in shaping how data, AI, and workflows converge to facilitate intelligent prospecting at scale. You won't just follow a roadmap; you will help craft it, transforming ambiguous challenges such as “who should I contact next and with what message?” into robust, transparent, production-grade systems utilized by millions of sales professionals.Key ResponsibilitiesDesign signal-driven prospecting systems: Define the integration of intent signals, firmographics, behavioral insights, and CRM context to create actionable prioritization and recommendations.Hands-on, impactful developer: Write production-quality code, steer complex projects from conception to completion, and scale prototypes into full-fledged systems.AI and systems integration: Guide the integration of machine learning and generative AI models into deterministic workflows, balancing efficiency with transparency and user trust.Influential technical leadership: Shape not only the construction of the product but also its vision, collaborating closely with Product to define interfaces, workflows, and necessary trade-offs.Extensibility focus: Design systems capable of functioning across diverse accounts, buying groups, and regions while ensuring adaptability and ongoing evolution.Cross-department collaboration: Work collaboratively across CRM, data, AI, and GTM teams to synchronize patterns and avoid localized optimizations.Elevate technical standards: Foster a culture of excellence in engineering practices and innovation.

Feb 6, 2026
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companyAECOM logo
Full-time|Hybrid|Cambridge

Are you ready to make a significant impact on the environment by joining a team of skilled ecologists? We invite you to become a vital member of our innovative Nature team as a Principal Ecologist in our expanding offices located in Cambridge, Basingstoke, Croydon, Leeds, Nottingham, Newcastle, Manchester, Birmingham, Glasgow, Edinburgh, Bristol, and Liverpool (other locations may also be considered). Enjoy the benefits of our flexible hybrid working model at AECOM, where we lead the way in delivering an exceptional portfolio of Ecology programs and projects through long-standing partnerships with key clients.We are currently engaged in a diverse array of projects across the power, renewables, infrastructure, environment, and transport sectors. Our collaborative efforts extend to other technical disciplines, including landscape, GIS, engineering, sustainability, and drainage. Recent projects include some of the largest solar farms in the UK, a cable tunnel beneath the River Thames, electricity network upgrades in Kent and Suffolk, and master planning for new residential developments.Your Responsibilities:Lead and support the delivery of high-quality ecological consultancy and advisory services to both internal and external clients.Oversee, plan, schedule, and organize all phases of ecological project work, ensuring that necessary resources, budgets, and controls are in place to meet program and budget requirements.Develop technically robust and pragmatic solutions to complex ecological challenges.Lead the production of ecology chapters for environmental statements and protected species license applications and ensure the high quality of project deliverables.Contribute to the ongoing development of our technical capabilities.Join Us in Our Growth Journey. Become part of our dynamic Nature business, which comprises around 230 professionals specializing in arboriculture, forestry, groundwater, surface water, and ecology. Our team includes national and global leaders in species licensing, impact assessment, habitat creation, ecosystem restoration, enhancement, and management. At AECOM, you will flourish in an inclusive and forward-thinking environment where your contributions are valued.Don't forget the amazing perks at AECOM! You will enjoy a variety of core and personalized benefits tailored to support your future and well-being, including career development opportunities, a flexible hybrid working model to enhance your work-life balance, technical practice networks, and access to AECOM University.

Mar 5, 2026
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companydev2 logo
Full-time|On-site|Cambridge

As a Principal Terrestrial Ecologist at dev2, you will play a pivotal role in leading and managing ecological projects that contribute to sustainable environmental practices. You will be responsible for conducting extensive field studies, analyzing ecological data, and providing expert guidance on terrestrial ecosystems. Your insights will help shape strategies that promote biodiversity and conservation.

Jan 23, 2023
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companyIntegrated Resources, Inc. logo
Principal Application Administrator

Integrated Resources, Inc.

Full-time|On-site|Cambridge

Join our dynamic team at Integrated Resources, Inc. as a Principal Application Administrator. In this pivotal role, you will oversee and manage our application systems, ensuring optimal performance and user satisfaction. You will collaborate with various departments to implement innovative solutions and enhance our technology infrastructure.

Mar 10, 2015
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companyThe Engine logo
Full-time|On-site|Cambridge

About The Engine The Engine is a nonprofit organization dedicated to supporting Tough Tech entrepreneurs who are working on solutions to major global challenges. The team provides founders with access to infrastructure, funding, and operational resources to help bring breakthrough science and technology to life in ways that benefit society. Chief Growth Officer Role Overview The Engine seeks a Chief Growth Officer (CGO) to guide the organization through its next stage of expansion. This executive will shape partnership strategies, lead revenue initiatives, and strengthen The Engine’s position in the market. The CGO will also act as a strategic advisor to the CEO and leadership team on key decisions. Who Should Apply This role calls for an experienced leader with a background in Tough Tech, either as an entrepreneur or a commercial executive. Candidates should have a history of scaling organizations, launching first-of-a-kind (FOAK) projects, and advocating for Tough Tech founders within the broader ecosystem. Location This position is based in Cambridge.

Apr 22, 2026
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companyFlagship Pioneering, Inc. logo
Full-time|$208K/yr - $286K/yr|On-site|Cambridge, MA USA

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence is a forward-thinking initiative that builds upon Flagship Pioneering's rich history of establishing groundbreaking scientific and computational enterprises. By leveraging cutting-edge advancements in artificial intelligence, machine learning, and data science, we aim to accelerate fundamental research and cultivate a dynamic portfolio of AI-first companies. As an integral part of Flagship's unique model that intertwines science, entrepreneurship, and investment, we transform revolutionary concepts into impactful companies, enhancing AI innovations that contribute to human health, sustainability, and more. THE ROLE We are on the lookout for a Principal Scientist specializing in Embedded Machine Learning and Computational Methods to spearhead various AI/ML and computational initiatives across early-stage ventures within our company origination framework. Your responsibilities will include defining and executing practical AI strategies, overseeing the development of methodologies and platforms (including systems design, drug design, molecular modeling, systems biology, protein design, and LLM-based workflows), and ensuring a high standard of rigor in model development, benchmarking, scaling, and reporting. You will also manage cross-functional teams as necessary, influence the strategic direction of our initiatives, and represent Pioneering Intelligence to venture teams and external collaborators. The ideal candidate is a self-motivated individual with a diverse skill set, capable of transitioning seamlessly from protein design to mass spectrometry or docking pipelines, and then creating LLM-based agents to streamline scientific workflows.

Jan 12, 2026

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