Director of Computational Drug Design

Role Overview Isomorphic Labs is seeking a Director of Computational Drug Design to join its Cambridge, MA site. This leader will shape computational chemistry strategy for both internal research and collaborative projects. The position sits within the Drug Design and Medical Research division, working closely with AI and machine learning specialists to advance the company’s drug design engine and accelerate new medicine development. About Isomorphic Labs Founded in 2021, Isomorphic Labs (IsoLabs) builds on the AlphaFold system, applying advanced AI to solve complex problems in human health. The team combines drug discovery expertise with machine learning to create predictive and generative models that speed up scientific discovery. The company’s mission is to design novel molecules, predict drug performance, and develop new treatments for challenging diseases by modeling biological systems with AI. Isomorphic Labs has developed an AI-driven drug design engine capable across various therapeutic areas and drug types. The organization continues to refine model architectures and expand capabilities, aiming to realize the promise of digital biology and ultimately eradicate disease through artificial intelligence. About the Computational Drug Design Team The Cambridge-based Computational Drug Design team brings together computational chemists focused on driving strategy, supporting both internal and partner projects. Close collaboration with AI/ML colleagues is central to the group’s work, ensuring the continued evolution of the Isomorphic Labs Drug Design Engine. The team values a supportive environment, ongoing learning, and professional development for every member.

Join Isomorphic Labs as the Head of Chemistry in Drug Design, where you will be at the forefront of innovative drug discovery. You will lead a talented team of chemists, collaborating with interdisciplinary groups to design and optimize drug candidates. Your expertise will guide the development of cutting-edge pharmaceutical solutions that have the potential to transform patient outcomes.

Scholar Rock, Inc. is a pioneering biopharmaceutical firm dedicated to the discovery, development, and delivery of transformative therapies for individuals suffering from serious diseases with significant unmet medical needs. As a recognized leader in the biology of the transforming growth factor beta (TGFβ) superfamily of proteins, Scholar Rock is committed to advancing innovative treatments where the modulation of protein growth factors is crucial. Over the last decade, we have developed a robust pipeline aimed at redefining the standard of care for neuromuscular conditions, cardiometabolic disorders, cancer, and other diseases where growth factor-targeted therapies can radically change patient outcomes. Scholar Rock is the first and only company to demonstrate clinical proof of concept for a muscle-targeted treatment in spinal muscular atrophy (SMA). Our commitment to unlocking unique therapeutic strategies is driven by our proprietary platform, which has generated novel monoclonal antibodies designed to modulate protein growth factors with remarkable precision. By leveraging cutting-edge scientific advancements in therapeutic areas that have historically been overlooked by conventional treatments, Scholar Rock tirelessly works to create new avenues for patient care. Discover more about our innovative approach at ScholarRock.com and follow us on @ScholarRock and LinkedIn.Position Overview:The Senior Medical Director of Drug Safety & Pharmacovigilance plays a critical role within the company, significantly influencing the development and lifecycle management of drug projects. This position is responsible for defining and implementing safety strategies and providing expert guidance during both pre- and post-approval phases for assigned products. The Senior Medical Director will proactively lead risk management initiatives in compliance with global regulatory standards, continuously evaluating safety data, conducting signal detection, and managing the safety profiles of compounds. Additionally, this role will involve close collaboration with cross-functional teams to achieve project objectives within established timelines and quality standards.

Isomorphic Labs is hiring a Head of Translational Sciences, Drug Design for its Cambridge, MA site. This senior leader will guide the translational strategy across the drug discovery portfolio, working closely with teams at the intersection of biology, artificial intelligence, and medicine. The position plays a central role in shaping how new therapies are advanced and how disease mechanisms are understood within the organization. Role overview This leadership role focuses on driving translational approaches for drug design. The Head of Translational Sciences will collaborate with colleagues to advance projects from early discovery through clinical evaluation. The team’s work includes strengthening biological insights into disease, supporting the selection of drug targets, and developing biomarkers to track pharmacodynamic effects and target engagement in clinical studies. Translational Sciences at Isomorphic Labs The Translational Sciences group in Boston is essential to the company’s mission. This team informs critical decisions across the portfolio, guiding projects through various stages of research and development. Close collaboration with other teams ensures that scientific progress benefits from both biological expertise and AI-driven insights. Company background Founded in 2021, Isomorphic Labs (IsoLabs) builds on the breakthroughs of the AlphaFold system. The company brings together drug discovery experts and machine learning specialists to develop predictive and generative AI models that accelerate scientific progress. The team uses AI to model complex biological systems, design new therapeutic molecules, and pursue treatments for challenging diseases. Ongoing innovation in model architecture supports work across diverse therapeutic areas and modalities. Culture Isomorphic Labs values interdisciplinary collaboration and a supportive environment. Every team member contributes to the shared goal of addressing serious diseases through AI-driven science and digital biology.

We are seeking a highly skilled Associate Director of Drug Safety and Pharmacovigilance to join our dynamic team at Nuvalent. This pivotal role involves overseeing drug safety operations, ensuring compliance with regulatory requirements, and enhancing the pharmacovigilance strategy. The ideal candidate will possess a deep understanding of drug safety processes and a passion for advancing patient safety in the pharmaceutical industry.

Scholar Rock is a pioneering biopharmaceutical organization dedicated to the discovery, development, and provision of transformative therapies aimed at addressing significant unmet medical needs for individuals suffering from serious health conditions. As a frontrunner in understanding the biology of the transforming growth factor beta (TGFβ) superfamily of cell proteins, our clinical-stage company is devoted to advancing innovative treatments that leverage the fundamental role of protein growth factors. Over the last decade, we have established a robust pipeline that aims to elevate the standard of care for conditions such as neuromuscular diseases, cardiometabolic disorders, cancer, and other illnesses where growth factor-targeted therapies can make a substantial difference. Scholar Rock is distinctively positioned as the only company to showcase clinical proof of concept for a muscle-targeted therapy in spinal muscular atrophy (SMA). Our unwavering commitment to exploring fundamentally novel therapeutic strategies is fueled by our proprietary platform, which has successfully developed innovative monoclonal antibodies designed to modulate protein growth factors with remarkable selectivity. By applying cutting-edge scientific advancements in traditionally under-addressed disease areas, we strive daily to forge new possibilities for patients. Discover more about our approach at ScholarRock.com and follow us on @ScholarRock and LinkedIn.Position Overview:Scholar Rock is actively seeking a highly skilled and technically adept Senior Director of Drug Product External Manufacturing to spearhead the external manufacturing of drug products across our portfolio of biologics, which includes monoclonal antibodies, fusion proteins, and bispecifics. In this pivotal role, you will lead and supervise all drug product manufacturing operations conducted through external contract manufacturing organizations (CMOs). This position is essential for ensuring the efficient production, quality assurance, and timely delivery of both clinical and commercial products, in alignment with our organizational objectives and stringent regulatory requirements. The ideal candidate will possess extensive expertise in biopharmaceutical manufacturing, demonstrate strategic leadership capabilities, and exhibit a strong aptitude for managing complex global operations.

Nuvalent is seeking a highly experienced and visionary Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) to lead our DMPK team. This role is crucial for the advancement of our drug development programs as we strive to create innovative treatments. Join us in our mission to transform the lives of patients with targeted therapies.

Position Overview Join our innovative team at Apriori Bio, where we harness the power of computational and data-centric methods to craft groundbreaking antigens and assess vaccine efficacy. Our cutting-edge AI/ML platform, Octavia™, allows us to navigate viral fitness landscapes, anticipate immune evasion patterns, and engineer vaccines that prime the immune system for future challenges. In this role, you will leverage computational techniques—including structural modeling, machine learning, and statistical inference—to enhance our vaccine design initiatives based on insights from Octavia™. Proficiency in protein engineering and immunological datasets is advantageous, alongside a keen interest or background in high-throughput functional genomics, virology, or vaccinology. The Scientist will collaborate closely with both computational and experimental teams to analyze outcomes, formulate hypotheses, and aid in antigen development. This position is perfect for scientists who are eager to engage in a unique learning environment characterized by innovation and interdisciplinary collaboration within a fast-paced startup.

As a Drug Safety Associate at Integrated Resources Inc., you will play a crucial role in ensuring the safety and efficacy of pharmaceutical products. You will be responsible for monitoring and evaluating adverse events, coordinating safety reports, and contributing to the overall pharmacovigilance efforts within our organization. Your attention to detail and analytical skills will be vital in supporting our commitment to patient safety.

Amylyx Pharmaceuticals is dedicated to revolutionizing the treatment of diseases with significant unmet needs. We embrace challenges as opportunities, driven by a sense of urgency, rigorous scientific methodology, and a steadfast commitment to the communities we serve. Our focus is on clinical-stage development for conditions such as post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).Our mission thrives on our talented team, which embodies core values of audacity, curiosity, authenticity, engagement, and accountability — all of which foster a culture of care. Amylyx has curated a skilled workforce ready to act swiftly because the communities we support cannot afford to wait. If you are passionate about addressing some of the most challenging issues in medicine, we invite you to explore the opportunity below and apply.The OpportunityThe Associate Director of Computer System Validation (CSV) & Quality Compliance will provide enterprise-level leadership, strategic direction, and governance for the validation, lifecycle management, and continuous compliance of GxP-relevant computerized systems, particularly focusing on the Veeva Quality Suite. This position is pivotal in ensuring that our digital quality solutions and supporting systems comply with global regulatory standards (FDA, EMA, ICH, GAMP 5), safeguard data integrity, and maintain a sustainable, inspection-ready status across the organization.This role entails close collaboration with Quality, IT, Regulatory, Clinical, and business process owners to define system requirements, oversee new system implementations and significant enhancements, and promote harmonized, risk-based validation practices. Additionally, this position supervises quality compliance processes such as Change Control, Deviations, CAPA, and continuous improvement, ensuring timely resolutions, trend analysis, and effective governance through leadership of key forums, including Quality Management Review and cross-functional compliance meetings.

Join Integrated Resources Inc. as a Senior Drug Safety Associate and contribute to the vital field of drug safety and pharmacovigilance. In this role, you will play a key part in monitoring and ensuring the safety of pharmaceutical products, working closely with cross-functional teams to assess risk and implement safety measures.

Join Eurofins Scientific as a Business Development Manager specializing in Drug Discovery. In this dynamic role, you will drive strategic initiatives to enhance our laboratory testing services, fostering collaboration with clients and stakeholders. You will leverage your expertise to identify market opportunities, develop client relationships, and contribute to the growth of our innovative drug discovery solutions.

Role overview Lila Sciences seeks a Scientist I/II in Drug Delivery Chemistry for its Cambridge, MA location. This role centers on advancing drug delivery systems that align with the company’s broader research objectives. Key responsibilities Collaborate with fellow researchers to design and refine drug delivery technologies. Apply chemistry expertise to enhance scientific strategies and laboratory processes. Contribute to projects focused on improving patient outcomes through innovative drug delivery solutions. Location This position is based in Cambridge, Massachusetts.

Riverlane seeks a Director of IT Infrastructure to lead technology operations at its Cambridge, UK headquarters. This permanent, full-time position offers a hybrid work arrangement and a salary range of £100,000 to £130,000 depending on experience. Role overview This senior leadership role oversees all aspects of IT at Riverlane, from managing corporate systems to optimizing high-performance computing (HPC) infrastructure. The Director will shape IT strategy, execute plans, and collaborate with engineering, operations, security, and finance teams to ensure infrastructure remains secure, scalable, and aligned with company growth. What you will do Lead and refine Riverlane's IT strategy, policies, and roadmap to support company objectives and security needs. Manage and improve corporate IT systems, including endpoint management, identity and access management (IAM), collaboration tools, SaaS platforms, and networking. Direct IT procurement, oversee vendor relationships, and optimize software licensing across all platforms. Establish and maintain IT support processes to ensure high availability and responsiveness for a team of scientists and engineers. Develop and manage Riverlane’s information security framework, covering policies, risk management, access controls, and compliance with standards such as ISO 27001. Compensation Salary: £100,000 to £130,000 DOE

We are seeking an experienced and innovative Device Development Lead to spearhead our efforts in advancing Drug Delivery Systems. The ideal candidate will possess a deep understanding of device development, coupled with a passion for enhancing patient outcomes through cutting-edge technology.Your role will involve leading cross-functional teams, driving product design, and ensuring compliance with regulatory standards. You will also be responsible for conducting feasibility studies, prototyping, and overseeing the entire development lifecycle from concept to clinical trials.

Join Riverlane as the Director of Systems in Cambridge, UK. This is a full-time, permanent position with a hybrid working model.Compensation: £125,000 to £150,000, dependent on experience, along with bonus and equity options.We welcome applications from candidates with varying levels of experience. Salary offers will be tailored to individual backgrounds, including industry experience, transferable skills, and notable achievements.We are open to part-time applications for this role; please specify your preferred schedule in your cover letter.

Your Impact at Lila Sciences Lila Sciences is seeking a dynamic and visionary Director of Product, Life Sciences to lead our innovative product strategies. In this pivotal role, reporting directly to the Vice President of Life Science Product, you will be at the forefront of enhancing our therapeutic research and development capabilities, shaping the future of drug discovery, chemical synthesis, and scientific intelligence. What You'll Be Building Steer the strategic direction for developing breakthrough AI solutions in drug discovery, chemical synthesis, and molecular characterization. Convert strategic goals into comprehensive target product profiles (TPPs) and development campaigns that will empower our science and engineering teams to achieve groundbreaking innovations in life sciences. Lead customer and internal-user discovery initiatives, acting as the primary technical liaison between external customers and partners. Pinpoint and cultivate product opportunities driven by real-world discovery challenges, collaborating closely with stakeholders to ensure relevance and maximize downstream value. Transform insights into precise product requirements, acceptance criteria, and experimental plans that will guide our engineering and science teams. Oversee product execution from inception to launch, leading cross-functional teams across various disciplines including science, machine learning, automation, and software engineering. Manage resource allocations effectively (budget, compute, lab access, personnel) against a complex array of priorities. Establish clear success metrics and milestones, communicating progress to the organization, including executive leadership. What You'll Need to Succeed Advanced degree (MS, PhD, or equivalent experience) in medicinal chemistry, chemical biology, chemical engineering, biochemistry, or a related field, with a solid foundation in experimental science. 7+ years of experience in Product Management, particularly in developing new or experimental products in drug discovery, molecular profiling, machine learning, or scientific software development. In-depth understanding of drug development processes, molecular and cellular research tools, as well as wet and dry lab workflows. Experience with small molecule discovery workflows (e.g., lead optimization, ADMET profiling, synthesis planning) is highly preferred.

Pioneering Medicines, part of Flagship Pioneering, develops a broad range of new treatments by applying advanced scientific platforms. The team combines deep drug development knowledge with creative approaches to uncover and advance new therapeutic ideas. Close collaboration with Flagship’s bioplatform companies and external partners helps align efforts with R&D priorities, aiming to move discoveries quickly toward development. Role overview The Senior Director, Head of Toxicology leads the toxicology function at Pioneering Medicines. This position sets and executes nonclinical safety strategies across a varied and fast-moving portfolio. The role covers both investigative and regulatory toxicology, supporting multiple therapeutic modalities. Key responsibilities Establish and oversee nonclinical safety strategies for a growing portfolio of drug candidates. Provide scientific and strategic guidance for investigative and regulatory toxicology activities. Collaborate with multidisciplinary teams to support candidate selection and preclinical development. Ensure programs are prepared for regulatory submissions and early clinical development. Requirements Strong analytical skills and scientific rigor. Clear, effective communication across teams and partners. Experience influencing projects from discovery through early clinical stages. This role is based in Cambridge, MA.

We are seeking a passionate and innovative Computational Biologist to join our dynamic team in Cambridge, MA. In this role, you will utilize advanced computational techniques to analyze biological data and contribute to groundbreaking research and development projects in the life sciences. You will collaborate closely with cross-functional teams to drive the integration of computational models with experimental data, ultimately advancing our understanding of complex biological systems.

Join our dynamic team at Integrated Resources Inc. as a Computational Biologist, where you will play a crucial role in advancing our research initiatives. You will leverage your expertise in computational biology to analyze complex biological data and contribute to innovative solutions in the life sciences sector.