Director of Business Development Transactions at Pioneering Medicines

Pioneering Medicines, part of Flagship Pioneering in Cambridge, MA, focuses on developing a wide range of new treatments by building on Flagship’s scientific platforms. The team collaborates with Flagship companies to expand into new therapeutic areas, aiming to bring innovative medicines to more patients faster. With a strong drug development team and access to Flagship’s broader network, Pioneering Medicines generates new therapeutic ideas both internally and through strategic partnerships. Role overview The Director of Business Development Transactions leads strategic transactions for Pioneering Medicines and selected Flagship companies. This position requires strong influence across all organizational levels, excellent organizational and communication skills, and the ability to present complex information clearly. Scientific understanding, strategic thinking, and a collaborative approach are essential, as is comfort working in an entrepreneurial setting. What you will do Lead the structuring, negotiation, and execution of in-licensing, out-licensing, and asset sale transactions for Pioneering Medicines. Negotiate a range of strategic transactions for companies within the Flagship ecosystem. Direct due diligence and financial analysis to support new deals. Present key findings and recommendations to company leadership and investment decision-makers. Additional responsibilities Collaborate with the Partnering team and cross-functional leaders to shape and execute Flagship’s business development strategy. Build credibility across the organization with a deep understanding of biotech and pharmaceutical deal-making. Prepare opportunity assessments, including scientific and portfolio rationale, partnership frameworks, financial evaluations, competitive analysis, and deal term comparisons.

Pioneering Medicines, part of Flagship Pioneering, develops a broad range of new treatments by applying advanced scientific platforms. The team combines deep drug development knowledge with creative approaches to uncover and advance new therapeutic ideas. Close collaboration with Flagship’s bioplatform companies and external partners helps align efforts with R&D priorities, aiming to move discoveries quickly toward development. Role overview The Senior Director, Head of Toxicology leads the toxicology function at Pioneering Medicines. This position sets and executes nonclinical safety strategies across a varied and fast-moving portfolio. The role covers both investigative and regulatory toxicology, supporting multiple therapeutic modalities. Key responsibilities Establish and oversee nonclinical safety strategies for a growing portfolio of drug candidates. Provide scientific and strategic guidance for investigative and regulatory toxicology activities. Collaborate with multidisciplinary teams to support candidate selection and preclinical development. Ensure programs are prepared for regulatory submissions and early clinical development. Requirements Strong analytical skills and scientific rigor. Clear, effective communication across teams and partners. Experience influencing projects from discovery through early clinical stages. This role is based in Cambridge, MA.

At Flagship Pioneering, we are pioneering advancements in biotechnology, creating innovative platform companies that aim to transform the world. We unite visionary scientific minds with entrepreneurial leaders and provide the necessary capital to boldly tackle humanity's most pressing health and sustainability challenges. Our work spans vital areas, including cancer detection and treatment, as well as nature-positive agriculture. What distinguishes Flagship is our unique ability to advance biotechnology by integrating life sciences innovation, company creation, and capital investment. This unprecedented approach unites our scientific founders, entrepreneurial leaders, and professional capital managers around a streamlined process that fosters innovation for the greater good of people and the planet. Our portfolio has made significant strides in addressing critical global issues: from rapidly vaccinating billions against COVID-19 to curing persistent diseases, enhancing health outcomes, preventing illness, and boosting agricultural resilience and sustainability. Flagship has been honored twice on FORTUNE’s “Change the World” list and recognized by Fast Company as one of the World’s Most Innovative Companies. Why Choose Flagship?At Flagship Pioneering, we offer inspiring leadership, a vibrant company culture, competitive compensation, comprehensive benefits, generous paid time off, a beautifully designed office stocked with unlimited snacks and daily free lunches, and meaningful work that promotes endless career growth.

Flagship Pioneering is a groundbreaking biotechnology firm dedicated to inventing and nurturing platform companies that aim to transform the world. We unite leading scientific experts with visionary entrepreneurs and secure the necessary capital for audacious advancements in human health and sustainability. Our innovative strides encompass critical areas including cancer detection and treatment as well as sustainable agriculture.What distinguishes Flagship is our unique capability to propel biotechnology forward by integrating life science innovation, company formation, and capital investment all within a singular framework. Our scientific founders, entrepreneurial leaders, and adept capital managers collaborate through a streamlined process that empowers us to innovate and drive positive change for both humanity and the planet.Flagship has founded numerous companies tackling urgent global challenges, from vaccinating billions against COVID-19 to curing chronic diseases, enhancing human health, preventing illness, and bolstering the sustainability of agriculture.We have been honored twice on FORTUNE’s “Change the World” list, recognizing companies that have made a significant social and environmental impact, and have also been featured on Fast Company’s list of the World’s Most Innovative Companies.

What if... we could leverage Flagship’s groundbreaking scientific platforms to develop innovative treatment options that reach more patients, sooner? Pioneering Medicines (PM), a flagship initiative of Flagship Pioneering, is establishing a world-class biopharmaceutical R&D capability dedicated to creating transformative treatments for patients by utilizing Flagship's unique scientific platforms. Our distinctive approach allows us to integrate various platforms, resulting in genuinely novel therapies for serious diseases with significant unmet medical needs. Position Summary: We are on the lookout for an Executive Director, CMC (Chemistry, Manufacturing & Controls) who possesses a strong history of driving portfolio-level CMC strategies and executing across multiple emerging modality programs simultaneously. This senior leadership role sits at the nexus of science, strategy, and operations, requiring the ability to navigate a complex multimodality pipeline and establish CMC functions as a competitive asset for Pioneering Medicines. Reporting directly to the SVP, CMC & Technical Operations, this position is pivotal. This leader will be responsible for the strategic and operational oversight of CMC across the entire PM portfolio, from research interface through early and late clinical development. They will excel in developing long-term CMC strategies at the portfolio level while adeptly resolving intricate technical challenges at the program level. They will define PM's approach to emerging modalities, build and utilize a premier external Contract Development and Manufacturing Organizations (CDMO) network, and possess the strategic insight to make portfolio-level resource decisions. Additionally, they will be regarded as a thought leader in innovative methodologies and will champion the adoption of AI-enabled CMC tools. Key Responsibilities: Act as a vital member of the Technical Operations leadership team, overseeing CMC functions such as Drug Substance Development, Drug Delivery/Pre-formulation, Analytical Development, Product Development, and Regulatory CMC. You will hold accountability for all aspects of CMC functional strategy and portfolio deliverables. Drive the growth and strategic direction of the CMC organization. This includes recruiting, developing, and retaining a high-performing CMC team while fostering a culture of excellence, accountability, and continuous improvement. Lead and ensure the execution of end-to-end CMC processes across a growing portfolio of multimodality compounds, ensuring timely and strategic program advancement. You will be responsible for identifying portfolio-level CMC risks.

Director of Business Development - USVCLS: Accelerating the Path to PatientsSince 1997, VCLS has been at the forefront of supporting innovators in biotech, Medtech, and Healthtech on their journey from discovery to market. We have a simple yet ambitious mission: to accelerate the delivery of life-changing products to patients. With over 230 industry experts globally, we are dedicated to our long-term vision of delivering 500 new healthtech products by 2050.We are currently on the lookout for a Director of Business Development - US—an experienced, hands-on leader—to implement our US commercial strategy with clarity, intention, and urgency. This role is perfect for an individual who views business development as a consultative art rather than just a transactional process, characterized by curiosity, empathy, and a genuine passion for Life Sciences.Key Results & AccountabilitiesDriving Growth Through Consultative Partnerships Propel significant revenue growth by cultivating strong, trust-based relationships within the biotech, medtech, healthtech, and investment sectors. Take charge of the complete business development lifecycle including listening, identifying opportunities, crafting solutions, and securing strategic partnerships. Exhibit total ownership of the sales process ensuring every client feels comprehensively understood and supported without any handoffs or gaps.Excellence in Client Engagement & Sales OwnershipThis role is committed to delivering a world-class consultative experience, anchored in scientific curiosity and deep client insight: Actively listen and convert client challenges into clear, actionable opportunities. Ensure that clients connect with the right VCLS experts at the right time to maximize value. Coordinate internal teams to facilitate meaningful discussions rather than generic interactions. Lead the development of proposals with meticulous attention, ensuring that each reflects a deep understanding and tailored solutions. Maintain outstanding responsiveness, clarity, and follow-through throughout the client engagement journey.Market Presence & Brand Elevation Represent VCLS credibly and passionately across the US market. Establish a prominent presence at industry events, within accelerators, investor networks, and innovation hubs. Enhance VCLS’s reputation as a reliable partner in regulatory strategy, clinical development, CMC, evidence generation, and commercialization.Stakeholder Leadership & Internal Alignment Collaborate closely with Business Unit leaders, scientific experts, and senior management to ensure seamless execution of business development initiatives. Encourage cross-functional teamwork to optimize client outcomes.

Flagship Pioneering seeks a Senior Director of Human Resources Business Partner based in Cambridge, MA. This role focuses on shaping and executing the people strategy for Flagship’s Pioneering Business Units. The Senior Director will work closely with business unit leaders and the broader HR team to influence key decisions and support organizational goals. What you will do Collaborate with business leaders to design and deliver people strategies for multiple business units Advise on leadership development, talent management, and succession planning Support organizational development and change management initiatives Participate in budgeting, compensation, and workforce planning discussions Guide efforts in performance management, employee engagement, and career growth Address employee relations and help shape internal communication strategies Reporting structure This position reports to the Vice President of HR.

About Flagship Pioneering, Inc. Flagship Pioneering is at the forefront of innovation, dedicated to inventing and nurturing platform companies that have the potential to revolutionize human health, sustainability, and more. Since our inception in 2000, we have successfully launched over 100 companies that tackle some of the world's most pressing challenges, such as vaccinating billions against COVID-19, curing difficult diseases, enhancing human health, preventing illness, and improving agricultural resilience and sustainability. Our commitment to impactful innovation has earned us recognition on FORTUNE's 'Change the World' list, highlighting companies that make a significant social and environmental impact, and we have appeared on Fast Company's annual list of the World’s Most Innovative Companies. Position Summary: We are looking for a passionate and experienced individual to join our Communications and Public Affairs team as the Senior Director of Communications. In this role, you will spearhead the development and implementation of communications and branding strategies for a selection of companies within Flagship Pioneering's diverse portfolio. The ideal candidate will possess a robust background in biotech corporate communications and excel in a fast-paced, startup atmosphere. This is a remarkable opportunity to influence the trajectory of groundbreaking life sciences and technology firms across human health, agriculture, and AI sectors. This full-time role requires in-office presence four days a week in Cambridge, MA. Key Responsibilities: Provide strategic counsel to the founders and leadership of emergent Flagship companies (Flagship NewCos) in developing their brand, voice, foundational messaging, and overall communication strategies. Oversee brand development, visual identity, and website design for NewCos, collaborating with external agencies. Create and implement tailored, integrated communication strategies for company launches, encompassing all written content, media engagement, and social media components. Manage PR agency support as necessary. Develop and execute communication strategies for both NewCos and more established companies (Flagship GrowthCos), including milestone announcements, internal communications, social and digital media strategies, speaking opportunities, and issue management, in close collaboration with company leadership.

THE ROLE As an Associate or Senior Associate within Molly Gibson’s Pioneering Business Unit (PBU) at Flagship Pioneering, you will engage in the ideation, research, and refinement of innovative venture hypotheses. Your primary responsibilities will include validating critical biological and technological unknowns and transforming rigorously tested concepts into a NewCo centered on scientific advancements. You will play a pivotal role in the origination of the company, encompassing the early stages of identifying and recruiting essential partners and advisors, establishing foundational intellectual property, leading the recruitment of the initial scientific team, and fostering a productive team culture. In this position, you will collaborate with stakeholders across the expansive Flagship ecosystem to leverage comprehensive support for your ventures. A successful candidate will become the authority on the foundational science of the enterprise, articulate and frame the strategic direction, and translate this strategy into actionable plans, operationalizing them alongside a Principal or Partner from the venture creation team.

Flagship Pioneering is a pioneering bioplatform innovation company dedicated to inventing and building platform companies that can transform the world. We unite leading scientific minds with entrepreneurial visionaries and mobilize the capital necessary to support their bold ventures. These initiatives are designed to significantly advance human health and sustainable practices, impacting areas such as cancer detection, treatment, and nature-positive agriculture.What distinguishes Flagship is our unique capability to propel biotechnology forward by consolidating life science innovation, company formation, and capital investment in an unprecedented manner. Our scientific founders, entrepreneurial leaders, and skilled capital managers collaborate through a structured process that fosters innovation and transformation for the greater good of society and the environment.Numerous companies founded by Flagship have tackled some of the most pressing challenges faced by humanity: from vaccinating billions against COVID-19 to curing complex diseases, enhancing human health, preventing illnesses, and bolstering agricultural resilience and sustainability.Flagship has received accolades, twice being featured on FORTUNE's 'Change the World' list, which recognizes companies that have made a significant social and environmental impact through their core business strategies, and has also been honored twice on Fast Company's list of the World's Most Innovative Companies.

Join Flagship Pioneering, a leader in the biotechnology sector, as a Corporate Counsel. In this pivotal role, you will provide legal guidance on various corporate matters, ensuring compliance with regulations and supporting strategic initiatives. You will work closely with our executive team to navigate complex legal challenges and help drive our innovative projects forward.

At Flagship Pioneering, we are dedicated to the inventive process that transforms human health, sustainability, and beyond. Since our inception in 2000, we have pioneered over 100 companies that tackle some of the most pressing challenges faced by humanity. Our innovations include efforts such as vaccinating billions against COVID-19, curing complex diseases, improving health outcomes, preventing illness, and enhancing agricultural sustainability.Flagship has earned prestigious recognition, appearing twice on FORTUNE’s “Change the World” list and being named among Fast Company’s World’s Most Innovative Companies. Explore more about our groundbreaking work at www.flagshippioneering.com.We embrace ambitious missions that require bold thinking, guided by our core values that lead us through uncertainty and towards meaningful impact.

Role Overview Flagship Pioneering, Inc. is hiring a Director of Executive and Administrative Services in Cambridge, MA. This leader will guide the strategy and daily operations for executive and administrative support across the organization. The position works closely with senior leadership to strengthen how teams operate and help the company meet its goals. Key Responsibilities Oversee executive and administrative services, setting direction and priorities for these functions Partner with senior leaders to improve organizational effectiveness Drive process improvements that support company objectives Lead, mentor, and develop high-performing teams Foster a collaborative environment that supports growth and innovation What We Look For Extensive experience in administrative operations Proven ability to lead teams and manage change Strong record of improving processes and organizational efficiency Comfort working with executive leadership

Flagship Pioneering, based in Cambridge, MA, builds and grows biotechnology platform companies. The organization brings together scientists, entrepreneurs, and investment to drive advances in areas like cancer diagnosis, disease treatment, and sustainable agriculture. Flagship’s portfolio has played a role in major public health and agricultural achievements and has earned recognition from FORTUNE and Fast Company for its impact and innovation. Role overview The Director of IT Service Delivery and Operations connects strategic IT goals with practical execution at Flagship Pioneering. This leader does not directly manage daily service delivery, but instead establishes the frameworks and governance that empower IT delivery teams. The position sets performance benchmarks, ensures transparency in operations, and oversees the rollout of new IT initiatives. Managing the transition of projects into ongoing operations, including structured hypercare support, is a key part of this role. Key collaboration and focus areas Partner with the Sr. Director of IT Service Delivery to define the service roadmap and set priorities Drive ITIL 4 service management maturity throughout the organization Promote operational discipline to help scale IT services for Flagship and its portfolio companies

Flagship Pioneering, Inc. is seeking a visionary and experienced Director of Antibody Discovery to lead our innovative research team in Cambridge, UK. In this pivotal role, you will be responsible for spearheading the development of novel antibody therapeutics that will define the future of medicine. You will leverage cutting-edge technologies and methodologies to drive our antibody discovery efforts, collaborating closely with cross-functional teams to bring groundbreaking solutions to patients.

Join Our Visionary Team!Pioneering Intelligence, a leader in leveraging cutting-edge advancements in AI and machine learning, invites talented individuals to apply for the position of Senior User Experience Designer. In this pivotal role, you will collaborate with cross-functional teams, including Product, AI research, engineering, legal, communications, and marketing, to tackle significant challenges in the life sciences sector.As we build a next-generation digital framework that integrates computational science, AI/ML, and data platforms, your contributions will be essential in transforming innovative concepts into impactful solutions. Help us shape the future of AI and contribute to projects that make a difference in human health, sustainability, and beyond.

Flagship Pioneering, Inc. is seeking a highly skilled and experienced Director of Financial Planning & Analysis (FP&A) to join our dynamic team. The ideal candidate will play a critical role in shaping financial strategies and driving business performance across our innovative portfolio of companies. You will lead the FP&A team, providing strategic insights and financial guidance to senior management, while ensuring robust financial planning and analysis processes are in place.In this key leadership role, you will be responsible for overseeing financial forecasting, budgeting, and variance analysis. You will collaborate with cross-functional teams to identify opportunities for growth and efficiency, enabling informed decision-making that aligns with our corporate objectives.

Role Overview Flagship Pioneering, Inc. is on the lookout for a visionary Senior/Executive Director to serve as the Head of Biology. In this pivotal role, you will spearhead the biological strategy and target validation within our causality-driven discovery platform. Your expertise will be essential in converting human genetic data—such as GWAS, rare variants, Mendelian randomization, and functional genomics—into robust biological validations that are pertinent to disease, while also shaping preclinical programs across a range of therapeutic areas. The ideal candidate will possess extensive target validation experience across various therapeutic modalities, with a strong emphasis on neurodegenerative diseases (including Parkinson’s disease), genomic perturbation tools, and the capability to make significant contributions to cardiovascular and immune-mediated biology. You will be responsible for building and mentoring an exceptional biology team, establishing high standards for scientific rigor and decision-making quality, and collaborating closely with data science, chemistry, and platform operations to progress targets to development readiness.

Imagine being part of an organization that pioneers life sciences companies dedicated to developing groundbreaking technologies that enhance human health and promote sustainability.Since its inception in 2000, Flagship Pioneering has effectively used its innovative venture creation engine to establish notable companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Flagship has successfully launched over 100 scientific ventures, generating an impressive aggregate value of more than $212 billion. With an investment of over $2.5 billion in capital towards founding and nurturing pioneering companies, alongside $19 billion in follow-on investments from various institutions, Flagship Pioneering was recognized as the 12th company globally on Fortune’s “Change the World” list in 2021 for its significant positive social and environmental impact.About Our Company:FL116, an innovative biotechnology company backed by Flagship Pioneering, is revolutionizing the synthesis of biomolecules. Our cutting-edge platform is set to redefine the design and construction of critical research, diagnostic, and therapeutic molecules. We are on the lookout for enthusiastic problem solvers eager to create an impactful change in biotechnology and therapeutic innovation.Position Overview:The Senior Manager of Corporate Development and Enablement will play a crucial role as a strategic and operational partner to the President, spearheading high-impact initiatives across corporate development, partnerships, investor and board communications, operations, and market-informed product strategies. This pivotal position will require collaboration with scientific and business leaders to translate intricate technical and market insights into coherent strategies and actionable plans. The ideal candidate will excel in navigating ambiguity, bring a methodical and analytical mindset to problem-solving, and be adept at both shaping strategy and executing it within a dynamic, early-stage biotechnology context.Key Responsibilities:Report directly to the President, leading the development of internal and external company presentations and reports, including board materials and pitches.Facilitate the weekly company leadership team meetings, managing the agenda and tracking key action items arising from discussions.Oversee major external partnerships, ensuring alignment with timelines and budget considerations.

As the Director of Biomarker Development at Scholar Rock, you will lead our innovative team in the discovery and validation of biomarkers that drive the development of transformative therapies. Your expertise will be crucial in guiding our biomarker strategies, collaborating with cross-functional teams, and ensuring alignment with our overall scientific objectives. We are seeking a visionary leader who is passionate about advancing precision medicine and dedicated to improving patient outcomes.