Contracts Systems Manager at Flagship Pioneering | Cambridge, MA

At Flagship Pioneering, we are dedicated to the inventive process that transforms human health, sustainability, and beyond. Since our inception in 2000, we have pioneered over 100 companies that tackle some of the most pressing challenges faced by humanity. Our innovations include efforts such as vaccinating billions against COVID-19, curing complex diseases, improving health outcomes, preventing illness, and enhancing agricultural sustainability.Flagship has earned prestigious recognition, appearing twice on FORTUNE’s “Change the World” list and being named among Fast Company’s World’s Most Innovative Companies. Explore more about our groundbreaking work at www.flagshippioneering.com.We embrace ambitious missions that require bold thinking, guided by our core values that lead us through uncertainty and towards meaningful impact.

Join Flagship Pioneering, a leader in the biotechnology sector, as a Corporate Counsel. In this pivotal role, you will provide legal guidance on various corporate matters, ensuring compliance with regulations and supporting strategic initiatives. You will work closely with our executive team to navigate complex legal challenges and help drive our innovative projects forward.

Flagship Pioneering’s Pioneering Medicines (PM) initiative focuses on creating new therapies for serious diseases by integrating multiple scientific platforms. The team aims to address significant unmet medical needs through advanced biopharmaceutical R&D. Role overview The Executive Director, CMC (Chemistry, Manufacturing & Controls) will provide both strategic and operational leadership across the full PM portfolio, spanning research through late-stage clinical development. This position reports to the SVP, CMC & Technical Operations and plays a central role in shaping CMC as a core strength for Pioneering Medicines. This leader will develop long-term CMC strategies, resolve technical challenges at both the portfolio and program levels, and define approaches for emerging modalities. Building and managing a top-tier network of external Contract Development and Manufacturing Organizations (CDMOs) is a key part of the role. The Executive Director will also guide resource allocation and promote adoption of innovative, including AI-enabled, CMC tools. Key responsibilities Serve as a senior member of the Technical Operations leadership team, overseeing CMC areas such as Drug Substance Development, Drug Delivery/Pre-formulation, Analytical Development, Product Development, and Regulatory CMC. Responsible for CMC strategy and portfolio deliverables. Grow and guide the CMC organization by recruiting, developing, and retaining talent. Foster a culture focused on excellence, accountability, and ongoing improvement. Lead end-to-end CMC processes for a diverse and expanding portfolio of multimodality compounds. Ensure timely advancement of programs and proactively identify and manage portfolio-level CMC risks. What sets this role apart This position sits at the intersection of science, strategy, and operations. The Executive Director will influence how Pioneering Medicines approaches new therapeutic modalities and will be recognized as a thought leader in the field, especially in adopting innovative methodologies and digital tools.

THE ROLE As an Associate or Senior Associate within Molly Gibson’s Pioneering Business Unit (PBU) at Flagship Pioneering, you will engage in the ideation, research, and refinement of innovative venture hypotheses. Your primary responsibilities will include validating critical biological and technological unknowns and transforming rigorously tested concepts into a NewCo centered on scientific advancements. You will play a pivotal role in the origination of the company, encompassing the early stages of identifying and recruiting essential partners and advisors, establishing foundational intellectual property, leading the recruitment of the initial scientific team, and fostering a productive team culture. In this position, you will collaborate with stakeholders across the expansive Flagship ecosystem to leverage comprehensive support for your ventures. A successful candidate will become the authority on the foundational science of the enterprise, articulate and frame the strategic direction, and translate this strategy into actionable plans, operationalizing them alongside a Principal or Partner from the venture creation team.

Flagship Pioneering is a pioneering bioplatform innovation company dedicated to inventing and building platform companies that can transform the world. We unite leading scientific minds with entrepreneurial visionaries and mobilize the capital necessary to support their bold ventures. These initiatives are designed to significantly advance human health and sustainable practices, impacting areas such as cancer detection, treatment, and nature-positive agriculture.What distinguishes Flagship is our unique capability to propel biotechnology forward by consolidating life science innovation, company formation, and capital investment in an unprecedented manner. Our scientific founders, entrepreneurial leaders, and skilled capital managers collaborate through a structured process that fosters innovation and transformation for the greater good of society and the environment.Numerous companies founded by Flagship have tackled some of the most pressing challenges faced by humanity: from vaccinating billions against COVID-19 to curing complex diseases, enhancing human health, preventing illnesses, and bolstering agricultural resilience and sustainability.Flagship has received accolades, twice being featured on FORTUNE's 'Change the World' list, which recognizes companies that have made a significant social and environmental impact through their core business strategies, and has also been honored twice on Fast Company's list of the World's Most Innovative Companies.

Flagship Pioneering Inc. creates and develops platform companies that address significant issues in human health and sustainability. Located in Cambridge, MA, the organization has launched over 100 companies since 2000. Its portfolio includes businesses that have played key roles in vaccination initiatives, chronic disease management, health improvement, illness prevention, and sustainable agriculture for food security. Role overview The Contracts Manager will handle the drafting, review, and management of contracts supporting Flagship Pioneering’s diverse portfolio. This position works to ensure that all agreements are consistent with company objectives and meet compliance requirements. What you will do Support the creation of contracts for various business needs across the company’s portfolio. Manage contract lifecycles, from initial drafting through execution and renewal. Help maintain compliance with internal standards and external regulations. Requirements Experience in contract management or a related legal or business function. Strong attention to detail and organizational skills. Ability to align agreements with company goals and compliance standards.

Flagship Pioneering builds bioplatform companies focused on solving challenges in human health and sustainability. The organization brings together scientists, entrepreneurs, and investors to advance projects in cancer detection, disease treatment, and sustainable agriculture. By combining innovation in life sciences, company creation, and investment under one roof, Flagship enables scientific founders, business leaders, and capital managers to work together through a structured process. This collaborative approach aims to create measurable improvements for people and the planet. Flagship’s portfolio features ventures that have immunized billions against COVID-19, developed treatments for diseases once considered untreatable, improved health outcomes, and promoted sustainable agriculture. The company has been recognized on FORTUNE’s “Change the World” list twice and named among Fast Company’s most innovative companies. Role overview The Senior Manager of HR Operations and Systems leads the management and ongoing development of Flagship’s HR technology environment. This position is responsible for UKG and oversees platforms such as Greenhouse, along with other HR systems. The scope includes daily operations, system governance, integrations, and long-term HR technology strategy. Reporting to the Associate Director of HR Operations & Analytics, this leader partners with HR, Legal, Payroll, Finance, and IT teams. The focus is on designing and maintaining scalable, compliant HR operations that provide reliable service, strong data integrity, and a smooth employee experience throughout the employee lifecycle. Key responsibilities Manage and improve the HR systems ecosystem, with a focus on UKG and Greenhouse Oversee daily HR systems operations, including governance and integrations Maintain compliance, data quality, and effective service delivery across HR platforms Work with cross-functional teams to support scalable HR processes Guide the strategic direction of HR systems to align with company growth Location Cambridge, MA, USA

About Us At Flagship Pioneering, we are at the forefront of biotechnology innovation. Our mission is to create and nurture transformative companies that are dedicated to solving the world’s most pressing challenges. By assembling leading scientific experts and entrepreneurial visionaries, we empower groundbreaking advancements in human health and sustainability, spanning areas from precision cancer therapies to sustainable agricultural solutions. What distinguishes Flagship is our unique methodology that integrates life science innovation, enterprise creation, and strategic investment within a single framework. Our dedicated scientific founders, entrepreneurial leaders, and investment professionals collaborate effectively, driving an institutionalized process that fosters innovation and delivers significant benefits to society and the environment. Many of our portfolio companies have made substantial contributions to global health and sustainability, including mass COVID-19 vaccination efforts, curing chronic diseases, enhancing overall health, and developing resilient agricultural practices. Flagship has received prestigious accolades, including placements on FORTUNE’s “Change the World” list and recognition as one of Fast Company’s Most Innovative Companies. Our Lab IT and Research Systems teams are committed to facilitating scientific breakthroughs throughout the Flagship ecosystem by providing robust, scalable, and secure technological solutions that support both laboratory and computational research. We work in close partnership with our research teams to optimize their tools, systems, and environments to enhance productivity, reproducibility, and innovation. Position Overview The Lab Systems Analyst I plays a key role in overseeing the management, reliability, and improvement of laboratory and research systems across Flagship’s internal and portfolio companies. This position emphasizes the maintenance of effective lab system environments, ensuring secure and compliant data handling, and supporting integrations that streamline the capture, storage, and analysis of scientific data. We seek a candidate who combines foundational IT support experience with a keen interest in scientific systems, cloud infrastructure, and data workflows. The Lab Systems Analyst will collaborate closely with Lab IT, Research Systems, and scientific teams to ensure laboratory environments are robust and aligned with research objectives. Key Responsibilities Lab Systems Management Assist in the administration and lifecycle management of lab systems, ensuring optimal performance and compliance.

Pioneering Medicines, part of Flagship Pioneering, develops a broad range of new treatments by applying advanced scientific platforms. The team combines deep drug development knowledge with creative approaches to uncover and advance new therapeutic ideas. Close collaboration with Flagship’s bioplatform companies and external partners helps align efforts with R&D priorities, aiming to move discoveries quickly toward development. Role overview The Senior Director, Head of Toxicology leads the toxicology function at Pioneering Medicines. This position sets and executes nonclinical safety strategies across a varied and fast-moving portfolio. The role covers both investigative and regulatory toxicology, supporting multiple therapeutic modalities. Key responsibilities Establish and oversee nonclinical safety strategies for a growing portfolio of drug candidates. Provide scientific and strategic guidance for investigative and regulatory toxicology activities. Collaborate with multidisciplinary teams to support candidate selection and preclinical development. Ensure programs are prepared for regulatory submissions and early clinical development. Requirements Strong analytical skills and scientific rigor. Clear, effective communication across teams and partners. Experience influencing projects from discovery through early clinical stages. This role is based in Cambridge, MA.

Flagship Pioneering Inc. is known for launching and nurturing life sciences companies that focus on advancing human health and sustainability. Since 2000, the organization has created over 100 ventures, including Moderna Therapeutics, Rubius Therapeutics, Sana Biotechnology, Generate Biomedicines, and Tessera Therapeutics. These efforts have led to a combined value exceeding $212 billion and recognition on Fortune’s “Change the World” list in 2021. FL116, a Flagship-backed biotechnology company, is developing a new platform for synthesizing biomolecules used in research, diagnostics, and therapeutics. The team values creative problem solvers who want to drive change in biotechnology and therapeutic innovation. Role overview The Senior Manager of Corporate Development and Enablement partners closely with the President to drive strategic and operational initiatives. This role covers corporate development, partnerships, investor and board communications, operations, and product strategy informed by market needs. Success in this position requires collaboration with both scientific and business leaders, translating complex technical and market insights into clear strategies and actionable plans. The environment is early-stage and fast-evolving, so adaptability and a structured, analytical approach are essential. What you will do Report directly to the President, preparing internal and external presentations and reports, including materials for the board and investor pitches. Facilitate weekly leadership team meetings, set agendas, and track action items from discussions. Oversee major external partnerships, ensuring projects stay on schedule and within budget. Requirements Strong ability to navigate ambiguity and solve problems methodically. Experience shaping and executing strategy in an early-stage biotechnology or similar context. Skilled at collaborating across scientific and business teams.

Company Overview: Flagship Labs 109, Inc. (FL109) is an innovative, privately held technology company that is at the forefront of revolutionizing biological sciences through the integration of artificial intelligence, physics, and advanced hardware. Founded by Flagship Pioneering, we are driven by a mission to achieve extraordinary results and redefine the future of science. Join our dedicated team and contribute to our transformative vision. Role Overview: As the Director of Sales, you will play a crucial role in spearheading customer acquisition, forging strategic partnerships, and driving revenue growth across our VaaS, SaaS, and platform offerings. This dynamic leadership position calls for a commercially adept structural biologist or a technical sales leader who excels in both strategic planning and tactical execution. You will be accountable for achieving defined bookings targets, leading comprehensive customer engagement, and acting as the commercial "mini-CEO" for our client relationships. Your responsibilities will also include shaping FL109’s market development strategy, identifying and nurturing prospective customers, participating in key industry events, and producing impactful content that enhances brand awareness and customer engagement. This is an ideal opportunity for a driven leader who thrives in building structures, establishing customer relations, and developing scalable business systems in a rapidly evolving market.

COMPANY DESCRIPTION Flagship Pioneering is a leading platform for innovation that not only invents but also builds transformative companies that aim to change the world. By uniting some of the most brilliant scientific minds with entrepreneurial builders and the necessary capital, we empower them to make bold advancements. Our efforts catalyze progress in crucial areas such as healthcare, sustainability, and beyond, driving scientific breakthroughs ranging from disease detection and treatment to sustainable agriculture and innovative AI applications. What distinguishes Flagship is our unique ability to propel science and technology forward by integrating innovation, company creation, and capital investment into a cohesive process that is largely unprecedented. Our team of scientific founders, entrepreneurial leaders, and professional capital managers collaborate through a systematic approach designed to foster innovation and transformation for the benefit of humanity and the planet. Many of the companies we have established have tackled some of humanity's most pressing challenges, including vaccinating billions against COVID-19, curing chronic diseases, enhancing human health, preventing illnesses, and improving agricultural resilience and sustainability. Flagship has received accolades on FORTUNE’s “Change the World” list for two consecutive years and has been recognized on Fast Company’s list of the World’s Most Innovative Companies. THE ROLE We are on the lookout for a highly motivated, proactive, and detail-oriented Laboratory Operations Associate to become a vital part of our rapidly expanding team. This role involves supporting our research team by managing laboratory operations and ensuring safety protocols are followed, while also addressing day-to-day operational needs and implementing best practices within the lab. The ideal candidate will assist in optimizing R&D operations, support purchasing processes, and contribute to ongoing projects. A high degree of organization, adaptability to a fast-paced entrepreneurial environment, and strong collaboration skills are essential.

At Flagship Pioneering, we are dedicated to inventing and developing transformative platform companies that address critical challenges in human health, sustainability, and more. Since our inception in 2000, we have established over 100 innovative companies, contributing to monumental advancements such as vaccinating billions against COVID-19, curing chronic diseases, enhancing human health, preventing illnesses, and strengthening agricultural resilience and sustainability.Flagship Pioneering has earned recognition on FORTUNE’s “Change the World” list multiple times for our commitment to creating positive social and environmental impacts through our core business strategies. Additionally, we have been honored on Fast Company’s annual list of the World’s Most Innovative Companies. Discover more about us at www.flagshippioneering.com.We embrace ambitious challenges to foster significant advancements, guided by our core values that navigate us through uncertainty towards lasting impact.Position Summary:As a Senior Accountant reporting to the Controller, you will play a crucial role in the accounting and financial operations for a portfolio of Flagship entities, supporting various business and operational initiatives. In this dynamic position, you will engage with diverse strategies, accounting processes, and financial reporting systems, collaborating closely with the VP of Finance and leadership teams.Key Responsibilities:Perform month-end, quarter-end, and year-end closing activities accurately and timely, including journal entries, balance sheet reconciliations, intercompany invoicing, account analyses, and accruals for multiple portfolio companies, adhering to the established close calendar.Work alongside the Controller and FP&A team to facilitate monthly financial reviews, maintain forecasting models, and assist in various financial analysis tasks.

Company Summary:At FL122, we are at the forefront of pioneering genomic technologies that redefine human health and assisted reproduction. Founded by the innovative Flagship Pioneering, we are dedicated to creating, funding, and nurturing first-in-category life sciences companies. Our portfolio includes over 100 groundbreaking companies developed over the past two decades, such as Moderna (MRNA), Generate Biomedicines, Tessera Therapeutics, and Quotient Therapeutics. We pride ourselves on being an equal opportunity employer.Position Summary:We are in search of our inaugural Computational Genomics Scientist to spearhead vital research that will underpin our scientific platform. As an early-stage team member, you will enjoy significant ownership of your work, shaping our analytical strategy from the ground up by integrating genomics, statistical genetics, and advanced modeling techniques. Your responsibilities will encompass the comprehensive delivery of computational research projects, including design, execution, interpretation, and communication of results to senior leadership. We seek a resourceful individual who thrives in a fast-paced, agile environment and possesses a proactive mindset. The ideal candidate will combine technical expertise with a growth-oriented approach, meticulous attention to detail, and a relentless drive for excellence. Collaboration is essential in our startup environment, where all team members work closely to push the boundaries of scientific discovery.

About Flagship Pioneering, Inc. Flagship Pioneering is at the forefront of innovation, dedicated to inventing and nurturing platform companies that have the potential to revolutionize human health, sustainability, and more. Since our inception in 2000, we have successfully launched over 100 companies that tackle some of the world's most pressing challenges, such as vaccinating billions against COVID-19, curing difficult diseases, enhancing human health, preventing illness, and improving agricultural resilience and sustainability. Our commitment to impactful innovation has earned us recognition on FORTUNE's 'Change the World' list, highlighting companies that make a significant social and environmental impact, and we have appeared on Fast Company's annual list of the World’s Most Innovative Companies. Position Summary: We are looking for a passionate and experienced individual to join our Communications and Public Affairs team as the Senior Director of Communications. In this role, you will spearhead the development and implementation of communications and branding strategies for a selection of companies within Flagship Pioneering's diverse portfolio. The ideal candidate will possess a robust background in biotech corporate communications and excel in a fast-paced, startup atmosphere. This is a remarkable opportunity to influence the trajectory of groundbreaking life sciences and technology firms across human health, agriculture, and AI sectors. This full-time role requires in-office presence four days a week in Cambridge, MA. Key Responsibilities: Provide strategic counsel to the founders and leadership of emergent Flagship companies (Flagship NewCos) in developing their brand, voice, foundational messaging, and overall communication strategies. Oversee brand development, visual identity, and website design for NewCos, collaborating with external agencies. Create and implement tailored, integrated communication strategies for company launches, encompassing all written content, media engagement, and social media components. Manage PR agency support as necessary. Develop and execute communication strategies for both NewCos and more established companies (Flagship GrowthCos), including milestone announcements, internal communications, social and digital media strategies, speaking opportunities, and issue management, in close collaboration with company leadership.

Flagship Pioneering, Inc. is seeking a highly skilled and experienced Director of Financial Planning & Analysis (FP&A) to join our dynamic team. The ideal candidate will play a critical role in shaping financial strategies and driving business performance across our innovative portfolio of companies. You will lead the FP&A team, providing strategic insights and financial guidance to senior management, while ensuring robust financial planning and analysis processes are in place.In this key leadership role, you will be responsible for overseeing financial forecasting, budgeting, and variance analysis. You will collaborate with cross-functional teams to identify opportunities for growth and efficiency, enabling informed decision-making that aligns with our corporate objectives.

Flagship Pioneering is at the forefront of innovation, dedicated to inventing and developing platform companies that aim to revolutionize human health, sustainability, and beyond. Since our inception in 2000, we have successfully established over 100 companies that tackle some of the world's most pressing challenges, including the global vaccination efforts against COVID-19, finding cures for chronic diseases, enhancing overall health, preventing illness, and bolstering the sustainability and resilience of agricultural practices. Recognized on multiple occasions in FORTUNE’s “Change the World” list for our positive social and environmental impact, and featured in Fast Company’s annual list of the World’s Most Innovative Companies, Flagship is committed to making a difference through our core business strategies. Discover more about our mission and values at www.flagshippioneering.com. At Flagship, we embrace challenging missions that inspire monumental progress. Our core values guide us through uncertainty, driving us towards impactful solutions.

At Flagship Pioneering, we are pioneering advancements in biotechnology, creating innovative platform companies that aim to transform the world. We unite visionary scientific minds with entrepreneurial leaders and provide the necessary capital to boldly tackle humanity's most pressing health and sustainability challenges. Our work spans vital areas, including cancer detection and treatment, as well as nature-positive agriculture. What distinguishes Flagship is our unique ability to advance biotechnology by integrating life sciences innovation, company creation, and capital investment. This unprecedented approach unites our scientific founders, entrepreneurial leaders, and professional capital managers around a streamlined process that fosters innovation for the greater good of people and the planet. Our portfolio has made significant strides in addressing critical global issues: from rapidly vaccinating billions against COVID-19 to curing persistent diseases, enhancing health outcomes, preventing illness, and boosting agricultural resilience and sustainability. Flagship has been honored twice on FORTUNE’s “Change the World” list and recognized by Fast Company as one of the World’s Most Innovative Companies. Why Choose Flagship?At Flagship Pioneering, we offer inspiring leadership, a vibrant company culture, competitive compensation, comprehensive benefits, generous paid time off, a beautifully designed office stocked with unlimited snacks and daily free lunches, and meaningful work that promotes endless career growth.

About Pioneering Intelligence Imagine harnessing the power of science, data, and artificial intelligence to revolutionize technology and accelerate innovation. This is the mission of Pioneering Intelligence, an initiative by Flagship Pioneering that aims to blend cutting-edge research with digital sciences. We are committed to creating AI and machine learning-driven platforms that can transform human health, sustainability, and more. Pioneering Intelligence builds upon Flagship's legacy of pioneering companies at the forefront of AI, driving advancements throughout the ecosystem and enabling the creation of groundbreaking innovations. Our team comprises computational scientists and engineers from diverse fields including applied mathematics, nuclear physics, engineering, and computational biology. We leverage our collective expertise to tap into the broad spectrum of scientific knowledge and promote innovative thinking that transcends conventional computational boundaries. We are constructing a next-generation digital foundation that combines computational science, AI/ML, knowledge engineering, data platforms, and workflow automation. These capabilities empower Flagship to explore uncharted territories and transform scientific insights into transformative enterprises. About the Role The Flagship Data Platform is a shared resource that facilitates swift progress for Flagship companies by providing secure and well-governed access to reliable data across our portfolio. As the Senior Director, Product Manager for the Data Platform, you will spearhead the product strategy, roadmap, and execution from initial use cases to widespread adoption. You will collaborate closely with software and ML engineers, UX designers, scientists, and senior stakeholders across various companies to convert ambiguous, high-value opportunities into impactful products that enhance scientific discovery and decision-making. You thrive in a dynamic, interdisciplinary environment and can seamlessly transition between strategic planning, discovery, and hands-on execution. Key Responsibilities Develop and maintain the comprehensive product vision and roadmap, establishing metrics and priorities to optimize impact. Swiftly conduct product discovery through user research, problem definition, prototyping, and validation. Coordinate priorities with an empowered technical lead. Utilize product analytics, qualitative feedback, and experimentation to guide decision-making. Effectively communicate results to stakeholders. Define and apply metrics to measure product effectiveness.

Didn't find your dream job? We invite you to submit your resume for future opportunities that may align with your skills and interests!Please complete the information below so we can better understand your capabilities.What We Offer:Make a meaningful impact as part of a Fortune “Change the World” companyWork alongside inspirational colleagues and visionary leadersExperience a dynamic and innovative environment that combines startup culture with robust support from the Flagship ecosystemA platform for professional growth, learning, and leadership