Associate/Senior Associate at Flagship Pioneering | Cambridge, MA

THE ROLE As an Associate or Senior Associate within Molly Gibson’s Pioneering Business Unit (PBU) at Flagship Pioneering, you will engage in the ideation, research, and refinement of innovative venture hypotheses. Your primary responsibilities will include validating critical biological and technological unknowns and transforming rigorously tested concepts into a NewCo centered on scientific advancements. You will play a pivotal role in the origination of the company, encompassing the early stages of identifying and recruiting essential partners and advisors, establishing foundational intellectual property, leading the recruitment of the initial scientific team, and fostering a productive team culture. In this position, you will collaborate with stakeholders across the expansive Flagship ecosystem to leverage comprehensive support for your ventures. A successful candidate will become the authority on the foundational science of the enterprise, articulate and frame the strategic direction, and translate this strategy into actionable plans, operationalizing them alongside a Principal or Partner from the venture creation team.

Join Flagship Pioneering, a leader in the biotechnology sector, as a Corporate Counsel. In this pivotal role, you will provide legal guidance on various corporate matters, ensuring compliance with regulations and supporting strategic initiatives. You will work closely with our executive team to navigate complex legal challenges and help drive our innovative projects forward.

Flagship Pioneering is a pioneering bioplatform innovation company dedicated to inventing and building platform companies that can transform the world. We unite leading scientific minds with entrepreneurial visionaries and mobilize the capital necessary to support their bold ventures. These initiatives are designed to significantly advance human health and sustainable practices, impacting areas such as cancer detection, treatment, and nature-positive agriculture.What distinguishes Flagship is our unique capability to propel biotechnology forward by consolidating life science innovation, company formation, and capital investment in an unprecedented manner. Our scientific founders, entrepreneurial leaders, and skilled capital managers collaborate through a structured process that fosters innovation and transformation for the greater good of society and the environment.Numerous companies founded by Flagship have tackled some of the most pressing challenges faced by humanity: from vaccinating billions against COVID-19 to curing complex diseases, enhancing human health, preventing illnesses, and bolstering agricultural resilience and sustainability.Flagship has received accolades, twice being featured on FORTUNE's 'Change the World' list, which recognizes companies that have made a significant social and environmental impact through their core business strategies, and has also been honored twice on Fast Company's list of the World's Most Innovative Companies.

At Flagship Pioneering, we are dedicated to the inventive process that transforms human health, sustainability, and beyond. Since our inception in 2000, we have pioneered over 100 companies that tackle some of the most pressing challenges faced by humanity. Our innovations include efforts such as vaccinating billions against COVID-19, curing complex diseases, improving health outcomes, preventing illness, and enhancing agricultural sustainability.Flagship has earned prestigious recognition, appearing twice on FORTUNE’s “Change the World” list and being named among Fast Company’s World’s Most Innovative Companies. Explore more about our groundbreaking work at www.flagshippioneering.com.We embrace ambitious missions that require bold thinking, guided by our core values that lead us through uncertainty and towards meaningful impact.

COMPANY DESCRIPTION Flagship Pioneering is a leading platform for innovation that not only invents but also builds transformative companies that aim to change the world. By uniting some of the most brilliant scientific minds with entrepreneurial builders and the necessary capital, we empower them to make bold advancements. Our efforts catalyze progress in crucial areas such as healthcare, sustainability, and beyond, driving scientific breakthroughs ranging from disease detection and treatment to sustainable agriculture and innovative AI applications. What distinguishes Flagship is our unique ability to propel science and technology forward by integrating innovation, company creation, and capital investment into a cohesive process that is largely unprecedented. Our team of scientific founders, entrepreneurial leaders, and professional capital managers collaborate through a systematic approach designed to foster innovation and transformation for the benefit of humanity and the planet. Many of the companies we have established have tackled some of humanity's most pressing challenges, including vaccinating billions against COVID-19, curing chronic diseases, enhancing human health, preventing illnesses, and improving agricultural resilience and sustainability. Flagship has received accolades on FORTUNE’s “Change the World” list for two consecutive years and has been recognized on Fast Company’s list of the World’s Most Innovative Companies. THE ROLE We are on the lookout for a highly motivated, proactive, and detail-oriented Laboratory Operations Associate to become a vital part of our rapidly expanding team. This role involves supporting our research team by managing laboratory operations and ensuring safety protocols are followed, while also addressing day-to-day operational needs and implementing best practices within the lab. The ideal candidate will assist in optimizing R&D operations, support purchasing processes, and contribute to ongoing projects. A high degree of organization, adaptability to a fast-paced entrepreneurial environment, and strong collaboration skills are essential.

Pioneering Medicines, part of Flagship Pioneering, develops a broad range of new treatments by applying advanced scientific platforms. The team combines deep drug development knowledge with creative approaches to uncover and advance new therapeutic ideas. Close collaboration with Flagship’s bioplatform companies and external partners helps align efforts with R&D priorities, aiming to move discoveries quickly toward development. Role overview The Senior Director, Head of Toxicology leads the toxicology function at Pioneering Medicines. This position sets and executes nonclinical safety strategies across a varied and fast-moving portfolio. The role covers both investigative and regulatory toxicology, supporting multiple therapeutic modalities. Key responsibilities Establish and oversee nonclinical safety strategies for a growing portfolio of drug candidates. Provide scientific and strategic guidance for investigative and regulatory toxicology activities. Collaborate with multidisciplinary teams to support candidate selection and preclinical development. Ensure programs are prepared for regulatory submissions and early clinical development. Requirements Strong analytical skills and scientific rigor. Clear, effective communication across teams and partners. Experience influencing projects from discovery through early clinical stages. This role is based in Cambridge, MA.

At Flagship Pioneering, we are pioneering advancements in biotechnology, creating innovative platform companies that aim to transform the world. We unite visionary scientific minds with entrepreneurial leaders and provide the necessary capital to boldly tackle humanity's most pressing health and sustainability challenges. Our work spans vital areas, including cancer detection and treatment, as well as nature-positive agriculture. What distinguishes Flagship is our unique ability to advance biotechnology by integrating life sciences innovation, company creation, and capital investment. This unprecedented approach unites our scientific founders, entrepreneurial leaders, and professional capital managers around a streamlined process that fosters innovation for the greater good of people and the planet. Our portfolio has made significant strides in addressing critical global issues: from rapidly vaccinating billions against COVID-19 to curing persistent diseases, enhancing health outcomes, preventing illness, and boosting agricultural resilience and sustainability. Flagship has been honored twice on FORTUNE’s “Change the World” list and recognized by Fast Company as one of the World’s Most Innovative Companies. Why Choose Flagship?At Flagship Pioneering, we offer inspiring leadership, a vibrant company culture, competitive compensation, comprehensive benefits, generous paid time off, a beautifully designed office stocked with unlimited snacks and daily free lunches, and meaningful work that promotes endless career growth.

Flagship Pioneering is at the forefront of innovation, dedicated to inventing and developing platform companies that aim to revolutionize human health, sustainability, and beyond. Since our inception in 2000, we have successfully established over 100 companies that tackle some of the world's most pressing challenges, including the global vaccination efforts against COVID-19, finding cures for chronic diseases, enhancing overall health, preventing illness, and bolstering the sustainability and resilience of agricultural practices. Recognized on multiple occasions in FORTUNE’s “Change the World” list for our positive social and environmental impact, and featured in Fast Company’s annual list of the World’s Most Innovative Companies, Flagship is committed to making a difference through our core business strategies. Discover more about our mission and values at www.flagshippioneering.com. At Flagship, we embrace challenging missions that inspire monumental progress. Our core values guide us through uncertainty, driving us towards impactful solutions.

Join Engine as a Senior Associate in Community OperationsAt Engine, we empower visionary founders who are tackling the world's most critical challenges in areas such as climate change, health, and advanced technologies. Our commitment includes providing robust support through founder programs, access to shared infrastructure and labs, and the opportunity to connect with a diverse national network of corporate partners, investors, and industry experts.

Join eGenesis as a Senior Clinical Research AssociateAt eGenesis, we are at the forefront of innovation in biotechnology, developing human-compatible engineered organs to combat the critical global organ shortage. Our cutting-edge genome engineering platform allows for extensive gene modifications, effectively removing biological barriers and introducing protective human transgenes. Our leading program, EGEN-2784, involves a genetically engineered porcine kidney currently under a multi-patient Expanded Access study at Massachusetts General Hospital (MGH). We are proudly headquartered in Cambridge, MA, and are dedicated to making a significant impact on healthcare.We are currently in search of a highly skilled Senior Clinical Research Associate with over 4 years of experience in monitoring intricate clinical trials within pharmaceutical, biotechnology, and CRO settings. The ideal candidate will demonstrate proven expertise in managing investigative sites, conducting site qualifications, initiation, routine monitoring (both on-site and remote), and closeout visits while ensuring adherence to ICH-GCP, regulatory requirements, and study protocols. You will be tasked with overseeing site performance, preserving data integrity through source data verification and CRF review, and maintaining timely documentation in eTMF, CTMS, and EDC systems. Additionally, you will support site start-up activities, provide training for investigators and site staff, and offer operational guidance to academic medical centers, particularly those with limited IND experience. The right candidate will possess strong capabilities in identifying operational risks, implementing effective mitigation strategies, and managing high volumes of clinical data to uphold patient safety, data quality, and study compliance. Reporting to the Lead CRA or Clinical Operations leadership, you will execute monitoring strategies and facilitate consistent oversight of assigned sites. We value collaboration and are looking for a team player who can work closely with investigative sites and cross-functional teams to enhance enrollment, address operational challenges, and ensure inspection readiness.

At Flagship Pioneering, we are dedicated to inventing and developing transformative platform companies that address critical challenges in human health, sustainability, and more. Since our inception in 2000, we have established over 100 innovative companies, contributing to monumental advancements such as vaccinating billions against COVID-19, curing chronic diseases, enhancing human health, preventing illnesses, and strengthening agricultural resilience and sustainability.Flagship Pioneering has earned recognition on FORTUNE’s “Change the World” list multiple times for our commitment to creating positive social and environmental impacts through our core business strategies. Additionally, we have been honored on Fast Company’s annual list of the World’s Most Innovative Companies. Discover more about us at www.flagshippioneering.com.We embrace ambitious challenges to foster significant advancements, guided by our core values that navigate us through uncertainty towards lasting impact.Position Summary:As a Senior Accountant reporting to the Controller, you will play a crucial role in the accounting and financial operations for a portfolio of Flagship entities, supporting various business and operational initiatives. In this dynamic position, you will engage with diverse strategies, accounting processes, and financial reporting systems, collaborating closely with the VP of Finance and leadership teams.Key Responsibilities:Perform month-end, quarter-end, and year-end closing activities accurately and timely, including journal entries, balance sheet reconciliations, intercompany invoicing, account analyses, and accruals for multiple portfolio companies, adhering to the established close calendar.Work alongside the Controller and FP&A team to facilitate monthly financial reviews, maintain forecasting models, and assist in various financial analysis tasks.

At Aditum Bio, we are dedicated to providing patients with access to transformative medicines. Co-founded by industry leaders Joe Jimenez, former CEO of Novartis, and Mark Fishman, former President of the Novartis Institutes for Biomedical Research, our firm explores scientific avenues with significant medical implications and seeks drug candidates that meet these opportunities. What sets Aditum apart is our commitment not only to identifying and licensing drug candidates but also to defining, preparing for, and conducting the initial definitive clinical trials.Position Summary:The Senior Associate will collaborate closely with Aditum Bio partners to identify promising investment opportunities and facilitate the due diligence processes related to these opportunities, including modeling and simulation. This role is critical throughout the investment lifecycle, from defining initial areas of interest to assisting in diligence, deal negotiations, and new company formation.Specific Responsibilities:Research and propose potential investment ideas. The Senior Associate will explore various pathways and indications, develop investment theses, and validate these with Aditum Partners, Advisors, and externally curated experts.Conduct research to uncover new investment opportunities. The Associate will engage with key contacts and prospects to evaluate drug assets that may interest the Aditum Bio investment team.Participate in scientific review panels: Collaborate with Aditum Bio partners and scientific advisors to discuss interim findings and utilize feedback to refine research and recommendations.Manage deal diligence and transactions: Perform due diligence on therapies of interest, including scientific, clinical, and financial evaluations. Work alongside Aditum Bio experts to develop clinical strategies, development plans, and budgets. Present findings to the Aditum Bio Investment Committee and collaborate with external partners on deal discussions and transactions.Lead new company incubation and operations: Assist in the incubation of new companies and operational activities.

Join Scismic, a trailblazing biotech startup in Cambridge, MA, dedicated to developing groundbreaking mRNA-modulating therapies aimed at curing a wide array of genetic disorders. Our innovative platforms are being applied to address critical challenges in neurological diseases, heart conditions, and muscular dystrophies.Position Overview: We are seeking a Research Associate (RA-I or RA-II) who possesses a creative approach, meticulous attention to detail, and a collaborative spirit to help propel our therapeutic candidates towards clinical application. This is a unique opportunity to make a significant impact on the lives of patients with serious unmet medical needs while working alongside our esteemed scientific team, including our visionary scientific co-founders. In this role, you will work closely with the in vivo pharmacology team to evaluate the effects of therapeutic lead candidates. The Research Associate will engage with animal models for rare genetic diseases, executing experiments that quantify molecular, cellular, and physiological outcomes, as well as supporting in vivo dosing studies and additional research activities within the in vivo pharmacology team. This position is ideal for a driven scientist eager to advance their knowledge in neuroscience, physiology, and gene therapy, all while contributing to the welfare of patients affected by rare diseases.

Company Summary:At FL122, we are at the forefront of pioneering genomic technologies that redefine human health and assisted reproduction. Founded by the innovative Flagship Pioneering, we are dedicated to creating, funding, and nurturing first-in-category life sciences companies. Our portfolio includes over 100 groundbreaking companies developed over the past two decades, such as Moderna (MRNA), Generate Biomedicines, Tessera Therapeutics, and Quotient Therapeutics. We pride ourselves on being an equal opportunity employer.Position Summary:We are in search of our inaugural Computational Genomics Scientist to spearhead vital research that will underpin our scientific platform. As an early-stage team member, you will enjoy significant ownership of your work, shaping our analytical strategy from the ground up by integrating genomics, statistical genetics, and advanced modeling techniques. Your responsibilities will encompass the comprehensive delivery of computational research projects, including design, execution, interpretation, and communication of results to senior leadership. We seek a resourceful individual who thrives in a fast-paced, agile environment and possesses a proactive mindset. The ideal candidate will combine technical expertise with a growth-oriented approach, meticulous attention to detail, and a relentless drive for excellence. Collaboration is essential in our startup environment, where all team members work closely to push the boundaries of scientific discovery.

Flagship Pioneering builds bioplatform companies that address major challenges in human health and sustainability. By bringing together scientific talent, entrepreneurs, and capital, Flagship advances projects in areas like cancer detection, disease treatment, and sustainable agriculture. Flagship’s approach combines life science innovation, company creation, and investment within one organization. Scientific founders, business leaders, and capital managers work together through a structured process to drive meaningful change for people and the planet. The company’s portfolio includes ventures that have immunized billions against COVID-19, developed cures for previously untreatable diseases, improved health outcomes, and promoted sustainable farming for food security. Flagship has been recognized on FORTUNE’s “Change the World” list twice and named one of Fast Company’s most innovative companies. Role overview The Senior Manager of HR Operations and Systems leads the management and evolution of Flagship’s HR technology landscape. This position holds primary responsibility for UKG and oversees platforms such as Greenhouse and other HR systems. The role covers daily operations, system governance, integrations, and long-term strategy for HR technologies. Reporting to the Associate Director of HR Operations & Analytics, this leader works closely with HR, Legal, Payroll, Finance, and IT teams. The goal: design and maintain scalable, compliant HR operations that deliver reliable service, strong data integrity, and a smooth employee experience throughout the employee lifecycle. Key responsibilities Own and enhance the HR systems ecosystem, with emphasis on UKG and Greenhouse Oversee day-to-day HR systems operations, including governance and integrations Ensure compliance, data quality, and effective service delivery across HR platforms Collaborate with cross-functional teams to support scalable HR processes Shape the strategic direction of HR systems to support company growth Location Cambridge, MA, USA

About Flagship Pioneering, Inc. Flagship Pioneering is at the forefront of innovation, dedicated to inventing and nurturing platform companies that have the potential to revolutionize human health, sustainability, and more. Since our inception in 2000, we have successfully launched over 100 companies that tackle some of the world's most pressing challenges, such as vaccinating billions against COVID-19, curing difficult diseases, enhancing human health, preventing illness, and improving agricultural resilience and sustainability. Our commitment to impactful innovation has earned us recognition on FORTUNE's 'Change the World' list, highlighting companies that make a significant social and environmental impact, and we have appeared on Fast Company's annual list of the World’s Most Innovative Companies. Position Summary: We are looking for a passionate and experienced individual to join our Communications and Public Affairs team as the Senior Director of Communications. In this role, you will spearhead the development and implementation of communications and branding strategies for a selection of companies within Flagship Pioneering's diverse portfolio. The ideal candidate will possess a robust background in biotech corporate communications and excel in a fast-paced, startup atmosphere. This is a remarkable opportunity to influence the trajectory of groundbreaking life sciences and technology firms across human health, agriculture, and AI sectors. This full-time role requires in-office presence four days a week in Cambridge, MA. Key Responsibilities: Provide strategic counsel to the founders and leadership of emergent Flagship companies (Flagship NewCos) in developing their brand, voice, foundational messaging, and overall communication strategies. Oversee brand development, visual identity, and website design for NewCos, collaborating with external agencies. Create and implement tailored, integrated communication strategies for company launches, encompassing all written content, media engagement, and social media components. Manage PR agency support as necessary. Develop and execute communication strategies for both NewCos and more established companies (Flagship GrowthCos), including milestone announcements, internal communications, social and digital media strategies, speaking opportunities, and issue management, in close collaboration with company leadership.

Serif Biomedicines, Inc., based in Cambridge, MA, is a privately-held biotechnology company developing gene therapy approaches for diseases without current effective treatments. Founded by Flagship Pioneering, the company is part of a network that includes organizations such as Moderna, Syros Pharmaceuticals, and Evelo Biosciences. Role overview This Research Associate position centers on cell biology research, with a focus on understanding how nucleic acids function within cells. The role is laboratory-based and involves close collaboration with a multidisciplinary team. What you will do Culture and maintain a range of cell lines, including immune and non-immune cells. Design, perform, and refine assays to study nucleic acid function in primary cells and established cell lines in vitro. Communicate experimental plans and results through presentations and written reports, maintaining thorough electronic lab records. Work both independently and as part of a diverse research team.

Join our dynamic team at Integrated Resources, Inc. as a Senior Associate. This role offers an exciting opportunity to contribute to impactful projects and collaborate with talented professionals. As a Senior Associate, you will leverage your expertise to drive our initiatives forward, ensuring excellence in all aspects of our work.

Company Overview: Flagship Labs 109, Inc. (FL109) is an innovative, privately held technology company that is at the forefront of revolutionizing biological sciences through the integration of artificial intelligence, physics, and advanced hardware. Founded by Flagship Pioneering, we are driven by a mission to achieve extraordinary results and redefine the future of science. Join our dedicated team and contribute to our transformative vision. Role Overview: As the Director of Sales, you will play a crucial role in spearheading customer acquisition, forging strategic partnerships, and driving revenue growth across our VaaS, SaaS, and platform offerings. This dynamic leadership position calls for a commercially adept structural biologist or a technical sales leader who excels in both strategic planning and tactical execution. You will be accountable for achieving defined bookings targets, leading comprehensive customer engagement, and acting as the commercial "mini-CEO" for our client relationships. Your responsibilities will also include shaping FL109’s market development strategy, identifying and nurturing prospective customers, participating in key industry events, and producing impactful content that enhances brand awareness and customer engagement. This is an ideal opportunity for a driven leader who thrives in building structures, establishing customer relations, and developing scalable business systems in a rapidly evolving market.

COMPANY DESCRIPTION We are a pioneering start-up dedicated to transforming the landscape of chemical discovery. Our innovative platform integrates artificial intelligence with a state-of-the-art laboratory discovery pipeline to redefine molecular formulation development. Our interdisciplinary team is exploring uncharted chemical territories, facilitating significant advancements in drug delivery, agricultural formulations, and sustainable, high-performance industrial chemicals. Backed by Flagship Pioneering, a leader in biotechnology origination, we have fostered over 115 scientific ventures in 25 years, generating more than $20 billion in aggregate value, 500+ patents, and over 50 clinical trials for groundbreaking therapeutic agents. THE ROLE We are on the lookout for a passionate and skilled Senior Research Associate or Associate Scientist to enhance our formulation discovery platform by characterizing biomolecules. This position involves utilizing a range of biophysical and biochemical methodologies to analyze the effects of formulations on biomolecular integrity, aggregation, and functional stability. You will collaborate closely with chemists and machine-learning experts to produce high-quality experimental data that drives formulation design and predictive modeling initiatives. The ideal candidate will possess a solid background in biochemistry, structural biology, or biopolymer engineering, complemented by practical experience with analytical instrumentation for biomolecular characterization. KEY RESPONSIBILITIES Conduct experiments assessing biomolecular stability and solubility across various formulation conditions. Evaluate cargo structural integrity and folding utilizing circular dichroism (CD) spectroscopy and complementary biophysical techniques. Measure biomolecular interactions and stability through spectroscopy, dynamic light scattering, and electrophoretic methods. Prepare samples for diverse external workflows to evaluate molecular integrity and degradation. Experimental Pipeline Support Collaborate with formulation chemists to investigate cargo-formulation interactions across different experimental contexts. Generate high-quality experimental datasets to assist internal modeling and data analysis processes. Support laboratory instrumentation maintenance and troubleshooting. Maintain organized laboratory records, analyze results, and communicate findings effectively to cross-functional teams.