Associate Scientist in LNP Formulations

We are seeking a highly motivated Associate Scientist specializing in LNP (Lipid Nanoparticle) formulations. The ideal candidate will be involved in the development and optimization of LNP delivery systems for mRNA therapeutics. You will work collaboratively within our dynamic team to design experiments, analyze data, and contribute to innovative solutions in the biotechnology field.

Join our innovative team at Flagship Pioneering, Inc., where we are dedicated to advancing biopharmaceutical technologies. We are seeking a Senior Scientist in LNP Formulations who will play a key role in the development of lipid nanoparticle (LNP) formulations. This position offers the opportunity to work on cutting-edge research and contribute to the creation of next-generation therapeutics.

Your Contribution at Lila Sciences Lila Sciences is actively seeking a dedicated (Senior) Research Associate to become an integral part of our dynamic Life Sciences team. This pivotal role will be centered around the formulation of lipid nanoparticles (LNPs), their functionalization with targeting ligands, and the characterization of the resulting targeted LNPs (tLNPs). The ideal candidate will possess substantial hands-on experience in LNP formulation and characterization, bioconjugation, protein characterization, and automation technologies. Your expertise will significantly enhance our understanding of the delivery space, enabling a high-throughput closed-loop screening cascade for tLNPs. You will work collaboratively with professionals across protein, cell biology, automation, chemistry, machine learning, and data science teams to establish advanced tools for targeted nucleic acid delivery. Your Key Responsibilities Design, execute, and characterize LNP formulations utilizing various scales and mixing modalities (e.g., DLS, ribogreen, TNS). Develop and optimize high-throughput ligand conjugation and purification methodologies, leveraging automation and robotics to maximize throughput. Collaborate with cell assay and antibody experts to screen candidates across diverse tissue targets in in vivo models. Engage with chemists, biologists, engineers, and data scientists to document processes, share insights, and refine best practices in autonomous flow chemistry. Create, implement, and uphold Standard Operating Procedures (SOPs) for both existing and emerging lab processes. Your Qualifications for Success MSc in Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences, or a closely related field with 3+ years of hands-on experience in targeted LNP production or a BSc with 5+ years of relevant experience. Industry experience is highly desirable. Strong proficiency in bioanalytical techniques (e.g., DLS, fluorescence spectroscopy, electrophoresis, in vitro assays). Experience in protein and antibody design and characterization. Familiarity with automation and high-throughput workflows is preferred. Exceptional troubleshooting, communication, and collaboration skills, with a proven ability to work effectively across interdisciplinary teams. About Lila Sciences Lila Sciences is at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory focused on life sciences, chemistry, and materials science. We are pioneering a new era of limitless discovery by harnessing AI capabilities to enhance every facet of the scientific method. Our mission is to leverage scientific superintelligence to address humanity's most pressing challenges.

COMPANY DESCRIPTION Flagship Pioneering is a transformative innovation platform that unites visionary scientific minds with entrepreneurial leaders to create and cultivate groundbreaking companies that aim to change the world. We provide the necessary capital and support to enable these innovators to undertake ambitious projects that advance human health, sustainability, and more. Our diverse portfolio spans critical areas including disease detection and treatment, sustainable agriculture, and pioneering applications of artificial intelligence that foster technological advancements. What distinguishes Flagship is our unparalleled ability to integrate scientific innovation, company creation, and strategic capital investment, offering a cohesive ecosystem that facilitates progress. Our founders, leaders, and capital managers collaborate through a structured process designed to foster innovation and enhance life on Earth. Our portfolio companies have tackled some of the world’s most pressing challenges: from vaccinating billions against COVID-19 to curing complex diseases, enhancing human health, preventing illness, and improving agricultural resilience and sustainability. Flagship has been recognized multiple times on FORTUNE’s “Change the World” list and has earned accolades on Fast Company’s annual list of the World’s Most Innovative Companies. THE ROLE We are seeking a dedicated Senior Research Associate to join our formulation and product development team. This critical position will focus on the design, screening, and optimization of dried powder formulations. The successful candidate will take a hands-on approach to executing formulation strategies utilizing techniques such as lyophilization and spray drying, while bringing experimental precision, physical insights, and data-driven decision-making to our early-stage platform development. The Senior Research Associate will collaborate closely with process development partners to create stable, robust, and scalable powder formulations. This role will also involve experimental design, data interpretation, and establishing best practices for formulation screening, characterization, and documentation within a dynamic early-stage environment. KEY RESPONSIBILITIES Design, execute, and optimize dried powder formulations using lyophilization and spray drying, focusing on stability, reproducibility, and performance across various formulations.

Join GT Biosciences, a pioneering techbio startup based in Cambridge, MA, dedicated to revolutionizing drug delivery through our innovative Deliveromics platform. We are seeking a passionate and multidisciplinary LNP Scientist to join our team, focusing on the advancement of cutting-edge non-viral delivery technologies.In this pivotal role, you will spearhead the design and development of novel ionizable lipids and engineer ligand-conjugated lipid nanoparticle formulations. Your expertise will support in vivo screening for Deliveromics and evaluate performance through both in vitro assays and in vivo animal models. You will be responsible for experimental planning, execution, data analysis, interpretation, and effectively communicating results.As one of the earliest scientific hires at this innovative startup, you will play a crucial role in shaping platform development and collaborating across various disciplines to create transformative solutions for genetic medicine delivery. This is a full-time, in-person position based in Cambridge, MA.

As an Associate Scientist III, you will play a crucial role in advancing our scientific research initiatives. You will collaborate with cross-functional teams to design, execute, and analyze experiments that contribute to our innovative projects. Your expertise will help drive our mission forward, ensuring that we continue to push the boundaries of scientific discovery.

Join our dynamic team at Integrated Resources Inc. as an Associate Scientist II, where you will play a crucial role in advancing our innovative projects. In this position, you will engage in various scientific experiments and analyses, contributing to the development of cutting-edge solutions.

Join Integrated Resources Inc. as an Associate Scientist I, where you will contribute to innovative scientific research and development projects. As a pivotal part of our team, your role will involve conducting experiments, analyzing data, and collaborating with multidisciplinary teams to advance our scientific objectives.

We are seeking a highly motivated and detail-oriented Associate Scientist I to join our dynamic team in Cambridge. The ideal candidate will assist in the design and execution of experiments, analysis of data, and contribute to various projects within our research initiatives.

AbbVie is seeking a talented and motivated Associate Scientist II or Scientist I to join our dynamic In Vivo Pharmacology team in Cambridge. As part of our innovative research environment, you will play a crucial role in advancing our understanding of pharmacological mechanisms through in vivo studies. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to transform patient care.

Join Nuvalent as the Senior Manager of Formulation Sciences, where you will play a pivotal role in advancing our innovative drug development pipeline. In this leadership position, you will oversee the formulation and development of new therapeutic candidates, guiding projects from conception through to clinical phases. Collaborate with cross-functional teams to ensure the successful translation of scientific research into viable products.

Join Integrated Resources Inc. as an Associate Scientist where you will engage in groundbreaking research and contribute to innovative projects. This role offers an exciting opportunity to work in a collaborative environment, driving advancements in our scientific endeavors.

We are seeking a highly motivated and detail-oriented Associate Scientist III to join our dynamic team in Cambridge. In this role, you will contribute to innovative research projects, performing experiments and analyzing data to help drive our scientific advancements. This position requires a collaborative spirit and the ability to communicate findings effectively.

We are seeking a dedicated and detail-oriented Associate Scientist to join our dynamic team at Artech Information Systems LLC. In this role, you will contribute to innovative scientific research, engage in laboratory experiments, and support various projects aimed at advancing our scientific objectives. Your work will play a crucial role in developing solutions that impact our field positively.

We are seeking a dedicated and passionate Associate Scientist II to join our team in Cambridge. In this role, you will contribute to cutting-edge research and development initiatives, supporting our mission to innovate and enhance scientific solutions. You will work collaboratively with a multidisciplinary team to conduct experiments, analyze data, and interpret results, driving projects forward and contributing to significant advancements in our field.

Join our team at Integrated Resources, Inc. as an Associate Scientist II, where you will contribute to cutting-edge research and development in a dynamic and collaborative environment. In this role, you will utilize your scientific expertise to support various projects and drive innovation.

Join Integrated Resources Inc. as an Associate Scientist III in Cambridge, where you will play a vital role in advancing scientific research and innovation. We are seeking a talented individual who is passionate about science and eager to contribute to groundbreaking projects that make a difference.

Join Integrated Resources Inc. as an Associate Scientist II. In this pivotal role, you will contribute to innovative scientific research and development projects, collaborating with a dynamic team of professionals. Your expertise will help drive advancements in our organization, making a significant impact in our field.

AbbVie Inc. is seeking an Associate Scientist II with a focus on In Vivo Pharmacology to join the team in Cambridge. This position supports research that aims to improve patient outcomes through new drug discovery. Role overview The Associate Scientist II will perform in vivo experiments and handle data analysis as part of ongoing research projects. Collaboration with colleagues from different scientific backgrounds is a key part of this role. Key responsibilities Conduct in vivo pharmacology experiments as part of drug discovery initiatives Analyze and interpret experimental data to support research goals Work closely with cross-functional teams to drive projects forward Location This position is based in Cambridge.

COMPANY DESCRIPTION We are a pioneering start-up dedicated to transforming the landscape of chemical discovery. Our innovative platform integrates artificial intelligence with a state-of-the-art laboratory discovery pipeline to redefine molecular formulation development. Our interdisciplinary team is exploring uncharted chemical territories, facilitating significant advancements in drug delivery, agricultural formulations, and sustainable, high-performance industrial chemicals. Backed by Flagship Pioneering, a leader in biotechnology origination, we have fostered over 115 scientific ventures in 25 years, generating more than $20 billion in aggregate value, 500+ patents, and over 50 clinical trials for groundbreaking therapeutic agents. THE ROLE We are on the lookout for a passionate and skilled Senior Research Associate or Associate Scientist to enhance our formulation discovery platform by characterizing biomolecules. This position involves utilizing a range of biophysical and biochemical methodologies to analyze the effects of formulations on biomolecular integrity, aggregation, and functional stability. You will collaborate closely with chemists and machine-learning experts to produce high-quality experimental data that drives formulation design and predictive modeling initiatives. The ideal candidate will possess a solid background in biochemistry, structural biology, or biopolymer engineering, complemented by practical experience with analytical instrumentation for biomolecular characterization. KEY RESPONSIBILITIES Conduct experiments assessing biomolecular stability and solubility across various formulation conditions. Evaluate cargo structural integrity and folding utilizing circular dichroism (CD) spectroscopy and complementary biophysical techniques. Measure biomolecular interactions and stability through spectroscopy, dynamic light scattering, and electrophoretic methods. Prepare samples for diverse external workflows to evaluate molecular integrity and degradation. Experimental Pipeline Support Collaborate with formulation chemists to investigate cargo-formulation interactions across different experimental contexts. Generate high-quality experimental datasets to assist internal modeling and data analysis processes. Support laboratory instrumentation maintenance and troubleshooting. Maintain organized laboratory records, analyze results, and communicate findings effectively to cross-functional teams.