Principal Applications Developer jobs in Boston – Browse 515 openings on RoboApply Jobs

Principal Applications Developer jobs in Boston

Open roles matching “Principal Applications Developer” with location signals for Boston. 515 active listings on RoboApply Jobs.

515 jobs found

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companyInterSystems logo
Full-time|$140K/yr - $193K/yr|On-site|Boston, MA

The Principal Applications Developer serves as a senior technical leader, charged with the innovative design, effective delivery, and ongoing evolution of subsystem capabilities or cross-team initiatives. This pivotal role demands the ability to make informed technical decisions that integrate diverse perspectives while guiding teams toward robust, standards-compliant solutions. A strong focus is placed on maintaining architectural integrity, shaping technical strategies, and managing risks across multiple teams and functional areas.Key ResponsibilitiesSteer the end-to-end design and implementation of sophisticated subsystems or solution capabilities.Convert high-level objectives into actionable technical strategies that align with solution direction and business goals.Assess, select, and recommend appropriate technologies, tools, and frameworks, facilitating their integration.Analyze solution methodologies by weighing effort, risk, quality, operability, and sustainability.Independently or collaboratively deliver software projects of substantial scope and complexity.Proactively identify and manage cross-system dependencies and architectural risks.Provide expert technical leadership throughout planning, execution, and resolution of critical challenges.Mentor developers throughout the software delivery lifecycle, guiding thoughtful technical decisions.Articulate technical perspectives in discussions with senior stakeholders, both internal and external.Contribute independently to engagement with customers and industry-related initiatives.

Mar 31, 2026
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companyVolta Labs logo
Full-time|On-site|Seaport District, Boston, MA

ABOUT VOLTA LABS:At Volta Labs, we are at the forefront of genomic innovation, transforming the way scientists interact with biological data. As a venture-backed biotech startup based in Boston, our flagship product Callisto simplifies the extraction of critical information from biological samples, making it as easy as a single button press. We accelerate processing times for researchers while enhancing access to essential genetic insights for patients. Join us as we bridge the gap between science and engineering, fostering a culture of curiosity where every team member contributes to the future of genomics.JOIN OUR TEAM:Become part of a dynamic team of forward-thinking innovators dedicated to collaboration and excellence. We are passionate about advancing automation, molecular biology, computing, robotics, design, and user experience to create impactful solutions for our customers and the global community.As a Genomics Technician reporting to a Senior Scientist, you will play a vital role in executing and validating genomic sample preparation applications on Volta’s cutting-edge digital fluidics automation platform. This opportunity is perfect for someone at the start of their career who enjoys meticulous hands-on work, is eager to learn new laboratory techniques, and is committed to developing strong laboratory practices in a professional environment. Your primary responsibilities will include running established workflows, generating high-quality data, and ensuring the reliability of protocols across multiple runs.You will collaborate closely with teams across applications, engineering, product, and field services, ensuring consistent execution of experiments both internally and at client locations. Our focus is on precision, repeatability, and comprehensive documentation.

Mar 11, 2026
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companyAsimov logo
Full-time|On-site|Boston, MA

Asimov builds tools for designing living systems, combining mammalian synthetic biology with software to support next-generation therapeutics. The Biologics Cell Line Development team in Boston, MA, is growing, and we're seeking a Principal Scientist to help lead our efforts in CHO-based cell line development for biologic therapeutics moving into clinical trials. Role Overview This Principal Scientist position calls for a scientific leader ready to manage a team and drive innovation in cell line development. The role involves designing and executing complex experiments, improving expression systems, and collaborating closely with teams across synthetic biology, modeling, process development, and analytics. The work directly supports Asimov’s mission to advance biological engineering in a startup environment. What You Will Do Oversee CHO cell line development, including transfection, cloning, characterization, and cell banking using advanced technologies. Develop new genetic components, engineer host cell lines, and refine development processes to improve biologics production. Stay current with emerging practices in biologics cell line development and manufacturing, applying new strategies to ongoing projects. Represent the cell line development group on cross-functional projects, making key decisions and communicating progress and plans. Contribute to the scientific community by presenting at conferences, filing patents, and publishing peer-reviewed research. Lead and mentor a team of at least three scientists, providing technical guidance and supporting their career growth. Qualifications At least 8 years of experience in CHO-based cell line development, with a focus on IgG and bispecific expression in an industrial setting. Demonstrated success in creating innovative solutions and experimental approaches in cell line development. Experience managing and developing scientific teams. Strong communication skills for effective work across multidisciplinary groups.

Apr 13, 2026
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companyMotional logo
Full-time|$123K/yr - $163.5K/yr|Remote|Boston, Massachusetts, United States; Pittsburgh, Pennsylvania, United States; Remote U.S.

Mission Overview: We are on the lookout for an enthusiastic and skilled Engineer for our Developer Platform team. Your role will be pivotal in facilitating swift and secure software delivery by creating a cohesive, efficient, and dependable platform for all developers at Motional. Join our dynamic team of engineers focused on enhancing the engineering experience and boosting developer productivity across Motional by providing essential tools and processes. You will collaborate with various teams within the organization to identify challenges and spearhead initiatives that empower teams to fulfill Motional’s mission. Your primary focus will be on our real-time data pipeline, which allows our autonomous vehicles (AVs) to interact with our cloud services, including Command Center, Over-The-Air update systems, and ride-hailing partner integrations. This is a remote-first position, available to candidates anywhere in the U.S.

Apr 7, 2026
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companyAsimov logo
Full-time|On-site|Boston, MA

Asimov is seeking a highly skilled and experienced Senior Scientist/Principal Scientist in Biologics Cell Line Development to join our innovative team in Boston, MA. In this pivotal role, you will lead the development of high-yield mammalian cell lines for the production of biologics. You will collaborate closely with cross-functional teams to optimize production processes and ensure the successful translation of cell line development from research to clinical applications.

Mar 10, 2026
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companyMotional logo
Full-time|$240K/yr - $330K/yr|Remote|Boston, Massachusetts, United States; Remote U.S.

Motional is on the lookout for a highly skilled Principal Engineer to join our Planning team. In this pivotal role, you will be responsible for designing innovative motion planning and control systems that ensure the safe, efficient, and comfortable operation of our autonomous fleet in intricate environments. We seek an individual with a strong background in advanced algorithm development and robust software engineering, committed to shaping production-ready autonomous vehicles. If you are passionate about autonomous driving and enjoy tackling real-world challenges in a dynamic field, we welcome your application.Key Responsibilities:Lead the research and development of groundbreaking algorithms and subsystems for motion planning within autonomous driving, enhancing the Operational Design Domain. This encompasses advanced search-based and geometry-driven methods, alongside decision-making under uncertainty, with a focus on probabilistic techniques.Oversee cross-functional initiatives to create or enhance interfaces aimed at solving complex problems.Continuously monitor system performance to pinpoint areas for enhancement and formulate technical strategies to address shortcomings.Guide cross-functional project teams to deliver comprehensive solutions, showcasing the ability to think beyond the planning system's limitations.Architect and integrate sophisticated motion planning and prediction algorithms, leading their assessment and optimization for real-world applications.Design and develop a resilient, scalable, and high-performance codebase that enables rapid exploration, prototyping, and thorough evaluation of new motion planning methodologies and algorithms.Facilitate technical collaboration and ensure seamless integration with upstream perception and prediction components, as well as downstream trajectory optimization, tracking, and control systems, guaranteeing optimal end-to-end system performance.Utilize your extensive software development and research expertise to mentor others in best software practices, fostering a culture of technical excellence.Mentor junior and senior team members, promoting a culture of product-focused engineering, rigorous research, and advanced development.

Mar 31, 2026
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company
Full-time|On-site|Boston, MA

About the RoleJoin Parallel Fluidics as we innovate the infrastructure powering the future of life science tools. As the Principal Mechanical Engineer, you will spearhead our most vital engineering initiatives, establish benchmarks for technical excellence, and influence the processes that guide our product development and manufacturing. We seek an experienced engineering leader with extensive knowledge in electromechanical system design, design for manufacturing, and automation. If you are passionate about making a significant impact by transforming groundbreaking products from concept to production in a fast-paced startup environment, we encourage you to apply.Key ResponsibilitiesEngineering LeadershipAct as the principal architect of the engineering processes at Parallel Fluidics.Lead critical engineering projects that align with our mission.Serve as a technical expert for various internal projects.Identify and implement improvements to our engineering systems and tools.Mentor junior and senior engineers across various disciplines.Provide progress reports and insights to company leadership.Product DevelopmentOversee the transition of Parallel’s next-generation hardware products from concept to scalable production.Identify and evaluate potential high-volume manufacturing partners.Facilitate the transfer of high-volume products from in-house production to third-party manufacturers.Manufacturing SystemsIdentify opportunities to enhance our in-house designed manufacturing equipment.Design experiments and testing methods to optimize manufacturing processes.Collaborate with the manufacturing team to pinpoint gaps and explore improvement opportunities.

Sep 25, 2025
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companyaccordion logo
Full-time|On-site|Atlanta; Boston; Charlotte; Chicago; Dallas; Los Angeles; New York; San Francisco

accordion is looking for an Application Architect to guide the design and delivery of new application solutions. This position is available in several major cities, including Atlanta, Boston, Charlotte, Chicago, Dallas, Los Angeles, New York, and San Francisco. Role overview The Application Architect leads efforts to create scalable and efficient applications that align with business goals. Collaboration with cross-functional teams is central to this role, ensuring that each solution supports both immediate needs and long-term growth. What you will do Design and implement application architectures that support business requirements Work closely with teams across departments to deliver effective solutions Apply architecture patterns and development best practices to all projects Help shape the direction of application development at accordion Requirements Strong background in application architecture and development practices Experience building scalable, high-performing applications Ability to collaborate effectively with diverse teams This role allows for meaningful input into how applications are developed and provides the chance to work alongside others who value innovation and teamwork.

Apr 29, 2026
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companyVeeva Systems, Inc. logo
Full-time|Hybrid|Massachusetts - Boston

Veeva Systems is a trailblazer in the industry cloud space, dedicated to accelerating the delivery of life-saving therapies to patients. As one of the fastest-growing SaaS enterprises in history, we achieved over $2 billion in revenue last fiscal year, with tremendous growth prospects ahead.At Veeva, our core values guide us: Do the Right Thing, Customer Success, Employee Success, and Speed. We are not just a typical public company; in 2021, we made history by becoming a public benefit corporation (PBC), committed to balancing the interests of customers, employees, society, and investors.As a Work Anywhere company, we embrace flexibility, allowing you to thrive in an environment that suits you, whether at home or in the office.Join us in transforming the life sciences industry, where we are committed to making a positive impact on our customers, employees, and the communities we serve.

Oct 4, 2024
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companyVeeva Systems Inc. logo
Full-time|Remote|Massachusetts - Boston

Join Veeva, a trailblazer in the industry cloud space and one of the fastest-growing enterprise SaaS companies with over $2 billion in revenue last year. We are dedicated to empowering life sciences companies to expedite the delivery of critical therapies to patients globally. As a public benefit corporation, we strive to balance the interests of our clients, employees, society, and investors, providing a distinct opportunity to create solutions that significantly enhance global health.Opportunity Overview: As a Principal Software Engineer at Veeva, you will be at the forefront of developing and steering the creation of robust, scalable, and maintainable enterprise applications that enhance operational efficiency and safety for our clients. Your leadership will be vital in influencing our technological direction. You will mentor junior engineers, spearhead essential technical decisions, and consistently produce high-quality code that advances our technological capabilities.Embrace Our Work Anywhere Culture: We empower you to work from your preferred location, whether from home or in the office within Canada or the US, ensuring seamless collaboration within your team's time zones.Become a pivotal player at Veeva and be instrumental in transforming the life sciences sector, contributing to significant advancements in global health.

Apr 5, 2022
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companyMotional logo
Full-time|$240K/yr - $330K/yr|Remote|Boston, Massachusetts, United States; Remote U.S.

Principal Engineer and Team Lead - Motion Planning Join our innovative Planning team at Motional, where your enthusiasm for robotics and software development will contribute to the advancement of production-ready autonomous vehicles. As the Principal Engineer and Team Lead, you will oversee a talented team dedicated to designing and implementing state-of-the-art motion planning software for autonomous vehicles. This pivotal role requires you to lead the definition of motion planning and control systems that ensure our fleet operates safely, efficiently, and comfortably in complex environments. Your leadership will be instrumental in developing cutting-edge motion planning algorithms, working in collaboration with cross-functional teams (Localization, Perception, Prediction, Controls, ML Products, and Systems Engineering), and mentoring a diverse group of engineers to deliver groundbreaking solutions. If you are driven by a passion for autonomous driving, enjoy tackling challenging real-world problems, and are eager to make a significant impact in a rapidly evolving industry, we would love to hear from you.

Mar 31, 2026
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company
Full-time|$60K/yr - $65K/yr|On-site|Boston, Massachusetts, United States

Role Overview WS Development is seeking a Property Coordinator for its Boston office in the Seaport District. This position supports the property management team with a mix of administrative and operational tasks. The Property Coordinator reports to the Senior Property Manager and works closely with leadership, including the Vice President of Property Management, Senior Director of Property Management, Senior Director of Engineering, and Senior Facilities Manager. The role focuses on keeping property operations organized and efficient. The Property Coordinator manages documents, processes invoices, drafts contracts, and communicates with internal teams across several properties in Boston’s Seaport and other locations. What You Will Do Assist with daily property management operations Coordinate meetings, manage agendas, and organize calendars for the team Support department-wide initiatives and projects led by the Senior Director of Property Management Draft contract documents, track expirations, and maintain contract records Process invoices, including tracking purchase orders and coding expenses Oversee property maintenance and act as the main contact for Seaport Field Offices, handling supply management and customer service requests Location This role is based onsite in Boston, Massachusetts, within the Seaport District.

Apr 14, 2026
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companyInterSystems Corporation logo
Principal Healthcare AI Developer

InterSystems Corporation

Full-time|$144K/yr - $205K/yr|On-site|Boston, MA

The Data Platforms Health team at InterSystems is dedicated to creating innovative, healthcare-centric solutions that harness the power of artificial intelligence. As a Principal Healthcare AI Developer within our Database Platforms department, you will play a key role in enhancing AI-driven features and workflows across our flagship products, including InterSystems Health Connect Cloud, InterSystems FHIR Server, and InterSystems IRIS for Health.We are seeking a dynamic developer who will lead the design and development of AI models and architectures, focusing on intelligent tools for healthcare builders and administrators. Your expertise will guide our adoption of cutting-edge AI technologies, positioning InterSystems as a frontrunner in the realm of AI-enhanced healthcare solutions.If this role excites you, we encourage you to apply, even if you have reservations about your qualifications. At InterSystems, we are committed to nurturing the growth of our team members.This position is based at our headquarters in Boston, MA.

Mar 20, 2026
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companyVeeva Systems logo
Full-time|Remote|Massachusetts - Boston

At Veeva Systems, we are dedicated to transforming the life sciences industry, enabling companies to expedite the delivery of essential therapies to patients worldwide. As a trailblazer in industry cloud solutions, we proudly achieved over $2 billion in revenue last fiscal year, with immense growth opportunities on the horizon.Our core values—Do the Right Thing, Customer Success, Employee Success, and Speed—drive everything we do. In 2021, we made history by becoming a public benefit corporation, committed to balancing the needs of our customers, employees, society, and investors.As a Work Anywhere organization, we empower you to choose your ideal work environment, whether from home or in the office, to foster your success and well-being.Your RoleWe are looking for a Principal Full Stack Engineer who will play a pivotal role in developing scalable cloud software that accelerates the innovation and distribution of critical medications and treatments globally. In this senior position, you will leverage your extensive technical expertise to create software that adapts with new features and capabilities, while also enjoying autonomy in directing project developments. You will serve as a mentor to junior engineers and collaborate closely with product leadership, significantly influencing our product strategy.

Oct 4, 2024
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company
Full-time|Hybrid|Boston, Massachusetts, United States

Join us in transforming how the Department of Defense (DoD) approaches multi-billion-dollar force design decisions. As a Senior Principal Software Engineer, you will integrate physics-based simulations, dynamic computing, and validated AI code generation to develop state-of-the-art wargaming platforms. We are looking for a proactive leader who can architect and develop a scalable, cloud-distributed simulation environment while motivating a small, dedicated team through hands-on leadership.Your ResponsibilitiesDesign & Implement: Create a robust, interactive physics simulation that operates efficiently across cloud and on-premises clusters.Own the Core Codebase: Manage the modern C++ codebase, focusing on multi-threaded performance optimization and continuous integration practices.Collaborate: Work closely with product and AI teams to incorporate verified, AI-generated algorithms directly into a developer SDK for platform enhancement.Prototype & Iterate: Deliver functional capabilities to government end-users in weeks, not months, through rapid prototyping.Set Engineering Standards: Uphold high coding standards, document processes thoroughly, and mentor team members through code reviews and pair programming.

May 8, 2025
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companyAkoya logo
Full-time|$140K/yr - $180K/yr|On-site|Boston, Raleigh, NYC

Join the Future of Financial Data!At Akoya, we are pioneering an API-based network supported by leading financial institutions to create a secure and transparent method for individuals to share their personal financial data with third-party applications. If you are passionate about cutting-edge technology that addresses real-world challenges, we invite you to join us in revolutionizing the way financial information is accessed and exchanged. Our vibrant and collaborative workplace fosters creativity and diversity, bringing together professionals with expertise in banking, securities, fintech, and data aggregation. As an equal opportunity employer, we encourage you to become part of our exciting journey – visit www.akoya.com for more details!Your RoleWe are on the lookout for a Principal Software Engineer (Frontend) to spearhead the development of our next-generation user experiences and frontend architecture. This position is perfect for a seasoned engineer who upholds high design standards, possesses advanced skills in modern JavaScript and React, and can drive technical strategies across intricate products. You will combine meticulous attention to detail with excellent communication skills and a fervor for crafting elegant, scalable, and user-friendly interfaces that empower our clients.As a Principal Engineer, your responsibilities will include:Leading the design and execution of Akoya's core frontend architecture, establishing benchmarks for code quality, performance, accessibility, and maintainability.Guiding the modernization of existing frontend systems, ensuring reliability of legacy components while transitioning them to more scalable, efficient, and maintainable frameworks.Writing clean, well-organized, and thoroughly documented code using React, TypeScript/JavaScript, and contemporary frontend tools.Collaborating closely with product managers, designers, and backend teams to define requirements and deliver polished, high-quality user experiences.Debugging and resolving complex production challenges across the frontend stack, ensuring robust and resilient interfaces.Enhancing the engineering team through mentorship, architectural guidance, and code reviews, enabling teams to achieve excellence.Promoting frontend best practices including performance optimization, component system design, and user experience improvements.

Dec 9, 2025
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companyKlaviyo logo
On-site|On-site|Boston, MA

At Klaviyo, we embrace the diverse experiences and perspectives that each Klaviyo (our affectionate term for team members) brings to our dynamic workplace. We believe that everyone deserves a chance to succeed and appreciate unique backgrounds beyond traditional qualifications. If you feel you align closely with this role, we encourage you to apply. To explore more about life at Klaviyo and how we empower creators to take charge of their destinies, please visit our careers page. As a hands-on Principal Engineer specializing in compute, networking, storage, runtimes (e.g., Kubernetes), CI/CD, and observability, you will be instrumental in architecting a robust service platform that facilitates rapid and secure deployments. This is an individual contributor role without direct reports; you will lead through exemplary design, coding practices, and incident management, establishing technical standards and service level objectives (SLOs) for our platform services.

Jan 29, 2026
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companyShield AI logo
Full-time|On-site|Boston, MA

Join Shield AI, a pioneering deep-tech company founded in 2015, dedicated to safeguarding service members and civilians through cutting-edge intelligent systems. With innovative products like the V-BAT and X-BAT aircraft, Hivemind Enterprise, and Hivemind Vision, we are at the forefront of technology that supports operations globally, with offices and facilities across the U.S., Europe, the Middle East, and Asia-Pacific. Discover more at www.shield.ai. Stay connected with us on LinkedIn, X, Instagram, and YouTube.Job Overview:As a Senior Software Engineer within the VBAT Software team, you will play a pivotal role in designing and developing sophisticated avionics software that integrates hardware, operating systems, and applications for advanced Unmanned Aerial Vehicles (UAV). Collaborating with a dynamic team of electrical engineers, GNC engineers, systems engineers, test engineers, and autonomy experts, you will create software systems that leverage state-of-the-art aerospace sensors, cutting-edge UAV avionics, and innovative Artificial Intelligence applications.Your responsibilities will include developing and sustaining robust software architectures, generating and maintaining comprehensive software requirements, documenting and presenting software designs, overseeing software development processes, and guiding the entire suite of VBAT software through rigorous testing, verification, release, and deployment phases.

Feb 11, 2026
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companyCarGurus logo
Full-time|On-site|Boston, Massachusetts, United States

Join CarGurus as a Principal Strategy Analyst and play a pivotal role in shaping the future of our organization. In this strategic position, you will leverage data-driven insights to guide our business decisions, enhance operational efficiency, and identify new growth opportunities. Collaborate with cross-functional teams to drive strategic initiatives and support the execution of our long-term objectives.

Mar 16, 2026
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companyMaven AGI logo
Full-time|On-site|Boston

Maven AGI seeks a Principal Solutions Architect based in Boston. This senior position plays a key role in shaping technology architecture for both client projects and internal efforts. Collaboration with teams across engineering, product, and business is central to the work, ensuring solutions meet client requirements and align with broader business goals. Role overview The Principal Solutions Architect designs technology architectures that address a range of client needs. The role involves guiding projects from initial concept through to implementation, ensuring solutions are scalable and practical. Working closely with cross-functional teams, this architect helps translate complex challenges into effective technical strategies. What you will do Create technology architectures tailored to client objectives and business priorities Collaborate with engineering, product, and business teams throughout each project lifecycle Lead the implementation of scalable solutions for diverse technical problems Requirements Significant experience in technology architecture Skill in turning complex client challenges into actionable solutions Interest in applying new technologies to address business needs This position requires working onsite in Boston.

Apr 28, 2026

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