Biology Scientist

Join AbbVie as a Senior Scientist I in the field of siRNA in vitro biology. In this role, you will leverage your extensive knowledge and skills in molecular biology to contribute to innovative research and development projects. Collaborate with a team of dedicated scientists to explore new therapeutic avenues and advance our understanding of RNA interference.

About Serif Biomedicines, Inc. Serif Biomedicines, Inc. is a privately held biotechnology company in Cambridge, MA. The team is developing new approaches to gene therapy for diseases that current medical solutions cannot address. Serif Biomedicines was founded by Flagship Pioneering, known for launching over 100 innovative life sciences organizations focused on human health and sustainability. Role Overview The Senior Scientist, Molecular Biology will design and develop next-generation DNA constructs for programmable medicine. This position suits scientists experienced in synthetic biology, high-throughput cloning, and computational sequence engineering. The role centers on building scalable platforms for plasmid DNA design, construction, and optimization, using automation, algorithm-driven sequence design, and data-centric workflows. This scientist will report to the Director of Molecular Biology and may supervise a direct report. Collaboration with other scientists and group leaders across the R&D team is a key part of the job. What You Will Do Lead the design and construction of plasmid DNA constructs, including vector architecture, gene synthesis strategies, and high-efficiency cloning (such as Gibson, Golden Gate, and recombination-based methods). Advance automated and computational sequence design by applying advanced tools and pipelines for codon optimization, regulatory element tuning, and multi-parameter construct optimization. Establish and manage vendor relationships to support both internal and external capabilities, helping projects move forward efficiently and minimizing disruptions.

Join us as a Senior Scientist in Computational Biology at Flagship Pioneering, Inc. In this pivotal role, you will leverage your expertise to drive innovative research and development in computational biology, contributing to groundbreaking discoveries and advancements in the field.

FL122, a new venture from Flagship Pioneering based in Cambridge, MA, is building genomic technologies aimed at advancing human health and assisted reproduction. Flagship Pioneering has launched over 100 life sciences companies in the past two decades, including Moderna, Generate Biomedicines, and Tessera Therapeutics. The team addresses complex challenges in human health and sustainability. Role overview The Scientist in Reproductive and Molecular Biology will play a key part in establishing FL122’s scientific platform. This role focuses on developing and standardizing laboratory workflows that involve handling human gametes and performing molecular characterization. As part of the early scientific team, the Scientist will work closely with senior scientists and company leadership to define technical standards and carry out experimental strategies. What you will do Develop and improve laboratory workflows for handling human gametes and conducting molecular analysis Work directly with sensitive human samples in an IVF or embryology laboratory setting Use molecular biology techniques to support experimental goals Collaborate with colleagues and leadership to establish technical standards Help plan and execute experimental strategies Requirements Background in reproductive biology and molecular biology Hands-on experience in IVF or embryology laboratory environments Proficiency in molecular biology techniques Strong attention to detail and ability to work with sensitive human samples Adaptable and comfortable working across different scientific areas Collaborative approach suited to an early-stage startup team

Imagine... being part of an innovative organization that cultivates and develops life sciences companies dedicated to pioneering groundbreaking technologies aimed at revolutionizing health care and sustainability. Company Overview Expedition Medicines is a dynamic, privately held, early-stage biotechnology company at the forefront of the Protein Editing field. We specialize in creating small molecules that modify protein structure and function to target currently undruggable options across various therapeutic strategies. Our advanced platform combines cutting-edge small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to facilitate generative design. Backed by Flagship Pioneering, we leverage their vision, courage, and resources to propel Expedition Medicines from platform validation to impactful patient solutions. We seek passionate, collaborative, and determined problem solvers to join our mission! Role Overview: The Senior/Principal Scientist in Structural Biology will concentrate on determining protein-ligand complex structures using X-ray crystallography and cryo-electron microscopy (cryo-EM). This role involves delivering structural insights and collaborating with project teams to advance structure-based drug design and uncover the mechanisms of action of small molecules. Key Responsibilities: Design and implement structural biology strategies for multiple projects. Oversee the design, expression, and purification of protein constructs for structural determination. Develop and execute protocols to achieve high-quality crystals for X-ray crystallography. Create and implement protocols for grid optimization, data collection, and analysis in cryo-EM. Refine and communicate structures of protein-ligand complexes, collaborating with project teams to drive hit-to-lead and lead optimization processes. Manage contract research organizations (CROs) to ensure efficient delivery of protein expression and structural biology services. Enhance our capabilities and serve as a trusted authority in the field of structural biology.

GT Biosciences is on the cutting edge of biotechnology, developing Deliveromics, the world’s first AI-driven, high-throughput, multiplexed in vivo data engine designed to decode the complexities of drug delivery. Established by a team of MIT scientists and supported by elite investors, we are pioneering next-generation, non-viral, cell-type-specific delivery vehicles, achieving notable advancements in crossing the blood-brain barrier and targeting specific brain cell types. Our dedicated and fast-paced team is committed to revolutionizing routine in vivo cell reprogramming.We are seeking a passionate and skilled Spatial Biology Platform Scientist to join our Platform Development Team. In this pivotal role, you will leverage your extensive knowledge in spatial biology, nucleic acid sequencing, and assay development to enhance our Deliveromics platform. As an early member of our scientific team, your collaborative efforts across biology, chemistry, and engineering will be crucial in generating high-quality data and insights driving our innovations. This full-time, in-person position is based in Cambridge, MA.

We are seeking a passionate and detail-oriented Scientist I to join our innovative team at Integrated Resources Inc. This entry-level position offers a fantastic opportunity to contribute to groundbreaking research and development projects. You will work closely with experienced scientists to support various laboratory activities, including experimental design, data collection, and analysis.

Role overview Eurofins Scientific seeks an Associate Scientist in Cambridge with a focus on molecular biology and protein purification. This role supports ongoing research projects and daily laboratory operations, working closely with experienced scientists in a well-equipped environment. Key responsibilities Perform experiments in molecular biology and protein purification Manage laboratory workflows to ensure accuracy and reliability Work collaboratively with team members on research projects Support initiatives that advance scientific knowledge Work environment The position is based in a modern laboratory with advanced equipment and a team of specialists. Daily work involves hands-on research and collaboration within a supportive scientific community.

We are seeking a motivated and detail-oriented Scientist I to join our dynamic team in Cambridge. The ideal candidate will have a strong background in scientific research, with a passion for innovation and problem-solving. This entry-level role offers an exciting opportunity to contribute to groundbreaking projects and advance your career in a collaborative environment.

Join our team as an In-vitro Pharmacologist, where you will contribute to groundbreaking research in pharmacology. This entry-level position offers you the opportunity to work with a dynamic team in a fast-paced environment, focusing on the development and optimization of in-vitro assays. You will play a crucial role in advancing drug discovery efforts, collaborating with scientists to design experiments that provide valuable insights into drug efficacy and safety.

Join our innovative team as an In Vitro Pharmacologist at Artech Information Systems LLC, located in the vibrant city of Cambridge, Massachusetts. In this exciting contract role, you will leverage your expertise in pharmacology to conduct in vitro studies that contribute to drug development and therapeutic solutions. The ideal candidate will be passionate about advancing scientific research and possess a strong background in pharmacological techniques.

Join the esteemed team at Harvard University as a Research Assistant I in the Department of Molecular and Cellular Biology. This full-time position offers an exciting opportunity to contribute to groundbreaking research in the sciences. You will assist in various research projects, working closely with senior researchers to gather and analyze data, prepare reports, and participate in laboratory activities.

Your Impact at Lila In this pivotal role, you will spearhead the innovation and validation of advanced pooled assays utilizing mammalian cells. Your work will encompass everything from proof of concept to automated screening processes, enabling the generation of intricate, high-dimensional datasets. This position involves collaboration across cell biology, protein design, and nucleic acid teams to facilitate biologic development programs, focusing on the rapid assessment of binding, stability, function, and immunogenicity of diverse biologics. What You'll Be Building Create next-generation mammalian display-based assays for binding, stability, function, and immunogenicity. Implement cutting-edge multiomic, single-cell, and in situ sequencing workflows to design innovative, highly multiplexed assays. Collaborate with protein design, nucleic acid, and automation teams to leverage these workflows in biologics development. Closed-Loop Experimentation and Execution: Work closely with engineering and automation teams to architect automated, high-throughput experimentation platforms that yield data-rich workflows. Join forces with the AI team to conduct iterative experiments in real time, facilitating rapid optimization and discovery cycles. Collaborate, Lead & Communicate: Engage with cell biologists, synthetic biologists, automation engineers, protein design scientists, and data scientists to document systems, share insights, and refine best practices in autonomous science. Mentor junior scientists, align project milestones with internal and external collaborators, contribute to intellectual property and publications, and present findings across the organization. What You’ll Need to Succeed Ph.D. in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, Immunology, or a related discipline (or M.S./B.S. with 5–8+ years of relevant industry experience). Proficiency in the development and/or application of mammalian display or similar pooled mammalian systems (perturb-seq, MPRA, etc.). Experience in designing, executing, and analyzing single-cell, in situ, or multiomic sequencing experiments. Expertise in creating complex libraries of defined sequences in mammalian cells. Experience in designing, executing, and analyzing flow cytometry and sorting experiments. Familiarity with next-generation sequencing (NGS) based experimental design and analysis.

Our MissionAt Altos Labs, our mission is to rejuvenate cell health and resilience, aiming to reverse diseases, injuries, and the associated disabilities that arise throughout life.For further details, visit our website at altoslabs.com.Our ValuesWe embrace a singular value at Altos: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe hold a firm belief that diverse perspectives are crucial to scientific advancement and inquiry. At Altos, outstanding scientists and industry leaders collaborate from across the globe to further our shared mission. We prioritize creating a sense of belonging, ensuring that every employee feels valued for their unique contributions. We are collectively responsible for maintaining a diverse and inclusive workplace.Your Contributions to AltosIn the role of Senior or Principal Machine Learning Scientist, you will be instrumental in the development of generative AI/ML models for multi-modal, multiscale biology, spanning from virtual cells to agentic target assessment. We seek a hands-on, innovative, and collaborative individual to join our multidisciplinary team of scientists and engineers dedicated to transforming the treatment of aging and disease. The ideal candidate will flourish in a dynamic environment that values teamwork, transparency, scientific excellence, originality, rigor, and integrity.

Flagship Pioneering, Inc. is seeking a Senior Research Associate in Chemical Biology for its FL116 team in Cambridge, MA. FL116 is dedicated to advancing biomolecule synthesis and is building a platform to transform the manufacturing of research, diagnostic, and therapeutic molecules. Role overview This position joins a collaborative group focused on applying chemical strategies to biological questions. The work centers on enzyme-mediated biomolecular synthesis, with careful attention to both mechanistic and molecular aspects. Main responsibilities Design and execute high-throughput experiments to investigate enzyme-substrate interactions Characterize biomolecular products using a range of established and new analytical methods Contribute to the development of scalable assays that support the growth of the platform Requirements Strong hands-on experimental skills and a close attention to detail Curiosity about the chemical nature of biological systems Interest in manipulating and measuring biological activity at the molecular scale Comfort working in an execution-focused, pipeline-driven environment Motivation to develop with a rapidly evolving technology platform Work environment The role provides the opportunity to deepen expertise at the intersection of chemistry and biology in a collaborative startup setting, supported by Flagship Pioneering. The team values problem solvers who enjoy tackling complex scientific challenges and building new tools for biotechnology and therapeutics.

Join AbbVie, a global biopharmaceutical company, as a Senior Scientist I in our Neuroscience division specializing in Biologics Screening. In this role, you will lead innovative research efforts to develop therapies that address unmet medical needs in the field of neuroscience.

Role Overview Flagship Pioneering, Inc. is on the lookout for a visionary Senior/Executive Director to serve as the Head of Biology. In this pivotal role, you will spearhead the biological strategy and target validation within our causality-driven discovery platform. Your expertise will be essential in converting human genetic data—such as GWAS, rare variants, Mendelian randomization, and functional genomics—into robust biological validations that are pertinent to disease, while also shaping preclinical programs across a range of therapeutic areas. The ideal candidate will possess extensive target validation experience across various therapeutic modalities, with a strong emphasis on neurodegenerative diseases (including Parkinson’s disease), genomic perturbation tools, and the capability to make significant contributions to cardiovascular and immune-mediated biology. You will be responsible for building and mentoring an exceptional biology team, establishing high standards for scientific rigor and decision-making quality, and collaborating closely with data science, chemistry, and platform operations to progress targets to development readiness.

Join our innovative team as a Senior Scientist where you'll drive critical research projects and make a significant impact in the field. We are seeking a highly motivated individual with a passion for scientific discovery and a strong background in relevant disciplines.

Join Integrated Resources Inc. as an Associate Scientist I, where you will contribute to innovative scientific research and development projects. As a pivotal part of our team, your role will involve conducting experiments, analyzing data, and collaborating with multidisciplinary teams to advance our scientific objectives.